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Jidong cognitive impairment cohort study: objectives, design, and baseline screening

Neural Regeneration Research 2020年第6期15卷 1111-1119页

作者： Dai-Yu song Xian-wei Wang Sa Wang Si-Qi Ge Guo-Yong Ding xue-Yu Chen Yan-Ru Chen Hua-Min liu xiao-Mei Xie wei-Jia Xing Dong li Yong zhou School of public health Shandong First Medical University&Shandong Academy of Medical SciencesTaianShandong ProvinceChina School of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Neuroepidemiology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Staff hospital of jidong oilfield Caofeidian districtTangshanHebei ProvinceChina Department of Neurology The Affiliated Wenling Hospital of Wenzhou Medical UniversityWenlingZhejiang ProvinceChina

The risk of dementia increases in patients with cognitive ***,it is not clear what factors contribute to the onset of dementia in those with cognitive *** this prospective cohort study,we will investigate the every-five-year incidence of cognitive impairment and prognostic factors for cognitive *** Jidong cognitive impairment cohort was established from April 2012 to August 2015,during which we recruited 5854 healthy participants(55.1%male)older than 45 years(mean,57 years).Participants received a health examination in the Staff Hospital,Jidong Oilfield Branch,China National Petroleum *** data and blood samples were *** impairment was evaluated using the Mini-Mental State Examination,and was defined as a Mini-Mental State Examination score of less than *** was assessed using the criteria of Diagnostic and Statistical Manual of Mental Disorders(Fourth edition),the International Working Group criteria,and the Mini-Mental State Examination *** follow-up will continue until December 2024,during which a prognostic model will be *** primary outcome is the presence/absence of dementia and the secondary outcome is quality of *** screening results showed the following:(1)Cognitive impairment was apparent in 320 participants(5.5%).These participants will be excluded from the Jidong cohort study,and the remaining participants will be followed up.(2)Of the 320 participants with cognitive impairment,there was a significantly higher prevalence of illiteracy than other education levels(35.9%,P<0.05).Age,arterial hypertension,alcohol consumption,and passive smoking differed significantly between the cognitive impairment and healthy groups(P<0.05).Multivariate logistic regression models showed that age(odds ratio[OR]=1.059,95%confidence interval[CI]:1.044-1.074)and arterial hypertension(OR=1.665,95%CI:1.143-2.427)were risk factors for mild cognitive *** the increase o

关键词： assessment cognitive impairment community dementia follow-up Mini-Mental Status Examination Scale model new basis prevention prognostic factors

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Tumor-Penetrating and Mitochondria-Targeted Drug Delivery Overcomes Doxorubicin Resistance in Lung Cancer

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Chinese Journal of Polymer Science 2023年第4期41卷 525-537,I0006页

作者： Meng-xue zhou Jia-Yu Zhang xiao-Meng Cai Rui Dou li-Fo Ruan Wen-Jiang Yang Wen-Chu lin Jun Chen yi Hu CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics and University of Chinese Academy of Sciences(UCAS)Chinese Academy of Sciences(CAS)Beijing100049China Key Laboratory of Tea Biology and Resource Utilization of Ministry of Agriculture Tea Research InstituteChinese Academy of Agricultural SciencesHangzhou310008China Division of Nuclear Technology and Applications Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing100049China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230026China

As one of the major challenges in tumor chemotherapy,multidrug resistance typically correlates with the poor drug penetration within tumor tissues and drug efflux by the ATP-driven efflux pumps in tumor ***,we design a kind of near-infrared(NIR)light-and acidity-activated micellar i PUTDN nanoparticle for mitochondria-targeting doxorubicin(DOX)delivery to combat DOX resistance in small-cell lung *** the PEGylated i PUTDN nanoparticles can keep stealth in blood circulation,NIR irradiation at the tumor region can peel off the PEG shell from the nanoparticles,and the exposed i RGD can facilitate deep tumor penetration of the *** being internalized by DOX-resistant H69AR cells,the poly(β-aminoester)s(PAE)-based nanoparticles can release the triphenylphosphonium(TPP)-conjugated DOX(TDOX)into the cytosol,which can further accumulate in mitochondria with the aid of ***,the mitochondrial membrane potential and ATP content are both reduced in DOX-resistant H69AR *** in vivo therapeutic results show that TDOX-loaded nanoparticles with the aid of NIR light irradiation can effectively suppress the DOX-resistant small-cell lung cancer without noticeable adverse effects.

关键词： Doxorubicin NIR/p H-dual sensitive nanoparticles Tumor penetration Mitochondria Drug resistance

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Assessment of China’s contributions to the Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses:a questionnaire survey

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Global Health Research and Policy 2021年第1期6卷 438-446页

作者： hong-Mei li ying-Jun Qian Kun Yang wei Ding Lu-Lu Huang xue-Jiao Ma Lei Duan Duo-Quan Wang Ya-yi Guan Ning xiao xiao-Nong zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025China Jiangsu Institute of Parasitic Diseases Wuxi 214064China

Background:The Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses(RNAS^(+))was established in 1998,which has developed close partnerships with Asian countries endemic for schistosomiasis and other helminthiasis in ***^(+)has provided an ideal regional platform for policy-makers,practitioners and researchers on the prevention,control and research of parasitic diseases in Asian ***,one of the initiating countries,has provided significant technical and financial support to the regional ***,its roles and contributions have not been explored so *** purpose of this study was to assess China's contributions on the supporting of RNAS^(+)***:An assessment research framework was developed to evaluate China’s contributions to RNAS^(+)in four aspects,including capacity building,funding support,coordination,and *** anonymous web-based questionnaire was designed to acquire respondents’basic information,and information on China’s contributions,challenges and recommendations for RNAS^(+)*** participant scored from 0 to 10 to assess China’s contribution:“0”represents no contribution,and“10”represents 100%*** who included their e-mail address in the 2017-2019 RNAS^(+)annual workshops were invited to participate in the ***:Of 71 participants enrolled,41 responded to the survey.37(37/41,90.24%)of them were from RNAS^(+)member countries,while the other 4(4/41,9.76%)were international *** of the respondents(38/41,92.68%)were familiar with RNAS^(+).Respondents reported that China’s contributions mainly focused on improving capacity building,providing funding support,coordination responsibility,and joint application of cooperation programs on RNAS^(+)*** average scores of China’s contributions in the above four fields were 8.92,8.64,8.75,and 8.67,respectively,with an overall assessment score of 8.81(10 for a maximum score).The challenge o

关键词： China RNAS^(+) Assessment Schistosomiasis Regional cooperation Contribution

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Artificial intelligence empowers the second-observer strategy for colonoscopy:a randomized clinical trial

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Gastroenterology Report 2023年第1期11卷 216-223页

作者： Pu Wang xiao-Gang liu Min Kang xue Peng Mei-ling Shu Guan-Yu zhou Pei-Xi liu Fei Xiong Ming-Ming Deng hong-Fen Xia Jian-Jun li xiao-Qi Long Yan song liang-Ping li Department of Gastroenterology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanP.R.China Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanP.R.China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqingP.R.China Department of Gastroenterology Suining Central HospitalSuiningSichuanP.R.China

Background:In colonoscopy screening for colorectal cancer,human vision limitationsmay lead to highermiss rate of lesions;artificial intelligence(AI)assistance has been demonstrated to improve polyp ***,there still lacks direct evidence to demonstrate whether AI is superior to trainees or experienced nurses as a second observer to increase adenoma detection during *** this study,we aimed to compare the effectiveness of assistance fromAI and human observer during ***:A prospective multicenter randomized study was conducted from 2 September 2019 to 29 May 2020 at four endoscopy centers in *** patients were randomized to either computer-aided detection(CADe)-assisted group or observer-assisted *** primary outcome was adenoma per colonoscopy(APC).Secondary outcomes included polyp per colonoscopy(PPC),adenoma detection rate(ADR),and polyp detection rate(PDR).We compared continuous variables and categorical variables by using R studio(version 3.4.4).Results:A total of 1,261(636 in the CADe-assisted group and 625 in the observer-assisted group)eligible patients were ***(0.42 vs 0.35,P=0.034),PPC(1.13 vs 0.81,Plinical outcome of colonoscopy and reduce disturbance to routine practice(*** No.:ChiCTR1900025235).

关键词： artificial intelligence colon cancer screening adenoma early detection computer-aided detection

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Measurements of the Cross-sections of Produced Short-lived Nuclei Induced by Neutrons around 14 MeV on Isotopes of Tungsten

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Chinese Physics Letters 2019年第11期36卷 10-13页

作者： xiao-Jun Sun Feng-Qun zhou Yue-li song Yong li Peng-Fei Ji Xin-yi Chang Henan Key Laboratory of Research for Central Plains Ancient Ceramics Pingdingshan UniversityPingdingshan 467000 School of Electrical and Mechanical Engineering Pingdingshan UniversityPingdingshan 467000

New experimental cross-section data for the^180 W(n,2 n)^179 mW,^186 W(n,2 n)185 mW and186 W(n,p)186 Ta reactions at the neutron energies of 13.5 and 14.4 MeV are obtained by the activation technique. The neutron beams are produced by means of the3 H(d,n)4 He reaction. The gamma activities of the product nuclei are measured by a high-resolution gamma-ray spectrometer with a coaxial high-purity germanium detector. The neutron fluence is determined using the monitor reaction^93 Nb(n,2 n)^92 mNb. The results in the current work are discussed and compared with the measurement results found in the literature. It is shown that these higher accuracy experimental cross-section data around the neutron energy of 14 MeV agree with some previous experimental values from the literature within experimental uncertainties.

关键词： technique. reaction. purity

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An universal in-situ phosphating strategy to fabricate high-performance Co_(2)P-based bifunctional oxygen electrocatalyst derived from conjugated polyaniline-phytic acid copolymer

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Rare Metals 2024年第11期43卷 5823-5834页

作者： Wen-xue Chen Yue Du li-Na zhou Zhi-yi Zhong Zhi-Xian Shi Yan Mao Zi-Quan zhou Hao-Yue Feng Yu Su Hai-Yan Hu Shi li Dong-Bin Xiong Jian-Qin zhou yi-Si liu Yao xiao Hubei Key Laboratory of Photoelectric Materials and Devices School of Material Science and EngineeringHubei Normal UniversityHuangshi 435002China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou325035China Hangzhou Hangyang Chemical and Medical Engineering Lo. Hangzhou310000China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China Innovative Centre for Flexible Devices(iFLEX) Max Planck-NTU Joint Lab for Artificial SensesSchool of Materials Science and EngineeringNanyang Technological UniversitySingapore 639798Singapore 不详

Electrocatalysts play a crucial role in the performance of rechargeable Zn-air batteries(ZABs),but it is still difficult to produce nonprecious materials with excellent bifunctional oxygen reduction reactions(ORR)and oxygen evolution reactions(OER).Herein,conjugated polyaniline-phytic acid polymer(pANI-PA)was directly calcined to fabricate Co_(2)P nanoparticles embedded in N,P-doped carbon network composites(Co_(2)P@pDC-PA)for metal-air *** resulting pANI-PA derived Co_(2)Pbased carbon composite exhibits exceptional bifunctional ORR/OER activities with a half-wave potential of 0.79 V for ORR and 1.62 V of over-potential for OER at 10mA·cm^(-2).Owing to the synergistic effect of its unique three-dimensional(3D)structure,N,P-doped carbon framework,and encapsulated Co_(2)P nanoparticles,as-fabricated composite can be used as a highly efficient air cathode in the rechargeable metal-air *** assembled rechargeable ZAB demonstrates a high-power density of 190.0 mW·cm^(-2)and remarkable cycling stability over1000 *** study introduced a novel approach that paves the way for the efficient,cost-effective,and scalable production of bifunctional electrocatalysts for rechargeable ZABs.

关键词： Co_(2)P nanoparticles Polyaniline-phytic acid polymers(pANI-PA) Bifunctional electrocatalysts Rechargeable Zn-air batteries(ZABs)

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Effect of GAPT Extract on Expression of Tau Protein and Its Phosphorylation Related Enzymes in Hippocampal Neurons of APPV717I Transgenic Mice

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Chinese Journal of Integrative Medicine 2017年第8期23卷 605-610页

作者： NI Jing-nian SHI Jing ZHANG xue-kai YANG yi-chang liU xiao-meng wei Ming-qing li Ting WANG Peng-wen TIAN Jin-zhou WANG Yong-yan Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Key Laboratory of Chinese Internal Medicine Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Institute of Clinical Basic Medicine China Academy of Chinese Medical SciencesBeijing 100700China

Objective：To investigate the effect of GAPT,an extract mixture from Radix Ginseng,Rhizoma Acor tatarinowii,Radix Polygalae and Radix Curcuma（containing ingredient of turmeric）,*** expression of tau protein and its phosphorylation related enzyme in hippocampal neurons of APPV717I transgenic ***：Sixty three-month-old APPV717I transgenic mice were randomly divided into model group,donepezil group[0.92 mg/（kg·d）],the low,medium and high dosage of GAPT groups[0.075,0.15,0.30 g/（kg·d）,12 in each group],and 12 three-month-old C57BL/6J mice were set as a normal control group,treatments were administered orally once a day respectively,and both the normal group and model group were given 0.5%sodium carboxymethyl cellulose ***（IHC）and Western blot analysis were used to detect the expression of total tau protein（Tau-5）,cyclin-dependent kinase 5（CDK5）and protein phosphatase 2A（PP2A）in hippocampal neurons of experimental mice after 8-month drug administration（11 months old）.Results：In the model group,the expression of Tau-5 and CDK5 were increased,whereas the expression of PP2A was decreased in hippocampal neurons,which were significantly different compared with that in the normal group（all P〈0.01）.IHC test indicated the number and area of either Tau-5 or CDK5 positive cells were decreased with a dose-depended way in GAPT groups,and an increase of *** with the model group,the changes were significant in GAPT groups（P〈0.05 or P〈0.01）.Similar results were shown by Western ***：GAPT could attenuate abnormal hyperphosphorylation of tau protein in hippocampal neurons of APPV717I transgenic mice via inhibiting the expression of CDK5 and activating the expression of PP2A.

关键词： Alzheimer's disease tau APPV7171 transgenic mice Chinese medicine

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Hypertension Exacerbates Severity and Outcomes of COVID-19 in Elderly Patients:A Retrospective Observational Study

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Current Medical Science 2022年第3期42卷 561-568页

作者： li-song DAI Meng-pei ZHU Yu-min li hong-mei zhou hong-li liAO Pan-pan CHENG Xin-yue XIA xue-yun YAO Hui-juan ZHANG xiao-qi liU wei HUANG Lei WAN Xiang-yang XU Fu-rong WANG Cheng-qi XU Department of Radiology Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China Department of Respiratory Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Radiology Wuhan Eighth HospitalWuhan 430014China Department of Cardiology Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China Department of Ultrasound Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China Key Laboratory of Molecular Biophysics of the Ministry of Education Cardio-X InstituteCollege of Life Science and Technology and Center for Human Genome ResearchHuazhong University of Science and TechnologyWuhan 430070China

Objective To evaluate the impact of hypertension on the clinical outcome of COVID-19 patients aged 60 years old and *** This single-center retrospective cohort study enrolled consecutive COVID-19 patients aged 60 years old and older,who were admitted to liyuan Hospital from January 1,2020 to April 25,*** included patients were divided into two groups:hypertension and nonhypertension *** baseline demographic characteristics,laboratory test results,chest computed tomography(CT)images and clinical outcomes were collected and *** prognostic value of hypertension was determined using binary logistic *** Among the 232 patients included in the analysis,105(45.3%)patients had comorbid *** to the nonhypertension group,patients in the hypertension group had higher neutrophil-to-lymphocyte ratios,red cell distribution widths,lactate dehydrogenase,high-sensitivity C-reactive protein,D-dimer and severity of lung lesion,and lower lymphocyte counts(all Plity of survival(Pline than those without *** may be an independent prognostic factor of poor clinical outcome in elderly COVID-19 patients.

关键词： COVID-19 SARS-CoV-2 hypertension prognosis mortality risk factor

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Expression dynamics of periodic transcripts during cancer cell cycle progression and their correlation with anticancer drug sensitivity

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Military Medical Research 2023年第4期10卷 444-460页

作者： Chun‑xiao li Jin‑song Wang Wen‑Na Wang Dong‑Kui Xu Yan‑Tong zhou Fang‑zhou Sun yi‑Qun li Feng‑Zhu Guo Jia‑Lu Ma xue‑Yan Zhang Meng‑Jiao Chang Bing‑He Xu Fei Ma Hai‑li Qian State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background:The cell cycle is at the center of cellular activities and is orchestrated by complex regulatory mechanisms,among which transcriptional regulation is one of the most important *** splicing dramatically expands the regulatory network by producing transcript isoforms of genes to exquisitely control the cell ***,the patterns of transcript isoform expression in the cell cycle are *** targeting cell cycle checkpoints are commonly used as anticancer therapies,but none of them have been designed or evaluated at the alternative splicing transcript *** utility of these transcripts as markers of cell cycle-related drug sensitivity is still unknown,and studies on the expression patterns of cell cycle-targeting drug-related transcripts are also ***:To explore alternative splicing patterns during cell cycle progression,we performed sequential transcriptomic assays following cell cycle synchronization in colon cancer HCT116 and breast cancer MDA-MB-231 cell lines,using flow cytometry and reference cell cycle transcripts to confirm the cell cycle phases of samples,and we developed a new algorithm to describe the periodic patterns of transcripts fluctuating during the cell *** of Drug Sensitivity in Cancer(GDSC)drug sensitivity datasets and Cancer Cell line Encyclopedia(CCLE)transcript datasets were used to assess the correlation of genes and their transcript isoforms with drug *** identified transcripts associated with typical drugs targeting cell cycle by determining correlation *** assays were used to confirm the effect of ENST00000257904 against cyclin dependent kinase 4/6(CDK4/6)***,alternative splicing transcripts associated with mitotic(M)phase arrest were analyzed using an RNA synthesis inhibition assay and transcriptome ***:We established high-resolution transcriptome datasets of synchronized cell cycle samples from colon cancer HCT11

关键词： Cell cycle Alternative splicing Transcriptome Drug resistance Cyclin dependent kinase 4/6 inhibitor,Dolichyl-phosphate mannosyltransferase polypeptide 2

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Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC(CTONG1804):a multicenter open-label phase II study

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Signal Transduction and Targeted Therapy 2024年第1期9卷 249-258页

作者： Si-Yang liu song Dong xue-Ning Yang Ri-Qiang liao Ben-Yuan Jiang Qun Wang xiao-song Ben Gui-Bin Qiao Jun-Tao lin hong-hong Yan li-Xu Yan Qiang Nie Hai-Yan Tu Bin-Chao Wang Jin-Ji Yang Qing zhou hong-Rui li Ke liu Wendy Wu Si-Yang Maggie liu Wen-Zhao Zhong yi-Long Wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Thoracic Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis FuzhouChina Berry Oncology Corporation FuzhouChina Chinese Thoracic Oncology Group(CTONG) GuangzhouChina Department of Hematology The First Affiliated HospitalJinan UniversityGuangzhouChina

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive(N)and nivolumab–chemotherapy(N/C)combinations based on PD-L1 *** patients exhibited resectable clinical stage IIA–IIIB(AJCC 8th edition)NSCLC without EGFR/ALK *** received either mono-nivolumab(N)or nivolumab+nabpaclitaxel+carboplatin(N/C)for three cycles based on PD-L1 *** primary endpoint was the major pathological response(MPR).Key secondary endpoints included the pathologic complete response(pCR),objective response rate(ORR),and event-free survival(EFS).Baseline PD-L1 expression and perioperative circulating tumor DNA(ctDNA)status were correlated with pCR and ***-two patients were enrolled,with 46 undergoing *** MPR was 50.0%(26/52),with 25.0%(13/52)achieving pCR,and 16.7%and 66.7%for patients with PD-L1≥50%in N and N/C groups,***(25.0%)patients experienced grade 3 or higher immune-related adverse events during neoadjuvant *** with post-neoadjuvant ctDNA negativity was more likely to have pCR(39.1%)compared with those remained positive(6.7%,odds ratio=6.14,95%CI 0.84-Inf,p=0.077).With a median follow-up of 25.1 months,the 18-month EFS rate was 64.8%(95%CI 51.9–81.0%).For patients with ctDNA–***+,the 18m-EFS rate was 93.8%vs 47.3%(HR,0.15;95%CI 0.04,0.94;p=0.005).Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with PD-L1 expression≥50%.ctDNA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits,which requires further confirmation in a prospective clinical trial(NCT04015778).

关键词： chemotherapy NSCLC treatment

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