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Effect of acupuncture at Foot-yangming Meridian on gastric mucosal blood flow, gastric motiiity and brain-gut peptide

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World Journal of Gastroenterology 2007年第15期13卷 2229-2233页

作者： Ya-Ping Lin Shou-Xiang Yi Jie yan xiao-Rong chang The Institute of Acupuncture Moxibustion and Massage Hunan University of Traditional Chinese Medicine Changsha 410007 Hunan Province China

AIM： To observe the effect of acupuncture at Foot- yangming Meridian on gastric mucosal blood flow （GMBF）, gastric motility and brain-gut peptide. METHODS： Sixty SD rats were randomly divided into 6 groups： normal control group, model group （group with gastric mucosal damage, GMD）, Sibai group （with acupuncture at Sibai point ＋ GMD）, Tianshu group （with acupuncture at Tianshu point ＋ GMD）, Zusanli group （with acupuncture at Zusanli point ＋ GMD） and non-acupoint group （with acupuncture at non-acupoint ＋ GMD）. The GMD model group was induced by infusing pure alcohol into gastric cavity. H2 Gas Clearance Test （HGCT） was used to measure GMBF, the frequency and amplitude of gastric motility were measured by the method of aerocyst, the content of brain-gut peptide in sinus ventriculi and bulbus medullae were detected by radioimmunoassay. RESULTS： Inhibitory effect of the frequency and amplitude of gastric motility were shown in model group, and the rates of frequency and amplitude changes were remarkably different from the normal control group （-19.41 ± 17.21 vs-4.71 ± 10.32, P 〈 0.05; -51.61 ± 29.02 vs 1.81 ± 14.12, P 〈 0.01）. In comparison with control group, the GMBF was 0.52 ± 0.161 mL vs 1.03 ± 0.255 mL per 100g tissue/min, P 〈 0.01, the content of motilin in sinus ventriculi and bulbus medullae was 63.04 ± 7.77 pg/mL vs 72.91 ± 8.42 pg/mL, P 〈 0.05 and 50.96 ± 8.77 pg/mL vs 60.76 ± 8.05 pg/mL, P 〈 0.05, but the content of somatostatin in sinus ventriculi and bulbus medullae was 179.85 ± 43.13 ng/g vs 90.54 ± 40.42 ng/g, P 〈 0.01 and 532.86 ± 122.58 ng/g vs 370.91 ± 76.29 ng/g, P 〈 0.05,respectively. In comparison with model group, the amplitude of gastric motility was 1.52 ± 20.13, -6.52 ± 23.31, 6.92 ± 25.21 vs -51.61 ± 29.02, P 〈 0.01 and GMBF was 0.694 ± 0.160 mL vs 0.893 ± 0.210 mL, 1.038 ± 0.301 mL vs 0.52 ± 0.161 mL per 100g tissue/rain, P 〈 0.01, respectively in Tianshu, Sibai and Zusanli groups, the content of motilin in sinus ventriculi and bulbus medul

关键词： Electro-acupuncture Foot-yangming Meridian Gastric motility Motilin Somatostatin

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Effect and mechanism of β-L-D4A on DNA polymerase α

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World Journal of Gastroenterology 2007年第46期13卷 6243-6248页

作者： yan Li Ju-Sheng Lin Ying-Hui Zhang xiao-yan Wang Ying chang Xing-Xing He Institute of Liver Diseases Tongji MedicalCollege Huazhong University of Science and Technology 1095Jiefang Street Wuhan 430030 Hubei Province China

AIM： To investigate the safety of β-L-D4A on DNA polymerase α.METHODS： Ion exchange chromatography was used to separate DNA polymerase cc from crude extract of human Hela cells. Detailed kinetic parameters were determined for β-L-D4A against DNA polymeraseα . RESULTS： DNA polymerase was purified with 4% yield and 31000 units/mg specific activity. The Michaelis constant （Km = 3.22 i^mol/L）, 50% inhibition concentration （IC50 = 178.49 μmol/L） and inhibition constant （Ki = 126 mol/L） of β-L-D4A were determined by kinetic analysis. CONCLUSION： β-L-D4A is a more safe nucleoside for hepatitis B virus （HBV） infection with a lower host toxicity.

关键词： Nucleoside β-L-D4A DNA polymeraseα Kinetic study Side effect Hepatitis B virus

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Effect of electro-acupuncture at Foot-yangming Meridian on somatostatin and expression of somatostatin receptor genes in rabbits with gastric ulcer

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World Journal of Gastroenterology 2006年第11期12卷 1761-1765页

作者： Shou-Xiang Yi Ren-Da yang Jie yan xiao-Rong chang Ya-Ping Ling Department of Acupuncture and Moxibustion Hunan College of Traditional Chinese Medicine Changsha 41007 Hunan Province China

AIM： To discuss the protective effect of electroacupuncture at the Foot-yangming Meridian on gastric mucosal lesion, somatostatin （SS） and the expression of SS receptor genes （SSR1mRNA） in rabbits with gastric ulcer and to further explore the relative specificity of meridians and viscera at gene expression level. METHODS： Forty rabbits were randomly divided into control group （A）, gastric ulcer model group （B）, Footyangming Meridian group （C）, Foot-Shaoyang Meridian group （D） and Foot-Taiyang Meridian group （E）. The gastric ulcer model was prepared by infusing alcohol into stomach. Groups C-E were treated with electroacupuncture at points along the above meridians using meridian stimulating instruments for 7 days respectively. By the end of treatment, the index of gastric ulcer was determined, the amount of epidermal growth factor（EGF） and somatostatin was measured by radioimmunoassay （PJA）. SS-R1mRNA expression in gastric mucosa was determined by RT-PCR. RESULTS： The value of EGF in model group was obviously lower（73.6±14.8 vs 91.3±14.9 pg/mL, P〈 0.01） than that in control group. The index of gastric ulcer, content of SS and expression of SSRtmRNA in gastric mucosa were significantly higher than those in control group （24.88 ± 6.29 vs 8.50 ± 2.98 scores, P〈 0.01; 2978.6 ± 587.6 vs 1852.4 ± 361.7 mIU/mL, P〈 0.01; 2.56±0.25 vs 1.04±0.36, P〈0.01） . The value of EGF in Foot-yangming Meridian group was higher than that in model group（92.2±6.7 vs 73.6±14.8 pg/mL, P〈 0.01）. The index of gastric ulcer, content of SS and expression of SS-R1mRNA in gastric mucosa were significantlylower than those in control group（10.88±3.23 vs 24.88±6.29 scores, P〈0.01; 1800.2±488 vs 2978.6±587.6 mIU/mL, P 〈 0.01; 1.07±0.08 vs 2.56±0.25mIU/mL, P〈0.01）. Compared to the model group, the content of SS and expression of SSRlmRNA in gastric mucosa in Foot-Shaoyang Meridian group decreased （2441.0±488. vs 2978.6± 587.6 mIU/mL, P〈 0.05; 1.73±0.16 vs 2.56±0.25 mIU/mL, P〈0.01）. But the above paramet

关键词： Foot-yangming Meridian Electro-acupuncture Somatostatin SSR1mRNA

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Effect of dexamethasone on the release of transforming growth factor-β1, interleukin-8, interleukin-10 and RANTES release by sputum cells in severe asthma

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Chinese Medical Journal 2006年第18期119卷 1567-1571页

作者： GAI xiao-yan SUN Yong-chang CAO Wen-li Department of Respiratory Medicine Peking University Third Hospital Beijing 100083 China

Bronchial asthma is a reversible obstructive airway disease characterized by persistent airway inflammation and airway remodeling, with eosinophil infiltration of the airway walls as the predominant feature. However, our previous work and other reports have demonstrated that neutrophil predominant inflammation is present in a subgroup of asthmatics, particularly severe asthmatics, and patients with airway neutrophilia are less responsive to glucocorticoid therapy. The mechanisms underlying airway neutrophilia in asthma are still under investigation, but interleukin （IL）-8 as an important neutrophil chemokine may play an important role.

关键词： asthma transforming growth factor interleukin-8 interleukin-10 dexamethasone

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Primary Studies on Burnup Estimation of Irradiated Uranium by Dtermining 236U/238U in Contaminated Environmental Samples JIANG xiao-yan,ZHANG Ji-long,ZOU Wei,chang Zhi-yuan

Primary Studies on Burnup Estimation of Irradiated Uranium b...

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作者： JIANG xiao-yan ZHANG Ji-long ZOU Wei chang Zhi-yuan

U/U of the environmental sample can indicate the existence of uranium irradiation,and even can be uesd to estimate the burnup of nuclear spent fuel.A study on the burnup estimation of irradiated uranium which was mixed with natural uranium was carried out by measuring the U/U and U/U in the samples by using MC-ICP-MS. According to the equation(1) and(2),a programme for calculating the burnup of the irradiated

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Guidelines for the diagnosis and treatment of chronic pancreatitis in China(2018 edition)

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 103-109页

作者： Wen-Bin Zou Nan Ru Hao Wu Liang-Hao Hu Xu Ren Gang Jin Zheng Wang Yi-Qi Du Ya-Nan Cao Lei Zhang xiao-yan chang Rong-Chun Zhang xiao-Bin Li yan Shen Peng Li Zhao-Shen Li Zhuan Liao Pancreatitis Group of Chinese Medical Doctor Association Department of Gastroenterology Digestive Endoscopy CenterChanghai HospitalNaval Medical UniversityShanghai 200433China Department of General Surgery Peking Union Medical College HospitalBeijing 100730China Department of Hepatobiliary Pancreatic Surgery First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003China Department of Digestive Endoscopy Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China 不详 Shanghai Institute of Pancreatic Diseases Shanghai 200433China Department of Gastroenterology Heilongjiang Provincial HospitalHarbin 150030China Department of Hepatobiliary Pancreatic Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Shanghai Clinical Center for Endocrine and Metabolic Diseases Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200025China Department of Radiology Shanghai First People’s HospitalShanghai 200080China Department of Pathology Peking Union Medical College HospitalBeijing 100730China Department of Gastroenterology Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Chronic pancreatitis(CP)is a progressive inflammatory disease of pancreas that alters the organ’s normal structure and *** seriously affects the quality of life of patients and greatly increases the public medical burden of *** recent years,the incidence of CP has increased *** concepts of etiology and therapies have been continuously updated.

关键词： Guidelines diagnosis and treatment pancreatitis

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政府研发补贴对创新绩效的影响:创新能力视角

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现代财经（天津财经大学学报） 2019年第1期39卷 59-71页

作者：颜晓畅北京大学经济学院北京100871

近年来,我国政府为鼓励科技创新活动投入了大量研发补贴,而政府研发补贴是否有效提升了创新绩效?其具体影响机制是怎样的?企业创新能力和区域创新能力又发挥着何种作用?这些问题都亟待研究。本文以全国31个省份规模以上工业企业为研究样... 详细信息

近年来,我国政府为鼓励科技创新活动投入了大量研发补贴,而政府研发补贴是否有效提升了创新绩效?其具体影响机制是怎样的?企业创新能力和区域创新能力又发挥着何种作用?这些问题都亟待研究。本文以全国31个省份规模以上工业企业为研究样本,基于2008—2016年的省级面板数据,通过构建五个固定效应面板回归模型,研究了政府研发补贴对创新绩效的影响,同时,从企业创新能力和区域创新能力的视角,探讨了该影响路径上的中介效应和调节效应。结果表明,我国政府研发补贴对创新绩效有一定的促进作用;同时,企业创新能力在该影响路径上起重要的中介作用,区域创新能力对研发补贴与企业创新能力的关系起正向调节作用。本文研究结果,填补了政府研发补贴影响创新绩效的路径上,关于内部影响机制研究的空白;同时,对我国制定并完善有利于市场竞争的研发补贴政策有一定参考价值。

关键词：政府研发补贴创新绩效创新能力中介机制调节作用

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一种全自动的肺裂分割方法

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电子学报 2018年第6期46卷 1319-1326页

作者：彭圆圆肖昌炎湖南大学电气与信息工程学院湖南长沙410006

CT(Computer Tomography)图像中自动分割肺裂是很困难的,肺裂往往存在不完整、形变、断裂和附裂等现象.本文提出一种融合肺部解剖结构特征来实现自动分割肺裂的方法.首先结合肺部气管和动脉血管信息定位肺裂感兴趣区域.然后利用肺裂方... 详细信息

CT(Computer Tomography)图像中自动分割肺裂是很困难的,肺裂往往存在不完整、形变、断裂和附裂等现象.本文提出一种融合肺部解剖结构特征来实现自动分割肺裂的方法.首先结合肺部气管和动脉血管信息定位肺裂感兴趣区域.然后利用肺裂方向信息增强肺裂,并利用多剖面滤波器滤除噪声从而对肺裂进行预分割.最后融合已定位的肺裂感兴趣区域和肺裂预分割结果来自动分割肺裂.与人工参考对比,提出的算法在人体左肺和右肺中分割的肺裂的F1-score中值分别为0.881和0.878.

关键词：自动分割肺裂肺裂感兴趣区域肺裂预分割多剖面滤波器

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Analysis of Genetic Difference Between Species in Lupins by AFLP

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Agricultural Sciences in China 2002年第8期1卷 856-860页

作者： HAI Lin, xiao Shi-he, yan chang-sheng and ZHANG Xiu-ying(Institute of Crop Breeding and Cultivation, Chinese Academy of Agricultural Sciences, Beijing 100081 , P. R . China) Institute of Crop Breeding and Cultivation Chinese Academy of Agricultural Sciences Beijing 100081 P.R. China

The genetic difference between species in 18 lupins (Lupinus L .) varieties including L. angus-tifolius L., L . albus L., L. pilosus Murr. was analyzed using AFLP. A total of 462 bands were observed, a-mong of which, 442 (95.7%) were polymorphic, with an average of 110.5 polymorphic bands for each AFLP primer combination. The average genetic diversity index was 0.781 in this study. The genetic difference between species was higher than that of between varieties, the average identification percentage of four AFLP primer combinations was 100% and 84.7% between species and between varieties, respectively. The cluster analysis indicated that 3 species were distinctly distinguished on the dendrogram using UPGMA method.

关键词： Lupins (Lupinus L.) Genetic difference AFLP

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基于A^2/O处理工艺的生活污水的成组生物毒性评价

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环境科学 2017年第3期38卷 1084-1092页

作者：张秋亚马晓妍王晓昌游猛西安建筑科技大学环境与市政工程学院西安710055

为了更加准确评估城市生活污水的综合生物毒性以及处理工艺对污水毒性的削减状况,本研究通过发光菌急性毒性、遗传毒性、雌激素活性检测方法对A^2/O工艺处理前后污水的毒性进行评价,同时通过斑马鱼暴露实验分析污水和回用水对水生生物... 详细信息

为了更加准确评估城市生活污水的综合生物毒性以及处理工艺对污水毒性的削减状况,本研究通过发光菌急性毒性、遗传毒性、雌激素活性检测方法对A^2/O工艺处理前后污水的毒性进行评价,同时通过斑马鱼暴露实验分析污水和回用水对水生生物内分泌干扰效应的作用模式.结果表明,污水厂进水具有较强的急性毒性、遗传毒性以及雌激素活性,水质较差.经二级生物处理后,上述毒性显著性降低,污水厂出水水质提高.但污水出水雌二醇当量为1.89 ng·L-1,仍可能会对受纳水体的水生生物产生潜在危害.浓缩2.5倍的水样导致雄性斑马鱼肝脏的卵黄原蛋白基因(vtg1)和雌激素受体基因(esr1)的表达水平显著上升,由此可以得出污水可通过干扰目的基因的表达来调控水生生物的内分泌活动.而esr1基因在肝脏的表达被抑制说明污水可能具有抗雌激素作用,同时反映进行生物毒性效应分析时应从多个组织或器官考虑,以获得比较全面的信息.

关键词：发光菌遗传毒性雌激素活性斑马鱼生活污水安全性级别

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