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Phyton-International Journal of Experimental Botany 2024年第3期93卷 467-486页

作者： xiaojie liang Wei An Yuekun Li Yajun Wang Xiaoya Qin Yanhong Cui Shuchai Su State Key Laboratory of Efficient Production of Forest Resources The College of ForestryBeijing Forestry UniversityBeijing100083China National Wolfberry Engineering Research Center Wolfberry Science Research InstituteNingxia Academy of Agriculture and Forestry SciencesYinchuan750002China

Goji berry(Lycium barbarum L.)is substantially dependent on nitrogen fertilizer application,which can signiﬁ-cantly enhance fruit yield and Goji berry industrial development in Ningxia,*** study aimed to analyze the functions of differential nitrogen application rates including low(N1),medium(N2),and high(N3)levels in soil microbial community structure(bacterial and fungal)at 2 diverse soil depths(0-20,20-40 cm)through high-throughput sequencing technology by targeting 16S RNA gene and ITS1&ITS2 *** the observed physicochemical parameters exhibited signiﬁcant improvement(p0.05)differences among three group treatments(N1,N2,and N3).Furthermore,the functional enrichment analysis demonstrated signiﬁcant(p<0.05)enrichment of quorum sensing,cysteine and methionine metabolism,and transcriptional machinery for bacterial communities,while various saprotrophic functional roles for fungal ***,moderately reducing the use of N-supplemented fertilizers is conducive to increasing soil nitrogen utilization rate,which can contribute to sustainable agriculture practices through improved soil quality,and microbial community structure and functions.

关键词： Goji berry production Ningxia,China differential nitrogen supplementation rates 16S RNA gene and IT1&IT2 region sequencing soil physicochemical properties

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翻译需要研究:溯源与展望

外语教学理论与实践 2024年第1期 71-78,8页

作者：梁筱婕朱健平湖南大学外国语学院

翻译因需而生,应需而起,翻译与需要关系紧密,因此很早便引起译界关注,并已有了一些初步的探讨,尤其是初步界定了“翻译需要”概念,但总体而言讨论还不够深入和系统,需作进一步的学理阐释。本文通过梳理有关翻译与需要关系的相关论述,总... 详细信息

翻译因需而生,应需而起,翻译与需要关系紧密,因此很早便引起译界关注,并已有了一些初步的探讨,尤其是初步界定了“翻译需要”概念,但总体而言讨论还不够深入和系统,需作进一步的学理阐释。本文通过梳理有关翻译与需要关系的相关论述,总结现有研究的不足,重申“翻译需要”研究的必要性,并以此为基础对这一课题的研究提出初步构想,试图为该主题的未来研究提供参考。

关键词：翻译需要翻译研究溯源与展望

深基坑支护设计及施工过程监测分析——以福建省儿童医院(区域儿童医学中心)为例

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福建建设科技 2024年第4期 65-68页

作者：梁晓劼福建建工集团有限责任公司福建福州350001

以福建省儿童医院(区域儿童医学中心)项目为例,针对该深基坑的特点,介绍了基坑支护设计和排水措施设计,施工过程对深层土体水平位移、基坑坡顶水平位移及沉降、支护桩内力、地下水位、周边建筑及地表进行监测。监测数据表明:基坑的开挖... 详细信息

以福建省儿童医院(区域儿童医学中心)项目为例,针对该深基坑的特点,介绍了基坑支护设计和排水措施设计,施工过程对深层土体水平位移、基坑坡顶水平位移及沉降、支护桩内力、地下水位、周边建筑及地表进行监测。监测数据表明:基坑的开挖对土体位移、地下水位和周边环境影响非常小,各监测项目的观测数据在监测周期内均在设计预警值内,从而保障了施工作业的安全。本案例可供其他类似项目参考。

关键词：深基坑施工过程监测预警值支护设计

香菇多糖的生物活性及在鸡、猪养殖中的应用研究进展

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中国畜牧杂志 2024年第4期60卷 64-69页

作者：刘馨颐梁晓杰马静阁魏峰吉林农业大学生命科学学院吉林长春130118

香菇多糖(Lentinan,LNT)是香菇的主要活性成分之一,是典型的真菌β-葡聚糖,其单糖组成包括甘露糖、半乳糖和葡萄糖等,立体结构呈三螺旋,该结构使LNT具备免疫调节、抗氧化、促肠道健康、抗炎和抗肿瘤等多种生物活性,广泛应用于医学、食... 详细信息

香菇多糖(Lentinan,LNT)是香菇的主要活性成分之一,是典型的真菌β-葡聚糖,其单糖组成包括甘露糖、半乳糖和葡萄糖等,立体结构呈三螺旋,该结构使LNT具备免疫调节、抗氧化、促肠道健康、抗炎和抗肿瘤等多种生物活性,广泛应用于医学、食品、养殖等领域。LNT作为饲料添加剂已进入《饲料添加剂品种目录》。本文主要综述了LNT的生物活性及在鸡、猪生产中的应用研究进展,以期为LNT作为新型饲料添加剂应用于鸡、猪养殖提供思路和理论支撑。

关键词：香菇多糖生物活性鸡猪

生物信息学技术分析人结直肠癌中蛋白磷酸酶2A催化亚基α(PPP2CA)表达与患者预后及免疫浸润的关系

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细胞与分子免疫学杂志 2024年第7期40卷 591-604页

作者：梁小洁程照翔尚维伟陈信浩李俊南京医科大学附属江宁医院普外科江苏南京211100 南京市江宁中医院普外科江苏南京211100 南京医科大学附属江宁医院肝胆胰外科江苏南京211100

目的通过分析蛋白磷酸酶2A催化亚基α(PPP2CA)在结直肠癌(CRC)中表达水平与患者预后及免疫浸润的关系,进一步了解CRC发生和进展中的相关机制。方法基于基因芯片数据库Oncomine和肿瘤免疫评估资源(TIMER)数据库分析在CRC组织和正常组织中... 详细信息

目的通过分析蛋白磷酸酶2A催化亚基α(PPP2CA)在结直肠癌(CRC)中表达水平与患者预后及免疫浸润的关系,进一步了解CRC发生和进展中的相关机制。方法基于基因芯片数据库Oncomine和肿瘤免疫评估资源(TIMER)数据库分析在CRC组织和正常组织中PPP2CA表达水平的差异性;基于阿拉巴马大学伯明翰分校癌症数据分析门户(UALCAN)和基因表达谱交互分析(GEPIA)数据库分析PPP2CA的表达水平对CRC患者预后的影响;基于LinkedOmics平台构建PPP2CA的共表达网络并进行基因本体论(GO)富集分析和京东基因和基因组百科全书(KEGG)通路分析;基于TIMER和GEPIA数据库分析PPP2CA与免疫浸润之间的相关性。基于c-BioPortal平台分析结肠腺癌(COAD)中PPP2CA的基因突变情况。结果与正常结直肠组织相比,在CRC组织中PPP2CA表达下调。高表达水平的PPP2CA预示着更好的总生存期(OS)和无进展生存期(PFS)。在COAD中,PPP2CA的表达水平与包括CD8^(+)T细胞、中性粒细胞和树突状细胞在内的免疫浸润细胞呈正相关。而某些免疫细胞标志物,包括B细胞的CD19和CD38、M1巨噬细胞的一氧化氮合酶2(NOS2)、M2巨噬细胞的精氨酸酶1(Arg1)和甘露糖受体C1(MRC1)、肿瘤相关巨噬细胞(TAM)的人类白细胞抗原G(HLA-G)和CD80、单核细胞的CD14和IgG Fc段受体Ⅲa(FCGR3A),却显示出不同的PPP2CA相关免疫浸润模式:即PPP2CA表达水平与COAD和直肠腺癌(READ)中的B细胞、巨噬细胞、单核细胞、TAM、1型辅助T(Th1)细胞、Th2细胞、调节性T细胞、衰竭T细胞和中性粒细胞均显著相关。结论PPP2CA在CRC组织表达水平下调,并且与免疫浸润密切相关。

关键词：蛋白磷酸酶2A催化亚基α基因(PPP2CA) 结直肠癌(CRC) 免疫浸润预后

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行星架锻件端面及销孔内亮斑原因分析

大型铸锻件 2024年第3期 46-51页

作者：刘志龙李超越梁晓捷张戈梁国平太原重型机械集团有限公司山西太原030024

在大功率风电机组锻件中,42CrMo4行星架销孔端面及销孔精加工过程中出现了大量的亮斑,通过对行星架锻件本体亮斑及附近基体进行成分、硬度检测,结合锻后正火冒口余料、锻件本体正火+回火态试环及锻件本体调质试环的高、低倍检测,对亮斑... 详细信息

在大功率风电机组锻件中,42CrMo4行星架销孔端面及销孔精加工过程中出现了大量的亮斑,通过对行星架锻件本体亮斑及附近基体进行成分、硬度检测,结合锻后正火冒口余料、锻件本体正火+回火态试环及锻件本体调质试环的高、低倍检测,对亮斑的形成进行了全流程分析。研究结果显示,钢锭在凝固结晶过程中,由于冷却速度缓慢,导致了斑点偏析的产生。这些斑点区域与基体区域由于成分不同,因此在调质淬火处理时,二者的相对冷速也不同,以致二者硬度差值较大,车削过程中在硬度较高的斑点偏析区域形成亮斑。在分析的基础上,通过热处理实验证实,行星架性能检测不理想并非亮斑存在导致,且亮斑组织为预期理想组织。

关键词： 42CrMo4 行星架斑点偏析亮斑

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Using quantitative CT to predict postoperative pulmonary function in patients with lung cancer

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Chinese Medical Journal 2005年第9期118卷 742-746页

作者： LIUFang HANPing FENGGan-sheng liangBo xiaojie TIANZhi-liang LEIZi-qiao DepartmentofRadiology AffiliatedUnionHospitalTongjiMedicalCollegeHuazhongUniversityofSciencesandTechnologyWuhan430022China（LiuFHanPFengGSLiangBXiaoJTian

Background At present, the therapy for patients with lung cancer that achieves a high rate of cure is surgical resection at an early stage of the disease. The aim of this study is to evaluate quantitative computed tomography (QCT) for predicting postoperative pulmonary function in patients with lung cancer. Methods The data of thirty-one patients with lung cancer who underwent both pulmonary functional tests and QCT scan before operations were collected. A CT program was used to quantify the volume of whole lung parenchyma with attenuation of -910 HU to -600 HU, which was defined as total functional lung volume (TFLV). Similarly, the volume of lung (lobes or segments) with attenuation of -910 HU to -600 HU was defined as regional functional lung volume (RFLV). Forced vital capacity (FVC), forced expiratory volume in first second (FEV_1), FVC% and FEV_1% (ratio to reference values of the matched population) were obtained from preoperational pulmonary functional tests. According to the formula: predicted FVC (pre-FVC)=preoperative FVC×[1-(RFLV/TFLV)]; predicted FEV_1 (pre-FEV_1)=preoperative FEV_1×[1-(RFLV/TFLV)], we obtained values of predicted FVC, predicted FEV_1, predicted FVC% (pre-FVC/reference values of the matched population), and predicted FEV_1% (pre-FEV_1/reference values of the matched population). The paired t test and Pearson correlation test were used to assess significance of differences and correlations between CT predicted values and postoperative measured results of FVC, FEV_1, FVC% and FEV_1%. Results QCT predicted values correlated well with postoperative FVC, FEV_1, FVC% and FEV_1% ( r =0.873, 0.809, 0.849 and 0.801 respectively, all P <0.01).Conclusions QCT is an effective and accurate way to predict postoperative pulmonary function in patients undergoing pulmonary resection, regardless of the patients’ preoperative pulmonary functional status.

关键词： lung neoplasms computed tomography X-ray respiratory function tests

1Cr13锻件低温冲击韧性不合格原因及热处理工艺优化研究

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大型铸锻件 2024年第4期 80-84页

作者：刘志龙张戈梁晓捷李超越太原重工股份有限公司山西太原030024 太原重工股份有限公司铸锻件分公司山西太原030024

针对1Cr13不锈钢锻件锻后坑冷、调质热处理后低温冲击韧性不达标的问题,通过金相组织观察与断口扫描分析,对比合格与不合格试样,明确导致低温冲击韧性不达标的关键影响因素。在此基础上通过试验摸索,分别研究淬火温度、回火温度对1Cr13... 详细信息

针对1Cr13不锈钢锻件锻后坑冷、调质热处理后低温冲击韧性不达标的问题,通过金相组织观察与断口扫描分析,对比合格与不合格试样,明确导致低温冲击韧性不达标的关键影响因素。在此基础上通过试验摸索,分别研究淬火温度、回火温度对1Cr13抗拉强度以及低温冲击韧性的影响,改进热处理工艺,显著提高了不锈钢锻件的抗拉强度与低温冲击韧性。

关键词： 1Cr13 低温冲击韧性影响因素热处理工艺研究

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Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts

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BIOCELL 2024年第7期48卷 1105-1113页

作者： CHUNLING liang JING CHEN xiaojie CHEN WEI YAN JIE YU Department of Emergency Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100102China Department of Radiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China

Background:A differential gene,triggering receptor expressed on myeloid cells 1(TREM1),was identiﬁed in blood sequencing datasets from myocardial infarction patients and healthy ***ﬁbrosis following myocardial infarction signiﬁcantly contributes to cardiac ***:This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardialﬁ***:Mimicking pathology by angiotensin II(Ang II)treatment of human cardiacﬁbroblasts(HCFs),the impacts of TREM1 knockdown on its proliferation,migration,and secretion of the pro-ﬁbrotic matrix were identiﬁ*** the Human Transcription Factor Database(HumanTFDB)website,lysine-speciﬁc demethylase 5B(KDM5B)was found to bind to the TREM1 promoter,which was further validated through luciferase reporter and chromatin immunoprecipitation(ChIP).By promoting KDM5B overexpression,its effect on the regulation of TREM1 was ***:TREM1 knockdown suppressed the proliferation,migration,and secretion of the pro-ﬁbrotic matrix in HCFs upon Ang II ***5B bound to the TREM1 promoter and upregulated its transcriptional ***,KDM5B overexpression reversed the regulation of the above cellular phenotypes by TREM1 ***:This study sheds light on the positive regulation of TREM1 by KDM5B,demonstrating their role in promoting myocardialﬁ***ﬁnding provides a theoretical foundation for understanding disease pathology and potentially advancing the development of new targeted therapies.

关键词： Cardiac fibroblasts Fibrosis Myeloid cell receptor Migration Proliferation

ERF5.1 modulates carotenoid accumulation by interacting with CCD4.1 in Lycium

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Horticulture Research 2023年第12期10卷 190-203页

作者： Jianhua Zhao Yuhui Xu Haoxia Li Xinlei Zhu Yue Yin Xiyan Zhang Xiaoya Qin Jun Zhou Linyuan Duan xiaojie liang Ting Huang Bo Zhang Ru Wan Zhigang Shi Youlong Cao Wei An National Wolfberry Engineering Research Center/Wolfberry Science Research Institute Ningxia Academy of Agriculture and Forestry SciencesYinchuan750002China Institute of Forestry and Grassland Ecology Ningxia Academy of Agriculture and Forestry SciencesYinchuan750002China College of Biological Science&Engineering North Minzu UniversityYinchuan 750021China

Carotenoids are important natural pigments and have medical and health functions for *** cleavage dioxygenase 4(CCD4)and ethylene responsive factor(ERF)participate in carotenoid metabolism,but their roles in Lycium have not been ***,we annotated LbCCDs from the Lycium reference genome and found that LbCCD4.1 expression was significantly correlated with the carotenoid metabolites during Lycium five fruit developmental ***-expression of LbCCD4.1 in NQ’s leaves resulted in a series of significantly lower contents of carotenoid metabolites,includingβ-carotene andβ-***,LbERF5.1,a transcription factor belonging to the ERF family that was located in the nucleus,was *** reductions in the carotenoids,especially lutein,violaxanthin and their derivatives,were observed in over-expressing ERF5.1 transgenic NQ’s ***-expression or virus-induced gene silencing of LbERF5.1 in NQ’s leaves induced a consistent up-or down-expression,respectively,of ***,yeast one-hybrid and dual-luciferase reporter assays showed that ERF5.1 interacted with the promoter of CCD4.1 to increase its expression,and LbERF5.1 could bind to any one of the three predicted binding sites in the promoter of LbCCD4.1.A transcriptome analysis of LbERF5.1 and LbCCD4.1 over-expressed lines showed similar global transcript expression,and geranylgeranyl diphosphate synthase,phytoene synthase,lycopeneδ-cyclase cytochrome,cytochrome P450-type monooxygenase 97A,cytochrome P450-type monooxygenase 97C,and zeaxanthin epoxidase in the carotenoid biosynthesis pathway were differentially *** summary,we uncovered a novel molecular mechanism of carotenoid accumulation that involved an interaction between ERF5.1 and CCD4.1,which may be used to enhance carotenoid in Lycium.

关键词： metabolism expressing Lycium