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Study on the efficacy of early treatment with pirfenidone on the lung function of patients with idiopathic pulmonary fibrosis

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World Journal of Clinical Cases 2024年第22期12卷 4913-4923页

作者： Ying Lei Jian-Hui Sheng Xu-ru Jin Xian-Bing Liu xiao-Yan Zheng xiao-Hua Xu Department of Pulmonary and Critical Care Medicine The Quzhou Affiliate Hospital of Wenzhou Medical UniversityQuzhou 324000Zhejiang ProvinceChina Department of Clinical Laboratory The Quzhou Affiliate Hospital of Wenzhou Medical UniversityQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Idiopathic pulmonary fibrosis(IPF)is classified under fibrotic interstitial pneumonia,characterized by a chronic and progressive *** predominant clinical features of IPF include dyspnea and pulmonary *** To assess the effects of pirfenidone in the early treatment of IPF on lung function in *** A retrospective analysis was performed on 113 patients with IPF who were treated in our hospital from November 2017 to January *** patients were divided into two groups:control group(n=53)and observation group(n=60).In the control group,patients received routine therapy in combination with methylprednisolone tablets,while those in the observation group received routine therapy together with *** applying these distinct treatment approaches to the two groups,we assessed several parameters,including the overall effectiveness of clinical therapy,the occurrence of adverse reactions(e.g.,nausea,vomiting,and anorexia),symptom severity scores,pulmonary function index levels,inflammatory marker levels,and the 6-min walk distance before and after treatment in both *** The observation group exhibited significantly higher rates than the control group after therapy,with a clear distinction(P<0.05).After treatment,the observation group experienced significantly fewer adverse reactions than the control group,with a noticeable difference(P<0.05).When analyzing the symptom severity scores between the two groups of patients after treatment,the observation group had significantly lower scores than the control group,with a distinct difference(P<0.05).When comparing the pulmonary function index levels between the two groups of patients after therapy,the observation group displayed significantly higher levels than the control group,with a noticeable difference(P<0.05).Evaluating the inflammatory marker data(C-reactive protein,interleukin-2[IL-2],and IL-8)between the two groups of patients after therapy,the observation group

关键词： Pirfenidone Early intervention Idiopathic pulmonary fibrosis Pulmonary function Effect evaluation

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头足类遗传变异研究进展

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水产学报 2001年第1期25卷 84-89页

作者：郑小东王如才王昭萍青岛海洋大学国家教育部海水养殖重点实验室!山东青岛266003

头足类在分类上属软体动物门头足纲动物,主要包括乌贼、枪乌贼、柔鱼和蛸四大类,全部海产.近几十年来,它逐步成为世界主要的海洋渔业之一,尤其在无脊椎动物中占有重要地位.1978-1988年间,全世界头足类产量已达2×106t[1].头足类具有高... 详细信息

头足类在分类上属软体动物门头足纲动物,主要包括乌贼、枪乌贼、柔鱼和蛸四大类,全部海产.近几十年来,它逐步成为世界主要的海洋渔业之一,尤其在无脊椎动物中占有重要地位.1978-1988年间,全世界头足类产量已达2×106t[1].头足类具有高营养、生活史较短(通常为一年)和生长快等特点,是一类很有前途的海水养殖种类和海洋中最大、最具潜在价值的蛋白质资源[2],而且占据着海洋生物食物链举足轻重的位置.现存的头足类种类有983种,共计206属,有效种名的650种左右[3].我国是世界捕捞头足类的主要国家之一,而且有丰富的种质资源,已发现的种类达95种,分属6目,21科,45属[4].

关键词：头足类遗传变异

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时间比值法测量水蒸气流导

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东北大学学报（自然科学版） 2024年第5期45卷 707-712页

作者：耿健王晓冬郭美如任正宜东北大学机械工程与自动化学院辽宁沈阳110819 兰州空间技术物理研究所真空技术与物理重点实验室甘肃兰州730000

目前很少有方法能够测量水蒸气通过小孔的流导.通过理论与实验相结合的方法分析了使用压升法测量水蒸气流导的可行性,该方法测量结果的误差随着进气量的减小而增加,这是因为水蒸气具有较强的吸附特性.为了准确得到水蒸气进气压力与流导... 详细信息

目前很少有方法能够测量水蒸气通过小孔的流导.通过理论与实验相结合的方法分析了使用压升法测量水蒸气流导的可行性,该方法测量结果的误差随着进气量的减小而增加,这是因为水蒸气具有较强的吸附特性.为了准确得到水蒸气进气压力与流导之间的关系式,基于压升法提出了时间比值法.该方法通过测量压力变化的时间计算流导,有效地减小了水蒸气吸附作用对测量结果的影响.使用该方法搭建了一个可以提供流量为3.7×10^(-9)~1.5×10^(-5)Pa·m^(3)·s^(-1)的装置.流导测量值与理论值一致性较好.时间比值法的相对标准不确定度是3.3%.

关键词：水蒸气流导不确定度测量

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Challenges and Suggestions of Ethical Review on Clinical Research Involving Brain-Computer Interfaces

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Chinese Medical Sciences Journal 2024年第2期39卷 131-139页

作者： Xue-Qin wang Hong-Qiang Sun Jia-Yue Si Zi-Yan Lin xiao-Mei Zhai Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Chinese Academy of Medical Sciences Research Unit(No.2018RU006)Beijing 100191China Department of Psychology University of CaliforniaDavis 95616USA Department of Psychology University of TorontoToronto M5S 1A1Canada School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Academy for Advanced Interdisciplinary Studies Peking-Tsinghua Centre for Life Sciences and Peking University-International Development Group/McGovern Institute for Brain ResearchPeking UniversityBeijing 100871China

Brain-computer interface(BCI)technology is rapidly advancing in medical research and *** an emerging biomedical engineering technology,it has garnered significant attention in the clinical research of brain disease diagnosis and treatment,neurological rehabilitation,and mental ***,BCI also raises several challenges and ethical concerns in clinical *** this article,the authors investigate and discuss three aspects of BCI in medicine and healthcare:the state of international ethical governance,multidimensional ethical challenges pertaining to BCI in clinical research,and suggestive concerns for ethical *** the great potential of frontier BCI research and development in the field of medical care,the ethical challenges induced by itself and the complexities of clinical research and brain function have put forward new special fields for ethics in *** ensure"responsible innovation"in BCI research in healthcare and medicine,the creation of an ethical global governance framework and system,along with special guidelines for cutting-edge BCI research in medicine,is suggested.

关键词： brain-computer interface clinical research bioethics ethical governance ethical review

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Oxygen vacancy promoting artificial atom(ruPd)by d-orbital coupling for efficient water dissociation

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Nano Research 2024年第8期17卷 7045-7052页

作者： ruofan Shen Yanyan Liu Shuling Liu Shuyan Guan Huanhuan Zhang Sehrish Mehdi Saima Ashraf Ting-Hui xiao Erjun Liang Jianchun Jiang Yongfeng wang Baojun Li Laboratory of Zhongyuan Light School of PhysicsZhengzhou UniversityZhengzhou 450001China Key Laboratory of Materials Physics Ministry of EducationSchool of PhysicsZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China College of Science Henan Agricultural UniversityZhengzhou 450002China Department of Chemistry Tsinghua UniversityBeijing 100084China National Engineering Lab.for Biomass Chemical Utilization Institute of Chemical Industry of Forest ProductsCAFNanjing 210042China Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices Department of ElectronicsPeking UniversityBeijing 100871China

Rational design of highly active catalysts for breaking hydrogen-oxygen bonds is of great significance in energy chemical reactions involving ***,an efficient strategy for the artificial atom(ruPd)established by d-orbital coupling and adjusted by oxygen vacancy(V_(O))is verified for water *** an experimental verification,the turnover frequency of ruPd-TiO_(2)-VO(ruPdTVO)catalyst in ammonia borane hydrolysis reaches up to 2750 min^(−1)(26,190 min−1 based on metal dispersion)in the absence of alkali,exceeding the highest active catalysts(Rh-based catalysts).The d-orbital coupling effect between ru and Pd simulates the outer electronic structure of *** transfer from V_(O) to(ruPd)constructs an electron-rich state of active sites that further enhances the ability of the artificial atom to dissociate *** work provides an effective electronic regulation strategy from V_(O) and artificial atom constructed by d-orbital coupling effect for efficient water dissociation.

关键词： ammonia borane hydrolysis d-orbital coupling oxygen vacancy artificial atom water dissociation

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Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases:Mechanisms and future perspectives

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World Journal of Gastroenterology 2024年第5期30卷 429-439页

作者： Ya-Wei Bi Long-Song Li Nan ru Bo Zhang xiao Lei Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Radiation Oncology Chinese PLA General HospitalBeijing 100853China

Pancreatitis and pancreatic cancer(PC)stand as the most worrisome ailments affecting the *** have dedicated efforts to unraveling the mechanisms underlying these diseases,yet their true nature continues to elude their *** this realm,oxidative stress is often believed to play a causal and contributory role in the development of pancreatitis and *** accumulation of reactive oxygen species(ROS)can cause oxidative stress,and the key enzyme responsible for inducing ROS production in cells is nicotinamide adenine dinucleotide phosphate hydrogen oxides(NOX).NOX contribute to pancreatic fibrosis and inflammation by generating ROS that injure acinar cells,activate pancreatic stellate cells,and mediate macrophage *** ROS production occurs during malignant transformation and pancreatic carcinogenesis,creating an oxidative microenvironment that can cause abnormal apoptosis,epithelial to mesenchymal transition and genomic ***,understanding the role of NOX in pancreatic diseases contributes to a more in-depth exploration of the exact pathogenesis of these *** this review,we aim to summarize the potential roles of NOX and its mechanism in pancreatic disorders,aiming to provide novel insights into understanding the mechanisms underlying these diseases.

关键词： Nicotinamide adenine dinucleotide phosphate hydrogen oxides Pancreatitis Pancreatic cancer Reactive oxygen species Mechanism

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氮添加和铵硝态氮配比对杉木幼苗光合特性及叶绿素荧光参数的影响

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植物生态学报 2024年第8期48卷 1050-1064页

作者：全小强王燕茹李小玉梁海燕王立冬闫小莉福建农林大学林学院福州350002 国家林业和草原局杉木工程技术研究中心福州350002

研究不同氮添加水平和铵硝态氮配比对杉木(Cunninghamia lanceolata)幼苗叶片光合特性和叶绿素荧光参数的影响,从光合生理生态的角度探讨杉木幼苗对氮逆境的短期响应,可以为杉木栽培中氮肥的经营管理提供理论依据。该研究以一年生杉木... 详细信息

研究不同氮添加水平和铵硝态氮配比对杉木(Cunninghamia lanceolata)幼苗叶片光合特性和叶绿素荧光参数的影响,从光合生理生态的角度探讨杉木幼苗对氮逆境的短期响应,可以为杉木栽培中氮肥的经营管理提供理论依据。该研究以一年生杉木幼苗为材料,设置3个氮添加水平:0.5(N_(1))、1.0(N_(2))和2.0 mmol·L^(-1)(N_(3))及7个铵态氮:硝态氮的配比:10:0(P_(1))、8:2(P_(2))、6:4(P_(3))、5:5(P_(4))、4:6(P_(5))、2:8(P_(6))和0:10(P_(7))的21个实验处理组,沙培盆栽处理180天后,测定幼苗叶绿素含量、光合特性、叶绿素荧光参数、生物量等指标。结果表明:(1)在N_(1)水平下,叶绿素a和b含量分别在P_(2)和P_(6)配比下最高;在N_(2)水平下,叶绿素a和b及叶绿素(a+b)含量均为P_(4)配比下最高;在N_(3)水平下,叶绿素a和b含量均在P_(3)配比下最高,整体上表现为N_(3)和N_(2)高于N_(1)。(2)叶片净光合速率(Pn)、气孔导度(Gs)、蒸腾速率(Tr)和水分利用效率(WUE)均为较高铵态氮浓度的配比处理高于较高硝态氮浓度的配比处理;Pn在N_(3)水平为P_(1)配比最高,但在N_(1)和N_(2)水平为P_(2)配比最高,整体上Pn和WUE均表现为:N_(3)>N_(2)>N_(1)。(3)各处理的最大光化学效率均在0.80-0.85的正常范围内,光系统II潜在光化学活性在P_(2)配比下N_(3)显著高于N_(1)和N_(2);叶片快速叶绿素荧光诱导曲线在N_(1)的P_(1)配比下曲线偏离程度大,N_(2)水平的P_(1)、P_(2)和P_(4)配比和N_(3)水平的P_(1)、P_(2)和P_(5)配比在I、P相逐渐降低,J相逐渐上升;P_(2)和P_(3)配比下单位面积吸收、捕获和传递的光能以及热耗散和反应中心的数量随氮浓度的升高明显增大,而P_(6)配比下单位反应中心吸收、捕获和传递的能力以及耗散掉的能量随氮浓度的升高明显降低,其他配比下差异不显著。最大光化学效率在各处理间无显著差异表明该研究模拟的低氮水平和氮形态异质性配比的环境未对杉木幼苗生长造成胁迫。(4)总生物量和地上生物量均表现为较高铵态氮浓度的配比处理大于较高硝态氮浓度的配比处理,其中N_(2)P_(2)处理下最高,氮添加水平间表现为N_(2)>N_(3)>N_(1)。根冠比在N_(1)和N_(3)水平均为P_(6)配比显著高于其他处理,N_(2)水平为P_(7)显著高于其他处理,且整体上N_(1)水平的根冠比显著高于N_(2)和N_(3)。相对较高的氮添加水平和铵态氮浓度配比的环境能提高杉木幼苗光化学反应效率,优化光系统II反应中心的能量利用,最终促进其光合作用和生物量的积累。

关键词：氮添加铵硝态氮配比光合特征叶绿素荧光杉木

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High-throughput screening of novel TFEB agonists in protecting against acetaminopheninduced liver injury in mice

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Acta Pharmaceutica Sinica B 2024年第1期14卷 190-206页

作者： xiaojuan Chao Mengwei Niu Shaogui wang xiaowen Ma xiao Yang Hua Sun Xujia Hu Hua wang Li Zhang ruili Huang Menghang Xia Andrea Ballabio Hartmut Jaeschke Hong-Min Ni Wen-Xing Ding Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160USA NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityHefei 230032China National Center for Advancing Translational Sciences National Institutes of HealthBethesdaMD 20892USA Telethon Institute of Genetics and Medicine TIGEMPozzuoliNaples 80131Italy Medical Genetics Department of Translational MedicineFederico II UniversityNaples 80131Italy Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Department of Internal Medicine Division of GastroenterologyHepatology&MotilityUniversity of Kansas Medical CenterKansas CityKS 66160USA

Macroautophagy(referred to as autophagy hereafter)is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and *** studies showed that autophagy protects against acetaminophen(APAP)-induced injury(AILI)via selective removal of damaged mitochondria and APAP protein *** lysosome is a critical organelle sitting at the end stage of autophagy for autophagic degradation via fusion with *** the present study,we showed that transcription factor EB(TFEB),a master transcription factor for lysosomal biogenesis,was impaired by APAP resulting in decreased lysosomal biogenesis in mouse *** loss-of and gain-of function of hepatic TFEB exacerbated or protected against AILI,***,overexpression of TFEB increased clearance of APAP protein adducts and mitochondria biogenesis as well as SQSTM1/p62-dependent non-canonical nuclear factor erythroid 2-related factor 2(NRF2)activation to protect against *** also performed an unbiased cell-based imaging high-throughput chemical screening on TFEB and identified a group of TFEB *** these agonists,salinomycin,an anticoccidial and antibacterial agent,activated TFEB and protected against AILI in *** conclusion,genetic and pharmacological activating TFEB may be a promising approach for protecting against AILI.

关键词： Autophagy DILI Drug screening Hepatotoxicity Lysosome Mitochondria Mitophagy NRF2

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Research progress of traditional Chinese medicine in the treatment of endocrine metabolic diseases in 2023

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Traditional Medicine Research 2024年第12期9卷 51-65页

作者： Ming-Yao Fan Jing ru Si wang Yan Chen xiao-Xia Zhang Guo-Long Li Qing-Shan Hai Wei-Bo Wen Huan-Tian Cui College of Basic Medical of Yunnan University of Chinese Medicine Kunming 650000China Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment Kunming 650000China The First Clinical Medical College of Yunnan University of Chinese Medicine Kunming 650000China Department of Endocrinology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650000China Yunnan Engineering Research Centre of Preventive Treatment of Chinese Medicine First Affiliated HospitalYunnan University of Chinese MedicineKunming 650000China

This study aimed to provide a comprehensive review of the research progress in Chinese medicine in the treatment of endocrine metabolic diseases in 2023,covering traditional Chinese medicine(TCM)monomers,TCM extracts,and TCM combinations,including non-alcoholic fatty liver disease,type 2 diabetes mellitus and its complications,obesity,hyperuricaemia,and thyroid *** systematic sorting and summary,we found that in 2023,the research focusing on the application of TCM for endocrine metabolic diseases was still on the mechanism of action at the cellular and molecular levels,which not only influenced the classical pathways of lipid metabolism,but also delved into the key mechanisms of anti-inflammation,anti-oxidation,anti-insulin resistance,and so ***,TCM has shown remarkable results in the treatment of endocrine metabolic diseases by improving intestinal flora disorders and abnormal cellular iron *** research results provide valuable ideas,methods,and tools for TCM in the prevention and treatment of endocrine metabolic diseases,and provide important references and guidance for future research and practice.

关键词： endocrine metabolic diseases traditional Chinese medicine Chinese medicine extracts Chinese medicine compound therapeutic mechanism

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数字经济、新质生产力与农业高质量发展

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科学管理研究 2024年第4期42卷 113-123页

作者：高祥晓王永强卢秀茹河北农业大学经济管理学院河北保定071000

选取2015-2022年274个地级市及以上面板数据,并以多种计量模型为基础,实证分析数字经济、新质生产力以及农业高质量发展三者间关系。研究结果显示,数字经济可有效赋能农业高质量发展,且经过稳健性检验后该结论依旧保持成立。异质性分析... 详细信息

选取2015-2022年274个地级市及以上面板数据,并以多种计量模型为基础,实证分析数字经济、新质生产力以及农业高质量发展三者间关系。研究结果显示,数字经济可有效赋能农业高质量发展,且经过稳健性检验后该结论依旧保持成立。异质性分析表明,数字经济的赋能效应在大型城市以及发达城市中更为显著。中介效应检验结果得出,新质生产力在数字经济与农业高质量发展间发挥中介效应。门槛效应检验结果发现,数字经济对农业高质量发展的作用存在非线性特征,在数字经济约束下该作用边际效应呈现倒“U”型特征,在新质生产力约束下呈现边际效应递增特征。故此,提出打造数字经济发展新优势、推动新质生产力多元化发展以及制定差异化数字经济发展策略的政策建议,为加快农业高质量发展提供助益。

关键词：数字经济新质生产力农业高质量发展农业强国

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