检索结果-南通市图书馆

Broad-spectrum ginsentides are principal bioactives in unraveling the cure-all effects of ginseng

Acta Pharmaceutica Sinica B 2024年第2期14卷 653-666页

作者： Shining Loo Antony Kam Bamaprasad Dutta Xiaohong Zhang Nan Feng Siu Kwan Sze Chuan-Fa Liu xiaoliang wang James P.Tam School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Institute of Materia Medica Chinese Academy of Medical SciencesBeijing 100050China Department of Health Sciences Brock UniversityNiagara RegionON L2S 3A1Canada

Stress and illness connection is complex and involves multiple physiological systems.Panax ginsengs,reputed for their broad-spectrum“cure-all”effect,are widely prescribed to treat stress and related illnesses.However,the identity of ginseng’s“cure-all”medicinal compounds that relieve stress remains unresolved.Here,we identify ginsentides as the principal bioactives that coordinate multiple systems to restore homeostasis in response to stress.Ginsentides are disulfide-rich,cell-penetrating and proteolytic-stable microproteins.Using affinity-enrichment mass spectrometry target identification together with in vitro,ex vivo and in vivo validations,we show that highly purified or synthetic ginsentides promote vasorelaxation by producing nitric oxide through endothelial cells via intracellular PI3K/Akt signaling pathway,alleviate a1-adrenergic receptor overactivity by reversing phenylephrine-induced constriction of aorta,decrease monocyte adhesion to endothelial cells via CD166/ESAM/CD40 and inhibit P2Y12 receptors to reduce platelet aggregation.Orally administered ginsentides were effective in animal models to reduce ADP-induced platelet aggregation,to prevent collagen and adrenalineinduced pulmonary thrombosis as well as anti-stress behavior of tail suspension and forced swimming tests in mice.Together,these results strongly suggest that ginsentides are the principal panacea compounds of ginsengs because of their ability to target multiple extra-and intra-cellular proteins to reverse stress-induced damages.

关键词： Ginseng Cysteine-rich peptides Microproteins Cure-all Stress Homeostasis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential pressure difference based altitude control of a stratospheric satellite

引用

High Technology Letters 2024年第1期30卷 1-12页

作者：陈丽 wang xiaoliang Flight College Shanghai University of Engineering ScienceShanghai 201620P.R.China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240P.R.China

An autonomous altitude adjustment system for a stratospheric satellite(StratoSat)platform is proposed.This platform consists of a helium balloon,a ballonet,and a two-way blower.The helium balloon generates lift to balance the platform gravity.The two-way blower inflates and deflates the ballonet to regulate the buoyancy.Altitude adjustment is achieved by tracking the differential pressure difference(DPD),and a threshold switching strategy is used to achieve blower flow control.The vertical acceleration regulation ability is decided not only by the blower flow rate,but also by the designed margin of pressure difference(MPD).Pressure difference is a slow-varying variable compared with altitude,and it is adopted as the control variable.The response speed of the actuator to disturbance can be delayed,and the overshoot caused by the large inertia of the platform is inhibited.This method can maintain a high tracking accuracy and reduce the complexity of model calculation,thus improving the robustness of controller design.

关键词： stratospheric satellite(StratoSat) differential pressure difference(DPD) altitude adjustment threshold switching strategy margin of pressure difference(MPD)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The use of electrokinetics promises a sustainable mining future

引用

The Innovation 2024年第3期5卷 17-18页

作者： Gaofeng wang xiaoliang Liang Jianxi Zhu Hongping He CAS Key Laboratory of Mineralogy and Metallogeny/Guangdong Provincial Key Laboratory of Mineral Physics and Material Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China University of the Chinese Academy of Sciences Beijing 100049China

Moving toward a zero-carbon economy is an ambitious goal of all human beings.Utilization of various metal resources plays a central role in such a transition.Rare earth elements(REEs),especially heavy REEs(HREEs),are crucial for the development of future green and zero-carbon economies due to their irreplaceable roles in many applications of renewable energy technologies;e.g.,solar panels,wind turbines,and hybrid vehicle batteries.Ion-adsorption rare earth deposits(IADs)are the primary repositories for HREEs and supply more than 95%of the global HREE demand.1 However,current mining technologies using excessive ammonium salts have caused devastating harm to the local environment while exhibiting a low recovery rate of REEs,a long mining period,and landslide risks.Since 2018,the adoption of ammonium salt-based techniques in REE mining has been prohibited,exacerbating the scarcity of REEs that could lead to disruptions of the supply chain.Moreover,metals are currently almost exclusively extracted from their ores via physical excavation or chemical leaching.These energy-intensive and environmentally damaging techniques remain among the foremost CO_(2) emitters.The mining industry is in desperate need of a new generation of mining technology.

关键词： mining replace earth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anti-inflammatory mechanism of the non-volatile ingredients performance liquid chromatography-heated electron spray ionization-high resolution mass spectroscope and cell metabolomics

引用

Journal of Traditional Chinese Medicine 2024年第2期44卷 260-267页

作者： JING Wenguang LIN Xiaoyu LI Chu ZHAO xiaoliang CHENG Xianlong wang Penglong WEI Feng MA Shuangcheng Institute of Control of Chinese Traditional Medicine and Ethnic Medicine National Institutes for Food and Drug ControlBeijing 102629China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To explore the anti-inflammatory components and mechanism of the non-volatile ingredients of patchouli.METHODS:High performance liquid chromatographyheated electron spray ionization-high resolution mass spectroscope(HPLC-HESI-HRMS)was used to analyze the chemical constituents of the non-volatile ingredients of patchouli.The anti-inflammatory activity of ingredients was evaluated using lipopolysaccharide(LPS)induced RAW264.7 cell inflammation model,and the antiinflammatory mechanism was investigated using multivariate statistical analysis of cell metabolomics.RESULTS:The non-volatile ingredients of patchouli were characterized by HPLC-HESI-HRMS,and 36 flavonoids and 18 other components were identified.These ingredients of patchouli not only had a good protective effect on the LPS-induced inflammation model of RAW264.7 cells,but also regulated the expression levels of arginine,L-leucine,cholesterol,fructose and sorbitol by down-regulating arginine metabolism,aminoacyl-tRNA biosynthesis,polyol/sorbitol pathway,so as to reduce inflammation and reduce cell damage.CONCLUSION:The non-volatile ingredients of patchouli had good anti-inflammatory effect and exerted its curative effect by regulating endogenous metabolic pathway to reduce inflammatory response.

关键词： Pogostemon non-volatile ingredients anti-inflammatory cell metabolomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sustainable management of campus fallen leaves through low-temperature pyrolysis and application in Pb immobilization

引用

Journal of Environmental Sciences 2024年第5期139卷 281-292页

作者： Rongli Tan Ke Li Yue Sun xiaoliang Fan Zhengtao Shen Lingyi Tang School of Environment Nanjing UniversityNanjing 210023China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China School of Earth and Engineering Sciences Nanjing UniversityNanjing 210023China Department of Earth and Atmospheric Sciences University of AlbertaEdmonton T6G 2E3Canada

Realizing campus sustainability requires the environmental-friendly and economical treatment of tremendous fallen leaves.Producing fallen leaf biochar at a low temperature is a candidate approach.In this study,six common types of fallen leaves on the campus were pyrolyzed at 300℃.The obtained biochars were characterized and the adsorption mechanisms of lead(Pb)by the fallen leaf biochars were investigated.The adsorption capacity of leaf biochar for Pb was relatively high,up to 209 mg/g(Yulania denudata leaf biochar).Adsorption of Pb onto active sites was the rate-limiting step for most leaf biochars.But for Platanus leaf biochar,intraparticle diffusion of Pb^(2+)dominated owing to the lowest adsorption capacity.However,the highest exchangeable Pb fraction(27%)indicated its potential for removing aqueous Pb^(2+).Ginkgo and Prunus cerasifera leaf biochar immobilized Pb by surface complexation and precipitation as lead oxalate.Hence,they were suitable for soil heavy metal remediation.This study shed the light on the sustainable utilization of campus fallen leaves and the application of fallen leaf biochars in heavy metal remediation.

关键词： Fallen leaves Waste management Biochar Lead removal Sorption Circular campus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure Recrystallization and Mechanical Properties of a Cold-Rolled TiNbZrTaHf Refractory High-Entropy Alloy

引用

Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 633-647页

作者： Chuan Rong Jieren Yang xiaoliang Zhao Ke Huang Ying Liu Xiaohong wang Dongdong Zhu Ruirun Chen College of Materials Science and Engineering Sichuan UniversityChengdu610065China Key Laboratory of Air-Driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou324000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

The equiatomic TiNbZrTaHf alloy was successfully rolled at room temperature with the reduction of ~ 85%. The microstructure and tensile properties were investigated after cold working and annealing. It was determined that the recrystallization temperature of the TiNbZrTaHf alloy between 850 and 900 ℃. Complete recrystallization and normal grain growth occurred, the high stability of single phase was maintained after annealing at 1000, 1200, and 1400 ℃. But the precipitated phase appeared after long term annealing, as seen after 500 h at 1000 ℃. After cold working, the tensile strength and the elongation of TiNbZrTaHf were 1137 MPa and 25.1%, respectively. The annealed alloy has a high tensile strength (σ_(b )= 863 MPa) and ductility (ε_(e )= 28.5%). Moreover, the oxidation of TiNbZrTaHf alloy at elevated temperatures has a significant impact on its mechanical properties. The poor oxidation resistance of TiNbZrTaHf can accelerate tensile failure by inducing fractures at grain boundaries.

关键词： Refractory high entropy alloy Cold rolling Recrystallization Oxidation resistance Mechanical properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preparation of Manganese Oxide and Its Adsorption Properties

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 1031-1040页

作者：贺跃王海峰 YANG Pan wang Song CHEN xiaoliang YANG Chunyuan 王家伟 School of Materials and Metallurgy Guizhou UniversityGuiyang 550025China Guizhou Provincial Engineering Technology Research Center of Manganese Materials for Batteries Tongren Guizhou 554300China Guizhou Provincial Key Laboratory of Metallurgical Engineering and Energy Saving Guiyang 550025China

The in-situ oxidation of manganese sulfate solution with H2O_(2),sodium hypochlorite,potassium permanganate and oxygen as oxidants was investigated by means of SEM,EDS,XRD,BET and infrared analysis,and the effects of different oxidants on the morphology,phase composition,surface properties and specific surface area of manganese oxides were investigated.The experimental results show that the diameter of manganese oxide particles prepared with H_(2)O_(2)is the smallest,about 50 nm,and the specific surface area is the largest,63.8764 m^(2)/g.It has the advantages of abundant surface hydroxyl groups,no introduction of other impurities and large adsorption potential.It is most suitable to be used as an oxidant for oxidizing manganese sulfate solution to prepare manganese oxide by in-situ oxidation.Nano manganese oxide prepard by H_(2)O_(2)in-situ oxidation method is used as adsorbent to adsorb cobalt and nickel impurities in manganese sulfate.When the reaction pH is 6,the reaction time is 30min and the amount of adsorbent is 1.0 g,the adsorption rates of cobalt and nickel impurities in 100ml manganese sulfate solution are 97.59%and 97.67%,respectively.The residual amounts of cobalt and nickel meet the industrial process standard of first-class products(Co,Ni w/%≤0.005)of high-purity manganese sulfate(Hg/t4823-2015)for batteries.The study plays a guiding role in the preparation and regulation of manganese oxide,and provides a new method with high efficiency,purity and adsorbent availability for the preparation of high-purity manganese sulfate solution.

关键词： manganese oxide in situ oxidation adsorbent regulation mechanism physical chemical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modulating the alloying mode in the doping-induced synthesis of Au-Pd nanowires

引用

Nano Research 2024年第4期17卷 3334-3343页

作者： Hui Jin xiaoliang Wei Lecheng Zhao Jialong Yu Qiao Pan Shumin Li Qian wang Zhaotong Yuan Dan Yang Donghui Zhao Hongyu Chen Yawen wang Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergistic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China School of Science Westlake UniversityHangzhou 310064China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310064China

Heterogeneous doping is one effective strategy for synthesizing metal alloy nanowires.Herein,the heterogeneous doping processes of Pd on the ultrathin Au nanowires were systematically modulated and investigated.Au-Pd alloy nanowires with various morphologies and lattice structures can be obtained by adjusting the morphology of the precursor Au nanowires and the kinetics of the heterogeneous doping processes.The effects of the rate of Pd reduction and the concentration of the ligand oleylamine(OAm)on the Pd deposition and alloying mode were articulated.Generally,as the Pd deposition rate decreases,the Pd deposition and alloying mode switches from the island-forming Stransky–Krastanov(SK)mode to the epitaxial Frank-van der Merwe(FM)mode,and eventually to an unconventional twisting alloying mode,where the interdiffusion of Pd and Au causes drastic rearrangement of the lattice structure and formation of helical structures.The kinetics-related variation of alloying mode could also be observed in the Au-Ag nanowires,demonstrating a general design principle for the synthesis of alloy nanostructures.In addition,the electrocatalytic performance of various Au-Pd nanowires was evaluated,and the alloy nanowire formed via the SK mode was found to be an excellent electrocatalyst for oxygen reduction and ethanol oxidation.

关键词： gold nanowires Au-Pd alloy oleylamine post-synthetic modification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solvent-free carbon sphere nanofluids towards intelligent lubrication regulation

引用

Friction 2024年第1期12卷 95-109页

作者： Sheng ZHANG Wen LI xiaoliang MA Xiaoqiang FAN Minhao ZHU Tribology Research Institute School of Mechanical EngineeringSouthwest Jiaotong UniversityChengdu 610031China Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

By simply switching the electrical circuit installed on steel/steel contact,the tribological behaviors of nanofluids(NFs)can be regulated in real time,thereby achieving the desired performance of friction reduction and wear resistance.Herein,solvent-free carbon spherical nanofluids(C-NFs)were successfully prepared for intelligent lubrication regulation.C-NFs with excellent lubrication performance can immediately reduce the coefficient of friction(COF)despite applying a weak electric potential(1.5 V).Moreover,polyethylene glycol 400(PEG400)containing 5.0 wt%C-NFs remained responsive to electrical stimulation under the intermittent voltage application with an average coefficient of friction(ACOF)reduction of 20.8%over PEG400.Such intelligent lubrication regulation of C-NFs under an external electric field(EEF)mainly depends on the orderly arranged double-electric adsorption film of ion canopy-adsorbed carbon spheres(CSs).The intermittent electrical application can continuously reinforce the adsorption film and its durability for real-time controlling the sliding interfaces.Electrical-stimulation-responsive intelligent lubricants provide a new technical support for realizing intelligent stepless control of devices.

关键词： solvent-free carbon spherical nanofluids(C-NFs) intelligent lubrication regulation lubrication performance adsorption film

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multifunctional electroactive bio-adhesive for robustly-integrated wound therapy and postoperative wound-status warning and assessment

引用

Nano Research 2024年第5期17卷 4359-4370页

作者： Ouyang Yue Xuechuan wang Mengdi Hou Siwei Sun Manhui Zheng xiaoliang Zou Zhongxue Bai Chunlin Liu Xinhua Liu College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXi’an 710021China College of Pharmacy Shaanxi University of Chinese MedicineXi’an 710021China Institute of Basic and Translational Medicine Xi’an Medical UniversityXi’an 710021China School of Mechanical Engineering Chengdu UniversityChengdu 610000China

Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures.The continuous treatment,healing induction,and real-time visualization of wound status and complications,including wound re-tearing,inflammation,and morphology,are key focal points for comprehensive healthcare.Herein,an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic double-layer gelatin-based bio-adhesive(DLGel)by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer chains.The subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue,providing a basis for reliable wound closure.DLGel achieves comprehensive wound-healing induction through electrical stimulation and possesses reversible underwater light/thermal adhesion,excellent hemostatic performance,outstanding antimicrobial properties,and self-repair capability.Furthermore,a novel deep-learning strategy is creatively established to respond to mechanical deformation due to wound anomalies.This strategy translates biological information into visual graphics,providing real-time early warning and assessment of postoperative wound-abnormality/-morphology,such as laceration,inflammation,and necrosis.Therefore,DLGel and its associated signal collection and processing protocol enable the integration of reliable wound closure,wound healing,and real-time postoperative wound-status warning and assessment within the unobservable and undetectable“black box”regions in a context of non-clinical comprehensive therapy.

关键词： electroactive bio-adhesive quadruple energy dissipation comprehensive wound therapy postoperative wound-status warning and assessment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：