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Effectiveness of Prophylactic Transvaginal Cervical Cerclage in Improving Clinical Outcomes among Pregnant Women with Cervical Insufficiency: Meta-Analysis

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Open Journal of Internal Medicine 2024年第2期14卷 228-246页

作者： Sreynit Chan xiaojing dong Department Name of Obstetrics and Gynecology The Second Affiliated Hospital of Chongqing Medical University Chongqing China

Background: Cervical insufficiency is one of the major causes of preterm birth among pregnant women that leads to severe mortality and morbidity issues among newborns. Prophylactic cervical cerclage is a surgical procedure performed between 11 and 14 weeks of gestation upon diagnosis of cervix insufficiency among pregnant women. Aims & Objectives: In this study, we aimed to evaluate the effectiveness of prophylactic cervical cerclage in comparison to other interventions to treat cervical insufficiency among pregnant women using a meta-analysis approach. Methods: We searched the three databases (Coachrane Library, PubMed, and MEDLINE) that were used for articles related to research aims by using MeSH keywords. The timeline of research was set from January 2015 to January 2024. The methodological quality assessment of included studies was performed by the Risk of Bias in Non-randomized Studies—of Interventions (ROBINS-I). A recent meta-analysis was conducted by using Review Manager 5.4.0 software. Results: About 441 research articles were extracted from three electronic databases and only 125 articles were assessed for eligibility criteria. Finally, 8 studies were included in the analysis for a recent meta-analysis. Six out of eight included retrospective or pilot studies were graded as having a moderate risk of bias, and two studies had low risk on the basis of owning bias. About 1008 pregnant women with cervical insufficiency were analyzed in a recent meta-analysis. By pooled analysis, it was evaluated that significant difference found in prolongation of delivery weeks (Mean difference = 1.05;Cl: 0.81 to 1.29: p > 0.00001), number of deliveries > 37 weeks (OR = 0.59;Cl: 0.19 to 1.84: p > 0.006), and preterm birth (OR = 0.73;Cl: 0.42 to 1.28: p > 0.50) among pregnant women receiving prophylactic cervical cerclage as compared to other treatment strategies. Conclusion: Recent meta-analysis suggested the prophylactic cervical cerclage reduces the rates of preterm birth, abortion rates, number of deliveries > 37 weeks

关键词： Prophylactic Transvaginal Cervical Cerclage Cervical Insufficiency Pregnant Women

Quasilinear Schrodinger-Poisson equations involving a nonlocal term and an integral constraint

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Science China Mathematics 2022年第11期65卷 2297-2324页

作者： xiaojing dong Anmin Mao School of Mathematical Sciences Beijing Normal UniversityBeijing 100875China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences Qufu Normal UniversityQufu 273165China

In this paper,we consider a class of quasilinear Schrodinger-Poisson problems of the form∫-(a+b∫_(R)^(N)|■μ|^(2)dx)■μ+V(x)u+Фu-1/2u■(u^(2))-λ|u|^(p-2)u=0 in R^(N),-ΔФ=u^(2),u(x)→0,|x|→∞in R^(N),∫_(R)^(N... 详细信息

关键词： quasilinear problem nonlocal term sign-changing solutions genus theory

Screening for inhibitors against SARS-CoV-2 and its variants

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Biosafety and Health 2022年第3期4卷 186-192页

作者： Weijing Yuan xiaojing dong Lan Chen Xiaobo Lei Zhuo Zhou Li Guo Jianwei Wang Institute of Pathogenic Biology Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China School of Life Science Peking UniversityBeijing 100871China Biomedical Pioneering Innovation Center Peking UniversityBeijing 100871China

Severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)continues to evolve,generating new variants that pose a threat to global health;therefore,it is imperative to obtain safe and broad‐spectrum antivirals against SARS‐CoV‐2 and its variants.To this end,we screened compounds for their ability to inhibit viral entry,which is a critical step in virus infection.Twenty compounds that have been previously reported to inhibit SARS‐CoV‐2 replication were tested by using pseudoviruses containing the spike protein from the original strain(SARS‐CoV‐2‐WH01).The cytotoxicity of these compounds was determined.Furthermore,we identified six compounds with strong antagonistic activity against the WH01 pseudovirus,and low cytotoxicity was identified.These compounds were then evaluated for their efficacy against pseudoviruses expressing the spike protein from B.1.617.2(Delta)and B.1.1.529(Omicron),the two most prevalent circulating strains.These assays demonstrated that two phenothiazine compounds,trifluoperazine 2HCl and thioridazine HCl,inhibit the infection of Delta and Omicron pseudoviruses.Finally,we discovered that these two compounds were highly effective against authentic SARS‐CoV‐2 viruses,including the WH01,Delta,and Omicron strains.Our study identified potential broad‐spectrum SARS‐CoV‐2 inhibitors and provided insights into the development of novel therapeutics.

关键词： SARS‐CoV‐2 Delta variant Omicron variant Trifluoperazine 2HCl Thioridazine HCl Antiviral therapy

Serosurvey for SARS-CoV-2 among blood donors in Wuhan,China from September to December 2019

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Protein & Cell 2023年第1期14卷 28-36页

作者： Le Chang Lei Zhao Yan Xiao Tingting Xu Lan Chen Yan Cai xiaojing dong Conghui Wang Xia Xiao Lili Ren Lunan Wang National Center for Clinical Laboratories Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Beijing Engineering Research Center of Laboratory Medicine Beijing HospitalBeijing 100730China Department of Laboratory Wuhan Blood CenterWuhan 430030China Confirmation Laboratory for Transfusion Transmitted Disease Institute of Blood Transfusion of Hubei ProvinceWuhan 430030China National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Quality Control Wuhan Blood CenterWuhan 430030China Graduate School Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

The emerging of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused COVID-19 pandemic.The first case of COVID-19 was reported at early December in 2019 in Wuhan City,China.To examine specific antibodies against SARS-CoV-2 in biological samples before December 2019 would give clues when the epidemic of SARS-CoV-2 might start to circulate in populations.We obtained all 88,517 plasmas from 76,844 blood donors in Wuhan between 1 September and 31 December 2019.We first evaluated the pan-immunoglobin(pan-Ig)against SARS-CoV-2 in 43,850 samples from 32,484 blood donors with suitable sample quality and enough volume.Two hundred and sixty-four samples from 213 donors were pan-Ig reactive,then further tested IgG and IgM,and validated by neutralizing antibodies against SARS-CoV-2.Two hundred and thirteen samples(from 175 donors)were only pan-Ig reactive,8(from 4 donors)were pan-Ig and IgG reactive,and 43(from 34 donors)were pan-Ig and IgM reactive.Microneutralization assay showed all negative results.In addition,213 screened reactive donors were analyzed and did not show obviously temporal or regional tendency,but the distribution of age showed a difference compared with all tested donors.Then we reviewed SARS-CoV-2 antibody results from these donors who donated several times from September 2019 to June 2020,partly tested in a previous published study,no one was found a significant increase in S/CO of antibodies against SARS-CoV-2.Our findings showed no SARS-CoV-2-specific antibodies existing among blood donors in Wuhan,China before 2020,indicating no evidence of transmission of COVID-19 before December 2019 in Wuhan,China.

关键词： severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 seroprevalence neutralizing antibodies blood donors

Removal of anaerobic soluble microbial products in a biological activated carbon reactor

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Journal of Environmental Sciences 2013年第9期25卷 1745-1753页

作者： xiaojing dong Weili Zhou Shengbing He School of Environmental Science and Engineering Shanghai Jiao Tong University

The soluble microbial products （SMP） in the biological treatment effluent are generally of great amount and are poorly biodegradable. Focusing on the biodegradation of anaerobic SMP, the biological activated carbon （BAC） was introduced into the anaerobic system. The experiments were conducted in two identical lab-scale up-flow anaerobic sludge blanket （UASB） reactors. The high strength organics were degraded in the first UASB reactor （UASB1） and the second UASB （UASB2, i.e., BAC） functioned as a polishing step to remove SMP produced in UASB1. The results showed that 90% of the SMP could be removed before granular activated carbon was saturated. After the saturation, the SMP removal decreased to 60% on the average. Analysis of granular activated carbon adsorption revealed that the main role of SMP removal in BAC reactor was biodegradation. A strain of SMP-degrading bacteria, which was found highly similar to Klebsiella sp., was isolated, enriched and inoculated back to the BAC reactor. When the influent chemical oxygen demand （COD） was 10,000 mg/L and the organic loading rate achieved 10 kg COD/（m 3 ·day）, the effluent from the BAC reactor could meet the discharge standard without further treatment. Anaerobic BAC reactor inoculated with the isolated Klebsiella was proved to be an effective, cheap and easy technical treatment approach for the removal of SMP in the treatment of easily-degradable wastewater with COD lower than 10,000 mg/L.

关键词： anaerobic treatment soluble microbial products biological activated carbon bacterial isolation biodegradation

New conditions of stability and convergence of Stokes and Newton iterations for Navier-Stokes equations

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Applied Mathematics and Mechanics(English Edition) 2015年第7期36卷 863-872页

作者： Guodong ZHANG xiaojing dong Yongzheng AN Hong LIU School of Mathematics and Statistics Xi'an Jiaotong University

This paper considers Stokes and Newton iterations to solve stationary Navier- Stokes equations based on the finite element discretization. We obtain new sufficient conditions of stability and convergence for the two iterations. Specifically, when 0 〈 σ =N｜｜f｜｜-1/v2≤1/√2＋1 , the Stokes iteration is stable and convergent, where N is defined in the paper. When 0 〈 σ ≤5/11, the Newton iteration is stable and convergent. This work gives a more accurate admissible range of data for stability and convergence of the two schemes, which improves the previous results. A numerical test is given to verify the theory.

关键词： Navier-Stokes equation Stokes iteration Newton iteration stability,convergence

Sulfur-based autotrophic denitrification from the micro-polluted water

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Journal of Environmental Sciences 2016年第6期28卷 180-188页

作者： Weili Zhou Xu Liu xiaojing dong Zheng Wang Ying Yuan Hui Wang Shengbing He School of Environmental Science and Engineering Shanghai Jiaotong University

Eutrophication caused by high concentrations of nutrients is a huge problem for many natural lakes and reservoirs. Removing the nitrogen contamination from the low C/N water body has become an urgent need. Autotrophic denitrification with the sulfur compound as electron donor was investigated in the biofilter reactors. Through the lab-scale experiment,it was found that different sulfur compounds and different carriers caused very different treatment performances. Thiosulfate was selected to be the best electron donor and ceramsite was chosen as the suitable carrier due to the good denitrification efficiency, low cost and the good resistibility against the high hydraulic loads. Later the optimum running parameters of the process were determined. Then the pilot-scale experiment was carried out with the real micro-polluted water from the West Lake, China. The results indicated that the autotrophic denitrification with thiosulfate as electron donor was feasible and applicable for the micro-polluted lake water.

关键词： Autotrophic denitrification Micro-polluted water Thiosulfate HRT Hydraulic loading rate

基于应用主体采纳行为的农业技术再分类及推广模式

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江苏农业科学 2024年第11期52卷 278-284页

作者：董小菁孙洪武江苏省农业科学院农业经济与发展研究所江苏南京210014

农业技术科学分类是制定适宜技术推广策略、提升技术推广效率、增加技术应用效果的前提与基础。随着市场经济发展、农业产业结构调整及经济发展方式的转变,农业技术应用主体不断分化,技术需求呈现出显著差异化,迫切需要对农业技术再分... 详细信息

农业技术科学分类是制定适宜技术推广策略、提升技术推广效率、增加技术应用效果的前提与基础。随着市场经济发展、农业产业结构调整及经济发展方式的转变,农业技术应用主体不断分化,技术需求呈现出显著差异化,迫切需要对农业技术再分类。因此,探索不同应用主体技术采纳行为,并结合技术属性对农业技术进行分类,制定与之匹配的技术推广模式具有重要意义。通过定量与案例相结合的分析方法,在剖析不同农业技术应用主体在资源禀赋、生产经营目标等差异的基础上,探索不同应用主体偏好下的技术类型与采纳方式,结合技术特点对农业技术重新分类。在探索不同类型的技术转移模式基础上,提出以下政策建议:明确四级行政农技推广体系职责,创新公益性技术推广服务方式;充实农技推广人员队伍,强化公益性农技推广服务保障水平;支持农业企业技术创新,探索农业企业技术推广新模式;以企业需求为准绳,探索“政府+科研院所+企业”的合作模式;以市场需求为导向,构建一主多元协同发展的技术推广体系。

关键词：采纳行为农业生产技术应用主体模式推广政策建议

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SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

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Signal Transduction and Targeted Therapy 2023年第1期8卷 302-313页

作者： Saisai Guo Xiaobo Lei Yan Chang Jianyuan Zhao Jing Wang xiaojing dong Qian Liu Zixiong Zhang Lidan Wang dongrong Yi Ling Ma Quanjie Li Yongxin Zhang Jiwei Ding Chen Liang Xiaoyu Li Fei Guo Jianwei Wang Shan Cen Department of Immunology Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryKey Laboratory of Major Diseases in ChildrenMinistry of EducationBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Lady Davis Institute Jewish General HospitalMcGill UniversityMontrealQCCanada CAMS Key Laboratory of Antiviral Drug Research Chinese Academy of Medical Sciences&Peking Union Medical SciencesBeijingChina

The coronavirus disease 2019(COVID-19)pandemic has devastated global health.Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have been quested for the preparedness of future viral outbreaks.Here,we have identified host proteins that associate with nonstructural protein 12(nsp12),the RNA-dependent RNA polymerase(RdRp)of SARS-CoV-2 using a mass spectrometry(MS)-based proteomic approach.Among the candidate factors,CDK2(Cyclin-dependent kinase 2),a member of cyclin-dependent kinases,interacts with nsp12 and causes its phosphorylation at T20,thus facilitating the assembly of the RdRp complex consisting of nsp12,nsp7 and nsp8 and promoting efficient synthesis of viral RNA.The crucial role of CDK2 in viral RdRp function is further supported by our observation that CDK2 inhibitors potently impair viral RNA synthesis and SARS-CoV-2 infection.Taken together,we have discovered CDK2 as a key host factor of SARS-CoV-2 RdRp complex,thus serving a promising target for the development of SARS-CoV-2 RdRp inhibitors.

关键词： CDK2 synthesis drugs