检索结果-南通市图书馆

Association of Interleukin-6-174G/C Polymorphism with the Risk of Diabetic Nephropathy in Type 2 Diabetes:A Meta-analysis

引用

Current Medical Science 2019年第2期39卷 250-258页

作者： Zhen-hai CUI xiao-ting lu Kang-li xiao Yang CHEN Hui-qing LI Department of Endocrinology Union HospitalTongji Medical CollegeHucizhong University of Science and TechnologyWuhan 430022China Department of Radiology Union HospitalTongji Medical CollegeHucizhong University of Science and TechnologyWuhan 430022China

Previous studies reported the association between interleukin-6(IL-6)-174G/C gene polymorphism and the risk of diabetic nephropathy in type 2 diabetes mellitus(T2DN).However,the results remain *** the present study,we conducted a meta-analysis to further examine this relationship between IL-6-174G/C gene polymorphism and *** databases(PubMed,SinoMed and ISI Web of Science)were used to search clinical case-control studies about IL-6-174G/C polymorphism and T2DN published until Apr.14,***-or random-effects n lodels were used to calculate the effect sizes of odds ratio(OR)and 95%confide nee intervals(95%CI).Moreover,subgroup analysis was performed in tenns of the excretion rate of *** the statistical analyses were con ducted using Stata 12.0.A total of 11 case-control studies were included in this study,involving 1203 cases of T2DN and 1571 cases of T2DM without *** showed that there was an association between IL-6-174G/C polymorphism and increased risk of T2DN under the allelic and recessive genetic models(G vs.C:OR=1.10,95%CI 1.03-1」&P=0.006;GG ***+GC:OR=1.11,95%CI 1.02-1.21,P=0.016).In the subgroup analysis by albuminuria,a significant association of IL-6-174G/C polymorphism with risk of T2DN was noted in the microalbuminuria group under the recessive model(OR=1.54,95%CI 1.02-2.32,P=0.038).In conclusion,this meta-analysis suggests that IL-6-174G/C gene polymorphism is associated with the risk of T2DN.

关键词： interleukin-6(IL-6)-174G/C gene polymorphism diabetic nephropathy type 2 diabetes mellitus meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Snail-borne parasitic diseases:an update on global epidemiological distribution,transmission interruption and control methods

引用

Infectious Diseases of Poverty 2018年第1期7卷 285-300页

作者： xiao-ting lu Qiu-Yun Gu Yanin Limpanont Lan-Gui Song Zhong-Dao Wu Kamolnetr Okanurak Zhi-Yue Lv School of Public Health Sun Yat-sen UniversityGuangzhou 510080China Faculty of Tropical Medicine Mahidol UniversityBangkok 10400Thailand Fifth Affiliated Hospital Zhongshan School of MedicineSun Yat-sen UniversityGuangdongChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhou 510080China Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou 510080China

Background:Snail-borne parasitic diseases,such as angiostrongyliasis,clonorchiasis,fascioliasis,fasciolopsiasis,opisthorchiasis,paragonimiasis and schistosomiasis,pose risks to human health and cause major socioeconomic problems in many tropical and sub-tropical *** this review we summarize the core roles of snails in the life cycles of the parasites they host,their clinical manifestations and disease distributions,as well as snail control *** body:Snails have four roles in the life cycles of the parasites they host:as an intermediate host infected by the first-stage larvae,as the only intermediate host infected by miracidia,as the first intermediate host that ingests the parasite eggs are ingested,and as the first intermediate host penetrated by miracidia with or without the second intermediate host being an aquatic ***-borne parasitic diseases target many organs,such as the lungs,liver,biliary tract,intestines,brain and kidneys,leading to overactive immune responses,cancers,organ failure,infertility and even *** countries in Africa,Asia and Latin America have the highest incidences of these diseases,while some endemic parasites have developed into worldwide epidemics through the global spread of ***,chemical and biological methods have been introduced to control the host snail populations to prevent ***:In this review,we summarize the roles of snails in the life cycles of the parasites they host,the worldwide distribution of parasite-transmitting snails,the epidemiology and pathogenesis of snail-transmitted parasitic diseases,and the existing snail control measures,which will contribute to further understanding the snail-parasite relationship and new strategies for controlling snail-borne parasitic diseases.

关键词： Snail-borne parasitic diseases Epidemiology Pathogenesis Snail control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Detection of bacterial DNA from cholesterol gallstones by nested primers polymerase chain reaction

引用

World Journal of Gastroenterology 1998年第3期4卷 54-57页

作者： WU xiao ting 1, xiao lu Jia 2, LI Xing Quan 3 and LI Jie Shou 1

AIM To search for bacterial DNA sequences in cholesterol gallstones with negative bacterial culture. METHODS DNA was extracted from cholesterol gallstones in gallbladders and nested primers polymerase chain reaction (NP PCR) was used to amplify bacterial gene fragments for identifying the existence of bacteria. The samples of bacterial DNA extracted from potentially causative or unrelated living bacteria were amplified in vitro as the standard markers and comparative 16S ribosomal RNA sequence analysis was made for bacterial identification. RESULTS The gallbladder gallstones of 30 patients were analyzed and bacterial DNA was found in 26 patients. Among them, gallstones with cholesterol content between 30%-69% were seen in 5 (5/5) patients, 70%-90% in 11 (11/14) patients, and more than 90% in 10 (10/11) patients. There was no difference either in cholesterol and water content of gallstones or in harboring bacterial DNA of gallstones. *** related DNA fragments appeared in the stones of 8 (26 67%) patients; propionibacteria type DNA in 7 (23 33%); and harbored bacterial gene fragments in 2 patients, similar to Streptococcus pyogenes . A more heterogeneous sequence collection was found in 7 (23 33%) patients, which could belong to multiple bacterial infections. Two (6 67%) patients had bacterial DNA with low molecular weight which might be related to some unidentified bacteria. CONCluSION Most cholesterol gallstones harbor bacterial DNA. It is important to determine whether these microorganisms are innocent bystanders or active participants in cholesterol gallstone formation.

关键词： cholelithiasis/microbiology propionibacterium acnes staphylococcus aureus DNA, bacterial polymerase chain reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The G-Protein β Subunit AGB1 Promotes Hypocotyl Elongation through Inhibiting Transcription Activation Function of BBX21 in Arabidopsis

引用

Molecular Plant 2017年第9期10卷 1206-1223页

作者： Dong-bei Xu Institute of Crop Sciences Chinese Academy of Agricultural Sciences (CAAS)/National Key Facility for Crop Gene Resources and Genetic Improvement Key Laboratory of Biology and Genetic Improvement of Crops Ministry of Agriculture Beijing 100081 China Institute of Botany Jiangsu Province and Chinese Academy of Sciences No.1 Qianhu Houcun Zhongshanmen Wai Nanjing Jiangsu Province 210014 PR China [∗]Corresponding author [∗∗]Corresponding author [∗∗∗]Corresponding authorThese authors contributed equally to this article.

Hypocotyl development in Arabidopsis thaliana is regulated by light and endogenous hormonal cues, mak- ing it an ideal model to study the interplay between light and endogenous growth regulators. BBX21, a B-box （BBX）-Iike zinc-finger transcription factor, integrates light and abscisic acid signals to regulate hypocotyl elongation in Arabidopsis. Heterotrimeric G-proteins are pivotal regulators of plant development. The short hypocotyl phenotype of the G-protein I^-subunit （AGB1） mutant （agbl-2） has been previously identified, but the precise role of AGB1 in hypocotyl elongation remains enigmatic. Here, we show that AGB1 directly interacts with BBX21, and the short hypocotyl phenotype of agbl-2 is partially suppressed in agb1-2bbx21-1 double mutant. BBX21 functions in the downstream of AGB1 and overexpression of BBX21 in agbl-2 causes a more pronounced reduction in hypocotyl length, indicating that AGB1 plays an oppositional role in relation to BBX21 during hypocotyl development. Furthermore, we demonstrate that the C-terminal region of BBX21 is important for both its intracellular localization and its transcriptional activation activity that is inhibited by interaction with AGB1. ChiP assays showed that BBX21 specifically associates with its own promoter and with those of BBX22, HY5, and GA2oxl. which is not altered in agbl-2. These data suggest that the AGB1-BBX21 interaction only affects the transcrip- tional activation activity of BBX21 but has no effect on its DNA binding ability. Taken together, our data demonstrate that AGB1 positively promotes hypocotyl elongation through repressing BBX21 activity.

关键词： Arabidopsis BBX21 G-protein 13 subunit hypocotyl elongation transcriptional activation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Betaine on the Regulation of the Lipid Metabolism in Laying Hen

引用

Agricultural Sciences in China 2002年第9期1卷 1043-1049页

作者： ZOU xiao-ting and lu Jian-jun( The Key Laboratory of Animal Nutrition , Ministry of Education/Feed Science Institute of Zhejiang University,Hangzhou 310029 ,P.R. China ) The Key Laboratory of Animal Nutrition Ministry of Education/Feed Science Institute of Zhejiang University Hangzhou 310029 P. R. China

The experiment was conducted to investigate the effects of betaine on lipid metabolism of laying hens. 1 600 ISA brown laying hens of 20 weeks of age were alloted randomly into 4 groups each with 4 replicates of 100 layers, the layers were given a corn-soybean basal diet with 0,400,600 and 800 mg/kg betaine re-spectirely. Results indicated that supplementation of 600 mg/kg betaine significantly improved lay performance, and increased egg production 8.67% (Pluclose (Glu) , FFA and phospholipid were increased by 44.50% (Pluclose (Glu), FFA and phospholipid were increased by 16.25%(P<0.05),22.51%(P<0.02) and 22.42%(P<0.01) in 70 weeks of age.

关键词： Hen Betaine Lipid metabolism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

带洞点云多层同步表面重建方法

引用

软件学报 2016年第10期27卷 2642-2653页

作者：王筱婷王璐孟祥旭山东大学计算机科学与技术学院山东济南250101 数字媒体技术教育部工程研究中心山东济南250101

针对法向信息缺失和采样点缺失的带有洞的散乱点云数据,提出了一种高效、高质量的多层同步表面重建方法.首先利用动态等高线检测出含有洞的八叉树节点,并且基于HPR(hidden point removal)映射计算出八叉树顶点的内外状态,建立带有顶点... 详细信息

针对法向信息缺失和采样点缺失的带有洞的散乱点云数据,提出了一种高效、高质量的多层同步表面重建方法.首先利用动态等高线检测出含有洞的八叉树节点,并且基于HPR(hidden point removal)映射计算出八叉树顶点的内外状态,建立带有顶点内外标识的空间有向状态八叉树,然后基于八叉树节点内法向测试方法保证基于k近邻表面重建过程中采样点的法向的正确性,且该空间有向状态八叉树可以支持不同层次的点云同步重建,在保证重建结果正确性的前提下,提高重建效率.

关键词：表面重建点云状态八叉树 k近邻 HPR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

引用

Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao Wang Jia Zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

引用

Nano-Micro Letters 2025年第1期17卷 176-190页

作者： xiaohong Zou Qian lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu xiaomin Xu xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

引用

Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： xiaoqin Li Jian Xiang lu Qiu xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

西北太平洋海水透明度遥感反演与融合方法

引用

中国海洋大学学报（自然科学版） 2016年第12期46卷 133-141页

作者：王晓菲张亭禄田林施英妮中国海洋大学信息科学与工程学院山东青岛266100

海水透明度是描述海水光学特性的一个重要参数。论文首先利用现场测量的遥感反射率和透明度数据建立了西北太平洋的透明度遥感反演模型,并应用于Seawifs、MODIS-aqua、MOIDS-terra及MERIS Level 2反射率数据,获取西北太平洋的透明度数... 详细信息

海水透明度是描述海水光学特性的一个重要参数。论文首先利用现场测量的遥感反射率和透明度数据建立了西北太平洋的透明度遥感反演模型,并应用于Seawifs、MODIS-aqua、MOIDS-terra及MERIS Level 2反射率数据,获取西北太平洋的透明度数据。然后将平均法、最优插值法2种融合方法分别应用于上述4颗卫星的透明度数据进行数据融合,并用现场测量的同步透明度数据对融合后的产品进行了印证。另外,利用2种融合方法分别对西北太平洋2007年Seawifs、MODIS-aqua、MODIS-terra和MERIS4颗传感器的透明度数据进行了月融合,分析了融合的西北太平洋的时空分布特征。研究结果表明,融合数据大幅度提高了空间覆盖率,并具有较高可信度。平均法和最优插值法两种融合方法性能有较大的不同,平均法对细节特征保留的较好,且具有较高的运行速度,但有时空间覆盖率仍不能满足要求;最优插值法具有高的空间覆盖率,但其运行速度较慢。

关键词：海水透明度遥感反演方法西北太平洋数据融合

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：