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Human immunodeficiency virus-associated dementia complex with positive 14-3-3 protein in cerebrospinal fluid:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2065-2073页

作者： Yun-Sen he xiao-Hong Qin Min Feng Qin-Jiang Huang Meng-Jun Zhang Li-Li Guo Ming-Bin Bao Ye tao Hong-Yuan Dai Bo Wu Department of Neurosurgery Sichuan Lansheng Brain Hospital&Shanghai Lansheng Brain Hospital Investment Co.Ltd.Chengdu 610036Sichuan ProvinceChina Department of Psychiatry Sichuan Provincial Center for Mental HealthChengdu 610072Sichuan ProvinceChina Department of Geriatrics Municipal People’s Hospital in LuzhouLuzhou 646000Sichuan ProvinceChina Department of Neurosurgery Wenjiang District People’s Hospital of ChengduChengdu 611100Sichuan ProvinceChina Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China ChengduChengdu 610072Sichuan ProvinceChina Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-associated dementia(HAD)is a subcortical form of dementia characterized by memory deficits and psychomotor ***,HAD often presents with symptoms similar to those of Creutzfeldt-Jakob disease(CJD),particularly in patients with acquired immune deficiency syndrome(AIDS).CASE SUMMARY We report the case of a 54-year-old male who exhibited cognitive dysfunction and secondary behavioral changes following HIV infection and suspected prion *** patient was diagnosed with HIV during hospitalization and his cerebrospinal fluid tested positive for 14-3-3 *** electroencephalogram showed a borderline-abnormal periodic triphasic wave ***-enhanced magnetic resonance imaging revealed moderate encephalatrophy and ***,symptomatic treatment and administration of amantadine were pursued for presumed CJD,but the patient’s condition continued to *** contrast,the patient’s condition improved following anti-HIV *** individual is also the only patient with this prognosis to have survived over 4 ***,the diagnosis was revised to *** In the diagnostic process of rapidly progressive dementia,it is crucial to rule out as many potential causes as possible and to consider an autopsy to diminish diagnostic *** 14-3-3 protein should not be regarded as the definitive marker for *** laboratory screening for infectious diseases is essential to enhance diagnostic precision,especially in AIDS patients with potential ***,a trial of diagnostic treatment may be considered when additional testing is not feasible.

关键词： HIV-associated dementia Cognitive dysfunction Creutzfeld-Jakob disease Rapidly progressive dementia Case report

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A deep learning model based on contrast-enhanced computed tomography for differential diagnosis of gallbladder carcinoma

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hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 376-384页

作者： Fei Xiang Qing-tao Meng Jing-Jing Deng Jie Wang xiao-Yuan Liang Xing-Yu Liu Sheng Yan Department of hepatobiliary Pancreatic Surgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Radiology Affiliated Chuzhou First People’s HospitalAnhui Medical UniversityChuzhou 239000China

Background:Gallbladder carcinoma(GBC)is highly malignant,and its early diagnosis remains *** study aimed to develop a deep learning model based on contrast-enhanced computed tomography(CT)images to assist radiologists in identifying ***:We retrospectively enrolled 278 patients with gallbladder lesions(>10 mm)who underwent contrast-enhanced CT and cholecystectomy and divided them into the training(n=194)and validation(n=84)*** deep learning model was developed based on ResNet50 *** and clinical models were built based on support vector machine(SVM)*** comprehensively compared the performance of deep learning,radiomics,clinical models,and three ***:Three radiomics features including LoG_3.0 gray-level size zone matrix zone variance,HHL firstorder kurtosis,and LHL gray-level co-occurrence matrix dependence variance were significantly different between benign gallbladder lesions and GBC,and were selected for developing radiomics *** regression analysis revealed that age≥65 years[odds ratios(OR)=4.4,95%confidence interval(CI):2.1-9.1,P37 U/mL(OR=4.0,95%CI:1.6-10.0,P=0.003)were significant clinical risk factors of *** deep learning model achieved the area under the receiver operating characteristic curve(AUC)values of 0.864(95%CI:0.814-0.915)and 0.857(95%CI:0.773-0.942)in the training and validation datasets,which were comparable with radiomics,clinical models and three *** sensitivity of deep learning model was the highest both in the training[90%(95%CI:82%-96%)]and validation[85%(95%CI:68%-95%)]***:The deep learning model may be a useful tool for radiologists to distinguish between GBC and benign gallbladder lesions.

关键词： Gallbladder carcinoma Computed tomography Deep learning Radiomics

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An efficient online histogram publication method for data streams with local differential privacy

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Frontiers of Information Technology & Electronic Engineering 2024年第8期25卷 1096-1109页

作者： tao tao Funan ZHANG Xiujun WANG xiao ZheNG Xin ZHAO School of Computer Science and Technology Anhui University of TechnologyMaanshan 243032China Anhui Engineering Research Center for Intelligent Applications and Security of Industrial Internet Maanshan 243032China Engineering Research Institute Anhui University of TechnologyMaanshan 243032China Shengli No.1 Middle School of Dongying City Dongying 257000China

Many areas are now experiencing data streams that contain privacy-sensitive *** the sharing and release of these data are of great commercial value,if these data are released directly,the private user information in the data will be ***,how to continuously generate publishable histograms(meeting privacy protection requirements)based on sliding data stream windows has become a critical issue,especially when sending data to an untrusted third *** histogram publication methods are unsatisfactory in terms of time and storage costs,because they must cache all elements in the current sliding window(sW).Our work addresses this drawback by designing an efficient online histogram publication(EOHP)method for local differential privacy data ***,in the EOHP method,the data collector first crafts a histogram of the current SW using an approximate counting ***,the data collector reduces the privacy budget by using the optimized budget absorption mechanism and adds appropriate noise to the approximate histogram,making it possible to publish the histogram while retaining satisfactory data *** experimental results on two different real datasets show that the EOHP algorithm significantly reduces the time and storage costs and improves data utility compared to other existing algorithms.

关键词： Data stream Differential privacy Sliding windows Approximate counting

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Optical multipath self-interference cancellation for a wideband in-band full-duplex system using a silicon photonic modulator chip

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Chinese Optics Letters 2024年第7期22卷 126-131页

作者： xiao Yu Jia Ye Lianshan Yan tao Zhou Yue Zhu Peng Li Xihua Zou Wei Pan Center for Information Photonics and Communications School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China Key Laboratory of Electronic Information Control Southwest China Research Institute of Electronic EquipmentChengdu 610029China Microwave Photonics Research Laboratory School of Electrical Engineering and Computer ScienceUniversity of OttawaOttawaONK1N6N5Canada

We propose and experimentally demonstrate a photonic method for wideband multipath self-interference cancellation using a silicon photonic modulator *** chip generates phase-inverted reference signals by leveraging the opposite phase between optical *** managing amplitude and phase imbalances between self-interference and reference signals,the approach rectifies discrepancies through consistent chip manufacturing and packaging *** photonic multi-dimensional multiplexing,including wavelength and polarization,enables the acquisition of multiple reference *** results show multipath cancellation depths of 25.53 dB and 23.81 dB for bandwidths of 500 MHz and 1 GHz,achieved by superimposing 2-path reference signals.

关键词： microwave photonics multipath self-interference silicon photonics

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Enhancement of–OH content on mechanical properties of antiperovskite solid electrolytes

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Nano Research 2024年第7期17卷 6139-6146页

作者： Zunqiu xiao Huaying Wang Ningyuan Cai Yutong Li Kejia Xiang Wei Wei tao Ye Zhongtai Zhang Shitong Wang Zilong Tang State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China College of New Energy Advanced Chemical Engineering and Energy Materials Research CenterChina University of Petroleum(East China)Qingdao 266580China Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

All-solid-state batteries,renowned for their enhanced safety and high energy density,have garnered broad *** solid electrolytes are highly anticipated for their balanced ***,their high Young’s modulus and inadaptability to volume change during cycling lead to poor contact and eventual battery *** this work,Young’s modulus of Li_(1+x)(OH)_(x)Cl samples is lowered to a level comparable to that of sulfide by regulating the–OH *** the–OH content increases,Young’s modulus of Li_(1+x)(OH)_(x)Cl samples decreases *** may be due to the local aggregation of–OH groups,forming cavities similar to LiOH structure,which reduces the bonding of the *** the premise of high Li-ion conductivity and electrochemical stability,the lowered Young’s modulus improves the contact between the solid electrolyte and the electrodes,forming a strong and stable interfacial layer,thereby improving interfacial and cycling *** symmetrical lithium metal cell shows excellent cycle performance of 600 h,and the assembled LiFePO_(4)|Li_(2.4)(OH)1.4Cl|Li cell shows significantly enhanced cycling endurance with 80%capacity retention after 150 *** work not only emphasizes the crucial importance of Young’s modulus in improving interface issues but also offers innovative approaches to advance the mechanical properties of solid electrolytes.

关键词： mechanical properties -OH content anti-perovskite solid electrolytes Li-ion batteries

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Preoperative prediction of perineural invasion of rectal cancer based on a magnetic resonance imaging radiomics model:A dual-center study

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World Journal of Gastroenterology 2024年第16期30卷 2233-2248页

作者： Yan Liu Bai-Jin-tao Sun Chuan Zhang Bing Li xiao-Xuan Yu Yong Du Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina.duyong@***

BACKGROUND Perineural invasion(PNI)has been used as an important pathological indicator and independent prognostic factor for patients with rectal cancer(RC).Preoperative prediction of PNI status is helpful for individualized treatment of ***,several radiomics studies have been used to predict the PNI status in RC,demonstrating a good predictive effect,but the results lacked *** preoperative prediction of PNI status is still challenging and needs further *** To establish and validate an optimal radiomics model for predicting PNI status preoperatively in RC *** This retrospective study enrolled 244 postoperative patients with pathologically confirmed RC from two independent *** patients underwent preoperative high-resolution magnetic resonance imaging(MRI)between May 2019 and August *** radiomics features were extracted and selected from oblique axial T2-weighted imaging(T2WI)and contrast-enhanced T1WI(T1CE)*** radiomics signatures were constructed using logistic regression analysis and the predictive potential of various sequences was compared(T2WI,T1CE and T2WI+T1CE fusion sequences).A clinical-radiomics(CR)model was established by combining the radiomics features and clinical risk *** internal and external validation groups were used to validate the proposed *** area under the receiver operating characteristic curve(AUC),DeLong test,net reclassification improvement(NRI),integrated discrimination improvement(IDI),calibration curve,and decision curve analysis(DCA)were used to evaluate the model *** Among the radiomics models,the T2WI+T1CE fusion sequences model showed the best predictive performance,in the training and internal validation groups,the AUCs of the fusion sequence model were 0.839[95%confidence interval(CI):0.757-0.921]and 0.787(95%CI:0.650-0.923),which were higher than those of the T2WI and T1CE sequence *** CR model constructed by combinin

关键词： Rectal cancer Perineural invasion Magnetic resonance imaging Radiomics Nomogram

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Photocatalytic uranium extraction boosted by dual effective active sites of porphyrin metal-organic frameworks

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Nano Research 2024年第7期17卷 6713-6720页

作者： Jianming Pan Bentian xiao Wei Zhu Yanan Yang Hongliang Huang Zichao Lian tao Zhang Fengxian Qiu Songlin Xue Huan Pang School of Chemistry and Chemical Engineering Jiangsu University301 Xuefu RoadZhenjiang 212013China Institute of Smart Liquid Crystal Technologies JITRI280 Huangpu Jiang RoadChangshu 215500China State key laboratory of Separation Membranes and Membrane Processes Tiangong UniversityTianjin 300387China School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China School of Chemistry and Chemical Engineering Institute for Innovative Materials and EnergyYangzhou UniversityYangzhou 225002China

Porphyrinoid metal-organic frameworks(MOFs)with dual effective uranium uptake sites were synthesized through combined insitu and post-synthetic *** MOF10@5 demonstrates the uptake amount of uranium reaches 1476 mg/g under visiblelight *** PN-MOF10@5 with dual uranyl uptake sites yields the amount of extracting uranyl of 1590 mg/g under visible-light *** density functional theory(DFT)calculations reveal strong interaction between uranyl and dual uranyl effective active *** MOFs demonstrate a powerful synthesis strategy for uranium extraction materials with dual effective active sites.

关键词： photocatalytic uranium extraction metal-organic framework(MOF) dual active sites in-suit synthesis post-synthetic

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Construction of a predictive model for acute liver failure after hepatectomy based on neutrophil-to-lymphocyte ratio and albuminbilirubin score

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1087-1096页

作者： xiao-Pei Li Zeng-tao Bao Li Wang Chun-Yan Zhang Wen Yang Department of Family Planning and Assisted Reproductive Technology The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Gastrointestinal Surgery The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Laboratory Medicine The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Gynecology The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina

BACKGROUND Acute liver failure(ALF)is a common cause of postoperative death in patients with hepatocellular carcinoma(HCC)and is a serious threat to patient *** neutrophil-to-lymphocyte ratio(NLR)is a common inflammatory indicator that is associated with the prognosis of various diseases,and the albumin-bilirubin score(ALBI)is used to evaluate liver function in liver cancer ***,this study aimed to construct a predictive model for postoperative ALF in HCC tumor integrity resection(R0)based on the NLR and ALBI,providing a basis for clinicians to choose appropriate treatment *** To construct an ALF prediction model after R0 surgery for HCC based on NLR and *** In total,194 patients with HCC who visited The First People’s Hospital of Lianyungang to receive R0 between May 2018 and May 2023 were enrolled and divided into the ALF and non-ALF *** compared differences in the NLR and ALBI between the two *** risk factors of ALF after R0 surgery for HCC were screened in the univariate *** risk factors were analyzed by multifactorial logistic *** then constructed a prediction model of ALF after R0 surgery for HCC.A receiver operating characteristic curve,calibration curve,and decision curve analysis(DCA)were used to evaluate the value of the prediction *** Among 194 patients with HCC who met the standard inclusion criteria,46 cases of ALF occurred after R0(23.71%).There were significant differences in the NLR and ALBI between the two groups(Phe univariate analysis showed that alpha-fetoprotein(AFP)and blood loss volume(BLV)were significantly higher in the ALF group compared with the non-ALF group(Phe multifactorial analysis showed that NLR,ALBI,AFP,and BLV were independent risk factors for ALF after R0 surgery in *** predictive efficacy of NLR,ALBI,AFP,and BLV in predicting the occurrence of ALT after R0 surgery for HCC was average[area under the curve(AUC)NLR=0.767,AUCALB

关键词： Acute liver failure hepatocellular carcinoma hepatectomy Neutrophil-to-lymphocyte ratio Albumin-bilirubin score

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Efficient electrocatalytic reduction of nitrate to ammonia at low concentration by copper-cobalt oxide nanowires with shell-core structure

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Nano Research 2024年第6期17卷 5087-5094页

作者： Chenhao xiao Yaxiao Guo Jiayuan Sun tao Guo Xinyuan Jia Shinuo Guo Guancheng Wu Yue Sun Zhaoyang Yao Yi Liu State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China Key Laboratory of Functional Polymer Materials College of ChemistryNankai UniversityTianjin 300071China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China

Electrocatalytic nitrate reduction to ammonia(NO3−RR)for removing nitrate from wastewater is a promising but challengeable technology that is increasingly ***,we developed an efficient CuO_(x)and CoCuO_(x)composed hybrid catalyst(CoCuO_(x)@CuO_(x)/copper foam(CF)),characteristic of distinctive shell-core nanowires grown on CF substrate with CuO_(x)core and CoCuO_(x)*** built-in electric field formed at the interface of the CoO/Cu_(2)O heterostructure promotes NO3−adsorption by modulating the charge distribution at the interface,which greatly improves the ammonia yield rate and Faradaic ***−0.2 V *** hydrogen electrode(Rhe),CoCuO_(x)@CuO_(x)/CF achieves not only an excellent ammonia yield rate of up to 519.1μg·h^(−1)·cm^(−2)and Faradaic efficiency of 99.83%at 1 mM NO3−concentration,but also excellent mechanical *** study provides a novel pathway to design electrocatalyst for the removal of nitrate from dilute nitric acid solutions(≤2 mM).

关键词： CoCuO_(x)@CuO_(x)/copper foam(CF) shell-core nanowires heterostructure low concentration nitrate electroreduction to ammonia

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液相共沉淀法制备钆镓石榴石(Gd_3Ga_5O_(12),GGG)多晶原料

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无机材料学报 2002年第3期17卷 443-447页

作者：赵广军李涛何晓明徐军肖筱华赵鹤明中国科学院上海光学精密机械研究所上海201800 苏州大学通信与电子工程系苏州215021

采用液相共沉淀的方法制备了钆镓石榴石(ＧＧＧ)的多晶原料,给出了液相合成ＧＧＧ多晶料的工艺步骤及其条件．就组分Ｇｄ２Ｏ３和Ｇａ２Ｏ３的配比,滴定氧化物溶解的混合溶液使其沉淀的ｐＨ值,共沉淀后烧结温度以及烧结时间等影响ＧＧ... 详细信息

采用液相共沉淀的方法制备了钆镓石榴石(ＧＧＧ)的多晶原料,给出了液相合成ＧＧＧ多晶料的工艺步骤及其条件．就组分Ｇｄ２Ｏ３和Ｇａ２Ｏ３的配比,滴定氧化物溶解的混合溶液使其沉淀的ｐＨ值,共沉淀后烧结温度以及烧结时间等影响ＧＧＧ多晶料合成的重要因素进行了讨论．通过和固相合成ＧＧＧ多晶料的条件比较可知,液相合成ＧＧＧ多晶原料的工艺具有合成的ＧＧＧ多晶料均匀充分、合成温度低与烧结时间短等优点．

关键词：液相共沉淀法制备钆镓石榴石多晶原料烧结光纤材料

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