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井穴放血对急性高原缺氧大鼠视网膜组织HIF-1α、VEGF的影响

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中国中医药现代远程教育 2024年第1期22卷 142-145页

作者：常晴晴杨艳洒玉萍廖晓青海大学医学院青海西宁810016

目的观察急性高原缺氧条件下视网膜各项指标的变化规律,探讨井穴点刺放血疗法对急性高原缺氧的干预机制。方法随机将健康SD大鼠分成3组:低氧模型组、低氧+井穴放血干预组及常氧对照组,前2组又分为6 h、24 h、48 h、72 h这4个亚组,每组4... 详细信息

目的观察急性高原缺氧条件下视网膜各项指标的变化规律,探讨井穴点刺放血疗法对急性高原缺氧的干预机制。方法随机将健康SD大鼠分成3组:低氧模型组、低氧+井穴放血干预组及常氧对照组,前2组又分为6 h、24 h、48 h、72 h这4个亚组,每组4只,采用动物实验模拟舱制备大鼠急性视网膜缺氧模型,低氧+井穴放血干预组进行井穴放血预处理。使用苏木精-伊红(HE)染色法观察大鼠视网膜组织的损伤情况,用酶联免疫吸附实验(ELIsa)法检测血清缺氧诱导因子-1α(HIF-1α)及网膜组织血管内皮生长因子(VEGF)的含量。结果与常氧对照组相比,低氧模型组各时点血清VEGF、HIF-1α含量升高,各时点视网膜均有不同程度的损伤;与同时点低氧模型组比较,低氧+井穴放血干预组视网膜损伤程度较轻,各时点视网膜血清VEGF、HIF-1α含量降低,差异均具有统计学意义(P<0.05)。结论井穴点刺放血法干预可改善急性视网膜缺氧所致的损伤,其机制可能与降低血清VEGF、HIF-1α的含量相关。

关键词：井穴放血疗法急性高原缺氧视网膜实验研究

Solitary Osteogenic Exostosis of the Femur Revealed by Recurring Acute Distal Thigh Pain: About a Case

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Open Journal of Pediatrics 2024年第4期14卷 719-726页

作者： Thierno saïdou Barry Mohamed Lamine sadou sacko Balla Keita Sory Sidimé Moussa Condé Daniel Agbo-Panzo Pediatric Surgery Department Donka National Hospital (HND) of the University Hospital of Conakry Gamal Abdel Nasser University of Conakry (UGANC) of Guinea Conakry Guinea Orthopedic and Trauma Surgery Department Donka National Hospital (HND) of the Conakry University Hospital Conakry Guinea

Introduction: Solitary exostoses are the most common benign tumors of the fertile metaphyses of the long bones of children. Their radiological diagnosis of metaphyseal bone growth must be confirmed on pathological examination. These tumors can remain asymptomatic for a long time and reveal themselves during a particularly vascular complication. The objective of this study was to describe the epidemiological, diagnostic, therapeutic and evolutionary aspects of these tumors. Patient and Observation: We report the case of a 15-year-old adolescent girl, with no particular pathological history, received in the pediatric surgery department of the Donka National Hospital (HND) of the Conakry University Hospital for recurrent acute painful swelling of the lower third of the left thigh in an afebrile context accompanied by lameness and stopping school for a few days (2 - 3 days). The symptoms appear to have evolved over the past 3 years and after physical activities. It regresses with rest, analgesics and non-steroidal anti-inflammatory drugs. The notion of trauma and sickle cell disease was not reported in the patient's clinical history. It is the persistence of the symptomatology which motivates the said consultation. On palpation, a small hard mass is noted at the expense of the internal metaphysis of the left distal femur. Deep palpation of this area causes a tingling sensation and during rapid mobilization of the knee. The remainder of the orthopedic examination was unremarkable. Standard x-ray of the femur shows a bony growth with a pointed tip from the distal metaphysis of the left femur. On surgical exploration, we noted a wedge-shaped exostosis oriented towards the vastus medialis muscle. Histological examination of the surgical specimen confirms osteogenic exostosis. There is no recurrence after 2 years. Conclusion: The distal femoral metaphysis is the most common location of solitary osteochondromas in children. Their definitive diagnosis requires the histology of

关键词： Osteogenic Exostosis Osteochondromas Fertile Long Bone Metaphyses Child

Local Criteria Used by Farmers to Evaluate the Agronomic Performance and the Fertilizing Capacity of Cowpea Varieties: Diversity, Variability and Proximal Relation with Agronomic Measurements in Contrasted sahelian Locations

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Agricultural Sciences 2024年第1期15卷 114-131页

作者： Nouhou salifou Jangorzo Abdoul-Aziz saïdou Abou-Soufianou sadda Abdoulaye Moussa Mamoudou Hassane Bil-Assanou Issoufou Département des Sciences du Sol et Télédétection Université Dan Dicko Dankoulodo de Maradi Maradi Niger. Unité Mixte de Recherche “Diversité et Adaptation des Plantes” (UMR DAP) Université Dan Dicko Dankoulodo de Maradi Maradi Niger Centre Imaan de Support en Recherche Transdisciplinaire (Imaan Research) Niamey Niger Institut de Recherche pour le Développement Niamey Niger Université Boubacar BA de Tillabéri Tillabéri Niger Département des Sciences et Techniques de Productions Végétales Université Dan Dicko Dankoulodo de Maradi Maradi Niger

When contributing to participatory research, farmers usually appreciate the performance of cowpea varieties using qualitative scores. The score they attribute to each variety are based on local knowledge. The specific criteria they individually use to attribute a score are not well described. The objectives of this work were to: 1) identify and describe exhaustively the local criteria used by farmers to measure the agronomic performance of cowpea;2) assess the variability and statistical structure of these farmer criteria across local contexts;3) and analyze the association between these farmer criteria and the classical agronomic measurement. To achieve these objectives, an augmented block design was implemented across fifteen locations in the regions of Maradi, Dosso and Tillabéri, representing a diversity of local contexts. From a set of 36 cowpea varieties, fifteen varieties were sown per location, including five varieties (controls) common to all locations. In each location, two replicates were sown in randomized Fisher’s blocks. After agronomic measurement and participatory evaluation (scoring of varieties by farmers), a group survey (focus group) was conducted in each location to identify the criteria considered by farmers to found their discretional scoring of varieties during the participatory evaluation. The analysis of the data identified, across locations, thirteen criteria defined by farmers to characterize the agronomic performance of cowpea. Some of these criteria were different according to location. Farmers ranked the three varieties with the best performance for each agronomical trait (Top 3 varieties). A comparison of the farmer ranking with the ranking based on agronomic measurements revealed similarity and complementary between both methods. This study highlighted the importance of considering both local and scientific knowledge in local varietal evaluations.

关键词： Agronomic Performance Participatory Research Cowpea Farmers’ Criteria

一种基于前向成像模型的光声层析图像重建方法

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中国光学（中英文） 2024年第2期17卷 444-455页

作者：程丽君孙正孙美晨侯英飒华北电力大学电子与通信工程系河北保定071003 华北电力大学河北省电力物联网技术重点实验室河北保定071003

在光声层析成像(photoacoustic tomography,PAT)时,不均匀光通量分布、组织复杂的光学和声学特性以及超声探测器的非理想特性等因素会导致重建图像质量下降。本文考虑不均匀光通量、非定常声速、超声探测器的空间脉冲响应和电脉冲响应... 详细信息

在光声层析成像(photoacoustic tomography,PAT)时,不均匀光通量分布、组织复杂的光学和声学特性以及超声探测器的非理想特性等因素会导致重建图像质量下降。本文考虑不均匀光通量、非定常声速、超声探测器的空间脉冲响应和电脉冲响应、有限角度扫描和稀疏采样等因素的影响,建立了前向成像模型。通过交替优化求解成像模型的逆问题,实现光吸收能量分布图和声速分布图的同时重建。仿真、仿体和在体实验结果表明,与反投影法、时间反演法和短滞后空间相干法相比,该方法重建图像的结构相似度和峰值信噪比可分别提高约83%、56%、22%和80%、68%、58%。由上述结果可知,对非理想成像场景采用该方法重建的图像质量有显著提高。

关键词：光声层析成像图像重建前向成像模型探测器脉冲响应有限角度扫描稀疏采样

腹主动脉预置球囊辅助凶险性前置胎盘伴胎盘植入剖宫产的临床应用研究

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海南医学 2024年第6期35卷 804-809页

作者：宋瑞香肖飒苗红艳三门峡市中心医院产科河南三门峡472000

目的探讨腹主动脉预置球囊术对凶险性前置胎盘(PPP)伴胎盘植入剖宫产产妇应激反应、凝血功能及母婴结局的影响。方法选取2021年1月至2023年6月三门峡市中心医院收治的62例PPP伴胎盘植入产妇,按照随机数表法分为观察组和对照组各31例。... 详细信息

目的探讨腹主动脉预置球囊术对凶险性前置胎盘(PPP)伴胎盘植入剖宫产产妇应激反应、凝血功能及母婴结局的影响。方法选取2021年1月至2023年6月三门峡市中心医院收治的62例PPP伴胎盘植入产妇,按照随机数表法分为观察组和对照组各31例。两组产妇均行剖宫产术,对照组行髂内动脉预置球囊术,研究组行腹主动脉预置球囊术。比较两组产妇的手术指标、手术前后的应激反应指标[肾上腺素(E)、促肾上腺皮质激素(ACTH)、皮质醇(Cor)、去甲肾上腺素(NE)]、凝血功能[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]、血红蛋白(Hb)、红细胞压积(HCT)水平,同时比较两组新生儿的相关情况及产妇的子宫切除率和并发症发生率。结果研究组产妇的手术时间、透视耗时、住院时间分别为(111.63±15.59)min、(15.67±3.27)s、(6.04±0.53)d,明显短于对照组的(128.75±20.03)min、(28.96±5.11)s、(6.65±0.74)d,放射剂量、术中与术后24 h出血量、术中输血量分别为(4.21±0.74)mGy、(752.31±153.66)mL、(135.47±20.37)mL、(357.92±32.40)mL,明显少于对照组的(15.63±2.39)mGy、(1026.47±212.52)mL、(328.19±38.92)mL、(950.30±85.61)mL,差异均有统计学意义(P<0.05);术后24 h,研究组产妇的血清Cor、ACTH、E、NE水平明显低于对照组,APTT、TT、PT、FIB、Hb、HCT明显高于对照组,差异均有统计学意义(P<0.05);出生1 min、5 min,研究组新生儿Apgar评分分别为(9.02±0.27)分、(9.52±0.24)分,明显高于对照组的(8.74±0.33)分、(9.13±0.30)分,新生儿窒息率为0,明显低于对照组的19.35%,差异均有统计学意义(P<0.05);研究组产妇的子宫切除率、并发症发生率分别为6.45%、6.45%,明显低于对照组的29.03%、32.26%,差异均有统计学意义(P<0.05)。结论腹主动脉预置球囊可减少PPP伴胎盘植入剖宫术中放射剂量、出血量及输血量,减少应激反应,改善凝血功能,促进术后早期恢复,同时提高手术安全性,改善新生儿分娩结局,降低窒息与子宫切除风险。

关键词：凶险性前置胎盘胎盘植入腹主动脉预置球囊术髂内动脉预置球囊术应激反应凝血功能新生儿情况子宫切除率并发症

Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening

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当代医学科学（英文） 2024年第4期44卷 748-758页

作者： Shan-shan HU Tong-yao WANG Lu NI Fan-xin HU Bo-wen YUE ying ZHENG Tian-lun WANG Abhishek KUMAR Yan-yan WANG Jin-e WANG Zhi-yong ZHOU Third-grade Pharmacological Laboratory of Traditional Chinese Medicine State Administration of Traditional Chinese MedicineChina Three Gorges UniversityYichang 443002China College of Medicine and Health Sciences China Three Gorges UniversityYichang 443002China Third-grade Pharmacological Laboratory of Traditional Chinese Medicine State Administration of Traditional Chinese MedicineChina Three Gorges UniversityYichang 443002China College of Basic Medical Science China Three Gorges UniversityYichang 443002China

Objective:Icariin(ICA)has a good neuroprotective effect and can upregulate neuronal basal autophagy in naturally aging *** dysfunction is associated with brain aging-related neurodegenerative *** opening of the mitochondrial permeability transition pore(mPTP)is a crucial factor in mitochondrial dysfunction and is associated with excessive *** study aimed to explore that ICA protects against neuronal injury by blocking the mPTP opening and down-regulating autophagy levels in a D-galactose(D-gal)-induced cell injury ***:A cell model of neuronal injury was established in rat pheochromocytoma cells(PC 12 cells)treated with 200 mmol/L D-gal for 48 *** this cell model,PC12 cells were pre-treated with different concentrations of ICA for 24 *** was used to detect cell *** associated β-galactosidase(sa-β-Gal)staining was used to observe cell *** blot analysis was performed to detect the expression levels of a senescence-related protein(p21),autophagy markers(LC3B,p62,Atg7,Atg5 and Beclin 1),mitochondrial fission and fusion-related proteins(Drp1,Mfn2 and Opa1),and mitophagy markers(Pink1 and Parkin).The changes of autophagic flow were detected by using mRFP-GFP-LC3 *** intracellular ultrastructure was observed by transmission electron *** was used to detect mPTP,mitochondrial membrane potential(MMP),mitochondrial reactive oxygen species(mtROS)and ROS *** and apoptosis levels were detected by flow ***:D-gal treatment significantly decreased the viability of PC12 cells,and markedly increased the sa-β-Gal positive cells as compared to the control *** the D-gal stimulation,the expression of p21 was significantly ***,D-gal stimulation resulted in an elevated LC3B Ⅱ/Ⅰ ratio and decreased p62 ***,autophagosomes and autolysosomes were significantly increased,indicating abnormal activation of autopha

关键词： autophagy icariin mitochondrial dysfunction mitochondrial permeability transition pore neuronal injury

Fabricating bio-inspired high impact resistance carbon nanotube network films for multi-protection under an extreme environment

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Nano Research 2024年第9期17卷 7793-7802页

作者： Mingquan Zhu Kailu xiao Wei Zhang Xudong Lei Yunxiang Bai Shijun Wang Peng Zhang Feng Gao Congying Wang Wenqiang Xu Huiyong Li Xianqian Wu Chao Wang Hui Zhang Luqi Liu Zhong Zhang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Materials Science and Engineering Texas A&M UniversityCollege StationTexas 77840USA Institute of Mechanics Chinese Academy of SciencesBeijing 100190China School of Astronautics Harbin Institute of TechnologyHarbin150001China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China

The fabrication of light-weight,highly impact-resistant,and energy-absorbent materials is urgently demanded in many facets of the society from body armor to aerospace engineering,especially under an extreme *** nanotubes(CNTs),one of the strongest and toughest materials ever found,also have good conductivity,chemical stability,and thermal stability,etc,making them a competitive candidate as building blocks to help achieve the above *** this work,a kind of CNT network was prepared by using chlorosulfonic acid(Csa)to release the internal stress of super-aligned carbon nanotube films(sa-CNTF)and dendritic polyamide amine(PAMAM)to further introduce multiple hydrogen bonds and interlocking *** fabricated bioinspired carbon nanotube network films(PAMAM@C-CNTF)have a high toughness of 45.97 MJ/m3,showing an increase of 420%compared to neat *** importantly,the anti-impact performance of the films(e.g.,with a maximum specific energy absorption of 1.40 MJ/kg under 80-100 m/s projectile impact)is superior to that of conventional protective materials from steel and Kevlar fiber,and also exceeds that of any other reported carbon-based *** hierarchical energy dissipation mechanism was further revealed through experiment and *** functions including intelligent heating/anti-icing,ultraviolet protection,as well as electromagnetic interference shielding properties make these network films have great potential in practical multi-protection applications,especially under an extreme environment.

关键词： carbon nanotubes composites mechanical properties multi-function

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预变形对6082铝合金人工时效性能的影响

塑性工程学报 2024年第9期31卷 144-151页

作者：邱飒蔚刘杰夏二立叶拓吴远志肖罡湖南工学院智能制造与机械工程学院湖南衡阳421002 湖南工学院汽车零部件技术研究院湖南衡阳421002 江西铜业技术研究院有限公司江西南昌330096

探究了预变形对6082铝合金时效析出行为及力学性能的影响。采用万能试验机测试材料的力学性能,通过扫描电镜观察拉伸断口形貌,使用光学显微镜和透射电镜表征微观组织。结果表明:当预变形量为4%时,6082铝合金的屈服强度和抗拉强度达到峰... 详细信息

探究了预变形对6082铝合金时效析出行为及力学性能的影响。采用万能试验机测试材料的力学性能,通过扫描电镜观察拉伸断口形貌,使用光学显微镜和透射电镜表征微观组织。结果表明:当预变形量为4%时,6082铝合金的屈服强度和抗拉强度达到峰值,分别为324和369 MPa,随预变形量的继续增大逐步下降。6082铝合金的伸长率随着预变形量的增大而不断下降。经不同热处理和预变形的6082铝合金在常温拉伸条件下均表现出韧性断裂。随着预变形量增加,断口处的韧窝尺寸变小,韧窝变浅。预变形有利于析出相的析出,当预变形量为4%时,析出相分布密度最大,尺寸细小。随着预变形量继续增加,析出相分布不均,且尺寸出现粗化,材料的强度和塑性均下降。

关键词： 6082铝合金预变形人工时效力学性能微观组织

基于sa-PSO算法优化CNN的电能质量扰动分类模型

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电力自动化设备 2024年第5期44卷 185-190页

作者：肖白李道明穆钢高文瑞董光德东北电力大学现代电力系统仿真控制与绿色电能新技术教育部重点实验室吉林吉林132012 国网重庆市电力公司电力科学研究院重庆401123

针对传统电能质量扰动分类模型中扰动特征复杂、识别步骤繁琐的问题,提出了一种通过模拟退火(sa)算法与粒子群优化(PSO)算法相结合来优化卷积神经网络(CNN)的电能质量扰动分类模型。将CNN卷积层中的二维卷积核替换成一维卷积核;采用sa... 详细信息

针对传统电能质量扰动分类模型中扰动特征复杂、识别步骤繁琐的问题,提出了一种通过模拟退火(sa)算法与粒子群优化(PSO)算法相结合来优化卷积神经网络(CNN)的电能质量扰动分类模型。将CNN卷积层中的二维卷积核替换成一维卷积核;采用sa算法对PSO算法进行改进,规避PSO算法陷入局部最优的困境;采用改进后的PSO算法对CNN进行参数寻优;利用优化CNN提取和筛选合适的特征,根据这些特征利用分类器得到最终分类结果。通过算例分析得出,使用基于sa-PSO算法优化的CNN的电能质量扰动分类模型能精确地识别出电能质量扰动信号。

关键词：电能质量扰动分类卷积神经网络粒子群优化算法模拟退火算法特征提取