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中国近现代散文精神之嬗变

衡阳师范学院学报 2013年第5期34卷 60-65页

作者：萧晓阳向永红中南民族大学文学与新闻传播学院湖北武汉430074 中南民族大学图书馆湖北武汉430074

中国近代散文在向现代演进的过程中呈现出了明显的阶段性特征:桐城古文在由雅言向俗语的转变中,道德法则被逻辑顺序所取代;在逻辑文中,古文逐渐被俗语取代,欧化的古文渐趋通俗化;当白话成为新的主流书写范式时,带有古意的俗语逐渐退出文... 详细信息

中国近代散文在向现代演进的过程中呈现出了明显的阶段性特征:桐城古文在由雅言向俗语的转变中,道德法则被逻辑顺序所取代;在逻辑文中,古文逐渐被俗语取代,欧化的古文渐趋通俗化;当白话成为新的主流书写范式时,带有古意的俗语逐渐退出文坛,摹写现象的逻辑文逐渐向营造意境的散文演进。近现代散文中道德法则的衰微、逻辑政论的兴起与艺术意境的呈现,标志着中国古典散文的终结与现代散文的兴起。

关键词：义法逻辑意境

1^H-MRS对慢性酒精中毒性脑病引起轻度认知功能障碍的评价

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中国地方病防治 2016年第10期31卷 1090-1092页

作者：景少巍余小骊杨晓燕解放军九四医院神经内科江西南昌330000

目的探讨氢质子波谱分析（^1H-MRS）对慢性酒精中毒性脑病引起轻度认知功能障碍（MCI）的评价方法搜集神经内科慢性酒精中毒性脑病引起的MCI患者共20例为实验组,采用西门子1.5T超导磁共振成像系统,头颅线圈,进行常规MRI检查及1^H-MRS。... 详细信息

目的探讨氢质子波谱分析（^1H-MRS）对慢性酒精中毒性脑病引起轻度认知功能障碍（MCI）的评价方法搜集神经内科慢性酒精中毒性脑病引起的MCI患者共20例为实验组,采用西门子1.5T超导磁共振成像系统,头颅线圈,进行常规MRI检查及1^H-MRS。选择正常组（NC）20例做对照组,年龄与试验组对比无差异,无认知功能障碍。结果1^H-MRS对慢性酒精中毒性脑病引起MCI的表现,MCI两组的NAA/Cr,Cho/Cr,m I/Cr水平比较NC组和MCI组的NAA/Cr和m I/Cr水平有显著性差异,MCI组的NAA/Cr水平较正常明显降低;MCI组的ml/Cr水平明显升高;两组的Cho/Cr水平差异无统计学意义P〉0.05）。结论^1H-MRS可以从形态学、功能、代谢等角度对慢性酒精性脑病引起的MCI进行研究,为早期诊断提供依据。

关键词：慢性酒精中毒性脑病轻度认知功能障碍常规MRI 氢质子波谱分析(1^H-MRS)

Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

用cDNA表达阵列分析遗传性癫痫易感大鼠海马和大脑皮质的基因表达

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生物化学与生物物理进展 2002年第3期29卷 439-443页

作者：吴志国肖波杨晓苏李国良谢光洁中南大学湘雅医院神经内科长沙410008

采用AtlasTM RatcDNAExpressionArray建立遗传性癫痫易感性P77PMC大鼠和正常对照Wistar大鼠的海马与大脑皮质基因表达谱 ,用EagleEyeⅡStillVideoSystem (Stratagene)图象分析仪分析两者基因表达谱差异 .结果发现海马和大脑皮质中各有 1... 详细信息

采用AtlasTM RatcDNAExpressionArray建立遗传性癫痫易感性P77PMC大鼠和正常对照Wistar大鼠的海马与大脑皮质基因表达谱 ,用EagleEyeⅡStillVideoSystem (Stratagene)图象分析仪分析两者基因表达谱差异 .结果发现海马和大脑皮质中各有 15个差异表达基因 .海马组织中 ,12个基因在P77PMC大鼠中高表达而在正常对照Wistar大鼠中低表达 ,3个基因在正常对照Wistar大鼠中高表达 ,而在P77PMC大鼠中低表达 ;大脑皮质中 ,13个基因在P77PMC大鼠中高表达 ,而在正常对照Wistar大鼠中低表达 ,2个基因在正常对照Wistar大鼠中高表达 ,而在P77PMC大鼠中低表达 .结果说明 ,P77PMC大鼠与正常对照Wistar大鼠海马和大脑皮质存在多个差异表达基因。

关键词： cDNA表达阵列遗传性癫痫易感大鼠海马大脑皮质基因表达

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： xiao-Yi Wang Yao Hao Zi-Jian Wang Xiu-Liang Xu Jiang-Hua yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： Hua Bai xiao-Feng Feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

A dry-electrode enabled ECG-on-Chip with arrhythmia-aware data transmission

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Science China(Information Sciences) 2025年

作者： Xinzi XU Yanxing SUO yang ZHAO Peiyi ZHOU xiao HAN Qiao CAI Min WANG Jiajun YUAN Liebin ZHAO Yongfu LI Guoxing WANG Yong LIAN Department of Micro-Nano Electronics and MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong University Pediatric AI Clinical Application and Research Center Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP) Child Health Advocacy Institute Shanghai Children's Medical Center School of MedicineShanghai Jiao Tong University Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP) Xin Hua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine

Early detection and treatment of cardiovascular diseases (CVDs) can be significantly enhanced through the use of flexible wearable electrocardiogram (ECG) sensors, potentially reducing CVD-related mortality. This paper introduces an ECG-on-Chip (EoC) solution tailored for flexible ECG sensors, incorporating novel features to address common challenges in wearable ECG technology. The EoC integrates a chopper-stabilized capacitively-coupled instrumentation amplifier (CS-CCIA),ensuring a high common-mode rejection ratio (CMRR) and low noise performance. Performance is further boosted via a positive feedback loop (PFL) and a programmable gain amplifier (PGA) with shared on-chip calibration logic, which enhances input impedance and minimizes gain variability to ensure consistent algorithm performance. Additionally, a secondary chopping technique is employed to further reduce noise, achieving an input-referred noise level of 454 nVrms. The embedded algorithm within the EoC is designed to extract clinically meaningful features, facilitating robust real-time arrhythmia analysis. Fabricated using a 0.18μm CMOS process, the EoC consumes 14.9μW with a supply voltage of 1.2 V. The algorithm’s efficacy has been validated over 0.4 million heartbeats, demonstrating a sensitivity of over 99.7%for R-peak detection and 98.3%for arrhythmia analysis. To demonstrate practical application, the EoC has been integrated with a commercial Bluetooth low energy (BLE)transceiver, forming a wireless arrhythmia monitoring sensor equipped with dry electrodes. This system consumes 292.04μW in arrhythmia-aware transmission mode, supporting 13 days of operation with a 30 mAh thin-film battery.

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黄昏后的偶像:再论“《选》学”与“桐城”——兼评周唯一《南朝学术文化与〈文选〉》

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衡阳师范学院学报 2017年第4期38卷 163-165页

作者：萧晓阳陈正博中南民族大学文学与新闻传播学院湖北武汉430074

《文选》之文与桐城古文作为古典文化的象征符号,近百年来经历了批判、沉寂与复兴三个阶段。"五四"抨击"妖孽"与"谬种",有矫枉过正之嫌;当代数十年间几无人问津,是将古典文化视为禁区的必然选择;新时期以来,桐城文化研究成果丰硕,骆鸿... 详细信息

《文选》之文与桐城古文作为古典文化的象征符号,近百年来经历了批判、沉寂与复兴三个阶段。"五四"抨击"妖孽"与"谬种",有矫枉过正之嫌;当代数十年间几无人问津,是将古典文化视为禁区的必然选择;新时期以来,桐城文化研究成果丰硕,骆鸿凯《文选学》、穆克宏《昭明文选研究》、周唯一《南朝学术文化与〈文选〉》在《选》学领域也各有独特的意义。

关键词：选学桐城文史研究学术文化

Unveiling an ancient whole-genome duplication event in Stentor,the model unicellular eukaryotes

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Science China Life Sciences 2025年

作者： Weibo Zheng Chao Li Zhaorui Zhou xiao Chen Michael Lynch Ying Yan School of Life Sciences Ludong University Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Biodesign Center for Mechanisms of Evolution Arizona State University Marine College Shandong University

Whole-genome duplication(WGD) events are widespread across eukaryotes and have played a significant role in moulding the genetic architectures of diverse organisms. In the present study, the newly sequenced genome of a giant ciliated protist, Stentor roeselii, provides an opportunity for the analysis of the collinearity and retention of reciprocal best-hit genes between two Stentor species. As a main result, we have unveiled a previously undetected ancient WGD event shaping the genome of its congener, Stentor coeruleus, a model protist used in cytological and evolutionary studies. Genomes of two congeners, S. coeruleus and S. roeselii, are compared and analyzed, revealing that:(i)the former exhibits a much higher retention rate of colinear-gene pairs(28%) than does S. roeselii, and in S. coeruleus, 75% of genes that have a RBH hit in S. roeselii, have paralogs with high amino-acid identity, consistent with a WGD event in the lineage leading to S. coeruleus;(ii) the S. roeselii genome possesses extremely short intergenic regions, implying that the lengths of intergenic regions are under strong selection;(iii) the unique characteristics of introns may have been shaped in the common ancestor of heterotrichs;(iv) gene families that play a role in activities of multiple protein kinases and voltage-gated ion channels expanded rapidly in the ancestor of both taxa, possibly relating to the remarkable regenerative ability in Stentor. This study offers new insights into the evolutionary dynamics of ciliate genomes,with implications for understanding of the processes underlying the evolution of genomic complexity.

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