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Predictive Value of Dynamic Peri-Transplantation MRD Assessed By MFC Either Alone or in Combination with Other Variables for Outcomes of Patients with T-Cell Acute Lymphoblastic Leukemia

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Current Medical Science 2021年第3期41卷 443-453页

作者： Zhi-dong WANG Yue-wen WANG Lan-ping XU xiao-hui ZHANG Yu WANG Huan CHEN Yu-hong CHEN Feng-rong WANG Wei HAN Yu-qian SUN Chen-hua yan Fei-fei TANG xiao-dong MO Ya-zhe WANG yan-rong LIU Kai-yan LIU xiao-jun HUANG Ying-jun CHANG Peking University People's Hospital and Peking University Institute of Hematology National Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical SciencesBeijing 100005China 3Peking-Tsinghua Center for Life SciencesBeijing 100871China Peking-Tsinghua Center for Life Sciences Beijing 100871China

We performed a retrospective analysis to investigate dynamic peri-hematopoieticstem cell transplantation(HSCT)minimal/measurable residual disease(MRD)on outcomes inpatients with T-cell acute lymphoblastic leukemia(T-ALL).A total of 271 patients were enrolledand classified into three groups:unchanged ncgative MRD pre-and post-HSCT group(group A),post-MRD non-increase group(group B),and post-MRD increase group(group C).The patientsin group B and group C experienced a higher cumulative incidence of relapse(CIR)(42%vs.71%vs.16%,P<0.001)and lower leukemia-free survival(LFS)(46%vs.21%vs.70%,P<0.001)andoverall survival(OS)(50%vs.28%vs.72%,P<0.001)than in group A,but there was no significantdifference in non-relapse mortality(NRM)among three groups(14%vs.12%vs.8%,P=0.752).Multivariate analysis showed that dynamic peri-HSCT MRD was associated with CIR(HR=2.392,95%CI,1.816-3.151,P<0.001),LFS(HR=1.964,95%CI,1.546-2.496,P<0.001)and os(HR=1.731,95%CI,1.348-2.222,P<0.001).We also established a risk scoring system based ondynamic peri-HSCT MRD combined with remission status pre-HSCT and onsct of chronic graft-versus-host disease(GVHD).This risk scoring system could better distinguish ClR(c=0.730)thanthat for pre-HSCT MRD(c=0.562),post-HSCT MRD(c=0.616)and pre-and post-MRD dynamics(c=0.648).Our results confirm the outcome predictive value of dynamic peri-HSCT MRD eitheralone or in combination with other variables for patients with T-ALL.

关键词： peri-transplantation minimal residual disease risk stratification risk scoring system T-cell acute lymphoblastic leukemia

Conodonts and Carbon Isotopes during the Permian-Triassic Transition on the Napo Platform, South China

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Journal of Earth Science 2019年第2期30卷 244-257页

作者： yan Chen qian Ye Haishui Jiang Paul B.Wignall Jinling Yuan State Key Laboratory of Biogeology and Environment Geology China University of Geosciences School of Earth Sciences China University of Geosciences Non-ferrous Metals Geological Exploration Bureau of Zhejiang Province School of Earth and Environment University of Leeds

Two Permian-Triassic boundary(PTB) sections(Pojue and Dala) are well exposed in an isolated carbonate platform(Napo Platform) on the southwestern margin of the Nanpanjiang Basin, South China. These sections provide an insight into the transition across the PTB and a detailed investigation of the conodont biostratigraphy and inorganic carbon isotopes is presented. The PTB at the Pojue Section is placed at the base of Bed 10 B(a dolomitized mudstone found below a microbialite horizon), defined by the first occurrence of Hindeodus parvus. At the Dala Section, four conodont zones occur. They are, in ascending order, the Hindeodus parvus Zone, Isarcicella staeschei Zone, Isarcicella isarcica Zone and Clarkina planata Zone. Comparison with the Pojue Section suggests the PTB at Dala also occurs at the base of dolomitized mudstone below a microbialite horizon, although the first occurrence of Hindeodus parvus is near the top of a microbialite bed: an occurrence that is also seen in other platform sections. The succeeding microbialite beds developed during the ongoing PTB mass extinction phase. This time was characterized by low carbon isotope values, and a microbialite ecosystem that provided a refuge for selected groups(bivalves, ostracods and microgastropods) that were likely tolerant of extremely high temperatures.

关键词： Permian-Triassic Napo Platform conodont biostratigraphy carbon isotope

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海洋环境下摄像机图像去雾技术研究

环境技术 2024年第5期42卷 55-60,66页

作者：王鹏飞刘岩蔡晓晰陶劲松肖伟海军装备部驻上海地区第二军事代表室上海200129 中国电子科技集团公司第五十二研究所杭州311121

针对海洋雾气环境下摄像机类设备图像对比度低、能见度差的问题,提出了一种基于图像前处理的单图融合增强去雾方法,首先对大气辉光分量进行校正,其次结合图像传感器R通道透射率高的特征利用小波融合技术提升图像细节,最后利用导向滤波... 详细信息

针对海洋雾气环境下摄像机类设备图像对比度低、能见度差的问题,提出了一种基于图像前处理的单图融合增强去雾方法,首先对大气辉光分量进行校正,其次结合图像传感器R通道透射率高的特征利用小波融合技术提升图像细节,最后利用导向滤波器以进行图像去雾增强,通过实际浓雾环境下采集的图像对比处理实验验证了所提出方法的可行性、有效性。

关键词：图像去雾海雾:大气散射模型:辉光校正:图像增强

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对“电路原理”课程思政的思考与实践

科教文汇 2024年第6期 63-67页

作者：肖冬萍李新李春燕张谦重庆大学电气工程学院重庆400044

思政教育是全面贯彻党的教育方针、落实立德树人根本任务的关键所在。“电路原理”课程是高校电气信息工程专业的专业基础课程,受众面广,提升其课程思政效果具有重要意义。结合教育部对课程思政的总体要求和“电路原理”课程自身特点,... 详细信息

思政教育是全面贯彻党的教育方针、落实立德树人根本任务的关键所在。“电路原理”课程是高校电气信息工程专业的专业基础课程,受众面广,提升其课程思政效果具有重要意义。结合教育部对课程思政的总体要求和“电路原理”课程自身特点,该文提出了实施“电路原理”课程思政的目标,阐述了课程思政高质量建设的四面体(师资、内容、方法、组织)构架,基于实践体会给出了“电路原理”课程思政的意见和建议。

关键词：课程思政电路原理课程特点

Ginkgolide C Stimulates CFTR-mediate Anion Conductance in Distal Colon:Implication for Therapy of Gastrointestinal Diseases

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Chemical Research in Chinese Universities 2009年第6期25卷 909-913页

作者： LIAO Qi MA xiao-yan WU Fu-ju yanG Li-xiao WANG Shuai Second Teaching Hospital of Jilin University Changchun 130041 P. R. China The Daqing Longnan Hospital Daqing 163453 P. R. China

The effects and the mechanisms of natural compounds ginkgolides on CFTR-mediate anion transport were investigated. The CFTR-mediate iodide influx rates were studied via a cell-based fluorescence assay done for FRT cells stably transfected by CFTR; transepithelial short-circuit current recordings of FRT cells and rat distal colon mucosa were respectively obtained. Cellular cAMP concentrations were measured via a radioimmunoassay analysis kit. Ginkgolide C dose-dependently increases CFTR-mediate anion transport, whereas ginkgolide A and B show no effect. The activation is sensitive to CFTR specific activator CFTRinh-172. Ginkgolide C stimulated amiloride and indomethacin pre-treated Cl currents in rat distal colon mucosa. Studies on FRT cells also manifest that ginkgolide C had additive effect with FSK/IBMX mixture and didn＇t elevate intracellular cAMP concentration, which implies it works through a direct binding mechanism. In conclusion, Ginkgolide C directly stimulates CFTR-mediate anion transport. Ginkgolide C may be a promising drug for the prevention and treatment of CFTR-related diseases such as idiopathic chronic pancreatitis（ICP）, habitual constipation, and kcratoconjunctivitis sicca（KCS）.

关键词： Ginkgolide Cystic fibrosis transmembrane conductance regulator Fluorescence Mucosa

颗粒活性炭-纳滤对二级出水中条件致病菌和有机物的去除效能

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中国农村水利水电 2024年第9期 1-7,14页

作者：孙丽华张凯权梅筱禹李瑞瑛张妍北京建筑大学城市雨水系统与水环境教育部重点实验室北京100044 北京建筑大学环境与能源工程学院北京100044 北京市水务规划研究院北京101117

再生水回用是解决水资源短缺的重要途经,被广泛应用于工业生产、城市绿化方面,但其中含有大量的条件致病菌,对环境及人体健康具有潜在威胁。研究拟对污水厂二级出水采用颗粒活性炭(Granular Activated Carbon,GAC)、生物活性炭(Biologic... 详细信息

再生水回用是解决水资源短缺的重要途经,被广泛应用于工业生产、城市绿化方面,但其中含有大量的条件致病菌,对环境及人体健康具有潜在威胁。研究拟对污水厂二级出水采用颗粒活性炭(Granular Activated Carbon,GAC)、生物活性炭(Biological Activated Carbon,BAC)两种过滤单元与纳滤(nanofiltration,NF)组合工艺,来达到水中三种条件致病菌(军团菌、铜绿假单胞菌和鸟分枝杆菌)、大肠杆菌和有机物的去除的目的,采用直接NF、GAC-NF和BAC-NF三种处理工艺对去除效果进行分析。结果表明:在GAC过滤的滤速为5 cm/h,NF的过滤压力为0.4 MPa条件下,直接NF及其组合工艺均可实现二级出水中条件致病菌的完全去除,相较于直接NF和GAC-NF,BAC-NF工艺对水中DOC、UV254、微生物代谢副产物类和腐殖酸类有机物的去除率最高,分别为85.2%、74.5%、76.2%和82.0%;水中条件致病菌与大肠杆菌、DOC之间均有显著相关性,可以通过强化水中大肠杆菌和有机物的去除,达到提高不同组合工艺对条件致病菌削减的目的;BAC表面生物膜细菌中的假单胞菌、气单胞菌、硝化螺旋菌和不动杆菌占比最高,上述细菌对条件致病菌的生长繁殖起抑制作用;生物膜真核微生物中的线虫和轮虫占比最高,这两种微生物能通过捕捉的方式实现对水中条件致病菌的削减。

关键词：条件致病菌纳滤颗粒活性炭二级出水有机物.

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Quantitative analysis by reversed-phase high-performance liquid chromatography and retinal neuroprotection after topical administration of moxonidine

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 390-398页

作者： qian Zhang Mei-Fang Chu yan-Hong Li Chun-Hua Li Run-Jia Lei Si-Cen Wang Bao-Jun xiao Jian-Gang yang Department of Ophthalmology Xi’an Fourth HospitalShaanxi Ophthalmological HospitalXi’an 710004Shaanxi ProvinceChina Xi’an Eye Hospital First Affiliated Hospital of Northwest UniversityXi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina School of Pharmacy Xi’an Jiaotong UniversityXi’an 710068Shaanxi ProvinceChina West Street Community Health Center of Lianhu District Xi’an 710002Shaanxi ProvinceChina

AIM:To determine moxonidine in aqueous humor and iris-ciliary body by reversed-phase high performance liquid chromatography(RP-HPLC),and to evaluate the retinal neuroprotective effect after topical administration with moxonidine in a high intraocular pressure(IOP)***:The eyes of albino rabbits were administered topically and ipsilaterally with 0.2%moxonidine.A RPHPLC method was employed for the identification and quantification of moxonidine between 2 and 480 min,which presented in the aqueous humor and iris-ciliary *** electroretinography(F-ERG)amplitude and superoxide dismutase(SOD)level were measured between day 1 and day 15 after topical administration with moxonidine in a rabbit model of high *** and ultrastructural observation underwent to analyze the changes of retinal morphology,the inner retinal layers(IRL)thickness,and retinal ganglion cell(RGC)***:Moxonidine was detectable between 2 and 480 min after administration,and the peak concentration developed both in the two tissues at 30 min,0.51μg/m Lin aqueous humor and 1.03μg/g in iris-ciliary *** comparison to control,F-ERG b-wave amplitude in moxonidine eyes were significantly differences between day 3 and day 15(P<0.01)in the high IOP model;SOD levels were significantly higher at all time-points(P<0.01)with a maximum level of 20.29 U/mgprot at day 15;and RGCs were significantly higher(P<0.05).CONCLUSION:Moxonidine is a viable neuroprotective agent with application to high IOP *** layers of retina,including RGC layer,retinal nerve fiber layer and INL,are more preserved after moxonidine *** plays a neuroprotective role in ocular hypertension-mediated RGC death.

关键词： reversed-phase high-performance liquid chromatography moxonidine retinal ganglion cell neuroprotection superoxide dismutase

基于健康信念模型的北京市某三级甲等医院孕妇口腔卫生保健行为及影响因素的分析

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中华预防医学杂志 2024年第3期58卷 331-336页

作者：张志媛郑丹萍王茜谢嫣王欣欣万阔付晨薇霍晓鹏中国医学科学院北京协和医学院、北京协和医院国际医疗部北京100730 中国医学科学院北京协和医学院、北京协和医院口腔科北京100730 中国医学科学院北京协和医学院、北京协和医院妇产科北京100730 中国医学科学院北京协和医学院、北京协和医院护理部北京100730

目的:基于健康信念模型分析孕妇口腔卫生保健行为的影响因素。方法:采用横断面调查的方法,于2022年7至12月在北京协和医院驻点,对到院做产前检查的316名孕妇应用孕妇口腔卫生保健行为的健康信念问卷及自我效能量表进行调查。采用 t检验... 详细信息

目的:基于健康信念模型分析孕妇口腔卫生保健行为的影响因素。方法:采用横断面调查的方法,于2022年7至12月在北京协和医院驻点,对到院做产前检查的316名孕妇应用孕妇口腔卫生保健行为的健康信念问卷及自我效能量表进行调查。采用 t检验和 χ^(2)检验分析健康信念、自我效能等社会心理学因素对口腔保健行为的影响。结果:纳入孕妇316名中,110(34.8%)名孕妇日常口腔保健行为不佳,120(38.1%)名的孕妇在孕前或孕期未行口腔检查。孕妇整体口腔保健的健康信念不高,得分为6.63+3.23、中位得分为7(5)。感知口腔疾病的易感性( OR=1.51,95% CI:1.026~2.213)、日常生活的自我效能( OR=2.64,95% CI:1.384~5.040)、口腔检查的自我效能( OR=1.74,95% CI:1.184~2.570)是孕妇日常口腔卫生保健行为的独立影响因素。健康动力( OR=2.47,95% CI:1.474~4.126)及口腔检查的自我效能( OR=4.17,95% CI:2.626~6.619)是孕妇孕前及孕期口腔检查行为的独立影响因素。结论:孕妇口腔保健的健康信念特别是感知易感性、健康动力及自我效能与孕妇口腔卫生保健行为密切相关。切实提升孕妇口腔保健的健康信念及自我效能,避免潜在障碍,利于有效地推进孕妇口腔保健工作。

关键词：孕妇健康信念模型口腔卫生自我效能

HTO联合关节清理富血小板血浆治疗膝内侧骨关节炎

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中国矫形外科杂志 2024年第1期32卷 11-17页

作者：董伟王晓明谷源林颜军尧李新炜威海卫人民医院山东威海264200

[目的]探讨胫骨高位截骨(high tibial osteotomy,HTO)联合关节镜清理(arthroscopic debridement,AD)和富血小板血浆(platelet-rich plasma,PRP)关节内注射治疗膝内侧骨关节炎(medial knee osteoarthritis,mKOA)的临床疗效。[方法]回顾性分析2015年11月—2019年7月本院采用HTO治疗mKOA 33例患者。根据医患沟通结果,17例行HTO+AD+PRP治疗(联合组),另外16例仅行HTO治疗。比较两组围手术期、随访及影像资料。[结果]两组患者手术顺利完成。两组手术时间、切口总长度、术中出血量、切口愈合、开始行走时间及住院时间差异均无统计学意义(P>0.05)。所有患者均获随访30个月以上,联合组恢复完全负重活动时间显著早于HTO组[(58.1±4.6)d vs(66.1±4.0)d,P0.05),末次随访时,联合组在VAS[(2.4±0.5)vs(2.8±0.5),P0.05),相应时间点,两组间上述影像指标的差异均无统计学意义(P>0.05)。[结论]HTO联合关节镜清理、PRP治疗,可显著改善膝关节功能,缓解疼痛,提高患者满意度,临床疗效优于单一HTO。

关键词：膝内侧骨性关节炎胫骨高位截骨关节镜清理富血小板血浆