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Nanoengineered hydrogels as 3D biomimetic extracellular matrix with injectable and sustained delivery capability for cartilage regeneration

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Bioactive Materials 2023年第1期19卷 487-498页

作者： Penglei Cui Panpan Pan Ling Qin Xinluan Wang Xiaodong Chen Yonghui Deng xiaoling zhang Department of Orthopedic Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200092People’s Republic of China Department of Chemistry Fudan UniversityShanghai200433People’s Republic of China Translational Medicine R&D Center Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518057People’s Republic of China Department of Spine Surgery Beijing Jishuitan HospitalPeking University Fourth School of Clinical MedicineBeijing100035People’s Republic of China

The regeneration of articular cartilage remains a great challenge due to the difficulty in effectively enhancing spontaneous ***,the combination of implanted stem cells,suitable biomaterials and bioactive molecules has attracted attention for tissue *** this study,a novel injectable nanocomposite was rationally designed as a sustained release platform for enhanced cartilage regeneration through integration of a chitosan-based hydrogel,articular cartilage stem cells(ACSCs)and mesoporous SiO_(2)nanoparticles loaded with anhydroicaritin(AHI).The biocompatible engineered nanocomposite acting as a novel 3D biomimetic extracellular matrix exhibited a remarkable sustained release effect due to the synergistic regulation of the organic hydrogel framework and mesopore channels of inorganic mSiO_(2)nanoparticles(mSiO_(2)NPs).Histological assessment and biomechanical tests showed that the nanocomposites exhibited superior performance in inducing ACSCs proliferation and differentiation in vitro and promoting extracellular matrix(ECM)production and cartilage regeneration in *** a novel multifunctional biocompatible platform was demonstrated to significantly enhance cartilage regeneration based on the sustained release of AHI,an efficient bioactive natural small molecule for ACSCs chondrogenesis,within the hybrid matrix of hydrogel and mSiO_(2)***,the injectable nanocomposite holds great promise for use as a 3D biomimetic extracellular matrix for tissue regeneration in clinical diagnostics.

关键词： Injectable nanocomposite Mesoporous silica 3D biomimetic extracellular matrix Sustained release of anhydroicaritin Cartilage regeneration

基于智慧物流理念的皮革企业“双中台”物流系统构建研究

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中国皮革 2024年第9期53卷 17-21页

作者：张晓玲程荣波唐荣芳唐荣文广西工业职业技术学院广西南宁530001 广西乔亿食品加工有限责任公司广西玉林537025

针对大中型皮革企业生产过程中物流管理业务量大、数据类型丰富及时效性要求较高等问题,借鉴“互联网+”与智慧物流等新型理念构建一种针对大中型皮革企业的智慧物流体系。该体系由业务中台和数据中台搭建而成,“双中台”的设计方式能... 详细信息

针对大中型皮革企业生产过程中物流管理业务量大、数据类型丰富及时效性要求较高等问题,借鉴“互联网+”与智慧物流等新型理念构建一种针对大中型皮革企业的智慧物流体系。该体系由业务中台和数据中台搭建而成,“双中台”的设计方式能够很好地解决皮革企业物流业务响应慢、重复操作多及“数据孤岛”等问题,有效提升企业物流系统工作效率。

关键词： “互联网+” 皮革企业业务中台数据中台智慧物流

THR mRNA、ALCAT1在甲亢性心脏病中的协同诊断作用

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检验医学 2024年第1期39卷 60-67页

作者：张晓玲金瑶李素芳彭海英张家口市妇幼保健院内一科河北张家口075001

目的探讨甲状腺激素受体(THR)mRNA、心磷脂酰基转移酶1(ALCAT1)在甲亢性心脏病中的临床意义。方法选取2020年2月—2022年3月张家口市妇幼保健院甲亢性心脏病患者69例(甲亢性心脏病组)、单纯甲状腺功能亢进患者69例(单纯甲亢组)、非甲亢... 详细信息

目的探讨甲状腺激素受体(THR)mRNA、心磷脂酰基转移酶1(ALCAT1)在甲亢性心脏病中的临床意义。方法选取2020年2月—2022年3月张家口市妇幼保健院甲亢性心脏病患者69例(甲亢性心脏病组)、单纯甲状腺功能亢进患者69例(单纯甲亢组)、非甲亢性心脏病患者69例(非甲亢性心脏病组)和健康体检者69名(正常对照组)。收集所有研究对象的一般资料和实验室检测结果,并检测THRα1 mRNA、THRβ1 mRNA和ALCAT1。采用Logistic回归分析评估甲亢性心脏病发生的危险因素。采用相对超危险度比(RERI)、归因比(AP)和交互作用指数(SI)分析THR mRNA、ALCAT1在甲亢性心脏病发生中的交互作用。采用受试者工作特征(ROC)曲线评价THR mRNA、ALCAT1诊断甲亢性心脏病的效能。结果甲亢性心脏病组THRβ1 mRNA相对表达量和ALCAT1水平高于单纯甲亢组(P<0.001),THRα1 mRNA、THRβ1 mRNA相对表达量和ALCAT1水平高于非甲亢性心脏病组、正常对照组(P<0.001)。单纯甲亢组THRα1 mRNA、THRβ1 mRNA相对表达量和ALCAT1水平高于非甲亢性心脏病组、正常对照组(P<0.05),非甲亢性心脏病组THRα1 mRNA、THRβ1 mRNA相对表达量和ALCAT1水平高于正常对照组(P<0.05)。多因素Logistic回归分析结果显示,校正甲状腺功能亢进病程、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)、总三碘甲状腺原氨酸(TT_(3))、总甲状腺素(TT_(4))后,THRβ1 mRNA相对表达量和ALCAT1水平升高是甲亢性心脏病发生的危险因素[比值比(OR)值分别为3.185、3.712,95%可信区间(CI)分别为1.524~6.658、1.967~7.006,P<0.001]。THRβ1 mRNA与ALCAT1对甲亢性心脏病的发生存在正向交互作用,二者均高表达时甲亢性心脏病风险是二者均低表达时的9.000倍;二者同时高表达时甲亢性心脏病风险是其他未知因子(其OR=1)的3.148倍(RERI=3.148);协同效应是二者单独存在产生效应之和的1.855倍(SI=1.855);在二者共存的甲亢性心脏病风险中,有34.98%(AP=34.98%)由二者交互作用引起。ROC曲线分析结果显示,THRβ1 mRNA、ALCAT1单项检测和联合检测诊断甲亢性心脏病的曲线下面积(AUC)分别为0.798、0.726、0.872。结论THRβ1 mRNA、ALCAT1是甲亢性心脏病的独立危险因素,且对甲亢性心脏病的发生具有协同促进作用,二者联合检测可提升对甲亢性心脏病的诊断效能。

关键词：甲状腺激素受体心磷脂酰基转移酶1 甲亢性心脏病交互作用

Integrated Active Suspension and Anti-Lock Braking Control for Four-Wheel-Independent-Drive Electric Vehicles

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 87-98页

作者： Ze Zhao Lei zhang xiaoling Ding Zhiqiang zhang Shaohua Li Liang Gu National Engineering Research Center for Electric Vehicles Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang 050043China

This paper presents an integrated control scheme for enhancing the ride comfort and handling performance of a four-wheel-independent-drive electric vehicle through the coordination of active suspension system(ASS)and anti-lock braking system(ABS).First,a longitudinal-vertical coupled vehicle dynamics model is established by integrating a road input *** the coupling mechanisms between longitudinal and vertical vehicle dynamics are *** ASS-ABS integrated control system is proposed,utilizing an H∞controller for ASS to optimize load transfer effect and a neural network sliding mode control for ABS ***,the effectiveness of the proposed control scheme is evaluated through comprehensive tests conducted on a hardware-in-loop(HIL)test *** HIL test results demonstrate that the proposed control scheme can significantly improve the braking performance and ride comfort compared to conventional ABS control methods.

关键词： Four-wheel-independent-drive electric vehicles Active suspension system(ASS) Anti-lock braking system(ABS) Vertical-longitudinal vehicle dynamics

基于可变荧光统计法的藻类活体细胞密度宽范围检测实验

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光学学报 2024年第12期44卷 164-173页

作者：王勰殷高方赵南京胡翔黄朋马明俊徐敏甘婷婷杨瑞芳方丽张小玲王翔程钊中国科学技术大学安徽合肥230026 中国科学院合肥物质科学研究院安徽光学精密机械研究所中国科学院环境光学与技术重点实验室安徽合肥230031 安徽大学物质科学与信息技术研究院信息材料与智能感知安徽省实验室安徽合肥230601 安徽工程大学电气工程学院安徽芜湖241200

提出区间增益系数动态调整的可变荧光统计学分布检测方法,以可变荧光统计分析法为基础,随机抽样测量,统计可变荧光值的方差σ^(2)。分析不同细胞密度样本的可变荧光值方差σ^(2)与区间增益系数a之间的关系,利用区间增益系数动态调整方... 详细信息

提出区间增益系数动态调整的可变荧光统计学分布检测方法,以可变荧光统计分析法为基础,随机抽样测量,统计可变荧光值的方差σ^(2)。分析不同细胞密度样本的可变荧光值方差σ^(2)与区间增益系数a之间的关系,利用区间增益系数动态调整方法准确测量宽细胞密度范围内的活体藻细胞密度。实验结果表明,该方法对羊角月牙藻细胞密度检测上限达到4640 cells·mL^(-1),较原始方法提高了近200倍;蛋白核小球藻、羊角月牙藻、斜生栅藻和杜氏盐藻检测结果与显微镜分析法的检测结果具有较高的一致性,相关系数R2均在0.999以上,相对误差绝对值均小于20.00%;直接测量楯形多甲藻与羊角月牙藻的混合藻种,检测结果与显微镜分析法的检测结果也具有较高的一致性,相对误差绝对值均小于20.00%。

关键词：海洋光学可变荧光活体藻细胞密度检测区间增益系数动态调整

Selenization of cotton products with NaHSe endowing the antibacterial activities

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Chinese Chemical Letters 2022年第1期33卷 205-208页

作者： Mingxuan Liu xiaoling zhang Sainan Chu Yanyu Ge Tao Huang Yonghong Liu Lei Yu School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China School of Pharmacy Nantong UniversityNantong 226001China

Selenization reaction with the in situ prepared NaHSe has been successfully developed to occur in aqueous *** technique affords a method to upload the bioactive Se element on cotton products in semi-industrial *** antibacterial tests revealed that the selenized cotton possessed a potent and prolonged antimicrobial effect against both Gram-positive *** and Gram-negative *** *** work discloses a practical method for preparing the selenium-containing antibacterial materials concisely and directly with industrial application potential.

关键词： Selenium Carbohydrate Cotton Selenization Antibacterial material

Uncovering the mysterious identity of Taisui——an old Chinese folk legend

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Science China(Life Sciences) 2020年第12期63卷 1942-1945页

作者： Erwei Li Jinwei Ren Qian Chen Hanxing zhang Bin Lin Hui zhang Shumin zhang xiaoling zhang Lei Cai Xingzhong Liu State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of Microbiology College of Life SciencesNankai UniversityTianjin 300071China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China

Dear Editor,Taisui(太岁) has attracted great attention in China because it has been described in ancient Chinese texts as an entity possessing mysterious properties. In Chinese mythology and folklore, Jupiter is the God of the "Sui"(year) and is worshiped in Daoism. Jupiter appears at the same location in the sky approximately every 12 years(Jupiter’s orbit is11.86 years). However, since each cycle of Jupiter lasts for exactly 11.86 years and one Chinese year cycle comprises exactly 12 years, after approximately 84.7 years, Jupiter travels one cycle more than the number of cycles assumed by the ancient Chinese, which is called Taisui. According to the belief of the ancient Chinese, people are alerted when Taisui is digging in the ground, foretelling the destruction of houses or occurrence of natural disasters, such as floods and earthquakes(Zhao et al., 2018).

关键词： Jupiter floods cycle

PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation

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Journal of Molecular Cell Biology 2020年第1期12卷 55-70页

作者： Xiaoying Zhao Penglei Cui Guoli Hu Chuandong Wang Lei Jiang Jingyu Zhao Jiake Xu xiaoling zhang Department of Orthopedic Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China The Key Laboratory of Stem Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200025China School of Pathology and Laboratory Medicine University of Western AustraliaPerthWestern Australia6009Australia Key Laboratory of Tibetan Medicine Research Northwest Plateau Institute of BiologyChinese Academy of SciencesXining 810001China

PIP5k1βis crucial to the generation of phosphotidylinosotol(4,5)***5k1βparticipates in numerous cellular activities,such as B cell and platelet activation,cell phagocytosis and endocytosis,cell apoptosis,and cytoskeletal *** the present work,we aimed to examine the function of PIP5k1βin osteoclastogenesis and osteogenesis to provide promising strategies for osteoporosis prevention and *** discovered that PIP5k1β deletion in mice resulted in obvious bone loss and that PIP5k1β was highly expressed during both osteoclast and osteoblast *** of the gene was found to enhance the proliferation and migration of bone marrow-derived macrophage-like cells to promote osteoclast ***5k1β-/-osteoclasts exhibited normal cytoskeleton architecture but stronger resorption ***5kip deficiency also promoted activation of mitogen-activated kinase and Akt signaling,enhanced TRAF6 and c-Fos expression,facilitated the expression and nuclear translocation of NFATC1,and upregulated Grb2 expression,thereby accelerating osteoclast differentiation and ***,PIP5k1β enhanced osteoblast differentiation by upregulating master gene expression through triggering smad1/5/8 ***,PIP5k1βmodulates bone homeostasis and remodeling.

关键词： PIP5k1β osteoclast differentiation osteoblast differentiation proliferation migration NFATC1

糖尿病胰岛素抵抗患者达格列净治疗决策用药方案的构建及应用实践

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糖尿病新世界 2024年第4期27卷 63-66页

作者：张晓玲肖晓琳颜昕冯惠平福建医科大学附属漳州市医院药学部福建漳州363000 福建医科大学附属漳州市医院乳腺外科福建漳州363000

目的探讨糖尿病胰岛素抵抗患者达格列净治疗决策用药方案的构建及应用实践效果。方法选取2022年3月—2023年4月福建医科大学附属漳州市医院外科收治的78例糖尿病胰岛素抵抗患者为研究对象,按照摸球法采用1∶1分配原则,将患者分为观察组... 详细信息

目的探讨糖尿病胰岛素抵抗患者达格列净治疗决策用药方案的构建及应用实践效果。方法选取2022年3月—2023年4月福建医科大学附属漳州市医院外科收治的78例糖尿病胰岛素抵抗患者为研究对象,按照摸球法采用1∶1分配原则,将患者分为观察组与对照组,各39例。对照组采用常规的用药模式,观察组采用治疗决策用药方案,比较两组的治疗效果。结果与对照组相比,观察组治疗总有效率较高,差异有统计学意义(P<0.05)。观察组的血糖相关水平以及胰岛功能优于对照组,差异有统计学意义(P均<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论基于治疗决策用药方案,对糖尿病抵抗患者增加达格列净药物的治疗效果较为显著,能够在一定程度上改善患者的血糖水平以及提高治疗效果,改善患者的胰岛功能以及减少不良反应的发生。

关键词：糖尿病胰岛素抵抗胰岛功能达格列净用药方案

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