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Comparative study on the renal protection and lesion of rhubarb extract to chronic renal failure and normal rats

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Comparative study on the renal protection and lesion of rhub...

Kinetic equilibrium reconstruction with internal safety factor profile constraints on EAST tokamak

中华中医药学会第九届中药鉴定学术会议

作者： Jiabo Wang,Huifang Li,xiaohe Xiao~*,Cheng jin PLA Institute of Chinese Materia Medica,302 Hospital of PLA,Beijing 100039,PR China

Chronic renal failure(CRF) is a worldwide public health issue with poor outcomes and high *** years, some plant-derived medicines,such as rhubarb,revealed desirable prospects to treat ***,the safeness of rhubarb is controversial for the reported nephrotoxicity caused by the anthraquinones(AQs) contained in *** this study,the renal risk of rhubarb was investigated by comparatively evaluating renal protection and concurrent lesion in both CRF and normal animals with histopathologic,biochemical and toxicokinetic *** histopathologic results showed that there was evidence of a treatment-related renal protection of rhubarb on CRF rats and no evidence of a treatment-related renal lesion on normal *** was the main anthraquinones absorbed after oral administration of rhubarb and was intensively investigated to evaluate the *** same dosage,the area under curve(AUC) and maximal blood concentration of CRF groups were lower than those of normal *** the elimination in CRF groups was faster than normal *** results showed that there is no unambiguous evidence of renal toxicity of rhubarb no matter to normal or CRF rats successively administered for 3 weeks.

关键词： Chronic renal failure(CRF) Rhubarb Renal protection and lesion Toxicokinetics Anthraquinones

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Plasma Science and Technology 2024年第4期26卷 61-67页

作者：樊皓尘李国强钱金平张学习邬潇河储宇奇朱翔连辉刘海庆吕波金仡飞臧庆黄佳 Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230031People’s Republic of China Shenzhen University Shenzhen 518060People’s Republic of China University of California Los Angeles Los Angeles 90095United States of America

Reconstruction of plasma equilibrium plays an important role in the analysis and simulation of plasma experiments. The kinetic equilibrium reconstruction with pressure and edge current constraints has been employed on EAST tokamak. However, the internal safety factor(q) profile is not accurate. This paper proposes a new way of incorporating q profile constraints into kinetic equilibrium reconstruction. The q profile is yielded from the Polarimeter Interferometer(POINT)reconstruction. Virtual probes containing information on q profile constraints are added to inputs of the kinetic equilibrium reconstruction program to obtain the final equilibrium. The new equilibrium produces a more accurate internal q profile. This improved method would help analyze EAST experiments.

关键词： equilibrium reconstruction tokamak data analysis kinetic equilibrium q profile polarimeter-interferometer

Microcalorimetric investigation of the effect of berberine alkaloids from Coptis chinensis Franch on Staphylococcus aureus growth

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Science China Chemistry 2008年第7期51卷 640-645页

作者： YAN Dan XIAO xiaohe jin Cheng DONG XiaoPing Institute of Chinese Medicine 302 Hospital of People’s Liberation ArmyBeijing 100039China Chengdu University of Traditional Chinese Medicine Chengdu 610075China

The inhibitory effects of three berberine alkaloids (BAs) from rhizome of Coptis chinensis Franch, a traditional Chinese medicinal (TCM) herb, on Staphylococcus aureus growth were investigated by mi- crocalorimetry. The power–time curves of S. aureus with and without BAs were acquired; meanwhile the extent and duration of inhibitory effects on the metabolism were evaluated by studying the growth rate constant (k), half inhibitory ratio (IC50), maximum heat-output power (Pmax), peak time of maximum heat-output power (tp) and total heat production (Qt). The value of k of S. aureus in the presence of the three BAs decreased with the increasing concentrations of BAs. Moreover, Pmax was reduced and the value of tp increased with increasing concentrations of the three drugs. The inhibitory activity varied with different drugs. The values of IC50 of the three BAs are respectively, 101.4 μg/mL for berberine, 241.0 μg/mL for palmatine and 792.3 μg/mL for jateorrhizine. The sequence of antimicrobial activity of the three BAs is: berberine > palmatine > jateorrhizine. It is suggested that the functional group me- thylenedioxy or methoxyl at C2 on the phenyl ring could possibly improve antimicrobial activity more strongly than hydroxyl at C2 on the phenyl ring.

关键词： berberine alkaloid microcalorimetry Staphylococcus aureus inhibitory effect

基于PMC指数模型的我国医防融合政策文本量化评价研究

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中国医院管理 2024年第7期44卷 26-30页

作者：金晨王小合张中一孙思怡涂斯婧钱宇杭州师范大学公共卫生学院浙江杭州311121 杭州市第一人民医院浙江杭州310006

目的旨在引入政策一致性(Policy Modeling Consistency,PMC)指数模型量化评估医防融合政策,以期为优化我国医防融合政策提供参考。方法以“医防融合”为关键词,在中央政府及相关部门的官方网站进行检索获取政策文本30份,基于ROST CM 6.... 详细信息

目的旨在引入政策一致性(Policy Modeling Consistency,PMC)指数模型量化评估医防融合政策,以期为优化我国医防融合政策提供参考。方法以“医防融合”为关键词,在中央政府及相关部门的官方网站进行检索获取政策文本30份,基于ROST CM 6.0软件与PMC指数模型对我国医防融合政策文本进行量化评价。结果医防融合政策文本的PMC指数均值为4.552,其中8项政策为可接受等级。结论应加强医防融合政策的顶层设计,优化政策工具的组合应用,有效利用中医、中西医结合在医防融合服务中的优势。

关键词：医防融合量化评价政策一致性指数模型

不同钒、氮含量对低碳贝氏体钢组织及析出行为的影响

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新技术新工艺 2017年第10期 3-8页

作者：李晓林崔阳肖宝亮杨孝鹤金钊孙林首钢技术研究院北京100043 绿色可循环钢铁流程北京市重点实验室北京100043 首钢京唐钢铁公司河北曹妃甸063200 中国兵器工业新技术推广研究所北京100089

借助场发射扫描电镜(SEM)、透射电子显微镜(TEM)和能谱仪(EDS)等方法研究了4种不同钒、氮含量的低碳贝氏体钢在控轧控冷过程中的微观组织、力学性能及碳氮化钒的析出行为。结果表明,在450℃卷取,4种试验用钢的组织都为粒状贝氏体,钒含量... 详细信息

借助场发射扫描电镜(SEM)、透射电子显微镜(TEM)和能谱仪(EDS)等方法研究了4种不同钒、氮含量的低碳贝氏体钢在控轧控冷过程中的微观组织、力学性能及碳氮化钒的析出行为。结果表明,在450℃卷取,4种试验用钢的组织都为粒状贝氏体,钒含量由0.05%增加到0.15%,试验用钢的屈服强度提高了163 MPa,抗拉强度提高了85 MPa。随着钢中钒、氮含量的增加,贝氏体组织明显细化;同时,在贝氏体铁素体基体中细小析出相的体积分数显著增加,析出相的平均尺寸为4~6nm。尺寸<10nm的析出颗粒呈细小碟片状,尺寸约为20nm的析出相一般呈长条状或者椭球状。经TEM分析,尺寸<10nm的析出相为具有面心立方结构的V(C,N)或(V,Cr)(C,N)复合析出相。

关键词：碳氮化钒粒状贝氏体 (V,Cr)(C,N) 面心立方结构

基于“创新编”德保麦编工艺日用品创新设计的研究

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鞋类工艺与设计 2023年第10期3卷 90-92页

作者：伊廷博张晓帆张耀金晓和翟柯涵百色学院美术与设计学院广西百色533000

麦编即为麦秆编织而成的工艺品等用途各异的艺术产品,德保麦秆花篮编织技艺是广西壮族自治区级特色非物质文化遗产。麦秸编制手工产品是中华民族传统手工艺种类之一,在中国,麦秸工艺已经有长达两千多年的历史,支撑起了中华传统农耕文化... 详细信息

麦编即为麦秆编织而成的工艺品等用途各异的艺术产品,德保麦秆花篮编织技艺是广西壮族自治区级特色非物质文化遗产。麦秸编制手工产品是中华民族传统手工艺种类之一,在中国,麦秸工艺已经有长达两千多年的历史,支撑起了中华传统农耕文化的时代精神,为传统工艺增加了独特的审美价值和超越平凡的创造力。这种高难度的技术水平和非凡的艺术价值,体现了劳动人民在日常生活和历史发展下非凡卓越的才能和丰富的艺术创造力,通过对德保麦编工艺深刻的认识,我们将麦编传统工艺文化与现代审美充分糅合来体现麦编的时代性与艺术性,探索麦编工艺在全球化和科技高速发展时代的创生之路。

关键词：创新编制麦编手工工艺日用品环保绿色

Impact of T_(i)/T_(e )ratio on ion transport based on EAST H-mode plasmas

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Plasma Science and Technology 2024年第4期26卷 68-78页

作者：刘建文臧庆梁云峰陈佳乐邬潇河 Alexander KNIEPS 扈嘉辉金仡飞张斌储宇奇刘海庆吕波段艳敏李妙辉陈颖杰龚先祖 the EAST Team Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China Forschungszentrum Jülich GmbH Institut für Energie-und Klimaforschung-PlasmaphysikPartner of the Trilateral Euregio Cluster(TEC)Jülich 52425Germany

At the EAST tokamak, the ion temperature(T_(i)) is observed to be clamped around 1.25 keV in electron cyclotron resonance(ECR)-heated plasmas, even at core electron temperatures up to 10 keV(depending on the ECR heating power and the plasma density). This clamping results from the lack of direct ion heating and high levels of turbulence-driven transport. Turbulent transport analysis shows that trapped electron mode and electron temperature gradient-driven modes are the most unstable modes in the core of ECR-heated H-mode plasmas. Nevertheless, recently it was found that the T_(i)/T_(e)ratio can increase further with the fraction of the neutral beam injection(NBI) power, which leads to a higher core ion temperature(Ti0). In NBI heating-dominant H-mode plasmas, the ion temperature gradient-driven modes become the most unstable ***, a strong and broad internal transport barrier(ITB) can form at the plasma core in high-power NBI-heated H-mode plasmas when the T_(i)/T_(e)ratio approaches ~1, which results in steep core Teand Tiprofiles, as well as a peaked neprofile. Power balance analysis shows a weaker Teprofile stiffness after the formation of ITBs in the core plasma region, where Ticlamping is broken,and the core Tican increase further above 2 keV, which is 80% higher than the value of Ticlamping in ECR-heated plasmas. This finding proposes a possible solution to the problem of Ticlamping on EAST and demonstrates an advanced operational regime with the formation of a strong and broad ITB for future fusion plasmas dominated by electron heating.

关键词： ion temperature clamping transport neutral beam injection stiffness internal transport barrier

A Visualization Analysis of Medical and Prevention Fusion Research in China via CiteSpace

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China CDC weekly 2023年第23期5卷 519-524,I0001,I0002页

作者： Chen jin Sijing Tu Yu Qian Xiaoyu Chen Zhiyi Peng xiaohe Wang School of Public Health Hangzhou Normal UniversityHangzhou CityZhejiang ProvinceChina School of Public Health and Management Guangxi University of Chinese MedicineNanning CityGuangxi Zhuang Autonomous RegionChina

Since the 1990s,the acceleration of population aging has led to an increased prevalence of chronic diseases and enhanced public health *** countries have proposed healthcare reforms,with a focus on creating an“integrated care”model that aims to improve the quality of medical services and reduce costs(1–2).In 2008,the World Health Organization(WHO)put forward the concept of Integrated Delivery Systems(IDS),advocating for continuous,timely and integrated medical services.

关键词： services CiteSpace acceleration

Geological context and vents morphology in the ultramafic-hosted Tianxiu field, Carlsberg Ridge

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Acta Oceanologica Sinica 2023年第9期42卷 62-70页

作者： jin Liang Chunhui Tao Xiangxin Wang Cheng Su Wei Gao Yadong Zhou Weikun Xu xiaohe Liu Zhongjun Ding Key Laboratory of Submarine Geosciences Ministry of Natural ResourcesHangzhou 310012China Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China National Deep Sea Center Qingdao 266237China School of Earth Sciences Zhejiang UniversityHangzhou 310027China Ocean College Zhejiang UniversityZhoushan 316021China

The Tianxiu hydrothermal field(TXHF) located on Carlsberg Ridge is one of the few active ultramafic-hosted venting systems known in the Indian Ocean. Despite numerous investigations, there is limited understanding of its sulfide structure morphology, and the factors controlling the formation of TXHF are poorly understood. In this study, we conducted detailed seafloor mapping using visual data obtained by dives using the human-occupied vehicle(HOV) Jiaolong. The TXHF is found to be an active, off-axis, ultramafic-hosted, high-temperature hydrothermal area in which serpentine peridotite is exposed. Two main hydrothermal sites were identified, i.e., P and Y, both of which feature a complex of chimneys and beehive diffusers constituting a “chimney jungle” and isolated large steep-sided structures developed on flat-lying sulfide mounds. In addition, some sporadic inactive chimneys and outcrops of hydrothermal deposits were noted. The chimneys are rich in Fe and Zn sulfide, and lack the central fluid channel formed by focused high-temperature fluid flow. Hydrothermal venting at TXHF is likely related to low-angle detachment faults that focus and transport hydrothermal fluids away from a heat source along the valley wall. Our results complement and expand upon previous works concerning sulfide chimney morphology and their corresponding mineral paragenesis in ultramafic-hosted hydrothermal systems in the Indian Ocean and further our understanding of modern seafloor hydrothermal systems.

关键词： hydrothermal activity sulfide accumulation morphology ultramafic-hosted Carlsberg Ridge