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脊髓损伤患者基础肺功能与日常生活能力的相关性研究

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联勤军事医学 2024年第7期38卷 568-572页

作者：林小东吴相波郭颖何霞薛白洁胡旭许招娣孙玮牛丹孙晓龙空军军医大学第一附属医院(西京医院)康复医学科陕西西安710032

目的探究脊髓损伤(spinal cord injury,SCI)患者基础肺功能与日常生活能力的相关性,为临床更好地应用基础肺功能指标指导心肺康复训练、提高患者日常生活能力提供理论依据。方法回顾性分析2017-08/2022-07月在作者医院住院治疗的148例... 详细信息

目的探究脊髓损伤(spinal cord injury,SCI)患者基础肺功能与日常生活能力的相关性,为临床更好地应用基础肺功能指标指导心肺康复训练、提高患者日常生活能力提供理论依据。方法回顾性分析2017-08/2022-07月在作者医院住院治疗的148例SCI患者临床资料。收集SCI患者的性别、年龄、病程、是否肺部感染、吸烟史、体质量指数(body mass index,BMI)、神经损伤平面、美国脊柱损伤协会(American spinal injury association,ASIA)分级和基础肺功能指标[包括潮气量(tidal volume,VT)、用力呼吸肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))与FVC比值(forced expiratory volume in one second,FEV_(1)/FVC)、最大通气量(maximum voluntary ventilation,MVV)、最大通气量占预计值百分比(maximal voluntary ventilation/maximal predicted voluntary ventilation,MVVpred)、呼气肺活量(expiratory vital capacity,EVC)、呼气峰流速(peak expiratory flow,PEF)、用力呼出25%肺活量呼气流速(forced expiratory flow at 25%of FVC exhaled,FEF_(25))、用力呼出50%肺活量呼气流速(forced expiratory flow at 50%of FVC exhaled,FEF_(50))、用力呼出75%肺活量呼气流速(forced expiratory flow at 75%of FVC exhaled,FEF_(75))]等资料。以改良Barthel指数(modified Barthel index,MBI)为因变量,利用单元及多元线性回归方法筛选SCI患者日常生活能力的独立危险因素。结果单元及多元线性回归结果显示,SCI患者MBI与VT(β=0.024,P<0.001),MVVpred(β=0.385,P<0.001),神经损伤平面T平面(β=10.613,P=0.009)、L平面(β=12.207,P=0.012)、S平面(β=27.994,P=0.005),ASIA分级(CDE)(β=24.550,P<0.001),性别(女性)(β=9.956,P=0.024)有显著相关性。结论基础肺功能指标VT、MVVpred与SCI患者日常生活能力密切相关,在治疗过程中应加强心肺康复,最大程度改善患者的日常生活能力。

关键词：脊髓损伤基础肺功能日常生活能力改良Barthel指数心肺康复

Immunostimulatory gene therapy combined with checkpoint blockade reshapes tumor microenvironment and enhances ovarian cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 854-868页

作者： Yunzhu lin Xiang Wang Shi He Zhongxin Duan Yunchu Zhang xiaodong Sun Yuzhu Hu Yuanyuan Zhang Zhiyong Qian Xiang Gao Zhirong Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacySichuan UniversityChengdu 610041China Department of Pharmacy Evidence-based Pharmacy CenterWest China Second University HospitalKey Laboratory of Birth Defects and Related Diseases of Women and ChildrenSichuan UniversityChengdu 610041China Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengdu 610041China Department of Radiation Oncology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengdu 610041China West China School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengdu 610041China

Immune evasion has made ovarian cancer notorious for its refractory features, making the development of immunotherapy highly appealing to ovarian cancer treatment. The immune-stimulating cytokine IL-12 exhibits excellent antitumor activities. However, IL-12 can induce IFN-γ release and subsequently upregulate PDL-1 expression on tumor cells. Therefore, the tumor-targeting folate-modified delivery system F-DPC is constructed for concurrent delivery of IL-12 encoding gene and small molecular PDL-1 inhibitor(i PDL-1) to reduce immune escape and boost anti-tumor immunity. The physicochemical characteristics, gene transfection efficiency of the F-DPC nanoparticles in ovarian cancer cells are analyzed. The immune-modulation effects of combination therapy on different immune cells are also studied. Results show that compared with non-folate-modified vector, folate-modified F-DPC can improve the targeting of ovarian cancer and enhance the transfection efficiency of p IL-12. The underlying anti-tumor mechanisms include the regulation of T cells proliferation and activation, NK activation,macrophage polarization and DC maturation. The F-DPC/p IL-12/i PDL-1 complexes have shown outstanding antitumor effects and low toxicity in peritoneal model of ovarian cancer in mice. Taken together, our work provides new insights into ovarian cancer immunotherapy. Novel F-DPC/p IL-12/i PDL-1 complexes are revealed to exert prominent anti-tumor effect by modulating tumor immune microenvironment and preventing immune escape and might be a promising treatment option for ovarian cancer treatment.

关键词： IL-12encodinggene Checkpointblocker Nanoparticles Targeted delivery Tumormicroenvironment Immune escape Ovarian cancer Immunotherapy

Polarization-dependent photoinduced metal–insulator transitions in manganites

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Science Bulletin 2024年第2期69卷 183-189页

作者： lina Deng Weiye Zhang Hanxuan lin Lifen Xiang Ying Xu Yadi Wang Qiang Li Yinyan Zhu xiaodong Zhou Wenbin Wang Lifeng Yin Hangwen Guo Chuanshan Tian Jian Shen State Key Laboratory of Surface Physics Institute for Nanoelectronic Devices and Quantum Computingand Department of PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Shanghai Branch CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum PhysicsShanghai 201315China

In correlated oxides,collaborative manipulation on light intensity,wavelength,pulse duration and polarization has yielded many exotic discoveries,such as phase transitions and novel quantum *** view of potential optoelectronic applications,tailoring long-lived static properties by light-induced effects is highly *** far,the polarization state of light has rarely been reported as a control parameter for this ***,we report polarization-dependent metal-to-insulator transition(MIT)in phaseseparated manganite thin films,introducing a new degree of freedom to control static ***,we observed giant photoinduced resistance jumps with striking features:(1)a single resistance jump occurs upon a linearly polarized light incident with a chosen polarization angle,and a second resistance jump occurs when the polarization angle changes;(2)the amplitude of the second resistance jump depends sensitively on the actual change of the polarization *** transmittance measurements reveal that the origin of the above phenomena is closely related to the coexistence of anisotropic *** results represent a first step to utilize light polarization as an active knob to manipulate static phase transitions,pointing towards new pathways for nonvolatile optoelectronic devices and sensors.

关键词： Metal-insulator phase transitions Polarization of light Electronic phase separation Selective domain controllability

Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： Xiaozhong Chen Wei Wang Qingfeng Zou xiaodong Zhu Qin lin Yi Jiang Yan Sun Liangfang Shen lin Wang Guorong Zou Xiaoyan lin Shaojun lin Minying Li Ying Wang Ruilian Xu Rui Ao Rensheng Wang Haifeng lin Shuang Huang Tingting Xu Wenting Li Mengying Xia Yu Xia Zhongmin Wang Baiyong Li Jingao Li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in China enrolled adult patients with metastatic nasopharyngeal carcinoma(NPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NPC patients,supporting further clinical development as third-line treatment of metastatic NPC.

关键词： metastatic nasopharyngeal supporting

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基于变分模态分解的复杂航天器姿态扰动分析

振动与冲击 2023年第13期42卷 303-309页

作者：林晓冬张锐刘芳兰青中国科学院微小卫星创新研究院上海201203 中国科学院大学北京100049

以复杂航天器姿态控制系统为研究对象,在考虑航天器配置挠性帆板和充液贮箱的复杂情况下,对姿态控制系统闭环中由于帆板挠性和液体晃动产生的干扰力矩进行特性分析。基于虚功率法建立复杂航天器整体动力学方程,同时建立帆板振动和液体... 详细信息

以复杂航天器姿态控制系统为研究对象,在考虑航天器配置挠性帆板和充液贮箱的复杂情况下,对姿态控制系统闭环中由于帆板挠性和液体晃动产生的干扰力矩进行特性分析。基于虚功率法建立复杂航天器整体动力学方程,同时建立帆板振动和液体晃动动力学方程;采用相平面控制律完成复杂航天器姿态闭环控制仿真,对帆板挠性和液体晃动产生的干扰力矩进行数据采集;基于变分模态分解法对扰动力矩时域数据进行时频分析得到其扰动特性,为后续扰动抑制算法的设计提供理论基础。通过数学仿真结果表明该方法的适用性和准确性。

关键词：变分模态分解(VMD) 帆板挠性液体晃动相平面控制

基于PCHD模型的MMC-SMES无源控制策略

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电网技术 2019年第3期43卷 1073-1082页

作者：林晓冬雷勇朱英伟四川大学电气信息学院四川省成都市610065

模块化多电平变换器(modulemultilevelconverter,MMC)由于其模块化、灵活性的特点,与传统的两电平、三电平变流器拓扑相比具有功率等级高、谐波畸变小、开关损耗低等显著优点,因此在拥有高功率密度的超导磁储能(superconducting magneti... 详细信息

模块化多电平变换器(modulemultilevelconverter,MMC)由于其模块化、灵活性的特点,与传统的两电平、三电平变流器拓扑相比具有功率等级高、谐波畸变小、开关损耗低等显著优点,因此在拥有高功率密度的超导磁储能(superconducting magnetic energy storage,SMES)系统中拥有广阔的应用前景。提出了基于MMC的SMES新型拓扑结构及其无源控制策略,可有效提高受控系统的输出电能质量和动态特性。首先,建立了MMC-SMES的数学模型及其端口受控耗散哈密尔顿模型;其次,针对其运行过程中的非线性特性,通过考虑受控系统的内外部互联结构,设计了MMCSMES的无源控制策略;然后,针对MMC运行中存在的均压和环流问题,分别采用了子模块电容电压的分级式均压控制和负序二倍频坐标变换下的相间解耦控制;最后,仿真结果验证了所提出的MMC-SMES新型拓扑及其无源控制策略的有效性。

关键词：超导磁储能模块化多电平变换器无源控制端口受控耗散哈密尔顿环流

超导磁储能—限流器用于提高光伏并网发电系统暂态稳定性

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高电压技术 2020年第1期46卷 90-99页

作者：李永凯雷勇林晓冬四川大学电气工程学院成都610065 国网四川省电力公司成都供电公司成都610041

针对光伏并网发电系统转动惯量小,在受到不同的干扰时容易脱网运行的问题,提出了一种基于超导磁储能—限流器(superconducting magnetic energy storage-fault current limiter,SMES-FCL)装置的控制策略以提高光伏并网发电系统的暂态稳... 详细信息

针对光伏并网发电系统转动惯量小,在受到不同的干扰时容易脱网运行的问题,提出了一种基于超导磁储能—限流器(superconducting magnetic energy storage-fault current limiter,SMES-FCL)装置的控制策略以提高光伏并网发电系统的暂态稳定性。SMES-FCL装置通过三相变压器串联在光伏电站与配电网间的公共耦合点,具有限流和储能的双重作用。但由于该装置具有高强度的非线性和耦合性,因此采用双闭环的滑模控制(sliding-mode control,SMC)方式控制,系统外环釆用SMC来稳定直流侧母线电压,内环采用SMC以实现电流的快速解耦。通过仿真算例分析验证了控制策略的有效性,仿真结果表明:外部增加SMES-FCL设备可以更有效地提高光伏并网发电系统的故障穿越的能力,减缓功率波动对配电网的冲击;与PI控制策略相比,所提出的SMC控制策略增强了SMES-FCL的抗扰动性。

关键词：光伏并网发电超导磁储能-限流器滑模控制故障穿越

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基础设施智慧服务系统(iS3)及其应用

土木工程学报 2018年第1期51卷 1-12页

作者：朱合华李晓军林晓东同济大学土木防灾国家重点实验室上海200092 同济大学岩土及地下工程教育部重点实验室上海200092 同济大学土木工程学院上海200092

随着建筑信息模型(BIM)、地理信息系统(GIS)、物联网、大数据和云计算等工程信息技术的快速发展,基础设施的智慧化管理将成为必然发展趋势。在基础设施数字化、建养一体化等研究基础上,该文从信息流的角度提出基础设施智慧服务系统(infr... 详细信息

随着建筑信息模型(BIM)、地理信息系统(GIS)、物联网、大数据和云计算等工程信息技术的快速发展,基础设施的智慧化管理将成为必然发展趋势。在基础设施数字化、建养一体化等研究基础上,该文从信息流的角度提出基础设施智慧服务系统(infrastructure Smart Service System,iS3)的理念,以此实现基础设施智慧化管理。首先,该文给出iS3的定义,即基础设施全寿命期的数据采集、处理、表达、分析和服务的一体化智慧决策系统;其次,概括地介绍iS3的目标与特点,阐明iS3与BIM和GIS等现有系统的关系,并介绍了iS3的五个组成部分,即基础层、数据层、服务层、应用层和用户层,同时分别从数据采集、处理、表达、分析和服务五个方面对系统进行描述;最后,给出了iS3在地铁区间隧道结构运营维护中的应用实例。

关键词：基础设施数字技术智慧技术建筑信息模型

人民币升值对出口商品价格传递效应的测度及其政策涵义——以中美贸易为例

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财贸研究 2012年第6期23卷 35-42页

作者：骆祚炎林晓东广东商学院金融学院广东广州510320

以单位值指数构造方法为基础,选取五种商品分别构建五个不同行业商品的出口价格指数,经过协整检验、自回归分布滞后检验以及脉冲响应函数检验,结果发现:五种行业出口产品的价格指数在短期内均存在不完全的汇率传递效应;相对于其他行业来... 详细信息

以单位值指数构造方法为基础,选取五种商品分别构建五个不同行业商品的出口价格指数,经过协整检验、自回归分布滞后检验以及脉冲响应函数检验,结果发现:五种行业出口产品的价格指数在短期内均存在不完全的汇率传递效应;相对于其他行业来说,劳动密集型行业的汇率的短期出口价格效应更加明显;汇率传递的长期出口价格效应要高于短期出口价格效应。其政策涵义是,为规避人民币升值的负面效应,中国应该积极推动全球化过程中贸易自由化进程,做好劳动密集型行业的升级和优化,稳步推进人民币汇率形成机制和管理体制改革,宏观政策做到微观审慎监管和宏观审慎监管相结合。

关键词：汇率传导效应出口商品价格贸易自由化