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Developments and perspectives on the precision forming processes for ultra-large size integrated components

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International Journal of Extreme Manufacturing 2019年第2期1卷 34-51页

作者： Shijian Yuan xiaobo fan School of Mechanical Engineering Dalian University of TechnologyDalian 116023People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China

In order to meet the requirements of high reliability,long-lifetime and lightweight in a new generation of aerospace,aviation,high-speed train,and energy power equipment,integrated components are urgently needed to replace traditional multi-piece,welded *** applications of integrated components involve in a series of large-size,complex-shaped,highperformance components made of difficult-to-deform materials,which present a huge challenge for forming ultra-large size integrated *** this paper,the developments and perspectives of several extreme forming technologies are reviewed,including the sheet hydroforming of ultra-large curved components,dieless hydroforming of ellipsoidal shells,radial-axial ring rolling of rings,in situ manufacturing process of flanges,and local isothermal forging of titanium alloy *** principle and processes for controlling deformation are briefly *** forming of typical ultra-large size integrated components and industrial applications are introduced,such as the high strength aluminum alloy,3m in diameter,integrated tank dome first formed by using a sheet blank with a thickness the same as the final component,and a 16m diameter,integrated steel ring rolled by using a single *** trends for extreme forming of ultra-large size integrated components are discussed with a goal of providing ideas and fundamental guidance for the further development of new forming processes for extreme-size integrated components in the future.

关键词： ultra-large size integrated components extreme forming hydroforming radial-axial ring rolling isothermal forging

Innovation for forming aluminum alloy thin shells at ultra-low temperature by the dual enhancement effect

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International Journal of Extreme Manufacturing 2022年第3期4卷 99-103页

作者： fan xiaobo Yuan Shijian School of Mechanical Engineering Dalian University of TechnologyDalianPeople’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbinPeople’s Republic of China

Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the cold forming and hot forming processes. An innovative technology of ultra-low temperature forming has been invented for aluminum alloy thin shells by the new phenomenon of ‘dual enhancement effect’. That means plasticity and hardening are enhanced simultaneously at ultra-low temperatures. In this perspective, the dual enhancement effect is described, and the development, current state and prospects of this new forming method are introduced. This innovative method can provide a new approach for integral aluminum alloy components with large size, ultra-thin thickness, and high strength. An integral tank dome of rocket with 2 m in diameter was formed by using a blank sheet with the same thickness as the final component, breaking through the limit value of thickness-diameter ratio.

关键词： aluminum alloy thin shell ultra-low temperature forming dual enhancement effect

Investigation on the Formability of 5A06 Sheet for Rapid Gas Forming

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稀有金属材料与工程 2011年第S3期40卷 144-147页

作者： He Zhubin, fan xiaobo, Xu Yongchao, Yuan Shijian Harbin Institute of Technology, Harbin 150001, China Harbin Inst Technol Sch Mat Sci & Engn Harbin 150001 Peoples R China

The formability of light-weight alloy, such as aluminum alloy, magnesium alloy, can be improved significantly when formed at elevated temperature. Superplastic forming (SPF) is a well-known manufacturing method to form complex part of these materials. In order to realize mass production of SPF in industry, forming at high strain rate should be realized. In this study, the mechanical properties of 5A06 sheet were tested by uniaxial tensile test at high strain rate and elevated temperatures up to 550 ℃. Free bulging test and forming of round cup were carried out to evaluate the formability of the 5A06 sheet. Results show that the total elongation of the 5A06 sheet began to increase rapidly after 200 ℃, and reached the maximum value at 450 ℃. At higher temperature, early brittle fracture occurred. In free bulging test, the bulging height remained almost constant about 27.0 mm, which means the formability of the sheet is not sensitive to forming temperature at elevated temperature. In the forming of round cup part, temperature has direct effect on the corner filling ability of the sheet, especially at temperature lower than 400 ℃.

关键词： 5A06 sheet formability superplastic forming (SPF) rapid gas forming (RGF) free bulging test

Super-sensitive bifunctional nanoprobe: Self-assembly of peptide-driven nanoparticles demonstrating tumor fluorescence imaging and therapy

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1473-1486页

作者： Han Xiao Rui Zhang xiaobo fan Xinglu Jiang Mingyuan Zou Xuejiao Yan Haiping Hao Guoqiu Wu Medical School Southeast UniversityNanjing 210009China Department of Clinical Laboratory the Fifth Affiliated Hospital of Sun Yat-sen UniversityNanjing 210009China Department of Cardiology the Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityNanjing 210009China State Key Laboratory of Natural Medicines Key Lab of Drug Metabolism and PharmacokineticsChina Pharmaceutical UniversityZhuhai 519000China Center of Clinical Laboratory Medicine Zhongda HospitalSoutheast UniversityNanjing 21009China Jiangsu Provincial Key Laboratory of Critical Care Medicine Southeast UniversityChangzhou 213000China

The development of nanomedicine has recently achieved several breakthroughs in the field of cancer treatment;however,biocompatibility and targeted penetration of these nanomaterials remain as limitations,which lead to serious side effects and significantly narrow the scope of their *** self-assembly of intermediate filaments with arginine-glycine-aspartate(RGD)peptide(RGDIFP)was triggered by the hydrophobic cationic molecule 7-amino actinomycin D(7-AAD)to synthesize a bifunctional nanoparticle that could serve as a fluorescent imaging probe to visualize tumor *** designed RGD-IFP peptide possessed the ability to encapsulate 7-AAD molecules through the formation of hydrogen bonds and hydrophobic interactions by a one-step *** fluorescent nanoprobe with RGD peptide could be targeted for delivery into tumor cells and released in acidic environments such as endosomes/lysosomes,ultimately inducing cytotoxicity by arresting tumor cell cycling with inserted *** is noteworthy that the RGD-IFP/7-AAD nanoprobe tail-vein injection approach demonstrated not only high tumor-targeted imaging potential,but also potent antitumor therapeutic effects in *** proposed strategy may be used in peptide-driven bifunctional nanoparticles for precise imaging and cancer therapy.

关键词： Nanoprobe 7-Amino actinomycin D Intermediate filament protein Tumor image Antitumor therapy Integrin avβ3

Reducing the radiation dose with the adaptive statistical iterative reconstruction technique for chest CT in adults： a parameter study

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Chinese Medical Journal 2014年第7期127卷 1284-1288页

作者： Liu Wenyun Ding xiaobo Kong Boyu fan Baoyan Chen Liang Department of Radiology The First Hospital of Jilin UniversityChangchun Jilin 130021 China

Background Currently there is a trend towards reducing radiation dose while maintaining image quality during computer tomography （CT） *** results from the concerns about radiation exposure from CT and the potential increase in the incidence of radiation induced *** study aimed to investigate the lowest radiation dose for maintaining good image quality in adult chest scanning using GE CT *** Seventy-two adult patients were examined by Gemstone Spectral *** were randomly divided into six *** set up a different value of noise index （NI） when evaluating each group every other number from 13.0 to *** original images were acquired with a slice of 5 mm *** each group,several image series were reconstructed using different levels of adaptive statistical iterative reconstruction （ASIR）（30％,50％,and 70％）.We got a total of 18 image sequences of different combinations of NI and ASIR *** one hand,quantitative indicators,such as CT value and standard deviation （SD）,were assessed at the region of *** signal-to-noise ratio （SNR） and contrast-to-noise ratio （CNR） were *** volume CT dose index （CTDI） and dose length product （DLP） were *** the other hand,two radiologists with ＞5 years of experience blindly reviewed the subjective image quality using the standards we had previously *** The different combinations of noise index and ASIR were *** was no significant difference in CT values among the 18 image *** SD value was reduced with the noise index＇s reduction or ASIR＇s *** was a trend towards gradually lower SNR and CNR with an NI *** CTDI and DLP were diminishing as the NI *** scores from subjective image quality evaluation were reduced in all groups as the ASIR *** Increasing NI can reduce radiation *** the premise of maintaining the same image quality,using a suitable percentage of ASIR can inc

关键词： chest computed tomography image quality noise index adaptive statistical iterative reconstruction

染色体异常致反复和后代5p12-15.3三体:一对叙利亚夫妇报道及文献复习（英文）

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中华男科学杂志 2015年第3期21卷 219-224页

作者： Walid AL-ACHKAR Faten Moassass Ayman Al-Ablog Thomas Liehr xiaobo fan Abdulsamad Wafa Department of Molecular Biology and Biotechnology Human Genetics DivisionAtomic Energy Commission Jena University Hospital Institute of Human Genetics

在本研究中,我们介绍一叙利亚夫妻发生孕早期反复流产、胎儿畸形和/或新生儿死亡。经检查,父亲表型正常,有一个平衡的染色体易位t(5;15),在无精子症因子(AZF)b座位s Y125基因发生了微缺失而且其伴有MTHFRC677T纯合子基因多态性。值得注... 详细信息

在本研究中,我们介绍一叙利亚夫妻发生孕早期反复流产、胎儿畸形和/或新生儿死亡。经检查,父亲表型正常,有一个平衡的染色体易位t(5;15),在无精子症因子(AZF)b座位s Y125基因发生了微缺失而且其伴有MTHFRC677T纯合子基因多态性。值得注意的是,他的妻子则伴有MTHFRA1298C纯合子基因多态性。这对夫妻经历了两次流产,有2个夭折的孩子均为严重畸形,为5号染色体短臂部分三体。夫妻结婚10年后没有任何存活后代。

关键词：反复流产染色体异常胎儿畸形死胎 5p三体 Y染色体缺失荧光原位杂交亚甲基四氢叶酸还原酶

央行数字货币跨境支付的法律挑战与监管协调路径研究

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政法论坛 2024年第6期42卷 86-97页

作者：范晓波中国政法大学国际法学院

随着央行数字货币的崛起,跨境支付领域迎来了全新的发展机遇,然而,央行数字货币跨境支付受限于技术、法律、政策等多方面因素,成为制约其广泛应用的重要瓶颈。针对央行数字货币跨境支付监管协调的问题,金融稳定理事会提出关于加强跨境... 详细信息

随着央行数字货币的崛起,跨境支付领域迎来了全新的发展机遇,然而,央行数字货币跨境支付受限于技术、法律、政策等多方面因素,成为制约其广泛应用的重要瓶颈。针对央行数字货币跨境支付监管协调的问题,金融稳定理事会提出关于加强跨境支付三个优先主题的针对性的策略建议。统一支付标准和协议、加强技术创新和优化监管框架是提升央行数字货币跨境支付的关键。同时,加强国际合作与交流、创新多央行数字货币的治理机制也具有重要意义。

关键词：央行数字货币跨境支付互操作性监管协调数据跨境流动

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澳洲坚果油水剂法提取工艺的研究

中国油脂 2016年第6期41卷 15-18页

作者：范晓波无锡市食品科技开发公司江苏无锡214000

以澳洲坚果为原料,探索研究水剂法提油工艺,确定了其最佳工艺参数,并对提取的油进行品质分析。结果表明:在烘烤温度150℃、烘烤时间20 min、料液比1∶3、兑浆p H 6.0、浸提温度60℃、离心转速4 800 r/min的工艺条件下,出油效率可达79.3%... 详细信息

以澳洲坚果为原料,探索研究水剂法提油工艺,确定了其最佳工艺参数,并对提取的油进行品质分析。结果表明:在烘烤温度150℃、烘烤时间20 min、料液比1∶3、兑浆p H 6.0、浸提温度60℃、离心转速4 800 r/min的工艺条件下,出油效率可达79.3%;澳洲坚果油相对密度(20℃)为0.900 6、折光指数为1.477 0、酸值(KOH)为1.988 mg/g、碘值(I)为73 g/100 g、皂化值(KOH)为202.5mg/g。

关键词：澳洲坚果油水剂法提取工艺

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侵害知识产权之不当得利问题探析

知识产权 2006年第3期16卷 56-59页

作者：范晓波北京化工大学文法学院

根据我国的立法和司法实践,在知识产权遭受侵害的情形下,权利人可以要求赔偿损失,却基本不行使不当得利请求权获得救济。侵权人因侵权所获利润一般都以权利人损失推定的名义赔偿给权利人。本文对侵害知识产权不当得利的构成、涵义、独... 详细信息

根据我国的立法和司法实践,在知识产权遭受侵害的情形下,权利人可以要求赔偿损失,却基本不行使不当得利请求权获得救济。侵权人因侵权所获利润一般都以权利人损失推定的名义赔偿给权利人。本文对侵害知识产权不当得利的构成、涵义、独立存在价值、不当得利与损害赔偿请求权的竞合等问题进行了分析,提出侵权人获得的不当得利不能被简单地推定为权利人的损失,不当得利返还作为一种独立的民事救济方式对于知识产权人具有重要意义。

关键词：知识产权不当得利损害赔偿