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Brain functional network connectivity based on a visual task: visual information processing-related brain regions are significantly activated in the task state

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Neural Regeneration Research 2015年第2期10卷 298-307页

作者： Yan-li yang Hong-xia Deng Gui-yang Xing xiao-luan xia Hai-fang Li School of Computer Science and Technology Taiyuan University of Technology

It is not clear whether the method used in functional brain-network related research can be applied to explore the feature binding mechanism of visual perception. In this study, we inves-tigated feature binding of color and shape in visual perception. Functional magnetic resonance imaging data were collected from 38 healthy volunteers at rest and while performing a visual perception task to construct brain networks active during resting and task states. Results showed that brain regions involved in visual information processing were obviously activated during the task. The components were partitioned using a greedy algorithm, indicating the visual network existed during the resting state.Z-values in the vision-related brain regions were calculated, conifrming the dynamic balance of the brain network. Connectivity between brain regions was determined, and the result showed that occipital and lingual gyri were stable brain regions in the visual system network, the parietal lobe played a very important role in the binding process of color features and shape features, and the fusiform and inferior temporal gyri were crucial for processing color and shape information. Experimental ifndings indicate that understanding visual feature binding and cognitive processes will help establish computational models of vision, improve image recognition technology, and provide a new theoretical mechanism for feature binding in visual perception.

关键词： nerve regeneration functional magnetic resonance imaging resting state task state brain network module division feature binding Fisher’s Z transform connectivity visual stimuli NSFC grants neural regeneration

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废水生物脱氮除磷机理与技术研究的进展

四川环境 2002年第2期21卷 25-29,39页

作者：杨朝晖曾光明李小明杨霞湖南大学环境科学与工程系湖南长沙410082

本文介绍了硝化-反硝化,短程硝化-反硝化,厌氧氨氧化等生物脱氮过程和生物除磷过程的机理及目前国内外的研究现状和比较成熟的技术,并对我国开展这方面的研究前景提出了展望。

关键词：技术研究进展生物脱氮生物除磷废水处理

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-xia yang Li-Ting Zhang xiao-Jun Liu Xue-Bin Peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

ON HERMITIAN POSITIVE DEFINITE SOLUTION OF NONLINEAR MATRIX EQUATION X＋A^＊X^-2A=Q

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Journal of Computational Mathematics 2005年第5期23卷 513-526页

作者： xiao xia Guo ICMSEC Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080

Based on the fixed-point theory, we study the existence and the uniqueness of the maximal Hermitian positive definite solution of the nonlinear matrix equation X＋A^＊X^-2A=Q, where Q is a square Hermitian positive definite matrix and A＊ is the conjugate transpose of the matrix A. We also demonstrate some essential properties and analyze the sensitivity of this solution. In addition, we derive computable error bounds about the approximations to the maximal Hermitian positive definite solution of the nonlinear matrix equation X＋A^＊X^-2A=Q. At last, we further generalize these results to the nonlinear matrix equation X＋A^＊X^-nA=Q, where n≥2 is a given positive integer.

关键词： Nonlinear matrix equation Hermitian positive definite solution Sensitivity analysis Error bound

Present and future of prophylactic antibiotics for severe acute pancreatitis

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World Journal of Gastroenterology 2012年第3期18卷 279-284页

作者： Kun Jiang Wei Huang xiao-Nan yang Qing xia Department of Integrated Traditional Chinese and Western Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Liverpool NIHR Pancreas Biomedical Research Unit Royal Liverpool University HospitalUniversity of LiverpoolLiverpool L693GAUnited Kingdom

AIM: To investigate the role of prophylactic antibiotics in the reduction of mortality of severe acute pancreatitis (SAP) patients, which is highly questioned by more and more randomized controlled trials (RCTs) and metaanalyses. METHODS: An updated meta-analysis was performed. RCTs comparing prophylactic antibiotics for SAP with control or placebo were included for meta-analysis. The mortality outcomes were pooled for estimation, and re-pooled estimation was performed by the sensitivity analysis of an ideal large-scale RCT. RESULTS: Currently available 11 RCTs were included. Subgroup analysis showed that there was significant reduction of mortality rate in the period before 2000, while no significant reduction in the period from 2000 [Risk Ratio, (RR ) = 1.01, P = 0.98]. Funnel plot indi-cated that there might be apparent publication bias in the period before 2000. Sensitivity analysis showed that the RR of mortality rate ranged from 0.77 to 1.00 with a relatively narrow confidence interval (P < 0.05). However, the number needed to treat having a minor lower limit of the range (7-5096 patients) implied that certain SAP patients could still potentially prevent death by antibiotic prophylaxis. CONCLUSION: Current evidences do not support prophylactic antibiotics as a routine treatment for SAP, but the potentially benefited sub-population requires further investigations.

关键词： Severe acute pancreatitis Prophylactic antibiotics Mortality Meta-analysis

Flexibility Analysis of Bacillus thuringiensis Cry1Aa

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Biomedical and Environmental Sciences 2015年第9期28卷 634-641页

作者： ZHAO Xin Min xia Li Qiu yang xiao Ping PENG xiao Yun Department of Chemistry and Environmental Engineering Hunan City University Key Laboratory of Microbial Molecular Biology of Hunan Province College of Life ScienceHunan Normal University Division of Medical Oncology Department of MedicineSchool of MedicineUniversity of Colorado Anschutz Medical Campus

Objective To investigate the flexibility and mobility of the Bacillus thuringiensis toxin Cry1 Aa. Methods The graph theory-based program Constraint Network Analysis and normal mode-based program NMsim were used to analyze the global and local flexibility indices as well as the fluctuation of individual residues in detail. Results The decrease in Cry1 Aa network rigidity with the increase of temperature was evident. Two phase transition points in which the Cry1 Aa structure lost rigidity during the thermal simulation were identified. Two rigid clusters were found in domains I and II. Weak spots were found in C-terminal domain III. Several flexible regions were found in all three domains; the largest residue fluctuation was present in the apical loop2 of domain II. Conclusion Although several flexible regions could be found in all the three domains, the most flexible regions were in the apical loops of domain II.

关键词： Flexibility Cry1Aa Bacillus thuringiensis Constraint Network Analysis NMSim

Phenanthroline Derivatives as Efficient Organic Photocatalysts for Visible-Light-Mediated PET-RAFT Polymerization

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Chinese Journal of Chemistry 2023年第20期41卷 2604-2610页

作者： yang xiao Wanchao Hu Zhinan xia Bingfeng Shi Changli Lv Institute of Chemistry Northeast Normal UniversityChangchunJilin 130024China

Phenanthroline is an excellent and stableπ-electron acceptor with a large conjugated *** derivatives are widely used in adsorption,photodegradation,solar cells,biology,and so *** present,there are still limited organic molecules utilized to efficiently photocatalyze reversible-deactivation radical polymerization(RDRP).Therefore,the design of organic photocatalysts(OPCs)for RDRP remains a ***,according to the strategy of combining the donor groups and weak acceptor groups,donor-acceptor(D-A)type OPCs based on phenanthroline were utilized for the first time in photoinduced electron transfer-reversible addition-fragmentation chain transfer(PET-RAFT)polymerization.1,10-Phenanthroline-5-amine(Aphen)with a donor group-amino was screened out for efficacious photo-controlled radical polymerization under blue light for various monomers with conjugated and unconjugated structures with high monomer conversion and well-defined narrow dispersity polymers(Đ<1.20).Controllable homo-polymers and block copolymers were successfully realized by chain extension reaction and block copolymerization of structurally diverse monomers.

关键词： Photopolymerization PET-RAFT polymerization Photoredox catalysis Organocatalysis Donor-acceptor Phenanthroline derivatives

Decoy-state method for quantum-key-distribution-based quantum private query

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Science China(Physics,Mechanics & Astronomy) 2022年第4期65卷 41-48页

作者： Bin Liu Shuang xia Di xiao Wei Huang Bingjie Xu yang Li College of Computer Science Chongqing UniversityChongqing 400044China Science and Technology on Communication Security Laboratory Institute of Southwestern CommunicationChengdu 610041China

The quantum private query(QPQ)is a quantum solution for the symmetrically private information retrieval *** study the security of quantum-key-distribution-based QPQ with weak coherent *** result shows that multiphoton pulses have posed a serious threat to the participant’s privacy in QPQ *** we propose a decoy-state method that can help the honest participant detect the attack by exploiting multiphoton pulses and improving the key distillation process to defend against such *** analysis demonstrates that our decoy-state method significantly improves the security of the QPQ with weak coherent pulses,which solves a major obstacle in the practical application of the QPQ.

关键词： quantum private query symmetrically private information retrieval quantum key distribution decoy state weak coherent pulse

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电针联合射频热凝靶点治疗腰椎管狭窄症38例

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针灸临床杂志 2016年第8期32卷 12-14页

作者：杨轶郑陶夏晓阳姚冰刘光锋李桂林唐山市中医医院河北唐山063000

目的:观察电针联合射频热凝靶点治疗腰椎管狭窄症的临床疗效。方法:将符合标准的76例腰椎管狭窄症患者随机分为治疗组38例和对照组38例,治疗组采用电针联合射频热凝靶点治疗,对照组采用单一电针治疗。治疗30天后比较两组患者的症状、体... 详细信息

目的:观察电针联合射频热凝靶点治疗腰椎管狭窄症的临床疗效。方法:将符合标准的76例腰椎管狭窄症患者随机分为治疗组38例和对照组38例,治疗组采用电针联合射频热凝靶点治疗,对照组采用单一电针治疗。治疗30天后比较两组患者的症状、体征及临床疗效。结果:两组治疗后ODI积分、VAS评分分别与治疗前比较,均有所降低,有显著性差异(P<0.05);两组组间比较,差异有统计学意义(P<0.05)。治疗组临床疗效总有效率89.47%,对照组为73.68%,两者疗效有显著性差异(P<0.05)。结论:电针联合射频热凝靶点治疗腰椎管狭窄症,为临床提供了更优的治疗方法。

关键词：电针射频热凝靶点腰椎管狭窄症