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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Enhancement of room-temperature magnetoresistance in La_(0.6)Dy_(0.1)Sr_(0.3)MnO_3/Ag_x

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Rare Metals 2010年第2期29卷 126-131页

作者： SONG Qixiang niu xiaofei WANG Guiying TANG Yonggang CAI Zhirang PENG Zhensheng Anhui Key Laboratory of Spintronic and Nanometric Materials (Cultivating Base) Suzhou College Suzhou 234000 China Structure Research Laboratory University of Science and Technology of China Hefei 230026 China

The samples of La0.6Dy0.1Sr0.3MnO3/（Ag2O）x/2（x = 0.00, 0.02, 0.04, 0.06, 0.08, 0.10, 0.20, 0.25, and 0.30） were prepared by using the solid-state reaction *** magnetic property, transport behavior, transport mechanism and magnetoresistance effect were studied through the measurements of magnetization-temperature（M-T） curves, ρ-T curves and the fitting of ρ-T *** results indicated that Ag could take part in the reaction when the doping amount is ***, when the doping amount is comparatively large, Ag as metallic state mainly deposits on the grain boundary of La0.6Dy0.1Sr0.3MnO3, and then the system forms a two-phase *** the Ag doping amount is 30% mole ratio, the resistivity of the sample is one order of magnitude smaller than that of low doped samples, and its peak of magnetoresistance at 292 K and in the magnetic field of 0.2 T strengthens apparently and reaches 16.3%, which is over 7 times as large as 2.2% of *** two-phase composite system of magnetoresistance based on perovskite manganite consists of two parts：intrinsic magnetoresistance and extrinsic ***, extrinsic magnetoresistance comes from spin-dependent scattering（SDS） and spin-polarized tunneling（SPT）.Magnetoresistance near TC increases due to the contribution of intrinsic magnetoresistance and extrinsic magnetoresistance formed by SDS, and magnetoresistance at low temperature is extrinsic magnetoresistance formed by SPT.

关键词： room temperature low-field magnetoresistance two-phase composite perovskite manganite

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Application of artificial hibernation technology in acute brain injury

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Neural Regeneration Research 2024年第9期19卷 1940-1946页

作者： Xiaoni Wang Shulian Chen Xiaoyu Wang Zhen Song Ziqi Wang xiaofei niu Xiaochu Chen Xuyi Chen Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina

Controlling intracranial pressure,nerve cell regeneration,and microenvironment regulation are the key issues in reducing mortality and disability in acute brain *** is currently a lack of effective treatment *** has the characteristics of low temperature,low metabolism,and hibernation rhythm,as well as protective effects on the nervous,cardiovascular,and motor *** hibernation technology is a new technology that can effectively treat acute brain injury by altering the body’s metabolism,lowering the body’s core temperature,and allowing the body to enter a state similar to *** review introduces artificial hibernation technology,including mild hypothermia treatment technology,central nervous system regulation technology,and artificial hibernation-inducer *** summarizing the relevant research on artificial hibernation technology in acute brain injury,the research results show that artificial hibernation technology has neuroprotective,anti-inflammatory,and oxidative stress-resistance effects,indicating that it has therapeutic significance in acute brain ***,artificial hibernation technology can alleviate the damage of ischemic stroke,traumatic brain injury,cerebral hemorrhage,cerebral infarction,and other diseases,providing new strategies for treating acute brain ***,artificial hibernation technology is currently in its infancy and has some complications,such as electrolyte imbalance and coagulation disorders,which limit its *** research is needed for its clinical application.

关键词： cute brain injury artificial hibernation hypothermia low metabolism mild hypothermia

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Enhancement of room-temperature magnetoresistance in La_(0.5)Sm_(0.2)Sr_(0.3)MnO_3/(Ag_2O)_(x/2)

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Rare Metals 2010年第1期29卷 45-49页

作者： PENG Zhensheng WANG Guiying TANG Yonggang LIU Peng niu xiaofei Anhui Key Laboratory. of Spintronics and Nano-materials Research Suzhou College Suzhou 234000 China Structure Research Laboratory University of Science and Technology of China Hefei 230026 China

La0.5Sm0.2Sr0.3MnO3/（Ag2O）x/2 （x = 0.00, 0.04, 0.08, 0.25, 0.30） samples were prepared by the solid-state reaction method, and their transport behaviors, transport mechanism, and magnetoresistance effect were studied through the measurement and fitting of p-T curves. The results show that the element Ag takes part in reaction when the doping amount is small. Ag is mainly distributed at the grain boundary of the host material and is in metallic state when the doping amount is relatively large; then the system becomes a two-phase composite. A small amount of Ag doping can apparently increase grain-boundary magnetoresistance induced by the spin-dependent scattering. The resistivity of the sample doped with 30 mol% Ag is one order of magnitude smaller than that of low-doped samples, and its magnetoresistance in the magnetic field of 0.5 T and at 300 K is strengthened apparently reaching 9.4%, which is connected not only with the improvement of the grain-boundary structure of the host material but also with the decrease of material resistivity.

关键词： low-field magnetoresistance room-temperature magnetoresistance grain-boundary magnetoresistance two-phase composite perovskite manganite

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6 - 14 Key Technical Research of Design of Cryogenic Chamber of Superconductor Magnet

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IMP & HIRFL Annual Report 2010年第1期 279-280页

作者： Jin Tao niu xiaofei Su Hailin Li Dapeng Guo Xiaohong Zhang Xiping

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The effect of transcranial direct current stimulation in medial prefrontal cortex on the gratitude of heterogeneous individual

The effect of transcranial direct current stimulation in med...

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第十二届（2017）中国管理学年会

作者： Pengcheng Wang Guangrong Wang xiaofei niu Huiliang Shang Jianbiao Li Business School Tianjin University of Economic and Finance Selten Laboratory Nankai University Neural Decision Science Laboratory Weifang University China Academy of Corporate Governance Nankai University

Gratitude is an important aspect of human sociality,which leads to benefits for both mental health and interpersonal *** is thus important to elucidate the neural mechanism of gratitude,which are only now beginning to be *** this end,the study verifies the specificity of medial prefrontal cortex（m PFC） engaged in gratitude of heterogeneous individuals using transcranial direct current stimulation（t DCS） *** neural studies showed that m PFC involved in social cognition and value evaluation were closely related to ***,the causal relationship between this neural area and gratitude has not been fully *** the effect of individual social heterogeneity is ignored,while behavioral economics studies suggested that abilities of employees in labor market would affect their feeling of gratitude and emotional ***,we designed an experiment based on the gift exchange game to further investigate the relationship between m PFC and gratitude of heterogeneous *** the experiment,participants were asked to form the self-cognition about their ability through an appropriately difficult *** then used the effort of participants to imply their gratitude andanalyzed effort levels of employees with different abilities under anodal,cathodal,and sham *** found that employees under anodal stimulation were significantly likely to exert more effort than those under sham stimulation,with cathodal stimulated employees ranking at the bottom of ***,the effort level of employees with low ability was obviously higher than that of high ability *** stimulation on m PFC significantly reduced the effort level of low ability employees,whereas anodal t DCS stimulation on m PFC increased the effort level of high ability *** found the relationship between m PFC and gratitude using t DCS,and provided neural evidence for incentive mechanism design in labor market to a certain exten

关键词： tDCS mPFC Gratitude Social Heterogeneity Gift Exchange Game

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6 - 7 Helium Recovery and Purification System

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IMP & HIRFL Annual Report 2012年第1期 247-248页

作者： niu xiaofei Zhang Junhui Guo Xiaohong Han Yanning Tan Fengguang Hu Chuanfei Zhang Peng

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轴流风扇动/静干涉噪声抑制的数值模拟与实验研究

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空气动力学学报 2021年第5期39卷 44-52页

作者：牛晓飞王勋年李勇温州大学机电工程学院温州325035 中国空气动力研究与发展中心空气动力学国家重点实验室绵阳621000

动/静干涉噪声是风扇单音噪声的重要组成部分,本文采用数值模拟与实验相结合的方式对某轴流冷却风扇转子与下游支柱之间干涉噪声的抑制进行了研究。数值计算采用大涡模拟(LES)与FW-H方程相结合的混合方法,噪声实验在全消声室中利用远场... 详细信息

动/静干涉噪声是风扇单音噪声的重要组成部分,本文采用数值模拟与实验相结合的方式对某轴流冷却风扇转子与下游支柱之间干涉噪声的抑制进行了研究。数值计算采用大涡模拟(LES)与FW-H方程相结合的混合方法,噪声实验在全消声室中利用远场麦克风测量。通过改变支柱迎风面宽度(H)和壁面开槽(对应不同穿孔率SP)两种方式来改变风扇模型的流动工况,分析不同控制策略对风扇气流流动和远场噪声特性的影响。结果表明,在下游支柱的干扰作用下,轴流风扇压力面的平均静压在叶片中部呈现周期性的分布。随着支柱迎风面宽度H的减小和壁面槽穿孔率SP的增大,支柱上的平均静压和风扇压力面的RMS压力逐渐降低。两种控制策略均能够有效减弱涡及其涡/固干扰强度,从而降低风扇噪声。数值模拟与实验结果吻合较好,显示风扇叶片通过频率BPF处的最大降噪量在所研究的流动配置下可以达到5 dB以上。

关键词：轴流风扇动/静干涉噪声控制数值模拟实验测量

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自组装[Pd_(6)(L)_(4)]^(8+)型大环配合物用于荧光传感HSO_(3)^(-)

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无机化学学报 2024年第7期40卷 1233-1242页

作者：牛晓菲王珂宋峰岩于澍燕北京工业大学化学与生命科学学院北京100124

在本研究中,通过金属定向的分级自组装反应,以芳基吡唑-吡啶配体与双金属钯组装子在水溶液中合成了平行四边形的大环超分子金属环[Pd_(6)(bpy)_(6)(L^(1))_(4)](PF_(6))_(8)(1a)和[Pd_(6)(bpy)_(6)(L^(2))_(4)](PF_(6))_(8)(2a),其中HL^(1)=1-(1H-pyrazole-4-yl)-4-(4-pyridyl)benzene,HL^(2)=9-(1H-pyrazole-4-yl)-10-(4-pyridyl)anthracene,bpy=2,2′-联吡啶。通过单晶X射线衍射证实了超分子钯平行四边形的结构。值得注意的是,这2个平行四边形金属环可以用作开启型荧光传感器,通过拆卸机制检测HSO_(3)^(-)。此外,基于配合物1a的传感器显示出对HSO_(3)^(-)的选择性检测,不受其他阴离子的干扰。检测限低至0.131μmol·L^(-1)。此外,配合物1a还通过荧光变化实现了在试纸模式下对HSO_(3)^(-)的半定量可视化检测。

关键词：自组装超分子钯平行四边形荧光检测超分子晶体亚硫酸氢根探针

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(Ca,Sr,Ba)_3V_2O_8的制备和发光性能研究

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材料导报 2013年第12期27卷 39-42页

作者：牛晓飞张明玉宿州学院自旋电子与纳米材料安徽省重点实验室宿州234000

采用微波辅助溶胶-凝胶法制备了自激发钒酸盐A3(VO4)2(A:Ca,Sr,Ba)。采用X射线衍射仪、傅里叶变换红外光谱仪、扫描电镜、透射电子显微镜、荧光谱仪对样品各项参数进行了表征,研究了A3(VO4)2的光致发光特性,探讨了不同制备工艺条件对其... 详细信息

采用微波辅助溶胶-凝胶法制备了自激发钒酸盐A3(VO4)2(A:Ca,Sr,Ba)。采用X射线衍射仪、傅里叶变换红外光谱仪、扫描电镜、透射电子显微镜、荧光谱仪对样品各项参数进行了表征,研究了A3(VO4)2的光致发光特性,探讨了不同制备工艺条件对其发光性质的影响。实验结果表明,Sr3V2O8样品发光强度随退火温度而变化,在680～900℃时,其发射光谱强度随温度上升而单调下降,达到1000℃时开始上升;pH值为4时,样品的发射光谱强度最大。

关键词：发光材料碱土金属钒酸盐稀土掺杂发光机理

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