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Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway

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Science China(Life Sciences) 2024年第7期67卷 1427-1440页

作者： Hongfeng Guo Qihang Sun Xiaoli Huang xiaohao wang Feng Zhang Wenzheng Qu Jinling Liu Xuejun Cheng Qiang Zhu Wen Yi Qiang Shu Xuekun Li The Children’s Hospital National Clinical Research Center for Child HealthSchool of MedicineZhejiang UniversityHangzhou 310052China The Institute of Translational Medicine School of MedicineZhejiang UniversityHangzhou 310029China College of Life Sciences Zhejiang UniversityHangzhou 310058China Binjiang Institute of Zhejiang University Hangzhou 310053China Zhejiang University Cancer Center Zhejiang UniversityHangzhou 310029China

Fucosyltransferase 8(Fut8)and core fucosylation play critical roles in regulating various biological processes,including immune response,signal transduction,proteasomal degradation,and energy ***,the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains *** have shown that Fut8 and core fucosylation display dynamic features during the differentiation of adult neural stem/progenitor cells(aNSPCs)and postnatal brain ***8 depletion reduces the proliferation of a NSPCs and inhibits neuronal differentiation of aNSPCs in vitro and in vivo,***,Fut8 deficiency impairs learning and memory in ***,Fut8 directly interacts with integrinα6(Itga6),an upstream regulator of the PI3kAkt signaling pathway,and catalyzes core fucosylation of *** of Fut8 enhances the ubiquitination of Itga6 by promoting the binding of ubiquitin ligase Trim21 to *** levels of Itga6 inhibit the activity of the PI3K/Akt signaling ***,the Akt agonist SC79 can rescue neurogenic and behavioral deficits caused by Fut8 *** summary,our study uncovers an essential function of Fut8 and core fucosylation in regulating adult neurogenesis and sheds light on the underlying mechanisms.

关键词： Fut8 adult neural stem/progenitor cells neurogenesis Itga6 PI3K/Akt

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基于锚杆系统横向振动频率响应特征的轴力检测方法

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山东科技大学学报（自然科学版） 2024年第3期43卷 11-20页

作者：王晓皓邢明录于凤海陈建崇山东科技大学能源与矿业工程学院山东青岛266590 山东科技大学矿山灾害预防控制省部共建国家重点实验室培育基地山东青岛266590 鄂尔多斯市昊华红庆梁矿业有限公司内蒙古鄂尔多斯017000

基于锚杆系统自由段横向振动特性的检测方法可实现对锚杆的大范围快速有效检测。为提升锚杆轴力检测精度,建立锚杆系统横向振动力学模型,测试了全尺寸锚杆系统轴向加载过程中的频率响应。结果表明:锚杆系统横向振动固有频率对转动刚度... 详细信息

基于锚杆系统自由段横向振动特性的检测方法可实现对锚杆的大范围快速有效检测。为提升锚杆轴力检测精度,建立锚杆系统横向振动力学模型,测试了全尺寸锚杆系统轴向加载过程中的频率响应。结果表明:锚杆系统横向振动固有频率对转动刚度及锚杆自由段长度比较敏感;通过试验校准理论模型的转动刚度,所得理论预计轴力与试验结果的吻合度较好,频率阶次越低,轴力检测误差越小;轴力较低时,基频轴力检测的平均相对误差为5.8%,轴力较高时,平均相对误差仅为0.6%;当锚杆杆体进入塑性或界面脱粘滑移后,锚杆自由段长度变化较大,通过实时修正锚杆自由段长度,可实现锚杆系统损伤阶段的轴力检测,基频轴力检测的平均相对误差在4.1%以内。锚杆轴力的快速、无损检测方法对于支护系统及围岩稳定性评估具有重要意义。

关键词：锚杆系统无损检测锚杆轴力振动模型固有频率

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Piezoelectric soft robot driven by mechanical energy

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Nano Research 2023年第4期16卷 4970-4979页

作者： Jiangfeng Lu Zicong Miao Zihan wang Ying Liu Dekuan Zhu Jihong Yin Fei Tang xiaohao wang Wenbo Ding Min Zhang Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen 518055China Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentsTsinghua UniversityBeijing100084China

Power sources and energy-harvesting schemes are still grand challenges for soft ***,compared with other power sources,triboelectric nanogenerators(TENGs)have shown great potential because of their low manufacturing and fabrication costs,outstanding resilience,remarkable stability,and environmental ***,a triboelectric effect-driven piezoelectric soft robot(TEPSR)system is proposed,which integrates a rotary freestanding triboelectric nanogenerator(RFTENG)to drive a soft robot comprising a piezoelectric unimorph and electrostatic *** on the natural triboelectrification,through converting mechanical energy into electricity,TENG provides a unique approach for actuation and manipulation of the soft *** perfect combination provides the most straightforward way for creating a self-powered ***,under the power of RF-TENG,the soft robot reaches a maximum moving speed of 10 cm per second and a turning rate of 89.7°per second,*** actuation and manipulation demonstration are intuitively accomplished by maneuvering the robot around a maze with a 71 cm track within 28 *** autonomous feedback controls,one practical application is carrying two infrared sensors on board to realize obstacle avoidance in an unstructured ***,a micro-camera was equipped with the soft robot to provide real-time“first-person”video streaming,enhancing its detection capability.

关键词： triboelectric nanogenerator piezoelectric soft robot rapid actuation agile trajectory manipulation energy efficiency

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Synthesis and thermal conductivity of microfluidic copper nanofluids

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Particuology 2010年第3期8卷 262-271页

作者： xiaohao Wei Liqiu wang Department of Mechanical Engineering The University of Hong Kong Pokfulam Road Hong Kong China

A microfluidic chemical solution method is developed for the synthesizing Cu nanofluids. The method replaces batch-based macroreactors in the conventional chemical solution method by continuous-flow microfluidic microreactors, thereby enabling the synthesis of nanofluids with various microstructures. The Cu nanofluids synthesized by this technology show a better stability, remaining stable even after more than 100 h standing. The measured thermal conductivity shows that the presence of nanoparticles can either upgrade or downgrade fluid conductivity, a phenomenon predicted by the recent thermal-wave theory of nanofluids.

关键词： Nanofluids Heat conduction Thermal conductivity Synthesis

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Mercury removals by existing pollutants control devices of four coal-fired power plants in China

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Journal of Environmental Sciences 2011年第11期23卷 1839-1844页

作者： Juan wang Wenhuawang Wei Xu xiaohao wang Song Zhao School of Environmental Science ＆ Engineering Shanghai Jiao Tong University Shanghai 200240 China Shanghai Environmental Monitoring Center Shanghai 200030 China

The mercury removals by existing pollution control devices and the mass balances of mercury in four coal-fired power plants of China were carried out based on a measurement method with the aluminum matrix *** the plants are equipped with a cold-side electrostatic precipitator （ESP） and a wet flue gas desulfurization （FGD） in *** the course of coal stream,the samples,such as coal,bottom ash,fly ash,gypsum and flue gas,were *** Hg concentrations in coals were measured by CVAAS after appropriate preparation and acid *** solid samples were measured by the RA-915 ＋ Zeeman Mercury *** vapor phase Hg was collected by a sorbent trap from flue gas and then measured using CVAAS followed by acid *** mercury mass balances were estimated in this study were 91.6%,77.1%,118% and 85.8% for the four power plants,*** total Hg concentrations in the stack gas were ranged from 1.56–5.95 μg/m *** relative distribution of Hg in bottom ash,ESP,WFGD and stack discharged were ranged between 0.110%–2.50%,2.17%–23.4%,2.21%–87.1%,and 21.8%–72.7%,*** distribution profiles were varied with the coal type and the operation *** Hg in flue gas could be removed by ESP and FGD systems with an average removal efficiency of 51.8%.The calculated average emission factor was 0.066 g/ton and much lower than the results obtained ten years ago.

关键词： mercury power plant mass balance distribution removal efficiency emission factor

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传染病学双语融合式教学的探索和实践

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中国继续医学教育 2024年第7期16卷 7-12页

作者：康娟罗敏邓欢王晓昊雷宇杨平蔡大川张大志重庆医科大学附属第二医院感染病科重庆401336 重庆医科大学附属第二医院重症医学科重庆401336

目的探索充分运用信息技术手段开展实时互动融合式教学的应用价值。方法2022年3—8月,以重庆医科大学2017级临床本科、2017级儿科本科、2018级影像系本科、2018级临床本科、2018级儿科本科、2019级影像系本科共854名学生为研究对象。其... 详细信息

目的探索充分运用信息技术手段开展实时互动融合式教学的应用价值。方法2022年3—8月,以重庆医科大学2017级临床本科、2017级儿科本科、2018级影像系本科、2018级临床本科、2018级儿科本科、2019级影像系本科共854名学生为研究对象。其中,2017级临床本科、2017级儿科本科和2018级影像系本科共570名学生,采用传统的课堂教学模式;2018级临床本科、2018级儿科本科、2019级影像系本科共284名学生,采用实时互动融合式教学,以重庆医科大学在线教育综合平台为线上同步自学平台,线下课程转变为腾讯直播联合雨课堂教学助手相结合的方式进行实时互动融合式教学,实时互动课堂精讲重点难点,学生参与病例汇报或分析、翻转课堂、提问、答疑平台;课前、课中、课后有机结合、环环相扣,采用多维度、多元化的评价体系,并将学习成绩与上学年同专业的学生进行比较。结果2018级临床本科学生和2017级临床本科学生的平均总成绩分别为(79.85±7.46)分vs.(82.42±8.75)分,2018级儿科本科学生和2017级儿科本科学生的平均总成绩分别为(79.93±7.14)分vs.(82.46±6.91)分,2018级临床本科学生和2017级临床本科学生的英语题得分分别为(40.18±3.70)分vs.(41.78±4.92)分,2018级儿科本科学生和2017级儿科本科学生的英语题得分分别为(41.18±3.42)分vs.(42.92±4.04)分,差异均有统计学意义(P0.05)。结论实时互动融合式教学模式可操作性强,将线下教学转换为线上实时互动融合式教学并未影响学生的学习效果,更优于线上线下混合式教学模式,能满足传染病学双语教学的需求,能保证教学工作的顺利开展和教学质量。

关键词：实时互动融合式教学传染病学混合式教学双语教学医学教育教学改革

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Factors Controlling Organic Matter Enrichment in Alkaline Lacustrine Source Rocks:A Case Study of the Late Paleozoic Fengcheng Formation in the Junggar Basin,NW China

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Acta Geologica Sinica(English Edition) 2023年第6期97卷 1744-1755页

作者： HUANG Renda JIANG Fujie HU Tao CHEN Di HUANG Liliang LIU Zheyu wang xiaohao ZHANG Chenxi LU Jiahao WU Yuping State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Research Institute of Petroleum Exploration and Development Xinjiang Oilfield CompanyCNPCKaramayXinjiang 834000China

The late Paleozoic Fengcheng Formation shale(LPF shale)in the Junggar Basin,NW China,is the oldest alkaline source rock discovered in the world,providing a unique perspective with which to explore organic matter(OM)enrichment in alkaline lake *** with the organic carbon isotope profile and paleoenvironmental proxies,this study reveals that the LPF shale was deposited in an arid climate with high salinity and a strong reducing environment,accompanied by frequent volcanic *** TOC values are concentrated in two intervals with frequent fluctuations in OM types.A negative excursion due to changes in sedimentary OM source is found in the δ^(13)C_(org) *** excursion corresponds to the OM enrichment interval and is accompanied by abnormally high values of Sr/Ba and Sr/*** implies that the extreme arid climate has led to high salinity,resulting in strong reducibility and changes in paleontological assemblages,which in turn controlled the differential enrichment of *** Fengcheng ***-quality source rocks are the result of the combined action of climatic events,volcanism,high-salinity water environment and superior hydrocarbon-generating *** results provide new insights into the formation conditions of terrestrial alkaline high-quality source rocks and the factors controlling alkaline OM enrichment.

关键词： organic matter enrichment control factors alkaline lake source rocks Fengcheng Formation Junggar Basin

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Bio-cementation for tidal erosion resistance improvement of foreshore slopes based on microbially induced magnesium and calcium precipitation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1696-1708页

作者： xiaohao Sun Junjie wang Hengxing wang Linchang Miao Ziming Cao Linyu Wu Institute of Geotechnical Engineering Southeast UniversityNanjing211189China School of Civil Engineering and Architecture Wuhan Polytechnic UniversityWuhan430070China

In most coastal and estuarine areas,tides easily cause surface erosion and even slope failure,resulting in severe land losses,deterioration of coastal infrastructure,and increased *** bio-cementation technique has been previously demonstrated to effectively improve the erosion resistance of *** contains magnesium ions(Mg^(2+))with a higher concentration than calcium ions(Ca^(2+));therefore,Mg^(2+)and Ca^(2+)were used together for bio-cementation in this study at various Mg^(2+)/Ca^(2+)ratios as the microbially induced magnesium and calcium precipitation(MIMCP)*** angles,surface strengths,precipitation contents,major phases,and microscopic characteristics of precipitation were used to evaluate the treatment *** showed that the MIMCP treatment markedly enhanced the erosion resistance of *** Mg^(2+)/Ca^(2+)ratios resulted in a smaller change in angles and fewer soil losses,especially the Mg^(2+)concentration below 0.2 *** decreased Mg^(2+)/Ca^(2+)ratio achieved increased precipitation contents,which contributed to better erosion resistance and higher surface ***,the production of aragonite would benefit from elevated Mg^(2+)concentrations and a higher Ca^(2+)concentration led to more nesquehonite in magnesium precipitation *** slopes with an initial angle of 53°had worse erosion resistance than the slopes with an initial angle of 35°,but the Mg^(2+)/Ca^(2+)ratios of 0.2:0.8,0.1:0.9,and 0:1.0 were effective for both slope stabilization and erosion mitigation to a great *** results are of great significance for the application of MIMCP to improve erosion resistance of foreshore slopes and the MIMCP technique has promising application potential in marine engineering.

关键词： Bio-cementation Erosion resistance Foreshore slope stabilization Magnesium ions Calcium ions

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The Influencing Factors of Disposable Acetylcholinesterase Biosensor for in Situ Detection of Organophosphorus Pesticide

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稀有金属材料与工程 2006年第A3期35卷 389-391页

作者： Xiaowen Xu xiaohao wang Fei Tang Zhaoying Zhou State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua University Beijing 100084 China

An amperometric biosensor based on acetylcholinesterase (ACHE) is assembled by simple adsorption of the AChE on 7,7,8,8-tetracyanoquinodimethane (TCNQ) modified screen-printed *** biosensor is used to detect the inhibitory effect of organophosphorus pesticides on AChE *** detection of organophosphorus pesticides is done with acetylthiocboline chloride (ATCh) as *** order to obtain the optimized response to substrate,the influencing factors of the biosensor are investigated,including temperature,pH,incubation time,substrate concentration and AChE concentration. The measurements were performed after inhibition by immersing the enzyme electrode into the parathion methyl solution. Under the optimized conditions,that is,500 U/ml AChE concentration,pH 7.2,10 min incubation time,2 mmol/L substrate concentration and temperature of 37℃,from 5×10^(-8) mol/L to 5×10^(-5) mol/L is close to linear (regression equation: y(%)=124.055+15.7991gx,R^2=0.99644),which corresponds to 8.7%～56.1% AChE *** the optimized conditions, the lowest detectable amount of parathion methyl is 13×10^(-9).

关键词： biosensor AChE screen-printed electrodes influencing factors organophosphorus pesticides

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An Automatic Implementation of Oropharyngeal Swab Sampling for Diagnosing Respiratory Infectious Diseases via Soft Robotic End-Effectors

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 55-67页

作者： Yafeng Cui Wenjie Yu Jingjing Li Qi Shao Ding Weng Guoping Yin xiaohao Zhang Xinjun Liu Jingying Ye Jiadao wang Huichan Zhao Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Beijing Huakang Tongbang Technology Company Beijing 102609China Department of Otorhinolaryngology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Tianjin Research Institute for Advanced Equipment Tsinghua UniversityTianjin 300300China

The most widely adopted method for diagnosing respiratory infectious diseases is to conduct polymerase chain reaction(PCR)assays on patients’respiratory specimens,which are collected through either nasal or oropharyngeal *** manual swab sampling process poses a high risk to the examiner and may cause false-negative results owing to improper *** this paper,we propose a pneumatically actuated soft end-effector specifically designed to achieve all of the tasks involved in swab *** soft end-effector utilizes circumferential instability to ensure grasping stability,and exhibits several key properties,including high load-to-weight ratio,error tolerance,and variable swab-tip stiffness,leading to successful automatic robotic oropharyngeal swab sampling,from loosening and tightening the transport medium tube cap,holding the swab,and conducting sampling,to snapping off the swab tail and sterilizing *** an industrial collaborative robotic arm,we integrated the soft end-effector,force sensor,camera,lights,and remote-control stick,and developed a robotic oropharyngeal swab sampling *** this swab sampling system,we conducted oropharyngeal swab-sampling tests on 20 *** Digital PCR assay results(RNase P RNA gene absolute copy numbers for the samples)revealed that our system successfully collected sufficient numbers of cells from the pharyngeal wall for respiratory disease *** summary,we have developed a pharyngeal swab-sampling system based on an“enveloping”soft actuator,studied the sampling process,and imple-mented whole-process robotic oropharyngeal swab-sampling.

关键词： Diagnosis Medical robot Soft end-effector Swab-sampling Digital PCR

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