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Synthesis and Antitumor Activities of Novel 4-Morpholinothieno [3,2-d]pyrimidine Derivatives

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Chemical Research in Chinese Universities 2014年第1期30卷 75-81页

作者： SONG Kaizhen MA Junjie WANG xiao gong ping ZHAO Yanfang Key Laboratory of Structure-based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives was designed and *** of them were screened for their cytotoxic activities against large cell lung cancer（H460）,colon cancer （HT-29） and adenocarcinomic lung cancer（A549） cell lines in *** pharmacological results indicate that most of the target compounds show moderate to significant *** compound 17 exhibits the most potent antitumor activities against H460,HT-29 and A549 cell lines with IC50 values of 0.57,0.45 and 1.45 μmol/L,respectively.

关键词： 2-Hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine Antitumor activity Cytotoxic activity

Synthesis and Antiproliferative Activity of Novel [1,2,4]Triazolo[1,5-a]pyrimidine-7-amine Derivatives

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Chemical Research in Chinese Universities 2009年第4期25卷 474-479页

作者： ZHAI Xin ZHANG Cun-long HE Lei LI Qi WANG Jiu-liang SHEN xiao-li gong ping Key Laboratory of New Drugs Design and Discovery of Liaoning Province School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of novel N-anilino-2-substituted-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer cell lines,Bel-7402 and *** of the compounds inhibited the cell proliferation at a low *** compounds,VI5,VI7,VI10,and VI12―VI15,possessed marked antiproliferative activity superior to that of *** these seven initial hits,compound VI10 was the most active.

关键词： Triazolo[ 1,5-a]pyrimidines Antiproliferative activity Anticancer

Palladium-Catalyzed One-Step Synthesis of Stereodefined Difunctionalized Glycals

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CCS Chemistry 2023年第3期5卷 741-749页

作者： xiao-ping gong Yuke Li Hong-Chao Liu Zhe Zhang Zhi-Jie Niu Ya-Nan Ding Yang An Xi Chen Yan-Chong Huang Rui-Qiang Jiao Xue-Yuan Liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000 Department of Chemistry Centre for Scientific Modeling and ComputationChinese University of Hong KongShatinHong Kong 999077

Efficiently modifying glycals by directly introducing functional groups into their double bonds is a longstanding ***,the strategy of introducing two different functional groups into 1-iodoglycals to obtain modified glycals in one step through palladium catalysis was reported for the first time,and the modified glycals contained stereodefined tetrasubstituted *** this method,various difunctionalized glycals that were difficult to form by other routes were synthesized in moderate to good *** experiments and density functional theory calculations show that the palladium catalyst played dual roles in this transformation,namely,inducing nucleophilic substitution and catalyzing Suzuki *** reaction intermediate was isolated and confirmed by X-ray crystallographic ***,the gram-scale synthesis and facile deprotection of the target compound enhances the practicality of this strategy.

关键词： palladium catalysis glycals tetrasubstitute olefins difunctionalization stereodefined threecomponent

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浅谈煤矿架空乘人装置中平面转弯机构的设计

煤矿开采 2009年第1期14卷 72-74页

作者：肖公平湘潭市恒欣实业有限公司湖南湘潭411207

介绍了架空乘人装置中水平转弯机构的设计理念,为水平转弯装置的设计提供了理论依据,该平面转弯装置已在很多煤矿中使用,适用于井下平面内多个转弯巷道的猴车运行,有很高的推广价值。

关键词：架空乘人装置水平转弯抱索器

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浅谈煤矿架空乘人装置中平面转弯机构的设计

煤炭工程 2006年第11期38卷 114-116页

作者：肖公平湘潭市恒欣实业有限公司湖南湘潭411207

论文简要介绍了架空乘人装置中水平转弯机构的设计理念,为水平转弯装置的设计提供了理论依据,该平面转弯装置已在很多煤矿中使用,适用于井下平面内多个转弯巷道的猴车运行,得到了高度的评价,它不仅填补了国内空白,而且还有很高的推广价值。

关键词：架空乘人装置零速度上下车水平转弯抱索器抗绳轮导轨绳轨分离

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方形钢管腰形槽冲模创新设计

煤矿机械 2012年第12期33卷 128-129页

作者：肖公平李家队湘潭市恒欣实业有限公司湖南韶山411300

论述了方形钢管腰形冲槽模超常规的创新设计以及详细结构和工作原理。经生产实际验证,与传统冲槽模比较,具有结构新颖,构思巧妙,低碳环保又节能,安全实用更可靠的特点,具有一定的应用前景。

关键词：方形钢管腰形槽 C形支架活动支撑块大间隙

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang Xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Entanglement transformation between three-qubit GHZ-type mixed states by LOCC

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Entanglement transformation between three-qubit GHZ-type mix...

静态上下车装置在矿山大坡度可摘挂抱索器架空乘人装置中的应用

第十四届全国量子光学学术会议

作者： Guo-Fu Weng,Yan-xiao gong,ping Xu,and Shi-Ning Zhu (National Laboratory of Solid State Microstructures and De partment of Physics, Nanjing University,Nanjing 210093,People''s Republic of China)

＜正＞We present a novel method to verify whether a three-qubit GHZ-type mixed state could be ransformed to another one by local operations and classical communication（LOCC）.This result highlights intriguing similar...

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山西煤炭 2013年第4期33卷 79-80页

作者：林春年肖公平湖南湘潭恒欣实业有限公司湖南湘潭411300

介绍了静态上下车装置的结构、原理、以及应用特点。

关键词：架空乘人装置静动态上下车装置