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Improvement of cardiac function and reversal of gap junction remodeling by Neuregulin-1β in volume-overloaded rats with heart failure

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Journal of Geriatric Cardiology 2012年第2期9卷 172-179页

作者： Xue-Hui wang xiao-Zhen Zhuo Ya-Juan Ni Min Gong Ting-Zhong wang qun Lu Ai-qun Ma Department of Cardiovascular Medicine the First Affiliated Hospital of Medical SchoolXi'an Jiaotong UniversityNo.277 West Yanta RoadXi'an 710061 Shaanxi ProvinceChina Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationXi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Cardiovascular Medicine First Hospital of 33nxiang Medical College33nxiang 453000Henan ProvinceChina

Objective We performed experiments using Neuregulin-1β （NRG-1β） treatment to determine a mechanism for the protective role derived from its beneficial effects by remodeling gap junctions （GJs） during heart failure （HF）. Methods Rat models of I-IF were established by aortocaval fistula. Forty-eight rats were divided randomly into the HF （HF, n = 16）, NRG-1β trealanent （NRG, n = 16）, and sham operation （S, n = 16） group. The rats in the NRG group were administered NRG-1β （10 μg/kg per day） for 7 days via the tail vein, whereas the other groups were injected with the same doses of saline, Twelve weeks after operation, Connexin 43 （Cx43） expression in single myocytes obtained from the left ventricle was determined by immunocytochemistry. Total protein was extracted from frozen left ventricular tissues for immunoblotting assay, and the ultrastmcture of myocytes was observed by transmission electron microscopy. Results Compared with the HF group, the cardiac fimction of rats in the NRG group was markedly improved, irregular distribution and deceased Cx43 expression were relieved. The ultrastmcture of myocytes was seriously damaged in HF rats, and NRG-1β reduced these pathological damages. Conclusions Short-term NRG-1β treatment can rescue pump failure in experimental models of volume overload-induced HF, which is related to the recovery of GJs structure and the improvement of Cx43 expression.

关键词： qeuregulin-1β Cardiac function Heart failure Connexin 43 Gap junction Remodeling

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MiR-146a rs2910164 polymorphism increases risk of gastric cancer:A meta-analysis

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World Journal of Gastroenterology 2014年第41期20卷 15440-15447页

作者： Wen-qun Xie Shi-Yun Tan xiao-Fan wang Department of Gastroenterology Renmin Hospital of Wuhan University

AIM: To systematically evaluate the association between the miR-146a rs2910164 polymorphism and susceptibility to gastric cancer.

关键词： Gastric cancer MiR-146a Polymorphism Risk Meta-analysis

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Effect of hydraulic fracturing induced stress field on weak surface activation during unconventional reservoir development

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Petroleum Science 2023年第5期20卷 3119-3130页

作者： Jie Bai xiao-Qiong wang Hong-Kui Ge Hu Meng Ye-qun Wen Unconventional Petroleum Research Institute China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China

Unconventional reservoirs usually contain many weak surfaces such as faults,laminae and natural fractures,and effective activation and utilization of these weak surfaces in reservoirs can significantly improve the extraction *** hydraulic fracturing,when the artificial fracture approaches the natural fracture,the natural fracture would be influenced by both the original in-situ stress field and the hydraulic fracturing-induced stress *** this paper,the hydraulic fracturing-induced stress field is calculated based on the relative position of hydraulic fracture and natural fracture,the original in-situ stress,the net pressure inside the hydraulic fracture and the pore pressure of the ***,the stability model of the natural fracture is established by combining the Mohr-Coulomb rupture criterion,and extensive parametric studies are conducted to explore the impact of each parameter on the stability of the natural *** validity of the proposed model is verified by comparing with the reservoir characteristics and fracturing process of the X-well 150e155 formation in the Songliao *** is found that the stress field induced by the hydraulic fracture inhibits the activation of the natural fracture after the artificial fracture crossed the natural ***,for similar reservoirs as X-well 150e155,it is suggested to connect natural fractures with hydraulic fractures first and then activate natural fractures which can effectively utilize the natural fractures and form a complex fracture network.

关键词： Hydraulic fracturing Induced stress field Weak surface Natural fracture stability Fracturing characteristics

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NiO nanoparticles-decorated ZnO hierarchical structures for isopropanol gas sensing

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Rare Metals 2022年第3期41卷 960-971页

作者： Shi-Chao wang xiao-Hu wang Gao-qun Qiao xiao-Yan Chen Xin-Zhen wang Nan-Nan Wu Jian Tian Hong-Zhi Cui School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

In this paper,a three-dimensional(3D)hierar-chical ZnO structure consisting of nanosheets modified with ultrafine NiO particles was synthesized via a facile two-step chemical precipitate *** techniques characterized the as-synthesized ZnO/NiO composites and pure *** p-NiO/n-ZnO junctions formed between adjacent ZnO and NiO nanoparticles,improving the gas sensing *** ZnO/NiO composite with the Ni:Zn atomic ratio of 7.42:100 exhibited the best iso-propanol sensing *** to pure ZnO,it showed high selectivity and sensitivity(R_(a)/R_(g)=221.3 toward 400×10^(-6)isopropanol),fast response rate(less than 10 s),short recovery time,and simultaneously low operating ***,the ZnO/NiO composite exhibited a wide sensing range(1×10^(-6)-1000×10^(-6))to isopropanol and processed good long-term *** experimental results suggested the potential application in fabricating efficient isopropanol sensors using this ZnO/NiO *** enhanced isopropanol sensing mech-anism is also discussed in charge transfer between heterojunctions,surface area,and surface defects.

关键词： ZnO NiO Hierarchical structure Gas sensor Isopropanol

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Simulation of the dynamic disturbance characteristics of the soft sediment in the Diexi ancient dammed lake,China

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Journal of Mountain Science 2021年第4期18卷 990-1002页

作者： wang xiao-qun WEI Jie ZHAO Jia-kang ZHOU Zhou HUANG Xin College of Environment Geology and Civil Engineering Chengdu University of TechnologyChengdu 610059China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China JSTI Group Nanjing 211100China

In an earlier study of the Diexi ancient dammed lake along the Minjiang River in Southwest China,10 disturbed layers with envelope and flame structures were found in more than 240 m of lacustrine *** this paper,the soft-sediment disturbances caused by earthquakes in the Diexi ancient dammed lake were studied based on field investigations and laboratory core observations.A two-to three-degree-of-freedom spring-type earthquake simulation vibration table was used to carry out disturbance tests on lacustrine sediments under different dynamic *** results support the following conclusions:(1)The disturbance layers in the lacustrine sediments were caused by strong earthquakes in the region.(2)The characteristics of the disturbance layers are related to the seismic parameters and the degree of sediment consolidation.(3)The greater the earthquake intensity is,the greater the disturbance amplitude is;moreover,the lower the consolidation degree is,the greater the disturbance amplitude.(4)The simulation tests verify that the disturbance layers in the sediments of the Diexi ancient dammed lake correspond to strong earthquakes in the *** results are valuable for ongoing palaeoseismic research in the region.

关键词： Ancient dammed lake Lacustrine sediment Soft sediment Palaeoearthquake Simulation test

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磁性纳米材料与磁场效应加速骨损伤修复

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中国组织工程研究 2025年第4期29卷 827-838页

作者：肖放黄雷王琳华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心湖北省武汉市430022 华中科技大学同济医学院附属协和医院检验科湖北省武汉市430022

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进... 详细信息

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进展。方法:在PubMed和Web of Science数据库中进行相关文献检索,检索词为“magnetic nanomaterials,magnetic field,bone repair,bone tissue engineering,stem cell,osteoblast,osteoclast”。检索文献时限为2003-2023年,将其进行筛选和分析,最终纳入98篇文献进行分析。结果与结论:①磁性纳米材料具有促成骨细胞分化、抑制破骨细胞形成和调节免疫微环境等生物效应;此外,磁性纳米材料可调节组织工程支架的机械性能和表面形貌等理化性质,并赋予其磁性,有利于调控干细胞的黏附、增殖与成骨分化。②磁场具有调控细胞内多条信号通路发挥促成骨细胞分化、抑制破骨细胞形成和刺激血管生成等生物学效应,从而加速损伤的骨组织愈合。③磁性纳米材料与磁场的联合应用,通过激活机械转导、增加细胞内磁性纳米粒子含量、增强微磁场效应等加速骨损伤修复,为骨组织工程的研究提供了新的思路。④磁场在临床骨折、骨质疏松症和骨关节炎疾病的治疗中展现出确切疗效,促进骨组织生长、减轻骨质流失和缓解疼痛,改善患者的生活质量。⑤磁性纳米材料与磁场在骨损伤修复与再生中应用潜力大,但磁性纳米材料、磁场和细胞之间的相互作用机制尚未完全阐明,而且磁场调控细胞内分子事件的关键参数,包括磁场类型、强度、频率、作用时间和作用方式等,以及特定磁场对骨细胞的精确生物效应和潜在机制仍有待明确。⑥未来需要进一步关注其对损伤组织微环境中的破骨细胞、神经、血管和免疫细胞的影响,而关于磁性材料用于人体安全性问题,有待系统性研究其分布、代谢以及急性和慢性毒性等。

关键词：磁性纳米材料磁场骨修复骨组织工程干细胞成骨细胞破骨细胞

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Amphiphilic miktoarm star copolymers can self-assemble into micelle-like aggregates in nonselective solvents: a case study of polyoxometalate based miktoarm stars

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Science China Chemistry 2020年第6期63卷 792-801页

作者： Jie xiao qun He Shengchao Qiu Haoquan Li Binghua wang Bin Zhang Weifeng Bu Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province State Key Laboratory of Applied Organic Chemistryand College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China School of Materials Science&Engineering Zhengzhou UniversityZhengzhou 450002China

It is well-known that amphiphilic star-shaped copolymers can self-assemble in selective solvents to form complicated micellar constructs as a synergistic result of both the topological constraints and relative volume fractions of the *** the association phenomena of amphiphilic stars have been observed in nonselective solvents,both the structural detail and formation mechanism of these associates are not clear ***,these experimental observations are controversial with respect to molecularly dispersed starlike copolymers in nonselective solvents as is popularly *** clarify these issues,we have synthesized a series of polyoxometalate-based polystyrene-poly(ethylene glycol)(PS-PEG)miktoarm star supramolecular copolymers(SEW-1–5)by coupling a Keggin-type polyoxometalate of K4[α-SiW12O40]with 1,2,3-triazolium bridged block copolymers of-PSn-b+-PEGmI-(n=17,26,39,57,81;m=45)through ionic exchange reactions,*** imaging,contact angle and 1H NMR studies reveal that SEW-2–5 self-assemble in chloroform,THF,and toluene to create micellelike aggregates ranging from cylinder to sphere with a PS corona and a PEG core,while for SEW-1,reverse bilayers are captured with a PEG corona and a PS *** these aggregates,the Keggin clusters of[α-SiW12O40]4-localize at the core-corona interfaces between PS and *** terms of solvent quality,chloroform,THF,and toluene are only slightly poorer for PEG than that for PS with a relative order of chloroform

关键词： miktoarm star copolymer self-assembly micellelike aggregate nonselective solvent polyoxometalate

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Segmental small bowel necrosis associated with antiphospholipid syndrome:A case report

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World Journal of Gastroenterology 2015年第13期21卷 4096-4100页

作者： qun-Ying wang xiao-Hua Ye Jin Ding xiao-Kang Wu Department of Gastroenterology and Hepatology Jinhua Municipal Central Hospital Jinhua Hospital of Zhejiang University Department of Hepato-Biliary-Pancreatic Surgery Jinhua Municipal Central Hospital

Antiphospholipid syndrome is a multi-system disease characterized by the formation of thromboembolic complications and/or pregnancy morbidity, and with persistently increased titers of antiphospholipid antibodies. We report the case of a 50-year-old, previously healthy man who presented with fever and new-onset, dull abdominal pain. A contrast-enhanced computed tomography scan showed segmental small bowel obstruction, for which an emergency laparotomy was performed. Histopathologic examination of resected tissues revealed multiple intestinal and mesenteric thromboses of small vessels. Laboratory tests for serum antiphospholipid(anticardiolipin Ig M) and anti-β2-glycoprotein I antibodies were positive. Despite proactive implementation of anticoagulation, steroid, and antibiotic therapies, the patient's condition rapidly deteriorated, and he died 22 d after admission. This case highlights that antiphospholipid syndrome should be suspected in patients with unexplainable ischemic bowel and intestinal necrosis presenting with insidious clinical features that may be secondary to the disease, as early diagnosis is critical to implement timely treatments in order to ameliorate the disease course.

关键词： Anticardiolipin antibodies Antiphospholipid syndro

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Wetting Behavior between Droplets and Dust

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Chinese Physics Letters 2012年第2期29卷 170-173页

作者： YU Yang WU qun wang Xue-Wei YANG xiao-Bin Biomechanics and Biomaterials Laboratory Department of MechanicsSchool of Aerospace EngineeringBeijing Institute of TechnologyBeijing 100081 School of Resource and Safety Engineering China University of Mining and Technology(Beijing)Beijing 100083

The wetting behavior of dust by droplets is investigated by experiments and numerical simulation *** observation reveals that the surface of a coal slice is hydrophilic in nature,while surfaces of coal dust stacks are *** show that water droplets settle on these surfaces following the Cassie-Baxter wetting model,as supported by theoretical,numerical analyses and experimental observations,*** droplets only wet the first layer of coal *** numerical simulation results also show that a water droplet could not enclose any coal dust inside it and many coal dust particles are adhered with a hexagonal close packing on a large water *** on these results,we conclude that the surface area of water droplets is an important factor on their wetting and capturing coal dust,and producing smaller water droplets can improve the efficiency of settling dust.

关键词： numerical settling packing

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： xiao-Yu Zhao Juan-Han Yu Yi-Hua wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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