检索结果-南通市图书馆

Aflatoxin B1 decreased flesh flavor and inhibited muscle development in grass carp(Ctenopharyngodon idella)

Animal Nutrition 2024年第3期18卷 27-38页

作者： Xiang Ning He Zhen Zhen Zeng Wei Dan Jiang pei Wu Yang Liu Sheng Yao Kuang Ling Tang Shu Wei Li Lin Feng xiao Qiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130China Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130China Key Laboratory for Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130China Animal Nutrition Institute Sichuan Academy of Animal ScienceChengdu 610066China

In nature,aflatoxins,especially aflatoxin B1(AFB1),are the common mycotoxins,which cause serious health problems for humans and *** paper aimed to study the effects of AFB1 on flesh flavor and muscle development of grass carp(Ctenopharyngodon idella)and its *** were 1440 individual fish in total,with 6 treatments and each treatment replicated 3 *** 6 treatments were fed a control diet with different doses of AFB1(0.04,29.48,58.66,85.94,110.43 and 146.92μg/kg diet)for 60 ***1 increased myofiber diameter,as well as decreased myofiber density of grass carp muscle(P<0.05).The contents of free amino acid decreased gradually(P<0.05)as dietary AFB1 increased in the muscle of grass *** levels of reactive oxygen species,malonaldehyde and protein carbonyl(PC)were increased(P<0.05)with the dietary AFB1 *** levels of antioxidant enzyme(glutathione peroxidase,glutathione,glutathione reductase,total antioxidant capacity,anti-superoxide anion,and anti-hydroxyl radical)were decreased(P<0.05)with the dietary AFB1 *** addition,dietary AFB1 decreased the content of collagen,and downregulated the mRNA and protein levels of transforming growth factor-β(TGF-β)/Smads signaling pathway in grass carp muscle(P<0.05).The mRNA and protein levels of myogenic regulatory factors were downregulated in grass carp muscle(P<0.05).Furthermore,the activities of matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9)were increased(P<0.05),and the protein levels of phosphorylate-38 mitogen-activated protein kinase(p-p38MAPK),phosphorylate-c-Jun N-terminal kinase,urokinase-type plasminogen activator(uPA),MMP-2 and MMP-9 were upregulated(P<0.05),but collagenⅠ,lamininβ1 and fibronectin were downregulated(P<0.05)with the dietary AFB1 increased in the muscle of grass *** on the results of this study,we can draw the following conclusion:dietary AFB1 might damage flesh flavor and inhibit the muscle development through MAPK/uPA/MMP/extrac

关键词： Aflatoxin B1 Flesh flavor Muscle development Grass carp

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Iron-Catalyzed Reductive C(aryl)—Si Cross-Coupling of Diaryl Ethers with Chlorosilanes

引用

Chinese Journal of Chemistry 2024年第6期42卷 578-584页

作者： pei Liu Baowei Wu Xuefeng Cong Jie Kong School of Chemistry and Chemical engineering Northwestern Polytechnical UniversityXi'anShaanxi710072 China Institute of Molecular Plus Department of Chemistry and Haihe Laboratory of Sustainable Chemical TransformationsTianjin University92 Weijin RoadTianjin300072 China

The reductive cross-coupling between C(aryl)—O and Si—Cl bonds is of much importance as a valuable strategy for the construction of C(aryl)—Si bonds but has remained a great ***,we report a reductive cross-coupling of diaryl ethers and chlorosilanes via strong electrophilic C(aryl)—O and Si—Cl bonds cleavage by iron catalysis,which constitutes an efficient protocol for the synthesis of a range of functionalized *** combination of low cost FeCl2 as the precatalyst and iPrMgCl as the reductant shows high activity in the successive cleavage of unactivated C(aryl)—O bonds of diaryl ethers and strong electrophilic Si—Cl bonds of chlorosilanes,allowing their cross-coupling in a reductive *** low-valent iron species generated in situ by reduction of FeCl2 with iPrMgCl was proposed,which prefers to initially cleavage the C(aryl)—O bond of diaryl ethers with the chelation help of an o-amide auxiliary.

关键词： Cross-coupling Diaryl ethers Chlorosilanes C—O bond cleavage Iron catalyst 3d transition metals Selectivity Regioselectivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

引用

World Journal of Pediatrics 2024年第3期20卷 259-271页

作者： Yi-Long Wang Meng-Ying Zhu Zhe-Feng Yuan xiao-Yan Ren xiao-Tong Guo Yi Hua Lu Xu Cong-Ying Zhao Li-Hua Jiang Xin Zhang Guo-Xia Sheng pei-Fang Jiang Zheng-Yan Zhao Feng Gao Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(CSF)samples[patients with MOGAD(MOG group,n=12);healthy controls(HC group,n=12);patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases(IND group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(PLS-DA)and orthogonal PLS-DA(O-PLS-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEPs)was performed using Gene Ontology,InterPro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEPs(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the HC group according to the P value and fold change(FC).Using the O-PLS-DA model,872 differentially abundant proteins were identified with variable importance projection(VIP)scores>*** proteins(gamma-glutamyl hydrolase,cathepsin F,interalpha-trypsin inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEPs with top-ranked P value and FC and top 30 proteins in PLS-DA VIP lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid biosynthesis compared to the HC *** The proteomic alterations in CSF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis Cerebrospinal fluid Complement cascades Myelin oligodendrocyte glycoprotein-associated disease Proteomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long way up:rethink diseases in light of phase separation and phase transition

引用

Protein & Cell 2024年第7期15卷 475-492页

作者： Mingrui Ding Weifan Xu Gaofeng pei Pilong Li State Key Laboratory of Membrane Biology&Frontier Research Center for Biological Structure School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China NuPhase Therapeutics Beijing 100083China

Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular dysfunction and physiological disorders. As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle, a transformative shift is occurring in our comprehension of disease. Consequently, significant strides have been made in unraveling the profound relevance and potential causal connections between abnormal phase separation and various diseases. This comprehensive review presents compelling recent evidence that highlight the intricate associations between aberrant phase separation and neurodegenerative diseases, cancers, and infectious diseases. Additionally, we provide a succinct summary of current efforts and propose innovative solutions for the development of potential therapeutics to combat the pathological consequences attributed to aberrant phase separation.

关键词： multivalency compartments aberant phase separation therapeutics gain or loss of phase separation diseases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Disparity estimation for multi-scale multi-sensor fusion

引用

Journal of Systems engineering and Electronics 2024年第2期35卷 259-274页

作者： SUN Guoliang pei Shanshan LONG Qian ZHeng Sifa YANG Rui Suzhou Automotive Research Institute Tsinghua UniversitySuzhou 215000China Beijing Smarter Eye Technology Co. Ltd.Beijing 100023China College of Artifical Intelligence Tianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Department of Precision Instrument Tsinghua UniversityBeijing 100084China

The perception module of advanced driver assistance systems plays a vital *** schemes often use a single sensor for data processing and environmental perception or adopt the information processing results of various sensors for the fusion of the detection *** paper proposes a multi-scale and multi-sensor data fusion strategy in the front end of perception and accomplishes a multi-sensor function disparity map generation scheme.A binocular stereo vision sensor composed of two cameras and a light deterction and ranging(LiDAR)sensor is used to jointly perceive the environment,and a multi-scale fusion scheme is employed to improve the accuracy of the disparity *** solution not only has the advantages of dense perception of binocular stereo vision sensors but also considers the perception accuracy of LiDAR *** demonstrate that the multi-scale multi-sensor scheme proposed in this paper significantly improves disparity map estimation.

关键词： stereo vision light deterction and ranging(LiDAR) multi-sensor fusion multi-scale fusion disparity map

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Trans-PRK for recurrent epithelial corneal erosion induced by cooking oil accidentally after EVO ICL

引用

International Journal of Ophthalmology(english edition) 2024年第10期17卷 1953-1956页

作者： Yong Ma Wan-Ru Shi Ling-Ling Niu pei-Jun Yao xiao-Ying Wang Xing-Tao Zhou Jing Zhao Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China Key Laboratory of Myopia and Related Eye Diseases NHCShanghai 200031China Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical SciencesShanghai 200031China Shanghai engineering Research Center of Laser and Autostereoscopic 3D for Vision Care Shanghai 200031China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200031China

Dear Editor,We report a case with trans-photorefractive keratectomy(PRK)for recurrent epithelial corneal erosion caused by cooking oil after EVO-implantable contact lens(ICL)(EVO Visian ICL;STAAR Surgical AG,Switzerland),which should be distinguished from postoperative complications of *** corneal burns are classified as chemical and thermal burns,referring to direct contact injury to the cornea.

关键词： cooking erosion corneal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development and Validation of an Impedimetric Sensor Modified with Molecularly Imprinted Polymer for Direct Determination of Bisphenol A in Bioanalytics

引用

Journal of Analysis and Testing 2024年第2期8卷 228-236页

作者： Wenjing Song Yingyi Guo Pengyu Liu Xiucong pei School of Public Health Shenyang Medical CollegeShenyang110034China Shenyang Institute for Food and Drug Control Shenyang110021China Key Laboratory of Food Pollutant Inspection and Risk Assessment in Liaoning Province Shenyang110021China

There is a strong correlation between bisphenol A(BPA)and the risks of endocrine disruption in ***,the mechanism behind this correlation is still unknown due to the challenge of accurately assessing BPA levels in biological ***,we demonstrate a molecularly imprinted polymer(MIP)modified impedimetric sensor treated with bovine serum albumin(BSA)not only reduces the impact of protein interference but also maintains both specificity and sensitivity for the precise analysis of *** platinum disc electrode was coated with MIP via electrochemical polymerization of o-phenylenediamine(o-PD)in the presence of BPA as a template,and free sites were then blocked with 1%*** impedance spectroscopy(EIS)was utilized for the detection of *** linear range for detection was between 1.0 pg/L and 10.0 ng/L,with a detection limit(LOD)of 0.28 pg/*** sensor presented a good selectivity over structurally similar steroid hormones and BPA *** validate the performance of the proposed sensor in the presence of possible interfering proteins,it was used to quantify BPA in real samples without any prior *** findings indicate that such an impedimetric sensor can be used to measure BPA in complex matrices.

关键词： Bisphenol A Molecularly imprinted polymers Impedimetric sensor Bovine serum albumin Biological matrices

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effective Ultra-High-Speed Identification Scheme of Lightning Strikes Suitable for VSC-Based DC Grids

引用

CSEE Journal of Power and Energy Systems 2024年第2期10卷 548-561页

作者： Longlong Chen Xiangyu pei xiaoguang Wei Pengzhi Li Guangfu Tang North China Electric Power University(NCEPU) Beijing 102206China Changsha University of Science and Technology Changsha 410114China State Key Laboratory of Advanced Power Transmission Technology State Grid Smart Grid Research Institute Co.Ltd.Beijing 102209China

To ensure their sound and continuous operation to the greatest extent,VSC-based DC girds have extremely stringent requirements for transmission line relay *** terms of guaranteeing their reliability,accurate identification of lightning strikes on DC transmission lines is one of the urgent key problems to be *** effective ultra-high-speed identification scheme of lightning strikes suitable for the VSC-based DC grid is proposed in this ***,an 1-mode reverse voltage traveling wave(RVTW)is constructed applying the pole-mode transformation ***,fault traveling wave propagation characteristics along the DC transmission line are analyzed in depth utilizing Peterson's ***,differences of time-frequency electromagnetic transient characteristics of 1-mode RVTWs between disturbances and faults caused by lightning strikes are distinguished in detail by means of the classical wavelet transformation multi-resolution analysis ***,extensive simulations are carried out to evaluate the performance of the proposed identification scheme,and by which its excellent rapidity,reliability and robustness are *** Terms-Lightning-strike identification,Multi-resolution analysis,Relay protection,Traveling-wave protection,VsC-based DC grid,Wavelet transformation.

关键词： Lightning-strike identification Multi-resolution analysis Relay protection Traveling-wave protection VsC-based DC grid Wavelet transformation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

引用

International Journal of Extreme Manufacturing 2024年第1期6卷 296-311页

作者： Cijun Shuai xiaoxin Shi Feng Yang Haifeng Tian pei Feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083People’s Republic of China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013People’s Republic of China College of Mechanical engineering Xinjiang UniversityUrumqi 830017People’s Republic of China

Bacterial infection is a major issue after artificial bone transplantation due to the absence of antibacterial function of bone scaffold,which seriously causes the transplant failure and even amputation in severe *** this study,oxygen vacancy(OV)defects Fe-doped Ti O2(OV-FeTiO2)nanoparticles were synthesized by nano TiO2and Fe3O4via high-energy ball milling,which was then incorporated into polycaprolactone/polyglycolic acid(PCLGA)biodegradable polymer matrix to construct composite bone scaffold with good antibacterial activities by selective laser *** results indicated that OV defects were introduced into the core/shell-structured OV-FeTiO2nanoparticles through multiple welding and breaking during the high-energy ball milling,which facilitated the adsorption of hydrogen peroxide(H2O2)in the bacterial infection microenvironment at the bone transplant *** accumulated H2O2could amplify the Fenton reaction efficiency to induce more hydroxyl radicals(·OH),thereby resulting in more bacterial deaths through·OH-mediated oxidative *** antibacterial strategy had more effective broad-spectrum antibacterial properties against Gram-negative Escherichia coli(***)and Gram-positive Staphylococcus aureus(***).In addition,the PCLGA/OV-FeTiO2scaffold possessed mechanical properties that match those of human cancellous bone and good biocompatibility including cell attachment,proliferation and osteogenic differentiation.

关键词： bacterial infection bone scaffold selective laser sintering Fenton reaction antibacterial properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Resolution of myopic macular schisis following cataract phacoemulsification

引用

International Journal of Ophthalmology(english edition) 2024年第8期17卷 1568-1570页

作者： Yan-Ting Li Bo Jiang Xin-Zhu Chen Hang Ren Yan-Hui xiao Zi-Yue Song pei-Rong Lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Ophthalmology Suzhou EENT HospitalSuzhou 215000Jiangsu ProvinceChina

Dear Editor,We write to introduce a case of high myopia who had bilateral macular schisis along with *** the following-up period from 2014 to 2021,the severity of macular schisis gradually ***,following cataract surgery,there was a gradual improvement in the macular schisis,ultimately leading to near-complete *** obtained the written informed consent from the patient,and this case study adhered to the principles in the Declaration of Helsinki.

关键词： cataract sch ultimately

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：