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Ultrathin GaN Film Derived from Amorphous Ga_(2)O_(3) Film

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 814-818页

作者：王鹏 ZHANG Binbin liu xiaofei ZHANG Xin TU Rong ZHANG Song 李宝文 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Silicate Materials for Architectures School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China

It remains a big challenge to synthesize two-dimensional(2D)GaN material for applications in power *** synthetic methods require complex equipment and processes and time ***,we reported a two-step route to prepare polycrystalline 2D GaN *** amorphous ultrathin Ga_(2)O_(3)film was first exfoliated from the surface of liquid *** a vapor phase reaction,2D Ga_(2)O_(3)film was then converted into 2D GaN film while maintaining the 2D *** and high-resolution transmission electron microscope(HRTEM)analysis implies the successful synthesis of wurtzite-type GaN ultrathin *** simple strategy proposed in this work will provide more opportunities for applications of GaN ultrathin film in many devices.

关键词： GaN Ga_(2)O_(3) liquid gallium

iTRAQ-based Quantitative Proteomic Profiling of the Regulatory Mechanisms on Immune Functions and Blood Lipids in Aged Mice Fed with Lentinula edodes-Derived Polysaccharides

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Food Science and Human Wellness 2024年

作者： xiaofei Xu xiaofei liu Jin Chen Jingjing Guan Donghui Luo College of Food Science and Engineering， Guangdong Ocean University

The mechanisms of mushroom polysaccharides on immune functions and lipid metabolism of aged mammals have not been fully elucidated. In the present study， after assessing the impacts of one type of Lentinula edodes-derived polysaccharides， named L2， on immune functions and blood lipid profiles， isobaric tags for relative and absolute quantification (iTRAQ)-based proteomic profiling of the small intestinal tissues from aged mice treated with L2 was performed. L2 reversed immune function declines and modulated the lipid metabolism of aged mice evidenced by increased levels of serum TC， HDL-C， and LDL-C， and reduced levels of serum TG. Moreover， a total of 95 differentially regulated proteins (DRPs) were identified， of which 75 were up-regulated and 20 were down-regulated. Most of the DRPs were involved in intracellular and extracellular structure organization， and cellular and metabolic regulation. Particularly， approximately 16 and 9 DRPs participated in the regulation of immune functions and lipid metabolism， respectively. Furthermore， protein-protein interaction analysis highlighted that cadherin 1， plectin， cadherin-17， Ras GTPase-activating-like protein IQGAP2， and ezrin might be key proteins in response to L2 treatment. These findings provide new insights into the biological mechanisms of mushroom polysaccharides in anti-aging from a proteomic perspective.

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Attenuation of arsenic-induced gut injury in mice by sulfated glycosaminoglycan from swim bladder via regulation of gut microbiota， metabolites， and intestinal barrier integrity

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Food Science and Human Wellness 2024年

作者： Jieying Ou xiaofei liu Jing Chen Houpei Huang Xuejing Jia Baojun Xu Zhiling Yu Saiyi Zhong Shenzhen Research Institute， Guangdong Ocean University Food Science and Technology Program， Department of Life Sciences， BNU-HKBU United International College Centre for Cancer and Inflammation Research， School of Chinese Medicine， Hong Kong Baptist University College of Food Science and Technology， Guangdong Ocean University， Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety

Arsenic， a known environmental carcinogen， disrupts intestinal homeostasis， posing a significant threat to human health. Mitigating its toxic effects is crucial， and this study explores the potential of swim bladder sulfated glycosaminoglycan (SBSG) in achieving this. Our previous in vitro studies have shown SBSG to ameliorate arsenic-induced damage in intestinal epithelial cells， but its in vivo effects remain elusive. The current investigation demonstrates that SBSG exhibits a beneficial prebiotic action in vivo， regulating gut microbiota， metabolites， and intestinal barrier function to counter arsenic's adverse effects. Specifically， SBSG regulates microbiota composition， suppressing pathogenic species like Alistipes and Candidatus＿Saccharimonas while promoting beneficial ones such as Ruminococcus and Akkermansia. In the colon， SBSG fermentation enhances the production of short-chain fatty acids (SCFAs)， leading to upregulation of GPR43， GPR109A， and Olfr78 receptors. Additionally， SBSG strengthens the intestinal barrier by increasing the expression of Claudin-1， Occludin， and ZO-1， and enhances mucin gene expression (MUC-1 and MUC-2) to address chemical barrier disruptions. Immunologically， SBSG modulates the RORγt/Foxp-3 pathway and the TLR4/MyD88/NF-κB signaling cascade， regulating the immune barrier. These findings suggest that SBSG could be a promising prebiotic candidate for maintaining intestinal health and may serve as a dietary supplement or adjunct in heavy metal detoxification therapies.

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Investigating the Immunogenic Cell Death‑Dependent Subtypes and Prognostic Signature of Triple‑Negative Breast Cancer

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Phenomics 2024年第1期4卷 34-45页

作者： Youyang Shi Yuanyuan Wu Feifei Li Kexin Jiang Xiaofang Fang Yu Wang Xiaoyun Song Rui Wang Lixin Chen Jinzhou Zheng Chunyu Wu Yuenong Qin xiaofei liu Sheng liu Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineWanping South Road725Shanghai 200033China First Clinical College Shandong University of Traditional Chinese MedicineNo.16369Jingshi RoadLixia DistrictJinan 250011ShandongChina

Recently,immunotherapy has emerged as a promising and efective method for treating triple-negative breast cancer(TNBC).However,challenges still *** cell death(ICD)is considered a prospective treatment and potential combinational treatment strategy as it induces an anti-tumor immune response by presenting the antigenic epitopes of dead ***,the ICD process in TNBC and its impact on disease progression and the response to immunotherapy are not well *** this study,we observed dysregulation of the ICD process and verifed the altered expression of prognostic ICD genes in TNBC through quantitative real-time polymerase chain reaction(qRT-PCR)*** investigate the potential role of the ICD process in TNBC progression,we determined the ICD-dependent subtypes,and two were *** of their distinct tumor immune microenvironment(TIME)and cancer hallmark features revealed that Cluster 1 and 2 corresponded to the immune“cold”and“hot”phenotypes,*** addition,we constructed the prognostic signature ICD score of TNBC patients and demonstrated its clinical independence and *** ICD score could also serve as a potential biomarker for immune checkpoint blockade and may aid in the identifcation of targeted efective agents for individualized clinical strategies.

关键词： Immunogenic cell death Triple-negative breast cancer Tumor immune microenvironment Prognostic signature

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同意本质的伦理学分析

道德与文明 2024年第3期 146-156页

作者：刘晓飞武汉大学哲学学院湖北武汉430072

同意在道德和法律关系中起着重要作用:它能将一个原本侵权的行为变成一个道德或法律上许可的行为。要回答实践中种种涉及同意的道德和法律问题,首先需要明确界定“何为同意”,它是指一个人的主观意愿还是其外在行为表示?学界对这一问题... 详细信息

同意在道德和法律关系中起着重要作用:它能将一个原本侵权的行为变成一个道德或法律上许可的行为。要回答实践中种种涉及同意的道德和法律问题,首先需要明确界定“何为同意”,它是指一个人的主观意愿还是其外在行为表示?学界对这一问题有几派不同的观点:主观论、行为论和综合论。这几派观点各有缺陷。伦理学上和实践上更全面的考量支持“两分论”,即认为依据具体的情况,一个转让权利的主观意愿或者一个公开表示转让权利的外在行为就可以构成同意。

关键词：同意主观论行为论两分论权利转让

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海南姜科植物药用价值研究进展

海南医学院学报 2024年第5期30卷 383-389页

作者：刘小飞林开文海南省妇女儿童医学中心药学部海南海口570312 海南医学院儿科学院海南海口571199

药食同源的中草药作为植物源性药物补充剂,亚洲国家不仅在各种烹饪制品中以香料和调味品的角色出现而且更以多靶点的药理活性成分在药物传递的多机制的功效和人体吸收的安全性被广泛用于保健、预防或治疗各种疾病。海南作为中国唯一的... 详细信息

药食同源的中草药作为植物源性药物补充剂,亚洲国家不仅在各种烹饪制品中以香料和调味品的角色出现而且更以多靶点的药理活性成分在药物传递的多机制的功效和人体吸收的安全性被广泛用于保健、预防或治疗各种疾病。海南作为中国唯一的热带省份,天然药用植物资源丰富而姜科植物多样且具有独特的重要价值,为食物、调料、药物、天然染料及香料等产品提供多样的选择。在国内外许多研究中表明,姜科植物中含有的众多活性药理化学成分具有潜在的植物医药用途作用且四大南药中姜科植物就占有两种,而2020版药典中记载入药的多种姜科属植物,海南均有盛产,可见姜科属植物在海南具有潜在的医药和研究价值。本文就海南主要的姜科植物作为治疗药物在相关疾病中的研究作一综述,为海南姜科植物的开发、研究和临床疾病治疗用药提供思路,同时也能更好地推动海南姜科植物种植产业,增加其产品附加值。

关键词：化学成分姜科植物药用价值研究进展

一种求解能量受限的最大圆盘覆盖问题的进化算法

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华中科技大学学报（自然科学版） 2024年第2期52卷 36-41页

作者：李伟东蓝欢刘晓非云南大学数学与统计学院云南昆明650504 云南大学信息学院云南昆明650504

面对大规模多数据监测任务,有限的能量将成为无线传感器的瓶颈,本文将该问题抽象为能量受限的最大圆盘覆盖问题.即试图寻找一种能量分配方案,使得在总能量受限的情况下,传感器网络覆盖的用户收益之和最大.基于贪婪策略,设计了一个多项... 详细信息

面对大规模多数据监测任务,有限的能量将成为无线传感器的瓶颈,本文将该问题抽象为能量受限的最大圆盘覆盖问题.即试图寻找一种能量分配方案,使得在总能量受限的情况下,传感器网络覆盖的用户收益之和最大.基于贪婪策略,设计了一个多项式时间(1/2)(1-1/e)-近似算法;进一步通过构造一个合理的代理函数,设计了一个分组进化算法,并证明在期望多项式时间内,该算法具有相同近似比.实验结果表明,分组进化算法输出解的目标函数值与最优值几乎相同.

关键词：圆盘覆盖问题能量受限贪婪算法进化算法近似比

提升学生工程学思维的“基因工程”二轮复习教学设计

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生物学教学 2024年第5期49卷 38-42页

作者：刘晓飞邢慧丽中国科学院附属实验学校北京100029

本节课从真实的科研情境出发,引导学生以科研工作者的思维设计基于CRISPR/Cas系统的靶向基因编辑器,成功获得白粉病抗性小麦。将基因工程的相关知识加以复习巩固并迁移运用,在此过程中训练学生的科学思维和工程学思维,同时充分彰显了基... 详细信息

本节课从真实的科研情境出发,引导学生以科研工作者的思维设计基于CRISPR/Cas系统的靶向基因编辑器,成功获得白粉病抗性小麦。将基因工程的相关知识加以复习巩固并迁移运用,在此过程中训练学生的科学思维和工程学思维,同时充分彰显了基因工程的实际应用价值。

关键词：基因编辑 CRISPR/Cas技术小麦白粉病工程学思维高中生物学

金属纳米团簇的模板合成及其在食品中的应用进展

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食品工业科技 2024年第14期45卷 390-397页

作者：张帅王富敏王艳刘晓飞辛嘉英哈尔滨商业大学食品工程学院黑龙江哈尔滨150028

金属纳米团簇(Metal Nanoclusters,MNCs)因其独特的物理化学性质,在食品安全领域显示出极大的应用潜力。通过模板合成法,可实现MNCs特定尺寸、形状和分散性的调控,进而提升其功能特性。本文结合近年来关于金属纳米团簇的研究,主要综述... 详细信息

金属纳米团簇(Metal Nanoclusters,MNCs)因其独特的物理化学性质,在食品安全领域显示出极大的应用潜力。通过模板合成法,可实现MNCs特定尺寸、形状和分散性的调控,进而提升其功能特性。本文结合近年来关于金属纳米团簇的研究,主要综述了模板辅助合成金属纳米团簇的机制及其在食品污染物检测、食品包装材料、抗菌剂和食品添加剂检测方面的应用,为模板法合成金属纳米团簇提供可参考的科学依据,为金属纳米团簇在食品安全监测领域提供见解和方向。

关键词：金属纳米团簇模板合成应用

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