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Mast Cells in Adjacent Normal Colon Mucosa rather than Those in Invasive Margin are Related to Progression of Colon Cancer

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Chinese Journal of Cancer Research 2011年第4期23卷 276-282页

作者： Qing Xia Ya Ding xiao-jun Wu Rui-qing Peng Qiang Zhou Jing Zeng Jing-hui Hou Xing zhang Yi-xin Zeng xiao-shi zhang Ying-bo Chen State Key Laboratory of Oncology in South China Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Medical Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China Biotherapy Center Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Colorectal Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Medical Oncology the First People Hospital of Yueyang Yueyang 414000 China Department of Pathology Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Gastric and Pancreatic Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China

Objective: Mast cells (MC) reside in the mucosa of the digestive tract as the first line against bacteria and toxins. Clinical evidence has implied that the infiltration of mast cells in colorectal cancers is related to malignant phenotypes and a poor prognosis. This study compared the role of mast cells in adjacent normal colon mucosa and in the invasive margin during the progression of colon cancer. Methods: Specimens were obtained from 39 patients with colon adenomas and 155 patients with colon cancers treated at the Sun Yat-sen University Cancer Center between January 1999 and July 2004. The density of mast cells was scored by an immunohistochemical assay. The pattern of mast cell distribution and its relationship with clinicopathologic parameters and 5-year survival were analyzed. Results: The majority of mast cells were located in the adjacent normal colon mucosa, followed by the invasive margin and least in the cancer stroma. Mast cell count in adjacent normal colon mucosa (MCCadjacent) was associated with pathologic classification, distant metastases and hepatic metastases, although it was not a prognostic factor. In contrast, mast cell count in the invasive margin (MCCinvasive) was associated with neither the clinicopathlogic parameters nor overall survival. Conclusion: Mast cells in the adjacent normal colon mucosa were related to the progression of colon cancer, suggesting that mast cells might modulate tumor progression via a long-distance mechanism.

关键词： Mast cell Colon cancer Mucosa Invasive margin Prognosis

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Targeted therapy: resistance and re-sensitization

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Chinese Journal of Cancer 2015年第11期34卷 496-501页

作者： Dao-Hong Chen xiao-shi zhang Biomedical Research Institute Yiling Pharmaceutical Company Biotherapy Center Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine

The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncol?ogy and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a number of novel synthesized chemical compounds and recombinant antibodies have been developed to selectively target oncogenic signaling pathways in a broad array of tumor types. Although targeted therapeutic agents show impressive clinical eicacy and minimized adverse efects compared with traditional treatments, the challenging drug?resistant issue has also emerged to limit their beneits to cancer patients. In this regard, we aim to improve targeted therapy by present?ing a systematic framework regarding the drug resistance mechanisms and alternative approaches to re?sensitize cancer cells/tissues therapeutically.

关键词： Targeted therapy Drug resistance Re-sensitization

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Translational medicine promising personalized therapy inoncology

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Frontiers of Medicine 2010年第4期4卷 351-355页

作者： Yi-Xin ZENG xiao-shi zhang Qiang LIU State Key Laboratory of Oncology in South China Sun Yat-sen UniversityGuangzhou 510060China Experimental Research Department Sun Yat-sen UniversityGuangzhouGuangdong 510060China Cancer Biotherapy Center Sun Yat-sen UniversityGuangzhou 510060China

Translational medicine has newly emerged to bridge the gap between bench-related basic science research and bedside clinical *** early diagnosis to late-stage disease treatment,translational medicine has transformed the clinical practice by making personalized medicine *** to the progress in translational medical research,cancer therapy has evolved from non-specific cytotoxic drugs against both tumor and normal proliferating cells to more specific small molecule chemical and immunotherapy *** molecular agents are directed at unique pathogenesis of cancer cells,whereas immunotherapeutic agents target the cancer immune *** approaches aim to produce less toxicity with high *** regimens with these agents in biomarker-classified sensitive populations promises a personalized approach in modern oncology.

关键词： clinical diagnosis drugs

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E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo

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World Journal of Gastroenterology 2015年第2期21卷 491-501页

作者： Wei-Yuan Wei Lin-Hai Yan xiao-Tong Wang Lei Li Wen-Long Cao xiao-shi zhang Ze-Xu Zhan Han Yu Yu-Bo Xie Qiang xiao Department of Surgery The First Affiliated Hospital of Guangxi Medical University Department of Surgery People’s Hospital of Guangxi Zhuang Autonomous Region Department of Anaesthesiology The First Affiliated Hospital of Guangxi Medical University

AIM: To evaluate the influence of E2F-1 on the growth of human gastric cancer(GC) cells in vivo and the mechanism involved. METHODS: E2F-1 recombinant lentiviral vectors were injected into xenograft tumors of MGC-803 cells in nude mice, and then tumor growth was investigated. Overexpression of transcription factor E2F-1 was assessed by reverse transcription-polymerase chain reaction(RT-PCR) and Western blotting analysis. Apoptosis rates were determined using a terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) assay. Expression levels of certain cell cycle regulators and apoptosis-related proteins, such as Bax, survivin, Bcl-2, cyclin D1, S-phase kinaseassociated protein 2, and c-Myc were examined by Western blotting and RT-PCR. RESULTS: Xenograft tumors of MGC-803 cells in nude mice injected with E2F-1 recombinant lentiviral vectors stably overexpressed the E2F-1 gene as measured by semi-quantitative RT-PCR(relative m RNA expression: 0.10 ± 0.02 vs 0.05 ± 0.02 for control vector and 0.06 ± 0.03 for no infection; both P < 0.01) and Western blotting(relative protein expression: 1.90 ± 0.05 vs 1.10 ± 0.03 in control vector infected and 1.11 ± 0.02 for no infection; both P < 0.01). The growth-curve of tumor volumes revealed that infection with E2F-1 recombinant lentiviral vectors significantly inhibited the growth of human GC xenografts(2.81 ± 1.02 vs 6.18 ± 1.15 in control vector infected and 5.87 ± 1.23 with no infection; both P < 0.05) at 15 d after treatment. TUNEL analysis demonstrated that E2F-1 overexpression promoted tumor cell apoptosis(18.6% ± 2.3% vs 6.7% ± 1.2% in control vector infected 6.3% ± 1.2% for no infection; both P < 0.05). Furthermore, lentiviral vector-mediated E2F-1 overexpression increased theexpression of Bax and suppressed survivin, Bcl-2, cyclin D1, Skp2, and c-Myc expression in tumor ***: E2F-1 inhibits growth of GC cells via regulating multiple signaling pathways, and may play an important ro

关键词： E2F-1 Gastric cancer Lentiviral vector Mouse model

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Gear-like array of (H_2O)_(12) as building blocks in one-dimensional supramolecular assembly

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Chinese Chemical Letters 2007年第11期18卷 1389-1391页

作者： Chun Hua Ge Xiang Dong zhang Yong Chao Ma Lei Guan Chun Yue shi xiao Yan zhang Ya Nan Guo Qi Tao Liu College of Chemistry Liaoning University Shenyang 110036 China

The preparation and crystal structure of complex Co（Hsae）2·2H2O （1, H2sae = N-salicylidene-2-iminoethanol） are reported. X- ray analysis revealed that every six Co（Hsae）2 forms a cyclic chip and every 12 water forms a novel gear-like cluster. Acting as building blocks, the gear-like water cluster and complex chip are connected in A-B fashion and extend into one-dimensional supramolecular chain. Hydrogen bond is the primary bridging force in the formation of supramolecular framework.

关键词： Co(Ⅱ) complex N-Salicylidene-2-iminoethanol Hydrogen bond Water cluster One-dimensional chain Supramolecular chemistry

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Longest survival with primary intracranial malignant melanoma:A case report and literature review

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World Journal of Clinical Cases 2022年第30期10卷 11162-11171页

作者： Tang-Fai Wong Yin-Sheng Chen Xiang-Heng zhang Wan-Ming Hu xiao-shi zhang Yan-Chun Lv Dong-Cun Huang Mei-Ling Deng Zhong-Ping Chen Department of Neurosurgery Macao Kiang Wu HospitalMacao 999078Sichuan ProvinceChina Department of Neurosurgery/Neuro-Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Pathology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Biotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Medical Imaging Sun Yat-sen University Cancer CenterCollaborative Innovation Center for Cancer MedicineGuangzhou 510060Guangdong ProvinceChina Department of Radiotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Primary intracranial malignant melanoma(PIMM)is rare,and its prognosis is very *** is not clear what systematic treatment strategy can achieve long-term *** case study attempted to identify the optimal strategy for long-term survival outcomes by reviewing the PIMM patient with the longest survival following comprehensive treatment and by reviewing the related *** SUMMARY The patient is a 47-year-old Chinese man who suffered from dizziness and gait *** underwent surgery for right cerebellum melanoma and was subsequently diagnosed by pathology in June *** the surgery,the patient received three cycles of chemotherapy but relapsed locally within 4 *** the second surgery for total tumor resection,the patient received an injection of Newcastle disease virus-modified tumor vaccine,interferon,andβ-elemene *** patient was tumor-free with a normal life for 21 years before the onset of the recurrence of melanoma without any symptoms in July 2021.A third gross-total resection with adjuvant radiotherapy and temozolomide therapy was *** magnetic resonance imaging showed no residual tumor or recurrence 3 mo after the 3rd operation,and the patient recovered well without neurological dysfunction until the last follow-up in June 2022,which was 22 years following the initial *** It is important for patients with PIMM to receive comprehensive treatment to enable the application of the most appropriate treatment ***-term survival is not impossible in patients with these malignancies.

关键词： Primary intracranial malignant melanoma Immunotherapy Newcastle disease virus-modified tumor vaccine β-elemene Long-term survival Case report

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Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells

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Chinese Journal of Cancer 2011年第10期30卷 690-700页

作者： Yao Wang Rui-Qing Peng Dan-Dan Li Ya Ding xiao-Qi Wu Yi-Xin Zeng xiao-Feng Zhu xiao-shi zhang State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Biotherapy Center Department of Experimental Research Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Chemotherapy Zhongshan People＇s Hospital Zhongshan Guangdong 528403 P. R. China

Although the anti-malaria drug chloroquine(CQ) has been shown to enhance chemotherapy and radiation sensitivity in clinical trials,the potential mechanisms underlying this enhancement are still ***,we examined the relevant mechanisms by which the multipotent CQ enhanced the cytotoxicity of topotecan(TPT).The lung cancer cell line A549 was treated with TPT alone or TPT combined with CQ at non-cytotoxic *** viability was assessed using the MTT *** percentage of apoptotic cells and the presence of a side population of cells were both determined by flow *** and the expression of Bcl-2 family proteins were examined by Western *** accumulation of YFP-LC3 dots and the formation of acidic vesicular organelles were examined by confocal *** sensitized A549 cells to TPT and enhanced TPT-induced apoptosis in a Bcl-2 family protein-independent *** inhibited TPT-induced autophagy,which modified the cytotoxicity of ***,CQ failed to modify the transfer of TPT across the cytoplasmic membrane and did not increase lysosomal *** study showed that CQ at non-cytotoxic concentrations potentiated the cytotoxicity of TPT by interfering with autophagy,implying that CQ has significant potential as a chemotherapeutic enhancer.

关键词：细胞毒作用肺癌细胞自噬拓扑氯喹细胞毒性共聚焦显微镜 A549细胞

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Determination of Resistance to Lodging by Stem Strength in Wheat

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Agricultural Sciences in China 2002年第3期1卷 280-284页

作者： xiao shi-he, zhang Xiu-ying, YAN Chang-sheng, zhang Wen-xiang,HAI Lin and GUO Hui-jun( Institute of Crop Breeding and Cultivation , CAAS , Beijing 100081 ) Institute of Crop Breeding and Cultivation CAAS Beijing 100081

Stem strength affects directly the resistance of wheat plant to lodging. Unfortunately, the determination of the stem strength is not perfect for wheat breeding and genetics up to now. In this study a prostrate tester was engaged for testing the stem strength of 661 wheat varieties and of 1183 single plants from a F2 population. The results showed that the suitable time to determine the stem strength should be from milk stage to dough ripe stage. The stem strength at the maturity would decrease and it was not easy to distinguish the difference among the varieties. The single plant with a strong stem could be judged using the prostrate tester from the F2 population. By testing the stem strength and anatomic characters of 30 varieties, a significant negative relationship between the pith diameter of the upper internodes and the stem strength was observed. On the other hand, there was a significant positive relationship between the stem diameter of the lower internodes and stem strength. It was suggested that a wheat breeder should breed the cultivar with a strong stem, because the spike weight and biomass yield were significantly related to the stem strength.

关键词： Wheat Lodging resistance Stem strength

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相位梯度界面对光传播规律的影响

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物理学报 2017年第2期66卷 147-158页

作者：肖啸谢世伟张志友杜惊雷四川大学物理科学与技术学院成都610064 乐山师范学院物理与电子工程学院乐山614000

在两种介质分界面上引入相位梯度形成相位梯度界面,这将使该界面的出射光和入射光之间产生相移.因此,与普通分界面不同,该界面对光的传播行为有着重大影响.为深入认识梯度相位界面的光学特性,本文研究了光在该类界面上的一般性传播规律... 详细信息

在两种介质分界面上引入相位梯度形成相位梯度界面,这将使该界面的出射光和入射光之间产生相移.因此,与普通分界面不同,该界面对光的传播行为有着重大影响.为深入认识梯度相位界面的光学特性,本文研究了光在该类界面上的一般性传播规律.从费马原理出发,采用稳态相位法推导了基于相位梯度界面条件下的二维和三维广义反射和折射定律,该定律表明分界面也会成为影响光传播行为的重要因素,可以作为新的波前调制工具.利用广义反射和折射定律讨论了相位梯度对光传播行为的影响规律,得出了二维和三维情形下的临界条件(全反射和全透射条件),阐明了反射角不等于入射角、异常反射和折射、非平面反射和折射等一些新颖光学现象出现的原因;提出了以相位梯度界面为光学变换核心单元,依据广义反射和折射定律进行光学设计的思路,并以平面透镜和平面轴锥镜为例进行了详细说明与实验验证,实验结果和理论值符合较好,可为拓展广义定律在平面光学设计、自由曲面光学设计以及复杂光束控制中的应用提供参考.

关键词：相位梯度界面广义反射定律广义折射定律平面光学

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A Convenient Synthesis of Octahydro-pyrazino [ 1,2- a ] pyrazine

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有机化学 2003年第Z1期23卷 248-248页

作者： LIANG Feng WU xiao-Jun zhang shi-Wei WU Cheng-Tai Department of Chemistry Wuhan University Wuhan 430072 Department of Chemistry Wuhan University Wuhan 430072 State Key Laboratory for Structural Chemistry of Stable and Unstable Species Peking University Beijing 100871 Department of Chemistry Wuhan University Wuhan 430072

　　The recent research results suggest that a series of octahydro-pyrazino[ 1,2-a ]pyrazines are useful as antiallergic agents.[1] Gubert et al. [2] developed a route from 1,4-dibenzyl-2-ethoxycarbonylpiperazine for the synthesis of this ring system. Under their conditions, this ring system was obtained with a low overall yield in six steps. Optimization of synthetic route to this ring system is still desirable. In this paper, we presented an efficient synthesis of octahydropyrazino[1,2-a]pyrazine by a new and efficient method starting from 1,3-dichloro-2-propanol and N-tosylated diethylenetriamine. The structure of title compound was determined by spectroscopy and X-ray diffraction technique.……

关键词： efficient synthesis antiallergic agents research results efficient method

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