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Article History Investigation and analysis of the quality of life of centenarians in Chongming area of Shanghai

Journal of Hainan Medical University 2019年第18期25卷 62-67页

作者： xiao-xiao huang Zhi-Heng Ma Hui Song Guo-Hong Li School of Public Health Shanghai Jiaotong University School of MedicineShanghai200025 Chongming Branch of Xinhua Hospital Shanghai Jiao Tong University School of MedicineShanghai202150

Objective:To investigate the status quo and influencing factors of the quality of life of the elderly aged≥100 years old in Chongming area of Shanghai,and provide a basis for the construction of a world-class ecological island in Chongming area and promote the cause of healthy ***:A cross-sectional survey was conducted to screen 71 elderly people who were 100 years old and reached the age of *** interview was conducted with a face-to-face questionnaire ***:The SF-36 health questionnaire of the centenarians in Chongming area scored and in the physiological functions,physiological functions,physical pain,general health status,energy,social function,emotional function and mental health is(36.35±13.45),(36.62±38.69),(62.56±21.57),(47.04±6.06),(67.23±18.76),(71.83±25.85),(60.09±45.29),(78.70±22.20).The total physical health assessment and mental health assessment scores are(181.577±50.271)and(277.855±81.636).Univariate statistics show that different genders,education levels,marital status,economic sources,urban or rural areas,insurance categories,chronic diseases,number of children,old-age patterns,preferred forms of residence,interval between child care,and whether children are in the same city Factors such as≥2 in the family,long-term diet,diet,eating habits,drinking habits,tea drinking habits,physical examination,lack of sleep 4h,nap habits and other factors in the different dimensions of the SF-36 scale,the difference is statistically significant(P<0.05);multivariate stepwise regression showed that the relevant influencing factors were pension mode,dietary preference,location(urban/rural),chronic disease,preferred lifestyle,lack of sleep 4 h,education level,marital status(P<0.05).Conclusion:The centenarians in Chongming area have a medium quality of life rating and a high overall mental health *** centenarians in Chongming have a good psychological *** life behavior pattern of the centenarians is worth *** is recommen

关键词： Centenarians Quality of life Influencing factors

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Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An xiao huang Qian Zhang Chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

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汽车空调外循环进水特性分析

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江苏大学学报（自然科学版） 2017年第2期38卷 144-149页

作者：王东肖露黄晓陈飞同济大学汽车学院上海201804

为了改善汽车空调外循环进气口在下雨天易进水的问题,采用CFD方法模拟了雨滴粒子随气流从空调外循环通风盖板进气格栅到空调外循环进气口的运动过程,研究了汽车空调外循环进水特性的机理.基于空调外循环盖板上进气格栅的位置、格栅开口... 详细信息

为了改善汽车空调外循环进气口在下雨天易进水的问题,采用CFD方法模拟了雨滴粒子随气流从空调外循环通风盖板进气格栅到空调外循环进气口的运动过程,研究了汽车空调外循环进水特性的机理.基于空调外循环盖板上进气格栅的位置、格栅开口面积以及格栅开口形状的不同分别建立仿真模型,在进气阻力大小允许范围内,通过优化空气气流的运动形态来减小空调外循环进水量.结果表明:空气气流的运动形态、雨滴粒子的大小和降雨强度是影响汽车空调外循环进水量的主要因素;增大进气格栅与进气口的距离、减小格栅的开口面积、改变进气格栅的开口形状,可以减小汽车空调外循环进气口的进水量.

关键词：汽车空调外循环进水 CFD方法进气格栅仿真

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BH3-only protein Bim is involved in myocardial injury induced by co-stress of ischemia and cold stress in rats

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岭南心血管病杂志 2011年第S1期17卷 236-237页

作者： huang Cha-hua,XIE Yao,BAO xiao-ming,huang xiao, WANG Yao-sheng,HONG Kui,CHEN xiao-shu (Department of Cardiovascular Disease,The Second Affiliated Hospitalof Nanchang University,Nanchang 330006,China)

Objectives To investigate the effect of co-exposure of myocardial ischemia and cold stress on myocardial injury in rats and the relative *** Myocardial ischemia model was established by ligation of left coronary *** rats were randomly allocated to 4 groups; sham+normal temperature(S group),sham+cold stress(SC group),myocardial ischemia+ normal temperature(Ⅰgroup), myocardial ischemia+cold stress(IC group).On the condition of 26℃,SC and IC groups were keeped in a 4℃artificial chamber for 8h(8;00-16:00) for 4 consecu- tive *** diac function was assessed by echocardiography;pathological change was analyzed by HE staining;myocardial infarct size was determined by TTC staining;Bim,Caspase-3 expression in myocardium was determined by western *** It was demonstrated that co-exposure of myocardial ischemia and cold stress could significantly make the cardiac muscle in abnormal shape,increase the infarct size and the expression of Bim and *** Co-exposure of myocardial ischemia and cold stress may aggravate the cardiac injury,pro- apoptosis protein Bim is involved.

关键词： BH3-only protein Bim is involved in myocardial injury induced by co-stress of ischemia and cold stress in rats

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Modified conditioning regimen busulfan-cyclophosphamide followed by allogeneic stem cell transplantation in patients with multiple myeloma

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Chinese Medical Journal 2007年第6期120卷 463-468页

作者： ZHANG xiao-hui huang xiao-jun LIU Kai-yan XU Lan-ping LIU Dai-hong CHEN Huan CHEN Yu-hong WANG Jing-zhi HAN Wei LU Dao-pei Institute of Hematology Peking University People＇s Hospital Beijing 100044 China

Background Allogeneic stem cell transplantation is a potential curative approach in patients with multiple myeloma. The very high transplant related mortality associated with standard allogeneic stem cell transplantation is currently the major limitation to wider use of this potentially curative treatment modality. The challenge for clinical investigators is to reduce the incidence of post-transplant complications for patients receiving autologous hematopoietic stem cell transplantion for multiple myeloma. In this study the toxicity and efficacy of modified myeloablative conditioning regimen followed by allogeneic stem cell transplantation was investigated in patients with multiple myeloma. Methods The conditioning regimen consisted of hydroxyurea, cytarabine, busulfan, cyclophosphamide, and semustine. Ten patients underwent allogeneic transplantation among them hydroxyurea （40 mg/kg） was administered twice on day -10 and cytarabine （2 g/ms） was given on day -9, busulfan was administered orally in four divided doses daily for 3 days （days -8 to -6）. The dose of busulfan was 12 mg/kg in the protocol followed by cyclophosphamide intravenously over 1 hour on days -5 and -4 （1.8 g/m^2）, and with semustine （Me-CCNU） 250 mg/m^2 on day -3. Results Chimerism data were available on all patients and all patients achieved full donor chimerism without graft failure. Six patients had not acute graft-versus-host disease （GVHD, 36.4%; 95% CI： 13.9%-38.6%）. Two patients （18.2%） developed grade Ⅰ acute GVHD （95% CI： 10.9%-35.9%） and grade Ⅱ acute GVHD occurred in one patient （9.1%; 95% Cl. 8.4%-32.3%）. Severe grade IVa GVHD was seen in one patient, who died from acute GVHD. The incidence of chronic GVHD was 22.2% （95% Cl： 11.7%-36.7%）, among them one died of severe grade IV GVHD and one developed multiorgan failure on day ＋170; the treatment-related mortality was 22.0% （95% Cl： 10.3%-34.1%）. The overall 4-year survival rate was 67.8% （95% Cl： 16.3%-46.7%）. The estimated 4-year progr

关键词： multiple myeloma stem cell transplantation modified conditioning regimen

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Antioxidant and anti-tyrosinase active dihydrobenzofuran neolignans from the seeds of Prunus Tomentosa

Antioxidant and anti-tyrosinase active dihydrobenzofuran neo...

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中国化学会第十届全国天然有机化学学术会议

作者： Qing-Bo Liu xiao-xiao huang Ling-Zhi Li Ming Bai Shao-Jiang Song School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) Shenyang Pharmaceutical University Periodicals Department of Shenyang Pharmaceutical University

Tyrosinase inhibitors and antioxidants are becoming increasingly important in the cosmetic and medicinal industries due to their preventive effects in pigmentation disorders and skin *** tomentosa *** to the Prunus subgenus Lithocerasus in the family Rosaceae,and is widely distributed in China,Japan and *** dried roots,fruits and seeds of ***

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Monoterpenes and flavones from the leaves of Crataegus pinnatifida with anticoagulative activities

Monoterpenes and flavones from the leaves of Crataegus pinna...

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中国化学会第十届全国天然有机化学学术会议

作者： Ling-Zhi Li Shao-Jiang Song Qing-Bo Liu Pin-Yi Gao xiao-xiao huang School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University College of Pharmaceutical and Biotechnology Engineering Shenyang University of Chemical Technology

＜正＞Crataegus pinnatifida Bge var major *** Crataegus pinnatifida Bge.,also known as hawthorn or shanzha（literally means"mountain hawthorn"）which belongs to the genus Crataegus,is deciduous and a member of the family Rosaceae（Froehlicher et al.,2009）.Antithrombotic activity-guided fractionation of the leaves of *** resulted in the isolation of four new

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Regulation of alternative splicing of Bcl-x by IL-6,GM-CSF and TPA

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Cell Research 2004年第6期14卷 473-479页

作者： Chang You LI, Jia You CHU, Jian Kun YU, xiao Qin huang, xiao Juan LIU, Li SHI, Yan Chun CHE, Jiu Yong XIE Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China. Department of Physiology, Faculty of Medicine, University of Manitoba, 420 BMSB, 730 William Ave., Winnipeg, MB R3E 3J7, Canada. Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China Department of Physiology Faculty of Medicine University of Manitoba Winnipeg Canada

The splicing of many alternative exons in the precursor messenger RNA (pre-mRNA) is regulated by extracellular factors but the underlying molecular bases remain unclear. Here we report the differential regulation of Bcl-x pre-mRNA splicing by extracellular factors and their distinct requirements for pre-mRNA elements. In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. In U251 glioma cells, however, TPA efficiently increased the Bcl-xL level. These regulations were also seen for a transfected splicing reporter mini-gene. Further analyses of deletion mutants indicate that nucleotides 1-176 of the downstream intron are required for the IL-6 effect, whereas additional nucleotides 177-284 are essential for the GM-CSF effect. As for the TPA effect, only nucleotides 1-76 are required in the downstream intron. Thus,

关键词： alternative splicing bcl-x gene cytokine TPA pre-mRNA element.

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Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun huang Zhu Chen Heng xiao Hai-Yang Hu Xing-Yu Chen Cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

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Measurements of fast-neutron capture cross sections for 159Tb and 169Tm

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Nuclear Science and Techniques 1998年第3期 10-13页

作者： Chen Jin Xiang, Shi Zhao Min, Tang Guo You, Zhang Guo Hui ( Institute of Heavy Ion Physics, Peking University, Beijing 100871) Lu Han Lin, Han xiao Gang and huang xiao Long ( China Institute of Atomic Energy, Beijing 102413)

１ＩｎｔｒｏｄｕｃｔｉｏｎＦａｓｔｎｅｕｔｒｏｎｃａｐｔｕｒｅｃｒｏｓｓｅｃｔｉｏｎｓａｒｅｉｍｐｏｒｔａｎｔｆｏｒｔｈｅｕｎｄｅｒｓｔａｎｄｉｎｇｏｆｎｕｃｌｅａｒｒｅａｃｔｉｏｎｍｅｃｈａｎｉｓｍｓａｎｄｆｏ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＦａｓｔｎｅｕｔｒｏｎｃａｐｔｕｒｅｃｒｏｓｓｅｃｔｉｏｎｓａｒｅｉｍｐｏｒｔａｎｔｆｏｒｔｈｅｕｎｄｅｒｓｔａｎｄｉｎｇｏｆｎｕｃｌｅａｒｒｅａｃｔｉｏｎｍｅｃｈａｎｉｓｍｓａｎｄｆｏｒｖａｒｉｏｕｓａｐｐｌｉｃａｔｉ...

关键词： Tb 169 Tm 197 Au Neutron capture cross sections Activation method

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