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新型BCL-2抑制剂的设计、合成及活性评价

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山东化工 2024年第10期53卷 8-12页

作者：杨柳王心悦高安慧刘晓玲白海云沈阳药科大学无涯创新学院辽宁沈阳110016 长三角药物高等研究院江苏南通226133 百极弘烨(南通)医药科技有限公司江苏南通226133

通过研究BGB-11417与靶蛋白结合的相互作用,创造性的在P2口袋引入并环,合成了6个结构新颖的BCL-2抑制剂,产物经1H NMR和MS确证。以时间分辨荧光共振能量转移法(TR-FRET)测定目标化合物对BCL-2蛋白及BCL-2突变蛋白G101V和D103Y的体外抑... 详细信息

通过研究BGB-11417与靶蛋白结合的相互作用,创造性的在P2口袋引入并环,合成了6个结构新颖的BCL-2抑制剂,产物经1H NMR和MS确证。以时间分辨荧光共振能量转移法(TR-FRET)测定目标化合物对BCL-2蛋白及BCL-2突变蛋白G101V和D103Y的体外抑制活性。活性结果表明化合物A、化合物B和化合物D对BCL-2及其突变蛋白G101V和D103Y有较好的抑制活性,可为合成活性更高的BCL-2抑制剂提供参考。

关键词： BCL-2抑制剂合成抗肿瘤活性

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Microbial phenolic metabolites 3-(3',4'-dihydroxyphenyl)propanoic acid and 3',4'-dihydroxyphenylacetic acid prevent obesity in mice fed high-fat diet

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Food Science and Human Wellness 2024年第1期13卷 327-338页

作者： Wanbing Chen Ruonan Liu xiaoling Zhu Qun lu Hong Yang Rui Liu College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430000China Key Laboratory of Environment Correlative Dietology(Huazhong Agricultural University) Ministry of educationWuhan 430000China Wuhan Engineering Research Center of Bee Products on Quality and Safety Control Wuhan 430000China Key Laboratory of Urban Agriculture in Central China Ministry of Agriculture and Rural AffairsWuhan 430000China Hubei Provincial Institute for Food Supervision and Test Wuhan 430070China

Obesity is associated with numerous metabolic disorders,and dietary polyphenols have been confirmed to have beneficial effects on the metabolism in ***,the effect of 3-(3’,4’-dihydroxyphenyl)propanoic acid(DHPA)and 3’,4’-dihydroxyphenylacetic acid(DHAA),two main metabolites of dietary polyphenols,on obesity remains poorly *** this study,DHPA and DHAA were found to alleviate obesity,as well as regulate insulin resistance,lipid metabolism,and oxidative stress response in high-fat diet(HFD)***,the 16S rRNA sequencing and UHPLC-Q-TOF/MS demonstrated that DHPA and DHAA only slightly disturbed the intestinal microbiome,but significantly altered the urine metabolome of HFD mice mainly by regulating pentose and glucuronate interconversion,tyrosine metabolism,pentose phosphate and tricarboxylic acid(TCA)cycle as indicated by metabolic pathway analysis based on Kyoto Encyclopedia of Genes and Genomes(KEGG)*** analysis revealed that the differential metabolites are strongly associated with body weight,blood glucose,insulin level,and superoxide dismutase(SOD)enzyme *** results revealed that DHPA and DHAA exert their anti-obesity effect by regulating important metabolites in the glucose,lipid and tyrosine metabolism pathways.

关键词： Obesity Dietary polyphenol metabolites Gut microbiota Metabonomics

Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cell Fusion Vaccine Synergistically Inhibit the Growth of Hepatocellular Carcinoma in Mice

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Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanop...

Stationary patterns for a Leslie-Gower type three species model with diffusion

第十一届全国免疫学学术大会

作者： lu xiaoling Guangxi Medical University immunization

Objective: Preparing folate(FA)-modified chitosan nanoparticles carrying mouse interferon-induced protein-10(mIP-10) gene(FA-chitosan/m IP-10) and explored the effect of combination of FA-chitosan/m IP-10 and DC/tumor cell fusion vaccine against hepatocellular carcinoma(HCC) and investigated its underlying mechanisms. Methods: Mouse IP-10 plasmid was encapsulated into FA-chitosan to obtain FA-chitosan/m IP10 by complex *** transform infrared spectroscopy(FTIR) were to evaluate the production of mannoselipid. Dynamic light scattering instrument(DLS) and scanning electron microscope(SEM) were to characterize the size, morphology, zeta potential of FA chitosan/m IP10. The gel retardation assay was to ensure that IP-10 plasmid was successfully encapsulated into the conjugated compounds of FA-chitosan. The phagocytosis experiment confirmed the specifically targeting to Hepa1-6 of FA-chitosan. We employed a mouse model of Hepa1-6 in C57BL/6 mice, and subcutaneous injection of FA-chitosan/m IP10 and DC2.4/Hepa1-6 fusion cells was applied to treat HCC in mice and measured tumor growth and mouse survival. Then using flow cytometry to measure the frequency of CXCR3+CD8T cells and myeloid-derived suppressor cells(MDSCs). Enzyme-linked immunospot assay(ELISPOT) were used to measure the levels of interferongamma(IFN-γ). And the IP-10 protein expression of local tumor vascular, density, proliferation, and apoptosis of tumor cells were evaluated using immunological histological chemistry staining. Results: Our results showed that combination of FA-chitosan/IP-10 and DC/tumor fusion vaccine effectively inhibited the growth of implanted HCC tumors and prolonged the survival of mice. Furthermore, the combination therapy significantly reduced Myeloid-derived suppressor cell(MDSC) in mouse spleen, local tumor, and bone marrow, but increased tumor-specific IFN-γ responses in mice. And the combination therapy significantly inhibited tumor cell proliferation while promoti

关键词： DC/tumor fusion cell vaccines interferon-induced protein-10 folic acid chitosan

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International Journal of Biomathematics 2014年第6期7卷 167-183页

作者： Guangping Hu xiaoling Li Shiping lu School of Mathematics and StatisticsNanjing University of Information Science and Technology Nanjing Jiangsu 210044 P. R. China

In this paper, a diffusive three species predator prey model with two Leslie--Cower terms is considered. The stability of the unique positive constant equilibrium for the reaction- diffusion system is obtained. Sufficient conditions are derived for the global stability of the positive constant equilibrium. In particular, we establish the existence and nonexistence of non-constant positive steady states of this system. The results indicate that the large diffusivity is helpful for the appearance of the non-constant positive steady states （stationary patterns）.

关键词： Diffusion predator-prey system priori estimates non-constant positivesteady state.

Strong Interaction Between Redox Mediators and Defect-Rich Carbons Enabling Simultaneously Boosted Voltage Windows and Capacitance for Aqueous Supercapacitors

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Energy & Environmental Materials 2024年第4期7卷 269-276页

作者： lu Guan Yifan Zhu Yi Wan Mengdi Zhang Qiang Li xiaoling Teng Yunlong Zhang Hao Yang Yan Zhang Han Hu Mingbo Wu State Key Laboratory of Heavy Oil Processing College of Chemical Engineering China University of Petroleum (East China) College of Physics University-Industry Joint Center for Ocean Observation and Broadband Communication Qingdao University

Energy density,the Achilles'heel of aqueous supercapacitors,is simultaneously determined by the voltage window and specific capacitance of the carbon materials,but the strategy of synchronously boosting them has rarel... 详细信息

关键词： defect-rich carbons redox mediators strong interaction supercapacitors voltage windows

基于时域特征的角位移传感器信号线间串扰方法研究

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传感技术学报 2021年第9期34卷 1211-1215页

作者：卢晓玲安徽汽车职业技术学院机电工程系安徽合肥230601

传统串扰方法计算得到的数据时域特征较弱,难以应用到不同的信号线间串扰问题分析中,为此提出基于时域特征的角位移传感器信号线间串扰方法。根据串扰基本原理,提取角位移传感器参数特性,通过相敏检波计算信号频率差异值,得到角位移传... 详细信息

传统串扰方法计算得到的数据时域特征较弱,难以应用到不同的信号线间串扰问题分析中,为此提出基于时域特征的角位移传感器信号线间串扰方法。根据串扰基本原理,提取角位移传感器参数特性,通过相敏检波计算信号频率差异值,得到角位移传感器信号的时域特征,构建基于时域特征的串扰模型。设置单线、绞线以及屏蔽线三组不同的信号线,利用本文提出的方法和传统方法获取串扰数据。实验结果表明,两组方法可以获得角位移传感器与单线间的串扰;当端接电阻值增大到100Ω时,本文方法能够获得角位移传感器与绞线间的串扰;当测试角位移传感器与屏蔽线间的串扰时,本文方法可以获得具有对称性质的近端与远端串扰波形。

关键词：角位移传感器信号线间串扰方法时域特征串扰数据

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原发性外耳道癌30例手术治疗及疗效分析

中国眼耳鼻喉科杂志 2024年第5期24卷 427-433页

作者：李亦蒙王雪乔吴净芳赵卫东梅红林鲁小玲王镜涵倪玉苏复旦大学附属眼耳鼻喉科医院耳鼻咽喉头颈外科上海200031 复旦大学附属金山医院耳鼻咽喉头颈外科上海201508 复旦大学附属眼耳鼻喉科医院神经外科上海200031

目的分析30例原发性外耳道癌的手术治疗方式及临床疗效。方法回顾分析2011年11月—2022年1月手术治疗的30例外耳道癌患者的临床资料。总结治疗要点,分析并评价术后1~5年肿瘤特异生存率(TSS)及无瘤生存率(TFS),观察术后并发症。结果30例... 详细信息

目的分析30例原发性外耳道癌的手术治疗方式及临床疗效。方法回顾分析2011年11月—2022年1月手术治疗的30例外耳道癌患者的临床资料。总结治疗要点,分析并评价术后1~5年肿瘤特异生存率(TSS)及无瘤生存率(TFS),观察术后并发症。结果30例患者中,鳞癌15例、腺癌(腺样囊性癌、耵聍腺癌、汗腺癌)15例。鳞癌组1年、3年、5年TSS分别为92.3%、84.6%、84.6%,TFS分别为92.3%、84.6%、84.6%。腺癌组1年、3年、5年TSS均为100%,TFS分别为92.3%、84.6%、76.9%。术后切口感染2例,一过性后组脑神经麻痹1例,经过治疗后均康复。结论彻底的手术治疗及辅助放化疗治疗外耳道癌效果良好,术后并发症可控。

关键词：外耳道癌颞骨外侧切除颞骨次全切除生存率

Dihydrochalcones and phenanthrene derivatives from Fissistigma bracteolatum

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Journal of Medical Colleges of PLA(China) 2010年第4期25卷 226-234页

作者： Zhu Hongping lu xiaoling Sun Xiaohong Xu Qiangzhi Jiao Binghua Department of Biochemistry and Molecular Biology College of Basic Medical Sciences Second Military Medical University Shanghai 200433 China

Three dihydrochalcones derivatives 1-3, flavone 4 and phenanthrene derivative 5 were isolated, together with 9 known compofinds, from the air-dried root bark of Fissistigma bracteolatum Chatterjee. Their structures we... 详细信息

关键词： Fissistigma Fissistigma bracteolatum Chatterjee Dihydrochalcone Phenanthrene

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美国信息素质教育的研究实施及其启示

情报杂志 2005年第6期24卷 111-113页

作者：卢小玲广州大学图书馆广州510006

介绍了美国信息素质教育的研究实施概况,分析了目前我国信息素质教育的现状及借鉴美国成功经验的启示。

关键词：信息素质教育美国成功经验