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Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF/EGFR and PI3K/AKT Pathways and Circ_0084443

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Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG Yue xiao Yan-wei ma Jing-xin WANG Ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and ***:HaCaT cells were treated with *** proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration *** mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,***_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with *** expression of circ_0084443 was detected by ***:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides

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Chinese Journal of Integrative Medicine 2024年第4期30卷 330-338页

作者： ma Jing SUN Bo TE Li-ger HUANG xin ZUO xin HAN xiao-ke WANG Shu-song Hebei Key Laboratory of Reproductive Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Graduate School of Hebei Medical University Shijiazhuang(050017)China School of Chemistry and materials Science Hebei Normal UniversityShijiazhuang(050024)China xingtai Infertility Specialist Hospital XingtaiHebei Province(054000)China

Objective To determine the possible protective effects of Jinghuosu,a dietary supplement(DS),on tripterygium glycosides(TG)-induced reproductive system injury in rats and its underlying *** A reproductive damage model was established in rats by feeding of ***-eight male Sprague Dawley rats were randomly divided into 4 groups using a random number table(n=7 in each):control(C)group,model(M)group,DS group and L-carnitine(LC)*** in M,DS and LC groups received 40 mg/kg TGs *** from the 5th week,after administration of TGs for 4 h every day,rats in DS and LC groups were administered with 2.7 g/kg DS and 0.21 g/kg LC,respectively,for protective treatment over the next 4 *** in Group C continued to receive the control ***-eosin staining was used for histopathological analysis of rat testicular ***-linked immunosorbent assay was performed to measure alkaline phosphatase(ALP),lactate dehydrogenase,alcohol dehydrogenase,total antioxidant capacity(T-AOC),superoxide dismutase,glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)*** assay was used to determine the serum testosterone *** real-time PCR and Western blotting were conducted to analyze the expression of genes and proteins related to the testosterone synthesis pathway and the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 antioxidant *** Oral administration of TGs induced significant increases in the testicular levels of zinc transporter 1 and MDA(P<0.05).On the other hand,sperm concentration,sperm motility,and serum testosterone,serum zinc,testicular zinc,Zrt-,Irt-like protein 1,ALP,luteinizing hormone(LH)receptor,steroidogenic acute regulatory protein,Cytochrome P450 family 11 subfamily A member 1,3β-hydroxysteroid dehydrogenase 1 T-AOC,GSH-Px,nuclear factor erythroid 2-related factor 2,heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1 levels decreased following TG

关键词： dietary supplement Jinghuosu tripterygium glycosides reproductive damage infertility

Effects of pyraclostrobin on growth,oxidative stress,and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymena thermophila

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Journal of Oceanology and Limnology 2024年第1期42卷 150-162页

作者： Yang LIU Jiale ZHANG Peng xiao xin LIU Yisifu ma Jing ZHANG Bangjun ZHANG Henan International Joint Laboratory of Aquatic Ecotoxicology and Health Protection Xinxiang 453007China College of Life Sciences Henan Normal UniversityXinxiang 453007China Journal of Henan Normal University Xinxiang 453007China College of Life and Environmental Science Wenzhou UniversityWenzhou 325035China Department of Ecosystem Studies School of Environmental ScienceUniversity of Shiga PrefectureShiga 522-8533Japan

Pyraclostrobin(PYR),a widely used fungicide,has negative effects on fish and algae,but its toxicity in protozoa remains *** this study,the effects of PYR on the growth,oxidative stress,and gene expression related to stress and ATP-binding cassette(ABC)transporters in Tetrahymena thermophila were *** result showed that the 96-h IC_(50)of PYR against *** was 17.2 mg/***,PYR inhibited the growth of *** in concentration-or time-dependent manner.A morphological study revealed that the shape and size of *** changed,and damage of cell membrane surface was observed by scanning electron microscopy after 96 h of PYR *** activities of superoxide dismutase(SOD)and catalase(CAT)increased throughout the *** contrast,the glutathione(GSH)content was increased at 24 h and 48 h of exposure and decreased at 96 ***,a significant increase in malondialdehyde(MDA)level was observed in *** after96 h of ***,PYR upregulated the HSP703,HSP705,GPx2,and ABAC15 gene expression in the 0.1–5-mg/L groups and downregulated the HSP704,HSP90,TGR,and ABCC52 mRNA levels at 96 h of *** results suggest that PYR may exert adverse effects on *** by inducing oxidative stress and changing the gene expression related to ABC transporters and stress,which may enrich the understanding of the toxicity mechanism of PYR in aquatic organisms and provide reference data for aquatic ecological risk assessments.

关键词： pyraclostrobin Tetrahymena thermophila growth oxidative stress gene expression

Choriocarcinoma with lumbar muscle metastases:A case report

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World Journal of Clinical Cases 2020年第20期8卷 5036-5041页

作者： Li Pang xiao-xin ma Department of Obstetrics and Gynecology Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Choriocarcinoma is a highly malignant trophoblastic tumor that presents with early symptoms similar to those of an ectopic *** we present a patient with suspected ectopic pregnancy diagnosed by laparoscopic surgery in our *** patient was found to have choriocarcinoma that had metastasized to the lumbar muscle and presented with symptoms similar to those of an ectopic *** SUMmaRY The patient was a 34-year-old female who complained of amenorrhea lasting 53 d,7 d of right lower back pain,and 3 d of right lower abdominal *** ultrasonography revealed the absence of a gestational sac in the uterus and a mass in the left *** 6 d of re-examination,ultrasound and computed tomography(CT)examination were performed on the mass located in the left adnexa *** also noted that the patient's serumβ-human chorionic gonadotropin(h CG)level was *** an ectopic pregnancy,we performed a laparoscopy and *** the operation,a left ovarian mixed echogenic mass approximately 2.5 cm×2.0 cm with no villous tissue was *** levels of serum h CG continued to *** CT examination showed lung *** CT and magnetic resonance imaging showed a mixed echogenic mass in the lumbar *** lumbar metastasis of choriocarcinoma,six courses of cisplatin,dactinomycin,and etoposide chemotherapy were given after *** patient's serumβ-h CG level decreased to normal and the mixed echogenic mass in the lumbar muscle decreased in size after the fifth course of *** symptoms subsequently disappeared after *** In summary,lumbar metastasis from choriocarcinoma is extremely *** chemotherapy can successfully treat these metastasized tumors.

关键词： Choriocarcinoma Ectopic pregnancy Lumbar malignant trophoblastic tumor Metastasis Human chorionic gonadotropin Case report

Species’ geographical range, environmental range and traits lead to specimen collection preference of dominant plant species of grasslands in Northern China

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Plant Diversity 2024年第3期46卷 353-361页

作者： Jingya Zhang Cui xiao xiaoyu Duan xin Gao Hao Zeng Rong'an Dong Gang Feng Keping ma Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau&Inner Mongolia Key Laboratory of Grassland Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010021China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China

many different factors,such as species traits,socio-economic factors,geographical and environmental factors,can lead to specimen collection *** study aims to determine whether grassland specimen collection in China is preferred by species traits(i.e.,plant height,flowering and fruiting period),environmental range(i.e.,the temperature and precipitation range)and geographical range(i.e.,distribution range and altitudinal range).Ordinary least squares models and phylogenetic generalized linear mixed models were used to analyze the relationships between specimen number and the explanatory *** Forest models were then used to find the most parsimonious multivariate *** results showed that interannual variation in specimen number between 1900 and 2020 was *** number of these species in southeast China was notably lower than that in northwest *** range and geographical range of species had significant positive correlations with specimen *** addition,there were relatively weak but significant associations between specimen number and species trait(i.e.,plant height and flowering and fruiting period).Random Forest models indicated that distribution range was the most important variable,followed by flowering and fruiting period,and altitudinal *** findings suggest that future floristic surveys should pay more attention to species with small geographical range,narrow environmental range,short plant height,and short flowering and fruiting *** correction of specimen collection preference will also make the results of species distribution model,species evolution and other works based on specimen data more accurate.

关键词： Biological specimen Collection preference Dominant plant species Environmental range Geographical range Species traits

GPa-level pressure-induced enhanced corrosion resistance in TiZrTaNbSn biomedical high-entropy alloy

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China Foundry 2024年第3期21卷 265-275页

作者： xiao-hong Wang Yu-lei Deng Qiao-yu Li Zhi-xin Xu Teng-fei ma xing Yang Duo Dong Dong-dong Zhu xiao-hong Yang Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina School of materials Science and Engineering Taizhou UniversityTaizhou 318000ZhejiangChina

TiZrTaNb-based high-entropy alloys(HEAs)are research frontier of biomedical materials due to their high hardness,good yield strength,excellent wear resistance and corrosion ***,as an essential trace element in the human body that plays a significant role in physiological *** has stable chemical properties and a low elastic *** this study,a new material,TiZrTaNbSn HEAs,was proposed as a potential biomedical *** Ti_(35)Zr_(25)Ta_(15)Nb_(15)Sn_(10)biomedical high-entropy alloys(BHEAs)were successfully prepared through an arc melting furnace and then remelted using a German high-temperature and high-pressure apparatus under GPa-level(4 GPa and 7 GPa).The precipitation behavior of the needle-like HCP-Zr_(5)Sn_(3)phase that precipitates discontinuously at the grain boundary was successfully *** phase constitution,microstructure,and corrosion resistance of the alloy were *** results show that the needle-like HCP-Zr_(5)Sn_(3)phase is eliminated and the(Zr,Sn)-rich nano-precipitated phase is precipitated in the microstructure under high pressure,which leads to the narrowing of grain boundaries and consequently improves the corrosion resistance of the *** addition,the formation mechanisms of(Zr,Sn)-rich nanoprecipitates in BHEAs were *** Zr and Sn dissolve in the matrix due to the effect of high pressure,during the cooling process,they precipitate to form a(Zr,Sn)-rich nano-precipitated phase.

关键词： biomedical HEAs precipitation grain boundary corrosion resistance TiZrTaNbSn

Collision-free parking recommendation based on multi-agent reinforcement learning in vehicular crowdsensing

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Digital Communications and Networks 2024年第3期10卷 609-619页

作者： xin Li xinghua Lei Xiuwen Liu Hang xiao College of Computer Science and Technology China University of Petroleum(East China)QingDao266580China

The recent proliferation of Fifth-Generation(5G)networks and Sixth-Generation(6G)networks has given rise to Vehicular Crowd Sensing(VCS)systems which solve parking collisions by effectively incentivizing vehicle ***,instead of being an isolated module,the incentive mechanism usually interacts with other *** on this,we capture this synergy and propose a Collision-free Parking Recommendation(CPR),a novel VCS system framework that integrates an incentive mechanism,a non-cooperative VCS game,and a multi-agent reinforcement learning algorithm,to derive an optimal parking strategy in real ***,we utilize an LSTM method to predict parking areas roughly for recommendations *** incentive mechanism is designed to motivate vehicle participation by considering dynamically priced parking tasks and social network *** order to cope with stochastic parking collisions,its non-cooperative VCS game further analyzes the uncertain interactions between vehicles in parking *** its multi-agent reinforcement learning algorithm models the VCS campaign as a multi-agent markov decision process that not only derives the optimal collision-free parking strategy for each vehicle independently,but also proves that the optimal parking strategy for each vehicle is ***,numerical results demonstrate that CPR can accomplish parking tasks at a 99.7%accuracy compared with other baselines,efficiently recommending parking spaces.

关键词： Incentive mechanism Non-cooperative VCS game Multi-agent reinforcement learning Collision-free parking strategy Vehicular crowdsensing

Infrared and Visible Image Fusion Based on Res2Net-Transformer Automatic Encoding and Decoding

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Computers, materials & Continua 2024年第4期79卷 1441-1461页

作者： Chunming Wu Wukai Liu xin ma Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology School of Electrical EngineeringNortheast Electric Power UniversityJilin132012China School of Electrical Engineering Northeast Electric Power UniversityJilin132012China School of Aeronautical Engineering Jilin Institute of Chemical TechnologyJilin132022China

A novel image fusion network framework with an autonomous encoder and decoder is suggested to increase thevisual impression of fused images by improving the quality of infrared and visible light picture fusion. The networkcomprises an encoder module, fusion layer, decoder module, and edge improvementmodule. The encoder moduleutilizes an enhanced Inception module for shallow feature extraction, then combines Res2Net and Transformerto achieve deep-level co-extraction of local and global features from the original picture. An edge enhancementmodule (EEM) is created to extract significant edge features. A modal maximum difference fusion strategy isintroduced to enhance the adaptive representation of information in various regions of the source image, therebyenhancing the contrast of the fused image. The encoder and the EEM module extract features, which are thencombined in the fusion layer to create a fused picture using the decoder. Three datasets were chosen to test thealgorithmproposed in this paper. The results of the experiments demonstrate that the network effectively preservesbackground and detail information in both infrared and visible images, yielding superior outcomes in subjectiveand objective evaluations.

关键词： Image fusion Res2Net-Transformer infrared image visible image

Constructing oxygen deficiency-rich V_(2)O_(3)@PEDOT cathode for high-performance aqueous zinc-ion batteries

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Rare Metals 2024年第2期43卷 635-646页

作者： Dong-Fei Sun Zi-Juan Wang Tian Tian xin Yu Dan-Dan Yu xiao-Zhong Zhou Guo-Fu ma Zi-Qiang Lei Key Laboratory of Eco-functional Polymer materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceSchool of College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou730070China

Aqueous zinc-ion batteries(AZIBs)have attracted widespread attention due to the advantages of high safety and environmental *** V_(2)O_(3) is a promising cathode,the strong electrostatic interaction between Zn^(2+) and V_(2)O_(3) crystal,and the sluggish reaction kinetics still limit their application in ***,the oxygen defects rich V_(2)O_(3) with conducive poly(3,4-ethylenedioxythiophene)(PEDOT)shell(V_(2)O_(3)-Od@PEDOT)was fabricated for AZIBs by combining the sulfur-assisted thermal reduction and in-situ polymerization *** introduced oxygen vacancies of V_(2)O_(3)–Od@PEDOT weaken the electrostatic interaction between Zn^(2+) and the host material,improving the interfacial electron transport,while the PEDOT coating enhances the structural stability and conductivity of V_(2)O_(3),thus accelerating the reaction *** on the advantages,V_(2)O_(3)–Od@PEDOT electrode delivers a reversible capacity of 495 mah·g^(−1) at 0.1 A·g^(−1),good rate capability(189 mah·g^(−1)at 8.0 A·g^(−1)),and an impressive cycling stability with 90.1%capacity retention over 1000 cycles at 8.0 A·g^(−1).The strategy may provide a path for exploiting the other materials for high performance AZIBs.

关键词： Oxygen defects V_(2)O_(3) PEDOT Electrochemical self-optimization Aqueous zinc-ion batteries