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KIF4A对巨噬细胞血管生成相关因子表达的调节作用

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山东大学学报（医学版） 2017年第1期55卷 39-43页

作者：陈意坤王克涛王华阳邵倩倩谈万业宋晓彬曲迅魏奉才山东大学齐鲁医院烧伤整形科山东济南250012 山东大学齐鲁医院口腔及颌面外科山东济南250012 山东大学齐鲁医院临床基础研究所山东济南250012

目的探讨驱动蛋白KIF4A对巨噬细胞不同亚群中血管生成相关因子表达的影响。方法 THP-1细胞在PM A及不同人重组细胞因子的外界刺激下分别分化为M0、M1、M2细胞,采用ELISA技术检测此3种巨噬细胞亚群中血管生成相关因子的表达水平。利用si... 详细信息

目的探讨驱动蛋白KIF4A对巨噬细胞不同亚群中血管生成相关因子表达的影响。方法 THP-1细胞在PM A及不同人重组细胞因子的外界刺激下分别分化为M0、M1、M2细胞,采用ELISA技术检测此3种巨噬细胞亚群中血管生成相关因子的表达水平。利用siRNA转染敲除M0、M1、M2细胞中KIF4A的表达,采用实时定量PCR检测敲除后血管生成相关因子的表达水平。结果巨噬细胞M0上清中可检测到LIF、VEGF、s VEGFR1及TIM P1,而s VEGFR2、Flt-3、Leptin、LeptinR、CD40L均不表达。其中LIF、VEGF、TIM P1在M0向M1、M2分化过程中,表达差异均无统计学意义(P>0.05);s VEGFR1在M0向M1分化过程中表达差异无统计学意义(P>0.05),向M2分化过程中表达显著上调(P0.05);M2细胞中LIF、VEGF、TIM P1表达差异均无统计学意义(P>0.05),但s VEGFR1表达水平明显降低(P<0.05)。结论 M2细胞s VEGFR1表达水平显著上调;KIF4A参与M2细胞中s VEGFR1的表达。

关键词：巨噬细胞血管生成相关因子 KIF4A 转染

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洁净手术室气流组织效果的影响因素综述

暖通空调 2024年第5期54卷 1-12页

作者：曾令杰魏晓宾高军刘燕敏叶蔚曹广宇刘志坚曹国庆同济大学上海挪威科技大学挪威南特伦德拉格郡华北电力大学保定中国建筑科学研究院有限公司北京

我国医院建设规模庞大、分布广泛,就医人数居世界第一,医疗洁净手术室空气洁净技术发展迅速。手术室的气流组织是其空气洁净技术的重要方面,与手术部位感染的关系一直存在争议。本文对手术室中的气流组织形式进行了综述。研究表明,层流... 详细信息

我国医院建设规模庞大、分布广泛,就医人数居世界第一,医疗洁净手术室空气洁净技术发展迅速。手术室的气流组织是其空气洁净技术的重要方面,与手术部位感染的关系一直存在争议。本文对手术室中的气流组织形式进行了综述。研究表明,层流通风和温控气流通风在去除携带细菌的颗粒方面具有优势,且层流通风对飞沫的控制能力更强。本文梳理了手术室内人员数量和位置、手术人员的动作和流动、医用设备的数量和发热量、人员着装和手术台次等因素对气流组织效果的影响。发现手术人员的动作和流动是相关研究的热点,气流组织与手术人员、患者热舒适的关联仍有待深入。未来研究方向包括手术室内局部气流组织与手术微环境空气质量的定量关系、新型气流组织形式和末端、个性化通风与手术人员热舒适等。

关键词：洁净手术室气流组织通风热舒适空气质量层流通风温控气流通风

Progress in membrane distillation crystallization： Process models, crystallization control and innovative applications

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Frontiers of Chemical Science and Engineering 2017年第4期11卷 647-662,F0004页

作者： xiaobin Jiang Linghan Tuo Dapeng Lu Baohong Hou wei Chen Gaohong He State Key Laboratory of Fine Chemicals Research and Development Center of Membrane Science and Technology School of Chemical Engineering Dalian University of Technology Dalian China School of Chemical Engineering and Technology State Key Laboratory of Chemical Engineering National Engineering Research Center of Industrial Crystallization Technology Tianjin University Tianjin China

Membrane distillation crystallization （MDC） is a promising hybrid separation process that has been applied to seawater desalination, brine treatment and wastewater recovery. In recent years, great progress has been made in MDC technologies including the promotion of nucleation and better control of crystallization and crystal size distribution. These advances are useful for the accurate control of the degree of supersaturation and for the control of the nucleation kinetic processes. This review focuses on the development of MDC process models and on crystallization control strategies. In addition, the most important innovative applications of MDC in the last five years in crystal engineering and pharmaceutical manufac- turing are summarized.

关键词： membrane distillation crystallization mathe-matics model nucleation separation hybrid process

Carbon emissions induced by farmland expansion in China during the past 300 years

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Science China Earth Sciences 2019年第2期62卷 423-437页

作者： Xuhong YANG xiaobin JIN Xiaomin XIANG Yeting FAN Jing LIU wei SHAN Yinkang ZHOU School of Geographic and Oceanographic Sciences Nanjing University

Scientific assessment of the accounting over carbon in the terrestrial ecosystem in the process land use/land cover changes caused by human activities will help reduce the uncertainty in estimating carbon emissions from the terrestrial ecosystem. This study employs a bookkeeping model to estimate the carbon emissions from farmland reclamation in China during the past 300 years based on the annual rate of land use changes(derived from historical natural vegetation, farmland data), preset carbon density and coefficients of disturbance curves. We find out that:(1) there was a net increase of 79.30×10~4km^2 in national farmland; about 65% of reclaimed farmland had been forest land and 26% of that had been grass land previously;(2) the total amount of carbon emissions from farmland expansion in China had been between 2.94 and 5.61 Pg with the median 3.78 Pg during the past 300 years; specifically, carbon emissions of vegetation were 1.58 Pg while those of soil ranged from 1.35 Pg to4.03 Pg with the median 2.20 Pg;(3) carbon emissions vary greatly across various ecosystems: the emissions were most from forest land, and then grass land and swamps, and the least from shrubs; deserts functioned more likely to be carbon stock in the process of land reclamation;(4) along the time line, carbon emissions had decreased first and then increased while the peak emissions occurred in the first half of 20 th century; and spatially, carbon emissions were most released in Northeast and Southwest China; Northwest China was of the minimum carbon emissions.

关键词： Farmland expansion Carbon emission Bookkeeping model China 300 years

N-doped defective carbon with trace Co for efficient rechargeable liquid electrolyte-/all-solid-state Zn-air batteries

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Science Bulletin 2018年第9期63卷 548-555页

作者： Zhiyan Chen Qichen Wang xiaobin Zhang Yongpeng Lei wei Hu Yao Luo Yaobing Wang College of Materials Science and Engineering Central South University of Forestry and Technology State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University Center for Nano Materials and Technology Japan Advanced Institute of Science and Technology School of Aeronautics and Astronautics & Science and Technology on High Strength Structural Materials Laboratory Central South University College of Basic Education National University of Defense Technology Design and Assembly of Functional Nanostructures Fujian Provincial Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Simple synthesis of multifunctional electrocatalysts with plentiful active sites from earth-abundant materials is especially fascinating. Here, N-doped defective carbon with trace Co （1.5 wt%） was prepared via a scalable one pot solid pyrolysis process. The sample exhibits efficient bifunctional OER/ORR activiW in alkaline, mainly ascribed to the unique micro-mesoporous structure （1-3 nm）, high population of graphitic-N doping （up to 49.0%）, abundant defects and the encapsulated Co nanoparticles with graphitized carbon. The according rechargeahle liquid Zn-air batteries showed excellent performance （maximum power density of 154.0 mWcm-2： energy density of 773Wh kg -1 at 5 mAcm 2 and charging-discharging cycling stability over 100 cycles）. As a proof-of-concept, the flexible, rechargeable all-solid-state Zn-air batteries were constructed, and displayed a maximum power density as high as 45.9 mW cm 2 among the top level of those reported previously.

关键词： Defect Oxygen electrocatalysts Rechargeable all-solid-state batteries

Exogenous rare earth element-yttrium deteriorated soil microbial community structure

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Journal of Rare Earths 2018年第4期36卷 430-439页

作者： Caigui Luo Yangwu Deng Jian Liang Sipin Zhu Zhenya wei xiaobin Guo Xianping Luo Faculty of Resource and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou 341000China National Engineering Research Center for Ionic Rare Earth Ganzhou 341000China Jiangxi Key Laboratory of Mining&Metallurgy Environmental Pollution Control Canzhou 341000China

In this study, we selected yttrium as the representative of REEs to investigate the impacts of exogenous yttrium on soil physicochemical properties and microbiota. The results showed that exogenous yttrium has no significant effect on soil physical properties but a significantly negative impact on soil chemical properties. The results of high-throughput sequencing demonstrate that exogenous yttrium significantly decreases the number of OTUs, ACE, Chao 1, and Shannon indices while increases the Simpson index（P 〈 0.05）, indicating the low soil microbial diversity. The relative abundances of soil microbes are significantly changed at phylum and genus level. Principal component analysis（PCA） showed the significant difference of microbial community between yttrium treatments（YCl_3-250 and YCl_3-500） and non-yttrium treatment（CK） and the similarity of that between YCl_3-250 and YCI_3-500. Proteobacteria and Bacteroidetes are found to be the most tolerant phyla to exogenous yttrium while Verrucomicrobia the most sensitive phylum. Redundancy analysis（RDA） results suggest that exogenous yttrium affects soil microbiota only through changing the soil chemical properties but not soil physical properties, and C/N ratio is the key environmental factor.

关键词： Soil physicochemical properties Soil microbial community High-throughput sequencing Rare earths

空间钢桁架结构卸载施工模拟及监测技术应用研究

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施工技术（中英文） 2023年第14期52卷 17-22页

作者：汤东婴魏晓斌孙正华郭建祥王若晨江苏省建筑工程质量检测中心有限公司江苏南京210033 江苏省建筑科学研究院有限公司江苏南京210008

空间钢桁架结构节点复杂,卸载过程应力状态多变,易出现个别杆件变形等质量缺陷,进而影响施工安全及成品质量。为避免此类问题发生,以盐城黄海湿地博物馆为例,针对空间桁架结构特点,设计了桁架监测方案,详细介绍空间桁架结构施工卸载过... 详细信息

空间钢桁架结构节点复杂,卸载过程应力状态多变,易出现个别杆件变形等质量缺陷,进而影响施工安全及成品质量。为避免此类问题发生,以盐城黄海湿地博物馆为例,针对空间桁架结构特点,设计了桁架监测方案,详细介绍空间桁架结构施工卸载过程监测指标,包括监测内容和测点布置,确保施工安全及施工质量。监测过程以钢结构屋盖桁架关键杆件应力、应变及支撑胎架、支撑柱倾角为主要指标,综合运行全站仪、应变计、倾角仪等监测设备,对桁架结构施工卸载过程的受力、变形及倾角等特征进行全面监测。最后利用MIDAS有限元软件对卸载过程进行模拟,给出施工监测节点应力、应变理论限值,进行卸载过程理论数据与监测数据对比,分析结构卸载过程中各关键部位受力和变形,探讨在施工卸载过程中需重点监测部位,得出卸载施工中桁架结构关键变形节点。

关键词：钢结构桁架卸载监测数值模拟

不同pH值土壤浸提液对苜蓿种子发芽和幼苗生长的影响

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中国农学通报 2013年第15期29卷 60-67页

作者：魏晓斌徐安凯王志锋于洪柱孙启忠中国农业科学院草原研究所呼和浩特010010 中国农业科学院研究生院北京100081 吉林省农业科学院畜牧科学分院吉林公主岭136100

本研究旨在研究不同品种紫花苜蓿对不同pH值土壤浸提液的适应性,为筛选和选育耐酸碱的紫花苜蓿品种提供理论基础。在10个不同pH值土壤浸提液处理下,研究了对不同紫花苜蓿(Medicago sativaL.)品种种子发芽和幼苗生长的影响。试验结果表明... 详细信息

本研究旨在研究不同品种紫花苜蓿对不同pH值土壤浸提液的适应性,为筛选和选育耐酸碱的紫花苜蓿品种提供理论基础。在10个不同pH值土壤浸提液处理下,研究了对不同紫花苜蓿(Medicago sativaL.)品种种子发芽和幼苗生长的影响。试验结果表明:在低pH值或高pH值浸提液处理下,各品种紫花苜蓿种子发芽受到显著抑制;pH值为6.17、8.76、9.20时,虽抑制苜蓿种子发芽,但能够促进已发芽苜蓿种子的生长;发芽率、幼根长度与幼苗高度的比适宜用作鉴定苜蓿耐酸碱性的指标;pH值在5.81～8.44时,各苜蓿品种的平均发芽率都在60%以上,能够正常生长;根据回归方程得,苜蓿生长的临界pH为5.06和9.17,极限pH为2.71和10.26。耐酸碱性强的苜蓿品种有‘中苜1号’、‘公农2号’和‘霍普兰德’。

关键词：苜蓿土壤浸提液萌发 pH值耐酸碱性

北马其顿时速140km内燃液力传动铰接动车组

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铁道机车与动车 2024年第2期 1-6,I0001页

作者：陈喜红陈爱军魏晓斌付江英颜志军范丽冰中车株洲电力机车有限公司湖南株洲412001 湖南省轨道车辆转向架工程技术研究中心湖南株洲412001

介绍了我国通过欧洲TSI认证、出口到北马其顿、适应低站台的时速140 km铰接式内燃液力传动动车组的整体结构、总体性能参数,以及内燃液力传动、电气、转向架、制动、机械、车内环境控制等主要系统及部件的结构、性能或技术特征,型式试... 详细信息

介绍了我国通过欧洲TSI认证、出口到北马其顿、适应低站台的时速140 km铰接式内燃液力传动动车组的整体结构、总体性能参数,以及内燃液力传动、电气、转向架、制动、机械、车内环境控制等主要系统及部件的结构、性能或技术特征,型式试验结果表明,整个动车组符合TSI指令和指令中所引述的相关欧盟技术标准。

关键词：内燃铰接式动车组 TSI认证低站台性能特征内燃液力传动系统转向架