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GPa-level pressure-induced enhanced corrosion resistance in TiZrTaNbSn biomedical high-entropy alloy

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China Foundry 2024年第3期21卷 265-275页

作者： xiao-hong Wang Yu-lei Deng Qiao-yu Li Zhi-xin Xu Teng-fei Ma Xing yang Duo dong dong-dong Zhu xiao-hong yang Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina School of Materials Science and Engineering Taizhou UniversityTaizhou 318000ZhejiangChina

TiZrTaNb-based high-entropy alloys(HEAs)are research frontier of biomedical materials due to their high hardness,good yield strength,excellent wear resistance and corrosion ***,as an essential trace element in the human body that plays a significant role in physiological *** has stable chemical properties and a low elastic *** this study,a new material,TiZrTaNbSn HEAs,was proposed as a potential biomedical *** Ti_(35)Zr_(25)Ta_(15)Nb_(15)Sn_(10)biomedical high-entropy alloys(BHEAs)were successfully prepared through an arc melting furnace and then remelted using a German high-temperature and high-pressure apparatus under GPa-level(4 GPa and 7 GPa).The precipitation behavior of the needle-like HCP-Zr_(5)Sn_(3)phase that precipitates discontinuously at the grain boundary was successfully *** phase constitution,microstructure,and corrosion resistance of the alloy were *** results show that the needle-like HCP-Zr_(5)Sn_(3)phase is eliminated and the(Zr,Sn)-rich nano-precipitated phase is precipitated in the microstructure under high pressure,which leads to the narrowing of grain boundaries and consequently improves the corrosion resistance of the *** addition,the formation mechanisms of(Zr,Sn)-rich nanoprecipitates in BHEAs were *** Zr and Sn dissolve in the matrix due to the effect of high pressure,during the cooling process,they precipitate to form a(Zr,Sn)-rich nano-precipitated phase.

关键词： biomedical HEAs precipitation grain boundary corrosion resistance TiZrTaNbSn

Influence of High-Density Bedding Plane Characteristics on Hydraulic Fracture Propagation in Shale Oil Reservoir

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 3051-3071页

作者： xiao yan Di Wang Haitao Yu State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Beijing102206China State Energy Center for Shale Oil Research and Development Beijing102206China Department of Geotechnical Engineering College of Civil Engineering Tongji UniversityShanghai200092China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Key Laboratory of Deep Earth Science and Engineering(Sichuan University) Ministry of EducationChengdu610065China

The existence of high-density bedding planes is a typical characteristic of shale oil *** the behavior of hydraulic fracturing in high-density laminated rocks is significant for promoting shale oil *** this study,a hydraulic fracturing model considering tensile failure and frictional slip of the bedding planes is established within the framework of the unified pipe-interface element method(UP-IEM).The model developed for simulating the interaction between the hydraulic fracture and the bedding plane is validated by comparison with experimental *** hydraulic fracturing patterns in sealed and unsealed bedding planes are ***,the effects of differential stress,bedding plane permeability,spacing,and the friction coefficient of the bedding plane are *** results showed that a single main fracture crossing the bedding planes is more likely to form in sealed bedding planes under high differential *** decrease in bedding plane permeability and the increase in the friction coefficient also promote the fracture propagating perpendicular to the bedding *** with high-density bedding planes has a poorer fracturing effect than that with low-density bedding planes,as the hydraulic fracture is prone to initiate and propagate along the bedding ***,higher injection pressure is needed to maintain fracture propagation along the *** increase in bedding density will lead to a smaller fracturing *** fluid seepage into the bedding planes slows shale *** is recommended that increasing the injection flow rate,selecting alternative fracturing fluids,and employing multi-well/multi-cluster fracturing may be efficient methods to improve energy production in shale oil reservoirs.

关键词： Hydraulic fracturing bedding planes shale unified pipe-interface element method

Esophageal cancer screening,early detection and treatment:Current insights and future directions

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1180-1191页

作者： Hong-Tao Qu Qing Li Liang Hao yan-Jing Ni Wen-Yu Luan Zhe yang xiao-dong Chen Tong-Tong Zhang yan-dong Miao Fang Zhang Department of Emergency Yantai Mountain HospitalYantai 264000Shandong ProvinceChina Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2nd Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival *** to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 *** 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and *** cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local ***,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United *** role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of *** effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated *** variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer *** areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive *** techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal *** screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer.

关键词： Esophageal cancer Screening Early detection Treatment Endoscopic mucosal resection Endoscopic submucosal dissection

New clinical trial design in precision medicine:discovery,development and direction

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1293-1321页

作者： xiao-Peng Duan Bao-dong Qin xiao-dong Jiao Ke Liu Zhan Wang Yuan-Sheng Zang Department of Medical Oncology Changzheng HospitalNaval Medical UniversityShanghaiChina

In the era of precision medicine,it has been increasingly recognized that individuals with a certain disease are complex and different from each *** to the underestimation of the significant heterogeneity across participants in traditional"one-sizefits-all"trials,patient-centered trials that could provide optimal therapy customization to individuals with specific biomarkers were developed including the basket,umbrella,and platform trial designs under the master protocol *** recent years,the successive FDA approval of indications based on biomarker-guided master protocol designs has demonstrated that these new clinical trials are ushering in tremendous *** the rapid increase in the number of basket,umbrella,and platform trials,the current clinical and research understanding of these new trial designs,as compared with traditional trial designs,remains *** majority of the research focuses on methodologies,and there is a lack of in-depth insight concerning the underlying biological logic of these new clinical trial ***,we provide this comprehensive review of the discovery and development of basket,umbrella,and platform trials and their underlying logic from the perspective of precision ***,we discuss future directions on the potential development of these new clinical design in view of the"Precision Pro","Dynamic Precision",and"Intelligent Precision".This review would assist trial-related researchers to enhance the innovation and feasibility of clinical trial designs by expounding the underlying logic,which be essential to accelerate the progression of precision medicine.

关键词： clinical approval successive

Review of the evolution and prevention of friction,wear,and noise for water-lubricated bearings used in ships

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Friction 2024年第1期12卷 1-38页

作者： Zhuo ZHANG Wu OUyanG Xingxin LIANG Xinping yan Chengqin YUAN Xincong ZHOU Zhiwei GUO Conglin dong Zhenglin LIU Yong JIN Jinhua xiao School of Transportation and Logistics Engineering Wuhan University of TechnologyWuhan 430063China Reliability Engineering Institute National Engineering Research Center for Water Transport SafetyWuhan 430063China School of Naval Architecture Ocean and Energy Power EngineeringWuhan University of TechnologyWuhan 430063China East Lake Laboratory Wuhan 420202China

With the development of green tribology in the shipping industry,the application of water lubrication gradually replaces oil lubrication in stern bearings and thrust *** terms of large-scale and high-speed ships,water-lubricated bearings with high performance are more strictly ***,due to the lubricating medium,water-lubricated bearings have many problems such as friction,wear,vibration,noise,*** review focuses on the performance of marine water-lubricated bearings and their failure prevention ***,the research of marine water-lubricated bearings is reviewed by discussing its lubrication principle,test technology,friction and wear mechanism,and friction noise generation *** performance enhancement methods have been overviewed from structure optimization and material ***,the potential problems and the perspective of water-lubricated bearings are given in detail.

关键词： water-lubricated bearings lubrication principles test techniques friction and wear friction noise evolution and prevention

Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome:A Systematic Review and Meta-Analysis

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Chinese Medical Sciences Journal 2024年第2期39卷 122-130页

作者： Xia-xiao yan Yue-Lun Zhang Yu-Pei Zhang Ying-Yun yang dong Wu Department of Gastroenterology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Eight-Year Medical Doctor Program Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To assess the diagnostic accuracy of bowel sound analysis for irritable bowel syndrome(IBS)with a systematic review and *** We searched MEDLINE,Embase,the Cochrane Library,Web of Science,and IEEE Xplore databases until September ***-sectional and case-control studies on diagnostic accuracy of bowel sound analysis for IBS were *** estimated the pooled sensitivity,specificity,positive likelihood ratio,negative likeli-hood ratio,and diagnostic odds ratio with a 95% confidence interval(CI),and plotted a summary receiver operat-ing characteristic curve and evaluated the area under the *** Four studies were *** pooled diagnostic sensitivity,specificity,positive likelihood ratio,nega-tive likelihood ratio,and diagnostic odds ratio were 0.94(95%CI,0.87‒0.97),0.89(95%CI,0.81‒0.94),8.43(95%CI,4.81‒14.78),0.07(95%CI,0.03‒0.15),and 118.86(95%CI,44.18‒319.75),respectively,with an area under the curve of 0.97(95%CI,0.95‒0.98).Conclusions Computerized bowel sound analysis is a promising tool for ***,limited high-quality data make the results'validity and applicability *** is a need for more diagnostic test accuracy studies and better wearable devices for monitoring and analysis of IBS.

关键词： irritable bowel syndrome bowel sound analysis diagnostic accuracy systematic review meta-analysis

Dissolution kinetics and reaction mechanism of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag

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Journal of Iron and Steel Research International 2024年第4期31卷 861-869页

作者： Yao-xin Du yan-wu dong Zhou-hua Jiang Ganna Stovpchenko Yu-shuo Li Jun Huang Xin-wei Wang Yu-xiao Liu School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Ecological Metallurgy of Multimetallic Mineral Northeastern UniversityShenyang 110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina E.O.Paton Electric Welding Institute of the National Academy of Science of Ukraine Kiev 03115Ukraine

The dissolution behavior of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag,a basic slag system of electroslag remelting process,was investigated by rotating cylinder method using corundum rods to simulate Al_(2)O_(3) inclusions in *** experimental results show that the dissolution rate of Al_(2)O_(3);rods in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in rotating speed and temperature,and the rate-controlling step is the mass transfer in the *** dissolution rate of Al_(2)O,in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in the ratio of CaO to Al_(2)O_(3),which is due to the increase in dissolution driving force and the decrease in slag *** apparent activation energy of the mass transfer of AlOs in slag C is calculated to be 222.86 kJ mol^(-1).During the dissolution of Al_(2)0,inclusions in the slag,it reacts with F in liquid slag at first,then reacts with CaO to form the intermediate compounds of xCaO-yAl_(2)O_(3) system,and finally dissolves in molten *** dissolution rate of Al_(2)O_(3) inclusions in CaF_(2)-CaO-Al_(2)O_(3) slag for electroslag remelting is positively correlated with the ratio of the dissolution driving force and slag viscosity,and the correlation coeficient is 2.487×10^(-11).

关键词： Inclusion Electroslag remelting Mass transfer:Dissolution rate-Dissolution driving force

Effect of magnetic resonance imaging in liver metastases

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World Journal of Gastroenterology 2024年第1期30卷 112-114页

作者： Xing-Liang Huang xiao-dong Wang Zhao-Miao Gong yan-Feng Zheng Jing-Xin Mao Department of Science and Education Dianjiang People's Hospital of ChongqingChongqing 408399China Department of Science and Industry Chongqing Medical and Pharmaceutical CollegeChongqing 400030China

This letter to the editor is a commentary on a study titled"Liver metastases:The role of magnetic resonance imaging."Exploring a noninvasive imaging evaluation system for the biological behavior of hepatocellular carcinoma(HCC)is the key to achieving precise diagnosis and treatment and improving *** review summarizes the role of magnetic resonance imaging in the detection and evaluation of liver metastases,describes its main imaging features,and focuses on the added value of the latest imaging tools(such as T1 weighted in phase imaging,T1 weighted out of phase imaging;diffusion-weighted imaging,T2 weighted imaging).In this study,I investigated the necessity and benefits of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid for HCC diagnostic testing and prognostic evaluation.

关键词： Liver metastases Magnetic resonance imaging Liver-specific contrast agents Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid Hepatocellular carcinoma Hepatobiliary contrast agents

Biphase-to-monophase structure evolution of Na_(0.766+x)Li_(x)Ni_(0.33-x)Mn_(0.5)Fe_(0.1)Ti_(0.07)O_(2) toward ultradurable Na-ion batteries

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Carbon Energy 2024年第9期6卷 66-79页

作者： Mengting Liu Zhiwei Cheng Xu Zhu Haojie dong Tianran yan Liang Zhang Lu Zheng Hu-Rong Yao Xian-Zuo Wang Lianzheng Yu Bing xiao Yao xiao Peng-Fei Wang State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringCenter of Nanomaterials for Renewable EnergyXi'an Jiaotong UniversityXi'anShaanxiChina Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhouJiangsuChina Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials College of Physics and EnergyFujian Normal UniversityFuzhouFujianChina Wenzhou Key Laboratory of Sodium-Ion Batteries Institute for Carbon NeutralizationWenzhou University Technology InnovationWenzhouZhejiangChina

Layered composite oxide materials with O3/P2 biphasic crystallographic structure typically demonstrate a combination of high capacities of the O3 phase and high operation voltages of the P2 ***,their practical applications are seriously obstructed by difficulties in thermodynamic phase regulation,complicated electrochemical phase transition,and unsatisfactory cycling ***,we propose an efficient structural evolution strategy from biphase to monophase of Na_(0.766+x)Li_(x)Ni_(0.33-x)Mn_(0.5)Fe_(0.1)Ti_(0.07)O_(2) through Li+*** role of Li+substitution not only simplifies the unfavorable phase transition by altering the local coordination of transition metal(TM)cations but also stabilizes the cathode–electrolyte interphase to prevent the degradation of TM cations during battery *** a result,the thermodynamically robust O_(3)-Na_(0.826)Li_(0.06)Ni_(0.27)Mn_(0.5)Fe_(0.1)Ti_(0.07)O_(2) cathode delivers a high capacity of 139.4 mAh g^(-1) at 0.1 C and shows prolonged cycling life at high rates,with capacity retention of 81.6%at 5 C over 500 *** work establishes a solid relationship between the thermodynamic structure evolution and electrochemistry of layered cathode materials,contributing to the development of long-life sodium-ion batteries.

关键词： electrochemistry Li+substitution Na-ion batteries O_(3)phase phase transition