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Prevalence of hypertension and its associations with body composition across Chinese and American children and adolescents

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World Journal of Pediatrics 2024年第4期20卷 392-403页

作者： Li-Wang Gao Yi-Wen Huang Hong Cheng Xi Wang Hong-Bo dong Pei xiao Yin-Kun yan Xin-Ying Shan xiao-Yuan Zhao Jie Mi Center for Non-Communicable Disease Management Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthNo.56 Nanlishi RoadXicheng DistrictBeijing100045China Department of Epidemiology Capital Institute of PediatricsNo.2 Yabao RoadChaoyang DistrictBeijing100020China Key Laboratory of Major Diseases in Children Ministry of EducationBeijingChina

Background The age of onset of hypertension(HTN)is decreasing,and obesity is a significant risk *** prevalence and racial disparities in pediatric HTN and the association between body composition and blood pressure are insufficiently *** study aimed to evaluate the prevalence of HTN in Chinese and American children and adolescents and to assess the relationship between various body composition indices and *** Seven thousand,five hundred and seventy-three Chinese and 6239 American children and adolescents aged 8–18 years from the 2013–2015 China Child and Adolescent Cardiovascular Health study and the 2011–2018 National Health and Nutrition Examination Surveys were *** pressure and body composition(fat and muscle)were measured by trained *** crude prevalence and age-standardized prevalence rate(ASPR)of primary HTN and its subtypes[isolated systolic hypertension(ISH)and isolated diastolic hypertension(IDH)]were calculated based on 2017 American Academy of Pediatrics ***-adjusted linear regression coefficients and odds ratios(ORs)were calculated to assess the associations of body composition indicators with HTN,ISH and *** The ASPR of HTN was 18.5%in China(CN)and 4.6%in the United States(US),whereas the obesity prevalence was 7.4%and 18.6%,and the population attributable risk of HTN caused by overweight and obesity was higher in the US than in *** fat mass,muscle mass and body fat percentage mass were associated with a higher risk of HTN in both *** percent of muscle body mass had a protective effect on HTN and ISH in both countries[HTN(CN:OR=0.83,95%CI=0.78–0.88;US:OR=0.72,95%CI=0.64–0.81);ISH(CN:OR=0.87,95%CI=0.80–0.94;US:OR=0.71,95%CI=0.62–0.81)],and the protective effect was more common among children and adolescents with high levels of physical *** The burden of HTN in Chinese children and adolescents was substantial and much greater than that in the US,and th

关键词： Body composition Children and adolescents China Child and Adolescent Cardiovascular Health Hypertension National Health and Nutrition Examination Surveys

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亚轨道飞行器返回轨道设计方法研究

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宇航学报 2008年第2期29卷 467-471页

作者：闫晓东唐硕西北工业大学航天学院西安710072

返回轨道的设计对于亚轨道飞行器安全返回地面起着十分重要的作用。依据气动力作用的显著性,将返回下降轨道分为初始下降段和过渡段,初始下降段采用定倾斜角的飞行方法,过渡段中,采用四次多项式建立标准高度-速度剖面,通过将各种约束表... 详细信息

返回轨道的设计对于亚轨道飞行器安全返回地面起着十分重要的作用。依据气动力作用的显著性,将返回下降轨道分为初始下降段和过渡段,初始下降段采用定倾斜角的飞行方法,过渡段中,采用四次多项式建立标准高度-速度剖面,通过将各种约束表示在高度速度空间中,得到轨道设计约束边界,在满足这些约束边界的前提下,得到标准高度-速度剖面的多项式系数,最后,通过对航程的调制,得到最终的标准轨道。

关键词：亚轨道飞行器返回轨道设计再入制导

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Miniaturized, Wide Stopband Filter Based on Shielded Capacitively Loaded SIW Resonators

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Chinese Journal of Electronics 2024年第2期33卷 456-462页

作者： yan ZHENG Hanyu TIAN Yuandan dong University of Electronic Science and Technology of China (UESTC)

Based on the full-mode capacitively loaded substrate integrated waveguide（SIW） resonator and the miniaturized shielded half-mode capacitively loaded SIW（S-HMCSIW） cavities, a novel compact high-performance filter is proposed. The footprint of the half-mode SIW（HMSIW） is further reduced due to the application of the capacitive-loading technique. By applying cross coupling, the proposed SIW filter's transmission zero enhances the stopband rejection and shows excellent selectivity. For the bandpass filter, the measured |S21| and |S11| are better than 1.09 d B and-14 d B, respectively. And a 3-d B fractional bandwidth（FBW） of 9.14–10.76 GHz（FBW=16.2%）is also observed. The filter achieves a wide stopband with a-20 d B out-of-band rejection up to 2.69f0（f0= 10 GHz）,with a size of 0.39λg× 0.51λgonly. Good agreement between measurement and simulation is obtained.

关键词： Band-pass filters Wireless communication Couplings Resonator filters Microwave theory and techniques Filtering theory Passband

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Outcome of childhood acute lymphoblastic leukemia： a report of 121 patients treated at Wuhan Union Hospital of China

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Chinese Medical Journal 2008年第5期121卷 469-472页

作者： WANG yan-rong JIN Run-ming XU Jia-wei xiao yan ZHOU dong-feng ZHANG Zhi-quan Department of Pediatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

Prognostic factors are biological or physical characteristics of a patient or the patient＇s cancer that can be used to predict the outcome of the individual. The prognosis of childhood acute lymphoblastic leukemia （ALL） has been improved greatly in the past 40 years, reaching a long-term event free survival （EFS） of about 75% and overall survival of about 80% in developed countries.3-6 The same result has also been achieved in China. The ALL-XH-99 Protocol at Shanghai Children＇s Medical Center adopted early intensification treatment and triple intrathecal chemotherapy with high-dose methotrexate treatment for all patients and intensive chemotherapy in median risk （MR） and high risk （HR） patients. More intensive chemotherapy might cause more complications. In order to reevaluate the outcome of childhood ALL treated with the ALL-XH-99 Protocol and to fully elucidate the prognostic factors and the sequelae, a retrospective analysis was carried out to evaluate patients diagnosed with childhood ALL who were treated with the ALL-XH-99 Protocol in the past decade.

关键词： acute lymphoblastic leukemia childhood prognostic factor event free survival

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Amplification effect of intra-seasonal variability of soil moisture on heat extremes over Eurasia

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Advances in Climate Change Research 2024年第1期15卷 1-8页

作者： Yi-Nuo WANG Zhi-yan ZUO Liang QIAO Kai-Wen ZHANG Mei-Yu CHANG dong xiao Zou-Xing LIN Huan WANG Department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China Key Laboratory of Cites Mitigation and Adaptation to Climate Change in Shanghai China Meteorological AdministrationShanghai 200030China Collaborative Innovation Centeron Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 211800China Shanghai Frontiers Science Center of Atmosphere-Ocean Interaction Shanghai 200123China College of Geography and Resources Science Sichuan Normal UniversityChengdu 610101China National Observations and Research Station for Wetland Ecosystems of the yangtze Estuary Shanghai 202183China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China

Drying soil has been conducive to a high frequency of extreme high-temperature events over many regions worldwide in recent ***,changes in the intraseasonal variability of soil moisture can also influence the likelihood of extremely high *** previous investigators have examined the association between extremely high temperatures and large-scale atmospheric circulation variability,the role of land-atmosphere coupling dominated by soil moisture variability in extremely high temperatures,particularly over the Eurasian continent,is not well *** this study,on the basis of the Land Surface,Snow,and Soil Moisture Model Intercomparison Project,we found that land-atmosphere feedback amplified the variability of soil moisture in most regions of Eurasia during summer from 1980 to *** amplification of soil moisture variability is closely correlated with more intensive intraseasonal variability of surface air temperature and more frequent occurrences of extreme high-temperature events,particularly in Europe,Siberia,Northeast Asia,and the Indochina *** correlation implies that increasing the intraseasonal variability of soil moisture results in a high likelihood of heat extremes during summer in most parts of Eurasia except Asian desert *** the intraseasonal timescale,the land-atmosphere coupling increases the variability of surface sensible heat flux and net long-wave radiation heating the atmosphere by intensifying the soil moisture variability,thus amplifying the variability of surface air temperature and enhancing the extreme high-temperature *** finding demonstrates the importance of changes in intraseasonal soil moisture variability for the increasing likelihood of heat extremes in summer.

关键词： Soil moisture Intraseasonal variability Land-atmosphere coupling Heat extremes

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Towards rational design in electrochemical denitrification by analyzing pH dependence

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National Science Review 2024年第6期11卷 223-232页

作者： Huan Li dong Luan Jun Long xiaoyan Fu Jianping xiao State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

A small fraction of NOx（<1%） always exists in CO2feedstock（e.g. exhausted gas）, which can significantly reduce the efficiency of CO2electroreduction by ～30%. Hence, electrochemical denitrification is the precondition of CO2electroreduction. The pH effect is a key factor, and can be used to tune the selectivity between N2and N2O production in electrochemical denitrification. However, there has been much controversy for many years about the origin of pH dependence in electrocatalysis. To this end, we present a new scheme to accurately model the pH dependence of the electrochemical mechanism. An extremely small pH variation from pH 12.7 to pH 14 can be accurately reproduced for N2O production. More importantly,the obviously different pH dependence of N2production, compared to N2O, can be attributed to a cascade path. In other words, the N2was produced from the secondary conversion of the as-produced N2O molecule（the major product）, instead of the original reactant NO. This is further supported by more than 35 experiments over varying catalysts（Fe, Ni, Pd, Cu, Co, Pt and Ag）, partial pressures（20%, 50% and100%） and potentials（from -0.2 to 0.2 V vs. reversible hydrogen electrode）. All in all, the insights herein overturn long-lasting views in the field of NO electroreduction and suggest that rational design should steer away from catalyst engineering toward reactor optimization.

关键词： electrocatalysis denitrification pH-dependence nitric oxide reduction reaction mechanism

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Solid-state non-volatile memories based on vdW heterostructure-based vertical-transport ferroelectric field-effect transistors

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Science China(Information Sciences) 2024年第6期67卷 198-206页

作者： Qiyu yanG Zheng-dong LUO Fei xiao Junpeng ZHANG Dawei ZHANG dongxin TAN Xuetao GAN yan LIU Zhufei CHU Yinshui XIA Genquan HAN Hangzhou Institute of Technology Xidian University State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University School of Artificial Intelligence Xidian University School of Materials Science and Engineering University of New South Wales (UNSW) Sydney ARC Centre of Excellence in Future Low-Energy Electronics Technologies (FLEET) University of New South Wales (UNSW) Sydney Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical University Faculty of Electrical Engineering and Computer Science Ningbo University

Driven by the explosive development of data-centric computation applications, it is becoming urgent to develop in-memory computing devices that are beyond the von Neumann architecture with an arrangement of separated logic and memory components. The transistor-type solid-state non-volatile memories,such as ferroelectric field-effect transistors(Fe FETs), have long been regarded as a competitive candidate for future in-memory computing architectures. However, the density scaling towards high-density arrays would require advanced Fe FETs with reduced footprints, which remains a great challenge so far. Here, a vertical-transport(VT) Fe FET that flips the charge transport channel perpendicular to the substrate plane is proposed, in which a ferroelectric gate and a van der Waals(vd W) heterojunction channel are vertically integrated, effectively reducing the device footprints. The proposed VT-Fe FET shows not only the robust binary non-volatile memory states but also several key synaptic functionalities at the device level. An artificial neural network with supervised learning was simulated based on the device conductance switching properties,showing excellent classification accuracy for the MNIST handwritten digits. These findings suggest that the proposed VT-Fe FET could offer a new solution for future non-volatile memories as well as more advanced neuromorphic systems.

关键词： vdW heterostructure non-volatile memory vertical-transport transistor ferroelectric field-effect transistor memristive devices

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Optimal proportioning of iron ore in sintering process based on improved multi-objective beluga whale optimisation algorithm

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Journal of Iron and Steel Research International 2024年第7期31卷 1597-1609页

作者： Zong-ping Li Xu-dong Li Xue-tong yan Wu Wen xiao-xin Zeng Rong-jia Zhu Ya-hui Wang Ling-zhi Yi Zhongye Changtian International Engineering Co. Ltd.Changsha 410205HunanChina College of Automation and Electronic Information Xiangtan UniversityXiangtan 411105HunanChina College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina

Proportioning is an important part of sintering,as it affects the cost of sintering and the quality of sintered *** address the problems posed by the complex raw material information and numerous constraints in the sintering process,a multi-objective optimisation model for sintering proportioning was established,which takes the proportioning cost and TFe as the optimisation ***,an improved multi-objective beluga whale optimisation(IMOBWO)algorithm was proposed to solve the nonlinear,multi-constrained multi-objective optimisation *** algorithm uses the con-strained non-dominance criterion to deal with the constraint problem in the ***,the algorithm employs an opposite learning strategy and a population guidance mechanism based on angular competition and two-population competition strategy to enhance convergence and population *** actual proportioning of a steel plant indicates that the IMOBWO algorithm applied to the ore proportioning process has good convergence and obtains the uniformly distributed Pareto ***,compared with the actual proportioning scheme,the proportioning cost is reduced by 4.3361¥/t,and the TFe content in the mixture is increased by 0.0367%in the optimal compromise ***,the proposed method effectively balances the cost and total iron,facilitating the comprehensive utilisation of sintered iron ore resources while ensuring quality assurance.

关键词： Sintering process Proportioning Iron ore Multi-objective beluga whale optimisation algorithm Proportioning cost

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气候变化对中国东北主要森林类型的影响

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生态学报 2008年第2期28卷 534-543页

作者：程肖侠延晓冬中国科学院大气物理研究所东亚区域气候-环境重点实验室

应用林窗模型-FAREAST,模拟未来气候变化对中国东北主要类型森林演替动态的影响。根据大气环流模型ECHAM5-OM和HadCM3预测的气候变化资料,模拟选择了目前气候情景、增暖情景、增暖且降水变化情景3种气候情景。结果表明:维持目前气候不变... 详细信息

应用林窗模型-FAREAST,模拟未来气候变化对中国东北主要类型森林演替动态的影响。根据大气环流模型ECHAM5-OM和HadCM3预测的气候变化资料,模拟选择了目前气候情景、增暖情景、增暖且降水变化情景3种气候情景。结果表明:维持目前气候不变,东北森林树种组成和森林生物量基本维持动态平衡。气候增暖不利于东北主要森林类型生长,主要针叶树种比例下降,阔叶树比例增加;温带针阔混交林垂直分布带有上移的趋势;增暖幅度越大,变化越明显。气候增暖基础上考虑降水变化,东北森林水平分布带有北移的趋势,降水对低海拔温带针阔混交林影响不大。

关键词： FAREAST 中国东北气候变化森林动态

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USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells

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Current Medical Science 2024年第4期44卷 707-717页

作者： xiao-hui yan Yin-na ZHU yan-ting ZHU Kidney Disease and Dialysis Center Shaanxi Provincial People's HospitalXi'an 710068China Department of Nephrology The Third Affiliated Hospital of Xi'an Medical UniversityXi'an 710000China Nephrology and Hemodialysis Center Shaanxi Provincial People's HospitalXi'an 710068China

Objective Obesity-induced kidney injury contributes to the development of diabetic nephropathy(DN).Here,we identified the functions of ubiquitin-specific peptidase 19(USP19)in HK-2 cells exposed to a combination of high glucose(HG)and free fatty acid(FFA)and determined its association with TGF-beta-activated kinase 1(TAK1).Methods HK-2 cells were exposed to a combination of HG and ***19 mRNA expression was detected by quantitative RT-PCR(qRT-PCR),and protein analysis was performed by immunoblotting(IB).Cell growth was assessed by Cell Counting Kit-8(CCK-8)viability and 5-ethynyl-2′-deoxyuridine(EdU)proliferation *** cycle distribution and apoptosis were detected by flow *** USP19/TAK1 interaction and ubiquitinated TAK1 levels were assayed by coimmunoprecipitation(Co-IP)assays and *** In HG+FFA-challenged HK-2 cells,USP19 was highly ***19 knockdown attenuated HG+FFA-triggered growth inhibition and apoptosis promotion in HK-2 ***,USP19 knockdown alleviated HG+FFA-mediated PTEN-induced putative kinase 1(PINK1)/Parkin pathway inactivation and increased mitochondrial reactive oxygen species(ROS)generation in HK-2 ***,USP19 stabilized the TAK1 protein through ***,increased TAK1 expression reversed the USP19 knockdown-mediated phenotypic changes and PINK1/Parkin pathway activation in HG+FFA-challenged HK-2 *** The findings revealed that USP19 plays a crucial role in promoting HK-2 cell dysfunction induced by combined stimulation with HG and FFAs by stabilizing TAK1,providing a potential therapeutic strategy for combating DN.

关键词： HK-2 cells high glucose free fatty acid dysfunction USP19 deubiquitination

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