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Electrochemical and colorimetric dual-signal detection of Staphylococcus aureus enterotoxin B based on AuPt bimetallic nanoparticles loaded Fe-N-C single atom nanocomposite

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Food Science and Human Wellness 2024年第4期13卷 2025-2035页

作者： Huan liang Hongcheng liu Haojian lin Guobao Ning xiaokang Lu Siying Ma Fei liu Hui Zhao Canpeng li School of Chemical Science and Technology Yunnan UniversityKey Laboratory of Medicinal Chemistry for Natural ResourceMinistry of EducationKunming 650091China Institute of Quality Standard and Testing Technology Yunnan Academy of Agricultural ScienceSupervision and Testing Center for Farm Product QualityMinistry of AgricultureKunming 650223China State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China Laboratory for Conservation and Utilization of Bio-resource Yunnan UniversityKunming 650091China

Sensitive detection of Staphylococcus aureus enterotoxin B(SEB)is of importance for preventing food poisoning from threatening human *** this work,an electrochemical and colorimetric dual-signal detection assay of SEB was *** probe(Ab2/AuPt@Fe-N-C)was bound to SEB captured by Ab1,where the Ab2/AuPt@Fe-N-C triggered methylene blue degradation and resulted in the decrease of electrochemical ***,the probe catalyzed the oxidation of 3,3’,5,5’-tetramethyl biphenyl to generate a colorimetric absorbance at 652 *** the target was captured and formed a sandwich-like complex,the color changed from colorless to *** detection by colorimetric and electrochemical methods showed a linear relationship in the concentration ranges of 0.0002-10.0000 and 0.0005-10.0000 ng/mL,with limits of detection of 0.0667 and 0.1670 pg/mL,*** dual-signal biosensor was successfully used to detect SEB in milk and water samples,which has great potential in toxin detection in food and the environment.

关键词： Staphylococcus aureus enterotoxin Electrochemical immunosensor Colorimetric assay MOF@borophene composite Dual-functional Fe-N-C signal atom catalyst

Late Mesozoic Exhumation of the Huangling Massif:Constraints on the Evolution of the Middle Yangtze River

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 250-264页

作者： SU Jianchao liN Xu li Chang’an Jolivet MARC WU lin CHENG Feng DENG Bin WU Zhonghai CHEN xiaokang HU Chengwei School of Geography and Information Engineering China University of GeosciencesWuhan 430074China College of Civil Engineering and Architecture China Three Gorges UniversityYichangHubei 443002China Géosciences Rennes CNRS-UMR6118Univ RennesRennesFrance State Key Laboratory of lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBejing 100029China Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing 100871China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation/Chengdu University of Technology Chengdu 100871China Institute of Geological Mechanics Chinese Academy of Geological ScienceBeijing 100081China

Plate subduction leads to complex exhumation processes on *** Huangling Massif lies at the northern margin of the South China *** the Huangling Massif was exhumed as a watershed of the middle reaches of the Paleo-Yangtze River during the Mesozoic remains under *** examined the exhumation history of the Huangling Massif based on six granite bedrock samples,using apatite fission track(AFT)and apatite and zircon(U-Th)/He(AHe and ZHe)*** samples yielded ages of 157–132 Ma(ZHe),119–106 Ma(AFT),and 114–72 Ma(AHe),*** modeling revealed that three phases of rapid cooling occurred during the Late Jurassic–Early Cretaceous,late Early Cretaceous,and Late *** exhumation processes led to the high topographic relief responsible for the emergence of the Huangling *** integrated of our new data with published sedimentological records suggests that the Huangling Massif might have been the watershed of the middle reaches of the Paleo-Yangtze River since the *** that time,the rivers flowed westward into the Sichuan Basin and eastward into the Jianghan *** subduction of the Pacific Plate beneath the Asian continent in the Mesozoic deeply influenced the geomorphic evolution of the South China Block.

关键词： apatite zircon (U-Th)/He fission track Huangling Massif Yangtze River

Regulating atomic Fe-Rh site distance for efficient oxygen reduction reaction

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Science China Chemistry 2024年第4期67卷 1352-1359页

作者： Tong liu Yudan Chen Airong Xu xiaokang liu Dong liu Sicheng li Hui Huang li Xu Shuaiwei Jiang Qiquan Luo Tao Ding Tao Yao National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Key Laboratory of Precision and Intelligent Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China

Exploring the atomic interaction mechanisms of dense single-atom catalysts(SACs)is of great significance for their application in oxygen reduction reaction(ORR).However,the intrinsic mechanism of the site-distance effect on the catalytic performance has been largely ***,we demonstrate the site-distance effect of Fe-Rh_(x)@NC catalysts in ORR theoretically and *** charge analysis reveals that the strong interaction between Fe and Rh atoms at a certain atomic distance(dFe-Rh)alters the catalytic electronic structure,facilitating the optimization of catalyst adsorption *** by the theoretical calculations,we designed and synthesized the Fe-Rhx@NC catalysts through a spatial confinement *** characterization results prove that the Fe-Rh_(2)@NC has the optimal d_(Fe-Rh),which improves its intrinsic ORR activity,providing a half wave potential of 0.91 V,higher than that of the commercial Pt/C(0.86 V).This study emphasizes the importance of determining the basic mechanism of the site-distance effect in dissimilar metal atoms catalysts,which is conducive to the design of efficient catalyst systems for practical applications.

关键词： Density functional theory single-atom catalyst in-situ encapsulating site-distance effect oxygen reduction reaction

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Direct intercellular communications dominate the interaction between adipose-derived MSCs and myofibroblasts aqainst cardiac fibrosis

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Protein & Cell 2015年第10期6卷 735-745页

作者： xiaokang li Hui Zhao Chunxiao Qi Yang Zeng Feng Xu Yanan Du Department of Biomedical Engineering School of Medicine Collaborative Innovation Center for Diagnosis and Treament of Infectious Diseases Tsinghua University Beijing 100084 China School of life Sciences Tsinghua University Beijing 100084 China MOE Key Laboratory Of Biomedical Information E~ngineering School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 China Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiao Tong University Xi'an 710049 China

The onset of cardiac fibrosis post myocardial infarction greatly impairs the function of heart. Recent advances of cell transplantation showed great benefits to restore myocardial function, among which the mesenchymal stem cells （MSCs） has gained much attention. However, the underlying cellular mechanisms of MSC therapy are still not fully understood. Although paracrine effects of MSCs on residual cardiomyocytes have been discussed, the amelioration of fibrosis was rarely studied as the hostile environment cannot support the survival of most cell populations and impairs the diffusion of soluble factors. Here in order to decipher the potential mecha- nism of MSC therapy for cardiac fibrosis, we investi- gated the interplay between MSCs and cardiac myofibroblasts （mFBs） using interactive co-culture method, with comparison to paracrine approaches, namely treatment by MSC conditioned medium and gap co-culture method. Various fibrotic features of mFBs were analyzed and the most prominent anti-fibrosis effects were always obtained using direct co-culture that allowed cell-to-cell contacts. Hepatocyte growth factor （HGF）, a well-known anti-fibrosis factor, was demonstrated to be a major contributor for MSCs＇ anti-fibrosisfunction. Moreover, physical contacts and tube-like structures between MSCs and mFBs were observed by live cell imaging and TEM which demonstrate the direct cellular interactions.

关键词： cardiac fibrosis stem cell therapy,adipose-derived mesenchymal stem cells myofibroblastscell-to-cell contact anti-fibrosis

Analysis on Three-Dimensional Gate Edge Roughness of Gate-All-Around Devices

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Chinese Journal of Electronics 2021年第5期30卷 861-865页

作者： SUN Shuang li Ming ZHANG Baotong li xiaokang CAI Qifeng li Haixia BI Ran XU Xiaoyan HUANG Ru Department of Micro-Nanoelectronics Peking University Beijing Laboratory of Future IC Technology and Science Peking University

As the physical size of metal-oxide-semiconductor field effect transistor approaches the end of scaling down, the effect of process-induced variations such as gate edge roughness on device performance cannot be neglected. For gate-all-around devices, the threedimensional gate profiles make the evaluation of gate edge roughness different and more complicated than that in planar metal-oxide-semiconductor field effect *** this work, an evaluation algorithm was proposed to model the three-dimensional gate edge roughness in a real gate-all-around device. The results show that the typical trapezoidal gate is more likely to suffer from gate edge roughness effect than the ideal rectangular gate. The effect of the size of the gate and the correlation coefficient of the edges on the effective channel length variation was also studied.

关键词： Insulated gate field effect transistors Semiconductor device modelling, equivalent circuits, design and testing Gate-all-around devices Trapezoidal gate profile Gate edge roughness Effective channel length Threshold voltage variation

A photomemory by selective-assembling hybrid porphyrin-silicon nanowire field-effect transistor

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Science China(Information Sciences) 2020年第6期63卷 253-255页

作者： Gong CHEN Bocheng YU xiaokang li Xiaoqiao DONG Xiaoyan XU Zhihong li Ru HUANG Ming li Key Laboratory of Microelectronic Devices and Circuits(MOE) Institute of MicroelectronicsPeking University National Key Laboratory of Science and Technology on Micro/Nano Fabrication Peking University Faculty of Information Technology Beijing University of Technology

Dear editor,Recently, the integration of photosensitive material and electronic nanodevice has been the center of attention with Internet of things (IoT)technology development [1–3]. The immobilization of such photoactive molecules on the semiconductor surface was necessarily adopted to employ their photoelectric characteristics which can be observed in the solution. Porphyrin-based hybrid transistors have emerged as promising candidates for photonic sensing application due to the

关键词： A photomemory by selective-assembling hybrid porphyrin-silicon nanowire field-effect transistor

Selective adsorption behaviors of guest molecules COR in the hexamer host networks at liquid/solid interface

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Chinese Chemical Letters 2021年第3期32卷 1077-1080页

作者： xiaokang li Jianqiao li Chunyu Ma Chen Chen Siqi Zhang Bin Tu Wubiao Duan Qingdao Zeng CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China Department of Chemistry School of ScienceBeijing Jiaotong UniversityBeijing 100044China Center of Materials Science and Optoelectonics Engineering University of Chinese Academy of SciencesBeijing 100049China

Here,the selective adsorption behaviors of guest molecule COR in two hexamer host grids were investigated by means of scanning tunnelling microscope(STM).The assembled structures of small functional organic molecules TTBTA and TATBA were thermodynamically ***,the introduction of the guest molecule COR destroyed the original hexamer structure of TTBTA and combined with it to form a new triangular host-guest *** from TTBTA,the introduction of the guest molecule COR did not affect the six-membered ring structure of ***,the co-assembly structure of TTBTA/TATBA/COR was established and the guest molecule COR showed preferential adsorption to the TATBA host *** functional theory(DFT)calculations had been performed to disclose the mechanism of the involved assemblies.

关键词： Scanning probemicroscopy(STM) Selective adsorption Host-guest chemistry Supramolecular chemistry Aromatic carboxylic acid

Discovery of synergistic activity of fluoroquinolones in combination with antimicrobial peptides against clinical polymyxin-resistant Pseudomonas aeruginosa DK2

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Chinese Chemical Letters 2020年第2期31卷 413-417页

作者： Xinyu Zheng Qiao Cao Qin Cao Fei Mao xiaokang li Jin Zhu Lefu Lan Jian li State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Polymyxin B(PB),as the last-line of defense against multidrug-resistant Gram-negative bacteria,has caused resistance to *** ***,synergistic treatment could preserve the last class of antibiotics and reduce the emergency of drug ***,we performed a screen of 970 approved drugs synergized with PB against the *** DK2,which is severely resistant to PB,MIC=512μg/***,we found fluoroquinolones could synergy with PB and achieved an obvious reduction in MIC of PB below the clinical susceptible breakpoint(2 μg/mL).Especially,gemifloxacin achieved the highest synergistic effect with PB,leading to a 4096-fold MIC reduction(reduced from512 μg/mL to 0.125 μg/mL).Furthermore,synergistic effect was also observed in the combination of gemifloxacin and ***,outer membrane permeabilization assay showed that gemifloxacin could increase the permeability of bacterial cell membranes for *** which partly explained the synergy *** results indicate that fluoroquinolones represent attractive synergists to address the emerging threat of polymyxin-resistant infections.

关键词： Polymyxin B Pseudomonas aeruginosa Fluoroquinolones Synergy Cystic fibrosis Antimicrobial peptides

Low power and high uniformity of HfOx-based RRAM via tip-enhanced electric fields

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Science China(Information Sciences) 2019年第10期62卷 164-170页

作者： xiaokang li Baotong ZHANG Bowen WANG Xiaoyan XU Yuancheng YANG Shuang SUN Qifeng CAI Shijie HU Xia AN Ming li Ru HUANG Key Laboratory of Microelectronic Devices and Circuits (MOE) Institute of MicroelectronicsPeking University

In this paper, the HfOx-based resistive random access memory（RRAM） devices with sub-100 nm pyramid-type electrodes were fabricated. With the help of tip-enhanced electric field around the pyramid-type electrodes, it was experimentally demonstrated that the novel devices have better cycle-to-cycle variation control, lower forming/set voltage（1.97/0.7V） and faster switching speed（≤30 ns under 0.9V pulse） as well as better endurance reliability than conventional flat electrode resistive memory devices. In addition,the novel RRAM is experimentally demonstrated with independence of electrode number for the first time to present great potential in scaling down. This novel structure metal-oxide based RRAM will be suitable for the future low-power non-volatile memory application.

关键词： RRAM pyramid-type electrode variation reliability switching speed conducting filament