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Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis

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World Journal of Hepatology 2024年第4期16卷 625-639页

作者： xiao-wei tang Wen-Sen Ren Shu Huang Kang Zou Huan Xu xiao-Min Shi wei Zhang Lei Shi Mu-Han Lü Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Nuclear Medicine and Molecular Imaging Key Laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology Lianshui People’Hospital of Kangda College Affiliated to Nanjing Medical UniversityHuaian 223499Jiangsu ProvinceChina

BACKGROUND Liver cirrhosis patients admitted to intensive care unit(ICU)have a high mortality *** To establish and validate a nomogram for predicting in-hospital mortality of ICU patients with liver *** We extracted demographic,etiological,vital sign,laboratory test,comorbidity,complication,treatment,and severity score data of liver cirrhosis patients from the Medical Information Mart for Intensive Care IV(MIMIC-IV)and electronic ICU(eICU)collaborative research database(eICU-CRD).Predictor selection and model building were based on the MIMIC-IV *** variables selected through least absolute shrinkage and selection operator analysis were further screened through multivariate regression analysis to obtain final *** final predictors were included in the multivariate logistic regression model,which was used to construct a ***,we conducted external validation using the *** area under the receiver operating characteristic curve(AUC),decision curve,and calibration curve were used to assess the efficacy of the *** Risk factors,including the mean respiratory rate,mean systolic blood pressure,mean heart rate,white blood cells,international normalized ratio,total bilirubin,age,invasive ventilation,vasopressor use,maximum stage of acute kidney injury,and sequential organ failure assessment score,were included in the multivariate logistic *** model achieved AUCs of 0.864 and 0.808 in the MIMIC-IV and eICU-CRD databases,*** calibration curve also confirmed the predictive ability of the model,while the decision curve confirmed its clinical *** The nomogram has high accuracy in predicting in-hospital *** the included predictors may help improve the prognosis of patients.

关键词： Liver cirrhosis Intensive care unit Nomogram Predicting model Mortality

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Establishment of a cholangiocarcinoma risk evaluation model based on mucin expression levels

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1344-1360页

作者： Chun-Yuan Yang Li-Mei Guo Yang Li Guang-Xi Wang xiao-wei tang Qiu-Lu Zhang Ling-Fu Zhang Jian-Yuan Luo Department of Pathology Institute of Systems BiomedicineSchool of Basic Medical Sciences Peking UniversityPeking University Third HospitalPeking University Health Science CenterBeijing 100191China Department of General Surgery Peking University Third HospitalBeijing 100191China Department of Medical Genetics Department of Biochemistry and BiophysicsSchool of Basic Medical Sciences Peking UniversityPeking University Health Science CenterBeijing 100191China

BACKGROUND Cholangiocarcinoma(CCA)is a highly malignant cancer,characterized by frequent mucin ***1 has been identified as a critical oncogene in the progression of ***,the comprehensive understanding of how the mucin family influences CCA progression and prognosis is still *** To investigate the functions of mucins on the progression of CCA and to establish a risk evaluation formula for stratifying CCA *** Single-cell RNA sequencing data from 14 CCA samples were employed for elucidating the roles of mucins,complemented by bioinformatic ***-quent validations were conducted through spatial transcriptomics and *** construction of a risk evaluation model utilized the least absolute shrinkage and selection operator regression algorithm,which was further confirmed by independent cohorts and diverse data *** CCA tumor cells with elevated levels of MUC1 and MUC4 showed activated nucleotide metabolic pathways and increased ***5AC-high cells were found to promote CCA progression through WNT ***5B-high cells exhibited robust cellular oxidation activities,leading to resistance against antitumoral ***13-high cells were observed to secret chemokines,recruiting and transforming macrophages into the M2-polarized state,thereby suppressing antitumor ***16-high cells were found to promote tumor progression through interleukin-1/nuclear factor kappa-light-chain-enhancer of activated B cells signaling upon interaction with *** the expression levels of these mucins,a risk factor evaluation formula for CCA was developed and validated across multiple *** samples with higher risk factors exhibited stronger metastatic potential,chemotherapy resistance,and poorer *** Our study elucidates the functional mechanisms through which mucins contribute to CCA development,and provides tools for risk stratification in CCA.

关键词： Mucin Cholangiocarcinoma Single-cell RNA sequencing Spatial transcriptomics Prognosis

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Evaluation of liquefaction-induced lateral displacement using Bayesian belief networks

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Frontiers of Structural and Civil Engineering 2021年第1期15卷 80-98页

作者： Mahmood AHMAD xiao-wei tang Jiang-Nan QIU Feezan AHMAD State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Department of Civil Engineering University of Engineering and Technology Peshawar(Bannu Campus)Bannu 28100Pakistan Faculty of Management and Economics Dalian University of TechnologyDalian 116024China Department of Civil Engineering Abasyn UniversityPeshawar 25000Pakistan

Liquefaction-induced lateral displacement is responsible for considerable damage to engineered structures during major ***,an accurate estimation of lateral displacement in liquefaction-prone regions is an essential task for geotechnical experts for sustainable *** paper presents a novel probabilistic framework for evaluating liquefaction-induced lateral displacement using the Bayesian belief network(BBN)approach based on an interpretive structural modeling *** BBN models are trained and tested using a wide-range casehistory records *** two BBN models are proposed to predict lateral displacements for free-face and sloping ground *** predictive performance results of the proposed BBN models are compared with those of frequently used multiple linear regression and genetic programming *** results reveal that the BBN models are able to learn complex relationships between lateral displacement and its influencing factors as cause-effect relationships,with reasonable *** study also presents a sensitivity analysis to evaluate the impacts of input factors on the lateral displacement.

关键词： Bayesian belief network seismically induced soil liquefaction interpretive structural modeling lateral displacement

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Application of machine learning algorithms for the evaluation of seismic soil liquefaction potential

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Frontiers of Structural and Civil Engineering 2021年第2期15卷 490-505页

作者： Mahmood AHMAD xiao-wei tang Jiang-Nan QIU Feezan AHMA Wen-Jing GU State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Department of Civil Engineering University of Engineering and Technology Peshawar(Bannu Campus)Bannu 28100Pakistan School of Economics&Management Dalian University of TechnologyDalian 116024China Department of Civil Engineering Abasyn UniversityPeshawar 25000Pakistan

This study investigates the performance of four machine learning(ML)algorithms to evaluate the earthquake-induced liquefaction potential of soil based on the cone penetration test field case history records using the Bayesian belief network(BBN)learning software *** BBN structures that were developed by ML algorithms-K2,hill climbing(HC),tree augmented naive(TAN)Bayes,and Tabu search were adopted to perform parameter learning in Netica,thereby fixing the BBN *** performance measure indexes,namely,overall accuracy(OA),precision,recall,F-measure,and area under the receiver operating characteristic curve,were used to evaluate the training and testing BBN models’performance and highlight the capability of the K2 and TAN Bayes models over the Tabu search and HC *** sensitivity analysis results showed that the cone tip resistance and vertical effective stress are the most sensitive factors,whereas the mean grain size is the least sensitive factor in the prediction of seismic soil liquefaction *** results of this study can provide theoretical support for researchers in selecting appropriate ML algorithms and improving the predictive performance of seismic soil liquefaction potential models.

关键词： seismic soil liquefaction Bayesian belief network cone penetration test parameter learning structural learning

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A step forward towards a comprehensive framework for assessing liquefaction land damage vulnerability:Exploration from historical data

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Frontiers of Structural and Civil Engineering 2020年第6期14卷 1476-1491页

作者： Mahmood AHMAD xiao-wei tang Jiang-Nan QIU Feezan AHMAD Wen-Jing GU State Key Laboratory of Coastal and Ofishore Engineering Dalian University of TechnologyDalian 116024China Department of Civil Engineering University of Engineering and Technology Peshawar(Bannu Campus)Bannu 28100Pakistan School of Economics&Management Dalian University of TechnologyDalian 116024China Deparment of Civil Enginering Abasyn UniversitPeshawar 25000Pakistan

The unprecedented liquefaction-related land damage during earthquakes has highlighted the need to develop a model that better interprets the liquefaction land damage vulnerability(LLDV)when determining whether liquefaction is likely to cause damage at the ground's *** paper presents the development of a novel comprehensive framework based on select case history records of cone penetration tests using a Bayesian belief network(BBN)methodology to assess seismic soil liquefaction and liquefaction land damage potentials in one *** BBN-based LLDV model is developed by integrating multi-related factors of seismic soil liquefaction and its induced hazards using a machine learming(ML)algorithm-K2 and domain knowledge(DK)data fusion *** with the C4.5 decision tree-J48 model,naive Bayesian(NB)classifier,and BBN-K2 ML prediction methods in terms of overall accuracy and the Cohen's kappa coefficient,the proposed BBN K2 and DK model has a better performance and provides a substitutive novel LLDV framework for characterizing the vulnerability of land to liquefaction-induced *** proposed model not only predicts quantitatively the seismic soil liquefaction potential and its ground damage potential probability but can also identify the main reasons and fault-finding state combinations,and the results are likely to assist in decisions on seismic risk mitigation measures for sustainable *** proposed model is simple to perform in practice and provides a step toward a more sophisticated liquefaction risk assessment *** study also interprets the BBN model sensitivity analysis and most probable explanation of seismic soil liquefed sites based on an engineering point of view.

关键词： Bayesian belief network liquefaction-induced damage potential cone penetration test soil liquefaction structural leaming and domain knowledge

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A Numerical Calculation Algorithm of the Inclination Function Based on the Representation of SO(3) Group

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 137-148页

作者： Yu-xiao wei Wen-lin tang Department of Geophysics School of Geology Engineering and GeomaticsChang’An UniversityXi’an710064China Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing100190China

In the determination of the Earth gravity field in satellite geodesy, the inclination functions represent the projection of data observed along the orbital plane of a satellite orbit into the sphere in the terrestial reference frame. The inclination functions in this work is studied from a group theoretical perspective. The inclination functions are proved to generate a representation of the SO(3) group. An orthogonal relation of the inclination functions is derived and some recurrence relations for the inclination functions are given, based on which an algorithm to calculate the inclination functions is proposed.

关键词： SO(3)group inclination function satellite geodesy representation of SO(3)

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Silver-nanoparticle-coated biliary stent inhibits bacterial adhesion in bacterial cholangitis in swine

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 87-92页

作者： wei Wen Li-Mei Ma wei He xiao-wei tang Yin Zhang Xiang Wang Li Liu Zhi-Ning Fan Department of Digestive Endoscopy Center First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Department of Gastroenterology The 81th Hospital of PLA Department of Gastroenterology Changzhou First People’s HospitalThird Affiliated Hospital of Suzhou University

BACKGROUND： One of the major limitations of biliary stents is the stent occlusion, which is closely related to the over- growth of bacteria. This study aimed to evaluate the feasibility of a novel silver=nanoparticle-coated polyurethane （Ag/PU） stent in bacterial cholangitis model in swine. METHODS： Ag/PU was designed by coating silver nanopar- tides on polyurethane （PU） stent. Twenty-four healthy pigs with bacterial cholangitis using Ag/PU and PU stents were ran- domly divided into an Ag/PU stent group （n=12） and a PU stem group （n=12）, respectively. The stents were inserted by standard endoscopic retrograde cholangiopancreatography. Laboratory assay was performed for white blood cell （WBC） count, alanine aminotransferase （ALT）, interleukin-1 [l （IL- 1 p）, tumor necrosis factor-a （TNF-~） at baseline time, 8 hours, 1, 2, 3, and 7 days after stent placements. The segment of bile duct containing the stent was examined histologically ex vivo. Implanted bili- ary stents were examined by a scan electron microscope. The amount of silver release was also measured in vitro. RESULTS： The number of inflammatory cells and level of ALT, IL-1β and TNF-α were significantly lower in the Ag/PU stent group than in the PU stent group. Hyperplasia of the mucosa was more severe in the PU stent group than in the Ag/PU stent group. In contrast to the biofilm of bacteria on the PU stent, fewer bacteria adhered to the Ag/PU stent. CONCLUSIONS： PU biliary stents modified with silver nanoparticles are able to alleviate the inflammation of pigs with bacterial cholangitis. Silver-nanoparticle-coated stents are resistant to bacterial adhesion.

关键词： biliary stent silver nanoparticles endoscopic retrograde cholangiopancreatography bacterial cholangitis

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Endoscopic submucosal tunnel dissection of upper gastrointestinal submucosal tumors: A comparative study of hook knife vs hybrid knife

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World Journal of Gastroenterology 2017年第10期23卷 1843-1850页

作者： Jie-qiong Zhou xiao-wei tang Yu-tang Ren Zheng-Jie wei Si-lin Huang qiao-ping Gao xiao-feng Zhang Jian-feng Yang wei Gong Bo Jiang Guangdong Provincial key laboratory of Gastroenterology Department of Gastroenterology Nanfang Hospital Southern Medical University Department of Gastroenterology Beijing Tsinghua Changgung Hospital Medical Center Tsinghua University Department of Gastroenterology Hangzhou First People’s Hospital Nanjing Medical University

AIM to compare the efficacy and safety of a hook knife(HO) with a hybrid knife(HK) during endoscopic submucosal tunnel dissection(EStD) *** Between August 2012 and December 2015, the ESt D procedure was performed for 83 upper GI submucosal lesions, which originated from the muscularis propria layer identified by upper endoscopy and endoscopic ultrasonography. Of these, 34 lesions were treated by a HO, whereas 49 lesions were treated by a HK. Data regarding age, gender, presenting symptoms, tumor location and size, procedure time, complications, en bloc resection rate and others were analyzed and compared between the two *** there were no significant differences in the age, gender, presenting symptoms and tumor location between the two groups. EStD was successfully completed in all the patients, and no case was converted to laparoscopy. the mean procedure time was significantly shorter in the HK group than in the HO group(41.3 ± 20.3 min vs 57.2 ± 28.0 min, p = 0.004). the mean frequency of device exchange was 1.4 ± 0.6 in the HK group and significantly less than 3.3 ± 0.6 in the HO group(p < 0.001). the differences in tumor size and histopathological diagnoses were not significant between the two groups(p = 0.813, p = 0.363, respectively). Both groups had an equal en bloc resection rate and complete resection rate. Additionally, the complication rate was similar between the two groups(p = 0.901). During the follow-up, no recurrence occurred in either *** We demonstrate for the first time that HO and HK do not differ in efficacy or safety, but HK reduces the frequency of device exchange and procedure time.

关键词： Endoscopic submucosal tunnel dissection submucosal tumor hook knife hybrid knife clinical outcome

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Brain-derived neurotrophic factor, sex hormones and cognitive decline in male patients with schizophrenia receiving continuous antipsychotic therapy

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World Journal of Psychiatry 2023年第12期13卷 995-1004页

作者： Jin Li Wen-Huan xiao Fei Ye xiao-wei tang Qiu-Fang Jia xiao-Bin Zhang Department of Psychiatry The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Psychiatry Affiliated Wutaishan Hospital of Medical College of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND There are systematic differences in clinical features between women and men with schizophrenia(SCZ).The regulation of sex hormones may play a potential role in abnormal neurodevelopment in ***-derived neurotrophic factor(BDNF)and sex hormones have complex interacting actions that contribute to the etiology of *** To investigate the influence of BDNF and sex hormones on cognition and clinical symptomatology in chronic antipsychotic-treated male SCZ *** The serum levels of follicle-stimulating hormone,luteinizing hormone(LH),estradiol(E2),progesterone,testosterone(T),prolactin(PRL)and BDNF were compared between chronic antipsychotic-treated male(CATM)patients with SCZ(n=120)and healthy controls(n=120).The Positive and Negative Syndrome Scale was used to quantify SCZ symptoms,while neuropsychological tests were used to assess *** tests,such as the Digit Cancellation Test(DCT),Semantic Verbal Fluency(SVF),Spatial Span Test(SS),Paced Auditory Serial Addition Test(PASAT),Trail Making Task(TMT-A),and Block Design Test(BDT),were used to assess executive functions(BDT),attention(DCT,TMT-A),memory(SS,PASAT),and verbal proficiency(SVF).RESULTS Although E2 levels were significantly lower in the patient group compared to the healthy controls,T,PRL,and LH levels were all significantly ***,the analysis revealed that across the entire sample,there were positive correlations between E2 Levels and BDNF levels as well as BDNF levels and the digital cancellation *** CATM patients with SCZ,a significant correlation between the negative symptoms score and PRL levels was *** Sex hormones and BDNF levels may also be linked to cognitive function in patients with chronic SCZ.

关键词： Brain-derived neurotrophic factor Clinical symptoms Cognitive function Schizophrenia Sex hormones

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Characteristics of metachronous gastric neoplasms after curative endoscopic submucosal dissection for early gastric neoplasms

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Chinese Medical Journal 2021年第21期134卷 2603-2610页

作者： Shan-Shan Xu Ning-Li Chai xiao-wei tang En-Qiang Linghu Sha-Sha Wang Bao Li Nankai University School of Medicine Nankai UniversityTianjin 300071China department of Gastroenterology and Hepatology The First Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100853China

Background:With the wide application of endoscopic submucosal dissection(ESD)for early gastric neoplasms,metachronous gastric neoplasms(MGN)have gradually become a *** study aimed to analyze the characteristics of MGN and evaluate the treatment and follow-up outcomes of MGN ***:A total of 814 patients were retrospectively *** these patients were treated by ESD for early gastric cancer or gastric dysplasia between November 2006 and September 2019 at The First Medical Center of Chinese People’s Liberation Army General *** risk factors for MGN were analyzed using Cox hazard proportional ***,the cumulative incidence,the correlation of initial lesions and MGN lesions,and the treatment and follow-up outcomes of MGN patients were ***:A total of 4.5%(37/814)of patients had MGN after curative *** 3-,5-,and 7-year cumulative incidences of MGN were 3.5%,5.1%,and 6.9%,respectively,and ultimately reaching a plateau of 11.3%at 99 months after *** was no significant correlation between initial lesions and MGN lesions in terms of gross type(P=0.178),location(long axis:P=0.470;short axis:P=0.125),and histological type(P=0.832).Cox multivariable analysis found that initial multiplicity was the only independent risk factor of MGN(hazard ratio:4.3,95%confidence interval:2.0-9.4,P<0.001).Seventy-three percent of patients with MGN were treated by endoscopic *** follow-up,two patients with MGN died of gastric cancer with lymph node *** disease-specific survival rate was significantly lower in patients with MGN than that in patients without MGN(94.6%vs.99.6%,P=0.006).Conclusions:The MGN rate gradually increased with follow-up time within 99 months after curative gastric ***,regular and long-term surveillance endoscopy may be helpful,especially for patients with initial multiple neoplasms.

关键词： Metachronous gastric neoplasms Early gastric cancer Endoscopic submucosal dissection Characteristics Follow-up

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