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Increased Expression of Serum Monocyte Chemoattractant Protein-1,Chemokine(C-C motif)Ligand 3,and Interleukins in Patients With Vitiligo

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International Journal of Dermatology and Venereology 2024年第1期7卷 40-43页

作者： xiao-Ling Zhao Ya-Lan Li Zi-Han Li xiao-Chong Zhang Li-Hui An yu-Jiao sun Deng-Xiang Liu Fang Cheng Cancer Laboratory Xingtai People’s HospitalXingtaiHebei 054001China Endocrine Department Xingtai People’s HospitalXingtaiHebei 130500China Dermatological Department Xingtai People’s HospitalXingtaiHebei 054001China

Objective:Vitiligo is a chronic,acquired depigmentation of the skin,which can be divided into active and stable *** stable and active stages are not immutable and often *** of internal markers would help to diagnose the active stage of vitiligo,and the purpose of this study was to find potential active markers in the progression of ***:We compared 30 healthy controls to 60 patients with vitiligo(30 with active disease and 30 with stable disease)regarding the expression of serum monocyte chemoattractant protein(MCP)-1,chemokine(C-C motif)ligand(CCL)3,CCL5,CCL21,interleukin(IL)-6,and *** were collected from May 2017 to December *** detection was carried out by enzyme-linked immunosorbent *** difference between groups was compared by Kruskal-Wallis H test and Mann-Whitney U ***:We found that the serum levels of MCP-1,CCL3,IL-6,and IL-17 were significantly higher in patients with vitiligo than in healthy controls(P<0.01)and that IL-17 was higher in patients with active vitiligo than in those with stable vitiligo(P<0.01).After 3months of treatment,the serum IL-17 level of patients with active vitiligo was not significantly different from that before treatment(P=0.526);after 6months of treatment,however,the serum IL-17 level had significantly decreased(P<0.01).Conclusion:These findings suggest that the serum IL-17 level can be used as a marker of vitiligo disease activity giving it certain guiding significance for clinical treatment.

关键词： clinical marker serum cytokines vitiligo

Systemic modulation of skeletal mineralization by magnesium implant promoting fracture healing: Radiological exploration enhanced with PCA-based machine learning in a rat femoral model

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Journal of Magnesium and Alloys 2024年第3期12卷 1009-1020页

作者： yu sun Heike Helmholz Regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonGermany

The clinical application of magnesium(Mg)and its alloys for bone fractures has been well supported by in vitro and in vivo ***,there were studies indicating negative effects of high dose Mg intake and sustained local release of Mg ions on bone metabolism or repair,which should not be ignored when developing Mg-based ***,it remains necessary to assess the biological effects of Mg implants in animal models relevant to clinical treatment *** primary purpose of this study was to validate the beneficial effects of intramedullary Mg implants on the healing outcome of femoral fractures in a modified rat *** addition,the mineralization parameters at multiple anatomical sites were evaluated,to investigate their association with healing outcome and potential clinical *** to the control group without Mg implantation,postoperative imaging at week 12 demonstrated better healing outcomes in the Mg group,with more stable unions in 3D analysis and high-mineralized bridging in 2D *** bone tissue mineral density(TMD)was higher in the Mg group at the non-operated femur and lumbar vertebra,while no differences between groups were identified regarding the bone tissue volume(TV),TMD and bone mineral content(BMC)in *** the surgical femur,the Mg group presented higher TMD,but lower TV and BMC in the distal metaphyseal region,as well as reduced BMC at the osteotomy *** component analysis(PCA)-based machine learning revealed that by selecting clinically relevant parameters,radiological markers could be constructed for differentiation of healing outcomes,with better performance than 2D *** study provides insights and preclinical evidence for the rational investigation of bioactive materials,the identification of potential adverse effects,and the promotion of diagnostic capabilities for fracture healing.

关键词： Magnesium Implants Bone fracture Mineralization Systemic modulation Principal component analysis.

GPa-level pressure-induced enhanced corrosion resistance in TiZrTaNbSn biomedical high-entropy alloy

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China Foundry 2024年第3期21卷 265-275页

作者： xiao-hong Wang yu-lei Deng Qiao-yu Li Zhi-xin Xu Teng-fei Ma Xing Yang Duo Dong Dong-dong Zhu xiao-hong Yang Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina School of Materials Science and Engineering Taizhou UniversityTaizhou 318000ZhejiangChina

TiZrTaNb-based high-entropy alloys(HEAs)are research frontier of biomedical materials due to their high hardness,good yield strength,excellent wear resistance and corrosion ***,as an essential trace element in the human body that plays a significant role in physiological *** has stable chemical properties and a low elastic *** this study,a new material,TiZrTaNbSn HEAs,was proposed as a potential biomedical *** Ti_(35)Zr_(25)Ta_(15)Nb_(15)Sn_(10)biomedical high-entropy alloys(BHEAs)were successfully prepared through an arc melting furnace and then remelted using a German high-temperature and high-pressure apparatus under GPa-level(4 GPa and 7 GPa).The precipitation behavior of the needle-like HCP-Zr_(5)Sn_(3)phase that precipitates discontinuously at the grain boundary was successfully *** phase constitution,microstructure,and corrosion resistance of the alloy were *** results show that the needle-like HCP-Zr_(5)Sn_(3)phase is eliminated and the(Zr,Sn)-rich nano-precipitated phase is precipitated in the microstructure under high pressure,which leads to the narrowing of grain boundaries and consequently improves the corrosion resistance of the *** addition,the formation mechanisms of(Zr,Sn)-rich nanoprecipitates in BHEAs were *** Zr and Sn dissolve in the matrix due to the effect of high pressure,during the cooling process,they precipitate to form a(Zr,Sn)-rich nano-precipitated phase.

关键词： biomedical HEAs precipitation grain boundary corrosion resistance TiZrTaNbSn

Convergent synthesis and immunological study of oligosaccharide derivatives related to galactomannan from Antrodia cinnamomea

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Chinese Chemical Letters 2024年第5期35卷 155-160页

作者： Shuying Li Weiwei ZhuGe Xuan sun Chongzhen sun Zhaojun Liu Chenghe Xiong Min xiao Guofeng Gu National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology Shandong UniversityQingdao 266237China NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine Shandong UniversityQingdao 266237China

The galactomannan from Antrodia cinnamomea(AC)is characterized as one of the important bioactive components that exhibits potential immunostimulatory *** biological function of its corresponding oligosaccharide fragments has not been revealed *** this study,we reported the first chemical synthesis of the series of oligosaccharide fragments related to AC galactomannan via the convergent glycosylation *** preliminary immunological evaluation of these synthesized AC oligosaccharides disclosed that the backbone tetrasaccharide 1d showed the best immunomodulatory ability on enhancing proliferation,phagocytosis and cytokines secretion of Raw264.7 macrophages in vitro,indicating its immense potential as an immunostimulant candidate.

关键词： Antrodia cinnamomea Galactomannan Oligosaccharide Immunostimulatory propriety Chemical synthesis

Rapid chemical recycling of waste polyester plastics catalyzed by recyclable catalyst

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Green Chemical Engineering 2024年第2期5卷 257-265页

作者： yu-Ji Luo Jia-Yin sun Zhi Li School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China

Waste plastics are serious environmental threats due to their low degradability and low recycling *** and efficient waste plastics recycling technologies are urgently demanded for a sustainable ***,we report a rapid,closed-loop,and streamlined process to convert polyesters such as poly(ethylene terephthalate)(PET)back to its purified *** trifluoromethanesulfonic acid or metal triflates as the recyclable catalyst,polyesters such as PET can be completely depolymerized by simple carboxylic acids within 1 *** coupling this acidolysis with a subsequent hydrogenolysis process,the consumed carboxylic acid was recovered and the closed-loop of PET depolymerization could be *** catalysts and depolymerization agents are fully recycled while only PET and hydrogen are consumed.

关键词： Chemical recycling Waste polyester plastics Acidolysis Recyclable catalyst

Wave Attenuation and Turbulence Driven by Submerged Vegetation Under Current-Wave Flow

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China Ocean Engineering 2024年第4期38卷 602-611页

作者： HUANG yu-ming Ding Lei WANG Yi-fei CHEN Ben YANG xiao-yu DOU Xi-ping School of Water Resources and Hydropower Engineering Wuhan UniversityWuhan430072China Key Laboratory of Port Waterway and Sedimentation Engineering of MOTNanjing Hydraulic Research InstituteNanjing 210029China

A set of laboratory experiments are carried out to investigate the effect of following/opposing currents on wave *** vegetation canopies with aligned and staggered configurations were tested under the condition of various regular wave heights and current velocities,with the constant water depth being 0.60 m to create the desired submerged *** show that the vegetation-induced wave dissipation is enhanced with the increasing incident wave height.A larger velocity magnititude leads to a greater wave height attenuation for both following and opposing current ***,there is a strong positive linear correlation between the damping coefficientβand the relative wave height H_(0)/h,especially for pure wave *** the velocity profile,the distributions of U_(min)and U_(max)show different patterns under combined wave and *** time-averaged turbulent kinetic energy(TKE)vary little under pure wave and U_(c)=±0.05 m/s *** the increase of flow velocity amplitude,the time-averaged TKE shows a particularly pronounced increase trend at the top of the *** vegetation drag coefficients are obtained by a calibration *** empirical relations of drag coefficient with Reynolds and Keulegane-Carpenter numbers are proposed to further understand the wave-current-vegetation interaction mechanism.

关键词： wave attenuation rigid vegetation following and opposing currents turbulent kinetic energy

The Spatiotemporal Distribution Characteristics of Cloud Types and Phases in the Arctic Based on CloudSat and CALIPSO Cloud Classification Products

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Advances in Atmospheric Sciences 2024年第2期41卷 310-324页

作者： yue sun Huiling YANG Hui xiao Liang FENG Wei CHENG Libo ZHOU Weixi SHU Jingzhe sun Key Laboratory of Cloud-Precipitation Physics and Severe Storms(LACS) and Department of Lower Atmospheric Observation Research(LAOR)Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth Sciences University of Chinese Academy of Sciences(UCAS)Beijing 100049China Beijing Institute of Applied Meteorology Beijing 100029China

The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 2017 is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud types(high cloud, altostratus, altocumulus, stratus, stratocumulus, cumulus, nimbostratus, and deep convection) and three phases(ice,mixed, and water) in the Arctic. Possible reasons for the observed interannual variability are also discussed. The main conclusions are as follows:(1) More water clouds occur on the Atlantic side, and more ice clouds occur over continents.(2)The average spatial and seasonal distributions of cloud types show three patterns: high clouds and most cumuliform clouds are concentrated in low-latitude locations and peak in summer;altostratus and nimbostratus are concentrated over and around continents and are less abundant in summer;stratocumulus and stratus are concentrated near the inner Arctic and peak during spring and autumn.(3) Regional averaged interannual frequencies of ice clouds and altostratus clouds significantly decrease, while those of water clouds, altocumulus, and cumulus clouds increase significantly.(4) Significant features of the linear trends of cloud frequencies are mainly located over ocean areas.(5) The monthly water cloud frequency anomalies are positively correlated with air temperature in most of the troposphere, while those for ice clouds are negatively correlated.(6) The decrease in altostratus clouds is associated with the weakening of the Arctic front due to Arctic warming, while increased water vapor transport into the Arctic and higher atmospheric instability lead to more cumulus and altocumulus clouds.

关键词： CloudSat and CALIPSO cloud type cloud phase temporal and spatial distribution interannual variation

System Strength Assessment Based on Multi-task Learning

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 41-50页

作者： Baoluo Li Shiyun Xu Huadong sun Zonghan Li Lin yu Key Laboratory of Power System Intelligent Dispatch and Control of Ministry of Education Shandong UniversityJinan 250014China China Electric Power Research Institute Beijing 100192China

Increase in permeability of renewable energy sources(RESs)leads to the prominent problem of voltage stability in power system,so it is urgent to have a system strength evaluation method with both accuracy and practicability to control its access scale within a reasonable ***,a hybrid intelligence enhancement method is proposed by combining the advantages of mechanism method and data driven ***,calculation of critical short circuit ratio(CSCR)is set as the direction of intelligent enhancement by taking the multiple renewable energy station short circuit ratio as the quantitative ***,the construction process of CSCR dataset is proposed,and a batch simulation program of samples is developed accordingly,which provides a data basis for subsequent ***,a multi-task learning model based on progressive layered extraction is used to simultaneously predict CSCR of each RESs connection point,which significantly reduces evaluation error caused by weak *** performance and anti-noise performance of the proposed method are verified on the CEPRI-FS-102 bus system,which provides strong technical support for real-time monitoring of system strength.

关键词： Critical short circuit ratio hybrid intelligence enhancement multi-task learning system strength

Low-resolution Kramers-Kronig detection system with error-feedback noise shaping

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Science China(Information Sciences) 2024年第5期67卷 259-269页

作者： Xiangyong DONG Zhenming yu Hongyu HUANG Kaixuan sun Kun XU State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications

In this paper, we investigated the effects of error-feedback noise shaping(EFNS) on a lowresolution Kramers-Kronig(KK) detection system for the first time. Both 16-ary quadrature amplitude modulation(16-QAM) and 64-ary quadrature amplitude modulation(64-QAM) were considered in the experiment. The carrier tone was added on the transmitter side using the virtual carrier-assisted single sideband(VCA-SSB) method to meet the minimum phase(MP) condition. Under the MP condition, KK detection only needs the intensity of the optical signal to be detected by one photodiode(PD) to retrieve the phase information. However, the virtual carrier tone increases the carrier-to-signal power ratio(CSPR), which results in a high peak-to-average power ratio(PAPR) at the transmitter, causing an increase in quantization noise. To mitigate quantization noise in the low-resolution KK detection system, EFNS was applied. The application of EFNS increased the optimal CSPR of the KK detection system and improved receiver sensitivity. Using a 4-bit DAC and the EFNS, 80 km transmission was achieved in the 60-Gbit/s 64-QAM KK detection system.

关键词： optical fiber communications Kramers-Kronig receiver error-feedback noise shaping quantization noise carrier-to-signal power ratio