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Contrast-enhanced multiple-phase imaging features in hepatic epithelioid hemangioendothelioma

World Journal of Gastroenterology 2011年第30期17卷 3544-3553页

作者： Ying Chen Ri-Sheng yu Ling-Ling Qiu Ding-Yao Jiang yan-Bin Tan yan-Biao Fu Department of Radiology Second Affiliated Hospital Zhejiang University School of Medicine 310009 Hangzhou Zhejiang Province China Department of Pathology Second Affiliated Hospital Zhejiang University School of Medicine 310009 Hangzhou Zhejiang Province China

AIM： To investigate and review the contrast-enhanced multiple-phase computed tomography （CEMP CT） and magnetic resonance imaging （MRI） findings in patients with pathologically confirmed hepatic epithelioid hemangioendothelioma （HEHE）. METHODS： Findings from imaging examinations in 8 patients （5 women and 3 men） with pathologically confirmed HEHE were retrospectively reviewed （CT images obtained from 7 patients and MR images obtained from 6 patients）. The age of presentation varied from 27 years to 60 years （average age 39.8 years）. RESULTS： There were two types of HEHE： multifocal type （n = 7） and diffuse type （n = 1）. Tn the multifocal-type cases, there were 74 lesions on CT and 28 lesions on MRI with 7 lesions found with diffusion weighted imaging; 18 （24.3%） of 74 lesions on plain CT and 26 （92.9%） of 28 lesions on pre-contrast MRI showed the target sign. On CEMP CT, 28 （37.8%） of 74 lesions appeared with the target sign and a progressive-enhancement rim and 9 （12.2%） of 74 lesions displayed progressive enhancement, maintaining a state of persistent enhancement. On CEMP MRI, 27 （96.4%） of 28 lesions appeared with the target sign with a progressive-enhancement rim and 28 （100%） of 28 lesions displayed progressive-enhancement, maintaining a state of persistent enhancement. In the diffuse-type cases, an enlarged liver was observed with a large nodule appearing with persistent enhancement on CEMP CT and MRI. CONCLUSION： The most important imaging features of HEHE are the target sign and/or progressive en- hancement with persistent enhancement on CEMP CT and MRI. MRI is advantageous over CT in displaying these imaging features.

关键词： Liver Neoplasm Epithelioid hemangioen-dothelioma Computed tomography Magnetic resonance imaging

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New perspectives on ferroptosis and its role in hepatocellular carcinoma

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Chinese Medical Journal 2022年第18期135卷 2157-2166页

作者： Tianhao Cong Yingen Luo yan Fu yu Liu yujie Li xiao Li Department of Interventional Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

For a long time,the morbidity and mortality rates of hepatocellular carcinoma(HCC)have remained *** the concept of ferroptosis was introduced in 2012,researchers’perspectives have shifted toward finding novel ferroptosis-related treatment strategies,especially for tumors that are resistant to *** recent years,there have been an increasing number of studies on ferroptosis,and these studies have found that ferroptosis has great potential and promise for cancer *** is a kind of regulated cell death(RCD);unlike apoptosis,ferroptosis is an iron-dependent type of RCD driven by lipid *** whole process of ferroptosis mainly revolves around three pathways(system xc-/glutathione peroxidase 4[GPX4]),lipid (peroxidation,and iron metabolism),which are also regulated by various metabolic *** review will attempt to analyze the relationship between the system xc-/GPX4 pathway,lipid peroxidation,iron metabolism,and ferroptosis from three aspects(triggering,execution,and regulation),and the regulatory factors for ferroptosis will be *** this review,we will also illustrate the relationship between ferroptosis and tumors as well as its application in tumors from the perspective of ***,we will summarize the current limitations and needs and provide perspectives related to the focus of development in the future.

关键词： Ferroptosis Hepatocellular carcinoma Molecular targets

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Transfer of Paralytic Shellfish Toxins via Marine Food Chains:A Simulated Experiment

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Biomedical and Environmental Sciences 2007年第3期20卷 235-241页

作者： ZHI-JUN TAN TIAN yan REN-CHENG yu MING-JIANG ZHOU Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 Shandong China Graduate School Chinese Academy of Sciences Beijing 100039 China

Objective To study the transfer of paralytic shellfish toxins （PST） using four simulated marine food chains： dinoflagellate Alexandrium tamarense→Artemia Artemia salina→Mysid shrimp Neomysis awatschensis; A. tamarense→N. awatschensis; A. tamarense→A, salina→Perch Lateolabrax japonicus; and A. tamarense→L, japonicus. Methods The ingestion of A. tamarense, a producer of PST, by L. japonicus, N. awatschensis, and A. salina was first confirmed by microscopic observation of A. tamarense cells in the intestine samples of the three different organisms, and by the analysis of Chl.a levels in the samples. Toxin accumulation in L. japonicus and N. awatschensis directly from the feeding on A. tamarense or indirectly through the vector of A. salina was then studied, The toxicity of samples was measured using the AOAC mouse bioassay method, and the toxin content and profile of A. tamarense were analyzed by the HPLC method. Results Both A. salina and N. awatschensis could ingest A. tamarense cells. However, the ingestion capability of A. salina exceeded that of N. awatschensis. After the exposure to the culture of A. tamarense （2 000 cells·mL^-1） for 70 minutes, the content of Chl.a in A. salina and N. awatschensis reached 0.87 and 0.024 μ***^-1, respectively. Besides, A. tamarense cells existed in the intestines of L. japonicus, N. awatschensis and A. salina by microscopic observation. Therefore, the three organisms could ingest A. tamarense cells directly. A. salina could accumulate high content of PST, and the toxicity of A. salina in samples collected on days 1, 4, and 5 of the experiment was 2.18, 2.6, and 2.1 MU.g^-1, respectively. All extracts from the samples could lead to death of tested mice within 7 minutes, and the toxin content in anemia sample collected on the 1st day was estimated to be 1.65×10 ^5 μg STX equal/individual. Toxin accumulation in L japonicus and N. awatschensis directly from the feeding on A. tamarense or indirectly from the vector ofA. salina was al

关键词： Paralytic shellfish poisoning toxins A.tamarense L.japonicus N.awatschensis A.salina Marine food chains Is: Paralytic shellfish poisoning toxins A. tamarense L. japonicus N. awatschensis A. salina Marine food chains

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Effects of perioperative rosuvastatin on postoperative delirium in elderly patients:A randomized,double-blind,and placebo-controlled trial

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World Journal of Clinical Cases 2021年第21期9卷 5909-5920页

作者： xiao-Qin Xu Jing-Zhi Luo xiao-yu Li Hai-Qin Tang Wei-Hong Lu Department of Anesthesiology Wuxi Clinical College of Anhui Medical University904th Hospital of Joint Logistic Support Force of PLAWuxi Clinical College of Anhui Medical UniversityWuxi 214044Jiangsu ProvinceChina

BACKGROUND Experimental evidence has indicated the benefits of statins for the treatment of postoperative ***,clinical trials did not reach definite conclusions on the effects of statins on *** clinical trials have indicated that statins reduce postoperative delirium and improve outcomes,while some studies have reported negative *** To evaluate whether perioperative rosuvastatin treatment reduces the incidence of delirium and improves clinical *** This randomized,double-blind,and placebo-controlled trial was conducted in a single center in Jiangsu,*** study enrolled patients aged greater than 60 years who received general anesthesia during elective operations and provided informed consent.A computer-generated randomization sequence(in a 1:1 ratio)was used to randomly assign patients to receive either rosuvastatin(40 mg/d)or ***,care providers,and investigators were all masked to group *** primary endpoint was the incidence of delirium,which was assessed twice daily with the Confusion Assessment Method during the first 7 postoperative *** were performed on intention-to-treat and safety *** Between January 1,2017 and January 1,2020,3512 patients were assessed.A total of 821 patients were randomly assigned to receive either placebo(n=411)or rosuvastatin(n=410).The incidence of postoperative delirium was significantly lower in the rosuvastatin group[23(5.6%)of 410 patients]than in the placebo group{42(13.5%)of 411 patients[odds ratios(OR)=0.522,95%confidence interval(CI):0.308-0.885;P<0.05]}.No significant difference in 30-d all-cause mortality(6.1%vs 8.7%,OR=0.67,95%CI:0.39-1.2,P=0.147)was observed between the two *** decreased the hospitalization time(13.8±2.5 vs 14.2±2.8,P=0.03)and hospitalization expenses(9.3±2.5 vs 9.8±2.9,P=0.007).No significant differences in abnormal liver enzymes(9.0%vs 7.1%,OR=1.307,95%CI:0.787-2.169,P=0.30)or rhabdomyol

关键词： Perioperative rosuvastatin Postoperative delirium Elderly General anesthesia Randomised controlled trial

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Luminescent Properties of Gd_(3)PO_(7):Eu in UV/VUV Region

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Chinese Physics Letters 2001年第5期18卷 690-691页

作者： ZENG xiao-Qing HONG Guang-yan YOU Hong-Peng WU Xue-yan KIM Chang-Hong PyuN Chong-Hong yu Byung-Yong BAE Hyun-Sook PARK Cheal-Hee KWON Il-Eok Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022 Solid State Chemistry Labortory Korea Institute of Science and TechnologyP.O.Box 131CheongryangSeoul 130-650Korea

The luminescent properties of Gd_(3)PO_(7):Eu were investigated in UV and VUV *** phosphor has so strong emissions around 618.5 nm under UV excitation,especially around 209\,nm,so that it has a better colour saturation than that of Y_(2)O_(3):*** would be a new potential red phosphor for lamp and other applications with UV-excitation source or even for displaying *** the VUV excitation spectrum of Eu^(3+)emissions,energy absorptions by Gd^(3+),Gd-O and PO_(4)^(3-) were observed,on which it can be inferred that there are three kinds of energy transferring processes to Eu^(3+)*** energy absorptions of Gd^(3+),Gd-O and PO_(4)^(3-) are induced by 4f→4f transitions,band-gap transition of Gd_(3)PO_(7) and intramolecular(2t_(2)→2a,3t_(2))transition,*** energy transfer efficiency of the PO_(4)^(3-) intramolecular transition is lower compared with that of the band-gap transition(Gd-O).

关键词： excitation intramolecular transition

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Efficiency and safety of radiofrequency-assisted hepatectomy for hepatocellular carcinoma with cirrhosis:A single-center retrospective cohort study

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World Journal of Gastroenterology 2015年第35期21卷 10159-10165页

作者： Fan Zhang Jun yan xiao-Bin Feng Feng Xia xiao-Wu Li Kuan-Sheng Ma Ping Bie Institute of Hepatobiliary Surgery Southwest Hospitalthe Third Military Medical University

AIM: To assess the efficiency and safety of radiofrequencyassisted hepatectomy in patients with hepatocellular carcinoma(HCC) and ***: From January 2010 to December 2013, 179 patients with HCC and cirrhosis were recruited for this retrospective study. Of these, 100 patients who received radiofrequency-assisted hepatectomy(RF+ group) were compared to 79 patients who had hepatectomy without ablation(RF- group). The primary endpoint was intraoperative blood loss. The secondary endpoints included liver function, postoperative complications, mortality, and duration of hospital ***: The characteristics of the two groups were closely matched. The Pringle maneuver was not used in the RF+ group. There was significantly less median intraoperative blood loss in the RF+ group(300 vs 400 m L, P = 0.01). On postoperative days(POD) 1 and 5, median alanine aminotransferase was significantly higher in the RF+ group than in the RF- group(POD 1: 348.5 vs 245.5, P = 0.01; POD 5: 112 vs 82.5, P = 0.00), but there was no significant difference between the two groups on POD 3(260 vs 220, P = 0.24). The median AST was significantly higher in the RF+ group on POD 1(446 vs 268, P = 0.00), but there was no significant difference between the two groups on POD 3 and 5(POD 3: 129.5 vs 125, P = 0.65; POD 5: 52.5vs 50, P = 0.10). Overall, the rate of postoperative complications was roughly the same in these two groups(28.0% vs 17.7%, P = 0.11) except that post hepatectomy liver failure was far more common in the RF+ group than in the RF- group(6% vs 0%, P = 0.04).CONCLUSION: Radiofrequency-assisted hepatectomy can reduce intraoperative blood loss during liver resection effectively. However, this method should be used with caution in patients with concomitant cirrhosis because it may cause severe liver damage and liver failure.

关键词： Hepatocellular carcinoma Blood loss Radiofrequency

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False positive anti-hepatitis A virus immunoglobulin M in autoimmune hepatitis/primary biliary cholangitis overlap syndrome:A case report

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World Journal of Clinical Cases 2021年第22期9卷 6464-6468页

作者： Jun yan yan-Sha He Yi Song Xin-yu Chen Hua-Bao Liu Chun-yan Rao Department of Hepatology Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China

BACKGROUND Autoimmune hepatitis(AIH)is an immune-mediated liver disease affecting all age *** between hepatitis A virus(HAV)and AIH have been described for many ***,we report a case of an AIH/primary biliary cholangitis(PBC)overlap syndrome with anti-HAV immunoglobulin M(IgM)false *** SUMMARY A 55-year-old man was admitted with manifestations of anorexia and jaundice along with *** had marked transaminitis and *** serology was positive for HAV IgM and negative for *** screening was positive for anti-mitochondria antibody but negative for *** ultrasound imaging was *** was diagnosed with acute hepatitis *** symptomatic treatment,liver function tests gradually *** months later,his anti-HAV IgM positivity persisted and transaminase and bilirubin levels were also more than 10 times above of the upper limit of *** histology was prominent,and HAV RNA was ***,AIH/primary biliary cholangitis(PBC)overlap syndrome diagnosis was made based on the“Paris Criteria”.The patient was successfully treated by *** This case highlights that autoimmune diseases or chronic or acute infections,may cause a false-positive anti-HAV IgM result because of cross-reacting ***,the detection of IgM should not be the only method for the diagnosis of acute HAV *** nucleic acid amplification tests should be employed to confirm the diagnosis.

关键词： Autoimmune hepatitis Primary biliary cholangitis Hepatitis A virus Case report

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Metal-encapsulated nitrogen-doped carbon nanotube arrays electrode for enhancing sulfion oxidation reaction and hydrogen evolution reaction by regulating of intermediate adsorption

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Chinese Chemical Letters 2024年第8期35卷 533-538页

作者： xiao Li Wanqiang yu yujie Wang Ruiying Liu Qingquan yu Riming Hu Xuchuan Jiang Qingsheng Gao Hong Liu Jiayuan yu Weijia Zhou Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJi’nan 250022China Institute for Smart Materials&Engineering School of Materials Science and EngineeringUniversity of JinanJi’nan 250022China College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China State Key Laboratory of Crystal Materials Shandong UniversityJi’nan 250100China

For treatment of sulfion-containing wastewater,coupling the electrochemical sulfion oxidation reaction(SOR)with hydrogen evolution reaction(HER)can be an ideal way for sulfur and H_(2)resources ***,we synthesize a metal-modified carbon nanotube arrays electrode(Co@N-CNTs/CC)for SOR and *** electrode has excellent performance for SOR and HER attributed to the unique array *** can achieve 99.36 mA/cm^(2)at 0.6 V for SOR,and 10 mA/cm^(2)at 0.067 V for *** functional theory calculations verify that metal modification is able to regulate the electronic structure of carbon nanotube,which is able to optimize the adsorption of *** Co@N-CNTs/CC as bifunctional elec-trodes to establish a hybrid electrolytic cell can reduce about 67%of energy consumption compared with the traditional water splitting electrolytic ***,the hybrid electrolytic cell is used to treat actual sulfion-containing wastewater,achieving the sulfur yield of 30 mg h^(−1)cm^(−2)and the hydrogen production of 0.64 mL/min.

关键词： Sulfion oxidation reaction Hydrogen evolution reaction Nitrogen-doping carbon nanotube Core-shell structure Resource upgrade

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Microstructure of AISI 304 stainless steel strips produced by a twin-roll caster

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Journal of University of Science and Technology Beijing 2008年第6期15卷 678-682页

作者： Chenxi Ji Jiongmmg Zhang Fuxiang Huang Xinhua Wang yuan Fang yan yu School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Advanced Technology Institute Technology Center of Baosteel Shanghai 201900 China

By optical inspection of macro-etched metallography and electron back-scattered diffraction （EBSD） mapping, this paper analyzed the microstructure of austenitic stainless steel strips produced with an equal-diameter twin-roll strip caster. The results indicate that the microstructure of the strips includes two columnar zones with highly compact dendrites and one equiaxed zone. The characteristics, such as grain size and growing direction of columnar grains and equiaxed grains, were investigated. An additional transitional area with many finer grains between the columnar zone and the equiaxed zone was found. As shown in EBSD analysis, small angle boundaries exist both in the columnar zone and the equiaxed zone, although they are especially more in the transitional area. Additionally, some 〈111〉 twin boundaries were found in the microstructure of the strips.

关键词： twin-roll strip casting austenitic stainless steel solidification microstructure electron back-scattered diffraction (EBSD) mapping

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Sublethal effects of sulfoxaflor on the fitness of two species of wheat aphids, Sitobion avenae(F.) and Rhopalosiphum padi(L.)

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Journal of Integrative Agriculture 2019年第7期18卷 1613-1623页

作者： XIN Juan-juan yu Wen-xin YI xiao-qing GAO Jun-ping GAO Xi-wu ZENG xiao-peng Department of Entomology China Agricultural UniversityBeijing 100193P.R. China Haidian District Center for Disease Prevention and Control Beijing 100094P. R. China Beijing Center for Disease Prevention and Control Beijing 100013P.R. China

Sitobion avenae(F.) and Rhopalosiphum padi(L.) are two important pests of wheat in *** typically coexist in fields during the late period of wheat *** is a novel sulfoximine insecticide that demonstrates broad-spectrum efficacy,especially in targeting sap-feeding *** study was carried out to investigate the sublethal effects of sulfoxaflor on the development,longevity,and reproduction of two species of wheat *** results showed that sublethal concentrations of sulfoxaflor did not cause significant effects on the fecundity or the longevity of the parent generation(F0 generation) of either *** or ***,it caused transgenerational sublethal *** ***,adult longevity of F1 generation was significantly *** significant differences were observed on the population parameters of *** in the F1 *** ***,the adult preoviposition period(APOP) and the total preoviposition period(TPOP) of F1 generation were significantly *** mean generation time(T) was significantly reduced in the *** F1 ***’s more,the intrinsic rate of increase(rm) and the finite rate of increase(λ) were significantly increased in the *** F1 *** together,these results suggest that exposure to the LC25 of sulfoxafl had no effects on the parent generation of *** or ***,but it reduced adult longevity of *** as a negative effect and increased the rm and λ of *** in the first progeny generation,which may have an impact on the population dynamics of ***.

关键词： Sitobion avenae Rhopalosiphum padi sulfoxaflor sublethal effect

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