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Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

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Frontiers of Medicine 2024年第3期18卷 538-557页

作者： Yue Yuan Jiaxuan Li Xun Lu Min chen Huifang Liang xiao-ping chen Xin Long Bixiang Zhang Song Gong xiaowei Huang Jianping Zhao Qian chen Division of Gastroenterology Department of Internal Medicine at Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Hepato–Pancreato–Biliary Diseases Wuhan430030China Department of Trauma Surgery Tongji Trauma CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Schistosoma infection is one of the major causes of liver *** roles of hepatic progenitor cells(HPCs)in the pathogenesis of liver fibrosis have been ***,the precise mechanism underlying the role of HPCs in liver fibrosis in schistosomiasis remains *** study examined how autophagy in HPCs affects schistosomiasis-induced liver fibrosis by modulating exosomal *** activation of HPCs was verified by immunohistochemistry(IHC)and immunofluorescence(IF)staining in fibrotic liver from patients and mice with Schistosoma japonicum *** coculturing HPCs with hepatic stellate cells(HSCs)and assessing the autophagy level in HPCs by proteomic analysis and in vitro phenotypic assays,we found that impaired autophagy degradation in these activated HPCs was mediated by lysosomal *** autophagy by the autophagy inhibitor chloroquine(CQ)significantly diminished liver fibrosis and granuloma formation in ***-infected ***-secreted extracellular vehicles(EVs)were further isolated and studied by miRNA ***-1306-3p,miR-493-3p,and miR-34a-5p were identified,and their distribution into EVs was inhibited due to impaired autophagy in HPCs,which contributed to suppressing HSC *** conclusion,we showed that the altered autophagy process upon HPC activation may prevent liver fibrosis by modulating exosomal miRNA release and inhibiting HSC activation in *** the autophagy degradation process may be a therapeutic strategy for liver fibrosis during Schistosoma infection.

关键词： schistosomiasis hepatic progenitor cell autophagy extracellular vesicle fibrosis miRNA

Novel compound heterozygous mutations in the hemojuvelin gene in a juvenile hemochromatosis patient:A case report

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World Journal of Clinical Cases 2024年第19期12卷 3961-3970页

作者： Ling-Ding Xie xiao-Mu Kong Jing-Xia Shen Tai-Ling Wang Jing Ma Yun-Fen Zhang xiao-ping chen Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China Department of Tumor Radiotherapy and Chemotherapy Qian’an People’s HospitalQian’an 064400Hebei ProvinceChina Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Endocrinology Aksu First People's HospitalAksu Region 843000Xinjiang Uygur Autonomous RegionChina Department of Metabolic Diseases Qian’an Traditional Chinese Medical HospitalQian’an 064400Hebei ProvinceChina

BACKGROUND Juvenile hemochromatosis(JH)is an early-onset,rare autosomal recessive disorder of iron overload observed worldwide that leads to damage in multiple *** mutations in the hemojuvelin(HJV)gene are the major cause of *** SUMMARY A 34-year-old male Chinese patient presented with liver fibrosis,diabetes,hypogonadotropic hypogonadism,hypophysis hypothyroidism,and skin *** test revealed a markedly elevated serum ferritin level of 4329μg/L and a transferrin saturation rate of 95.4%.Targeted exome sequencing and Sanger sequencing revealed that the proband had a novel mutation c.863G>A(p.R288Q)in the HJV gene which was transmitted from his father,and two known mutations,c.18G>C(p.Q6H)and c.962_963delGCinsAA(p.C321*)in cis,which were inherited from his *** p.R288W mutation was previously reported to be pathogenic for hemochromatosis,which strongly supported the pathogenicity of p.R288Q reported for the first time in this *** 72 wk of intensive phlebotomy therapy,the patient achieved a reduction in serum ferritin to 160.5μg/*** patient's clinical symptoms demonstrated a notable *** This study highlights the importance of screening for hemochromatosis in patients with diabetes and hypogonadotropic *** also suggests that long-term active phlebotomy could efficiently improve the prognosis in severe JH.

关键词： Juvenile hemochromatosis Liver cirrhosis Diabetes Iron overload Phlebotomy Case report

KeJia:towards an autonomous service robot with tolerance of unexpected environmental changes

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Frontiers of Information Technology & Electronic Engineering 2019年第3期20卷 307-317页

作者： Wei SHUAI xiao-ping chen Department of Computer Science and Technology University of Science and Technology of China

KeJia is a domestic service robot, consisting of a mobile base, an arm, two cameras, and a set of software components for perception, manipulation, natural language understanding, motion and task planning, and decision making. With on-line running of these functions, a robot can adapt to dynamic environments which may have unexpected changes. In this paper, we propose a novel hierarchical method which combines motion planning with a neural network, so that the robot can tolerate errors from sensors, wear of parts, and human disturbances during motion execution. We evaluate our work on KeJia that cooks popcorn using a microwave oven, where humans try to disturb KeJia during the operation.

关键词： Robot Task planning Manipulation

Thanks to all medical workers fighting against COVID-19

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Frontiers of Medicine 2020年第2期14卷 249-250页

作者： xiao-ping chen Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

As the saying goes,spring always comes after *** winter has been driven away by vibrant spring in the past three ***,Wuhan where I live,like a patient,has just recovered from a dangerous illness,and has managed to achieve major phased results in the fight against ***,Wuhan will be re-opened,and over ten million heroic people here will work hard for the rebirth of this great city.

关键词： spring winter fighting

Experimental study on desorption of soluble matter as influenced by cations in static water

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Water Science and Engineering 2014年第4期7卷 384-394页

作者： Wen-sheng XU Li chen xiao-xia TONG xiao-ping chen ping-cang ZHANG Division of Soil and Water Conservation Changjiang River Scientific Research Institute State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University

With variation of drainage basin environments, desorption of soluble matter has become one of the significant erosion processes in rivers. It has a considerable impact on flow and sediment transport, as well as processes of river bed deformation and landform evolution throughout a watershed. In this study, considering influences on sediment movement, especially on cohesive sediment transport, Ca^2＋ and H^＋ were chosen as characteristic ions of soluble matter, and the total desorption quantity of Ca^2＋ and pH value when the desorption equilibrium is reached were employed as two indexes representing the desorption of soluble matter. By means of an indoor experiment, desorption of soluble matter as influenced by cations in static water was investigated. The results show that the total desorption quantity of soluble matter increases with the initial cation concentration until a maximum desorption quantity value is obtained and maintained. The total desorption quantity of soluble matter depends on properties of the specific cations in static water, and the stronger the affinity is between the cation and sediment surface, the higher the total desorption quantity will be. Finally, a strong approximate linear relationship between desorption quantities for different kinds of soluble matters was obtained, which means that variation of pH values can accurately reflect the desorption results of soluble matter.

关键词： soluble matter desorption cation sediment static water indoor experiment

Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status and future directions

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Frontiers of Medicine 2020年第3期14卷 251-261页

作者： Li Jiang Deng Ning xiao-ping chen Department of Biliary and Pancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Postoperative pancreatic fistula (POPF) is the most common and critical complication after pancreatic body and tail *** to effectively reduce the occurrence of pancreatic fistula and conduct timely treatment thereafter is an urgent clinical issue to be *** research standardized the definition of pancreatic fistula and stressed the correlation between POPF classification and patient *** to the literature,identification of the risk factors for pancreatic fistula contributed to lowering the rate of the *** management of the pancreatic stump and perioperative treatment are of great significance to reduce the rate of POPF in clinical *** the occurrence of POPF,the treatment of choice should be determined according to the classification of the pancreatic ***,despite the progress and promising treatment approaches,POPF remains to be a clinical issue that warrants further studies in the future.

关键词： pancreatic fistula pancreatic body and tail resection distal pancreatectomy

Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

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Frontiers of Medicine 2021年第2期15卷 155-169页

作者： Wei Zhang Bixiang Zhang xiao-ping chen Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Hepatic resection represents the first-line treatment for patients with resectable hepatocellular carcinoma(HCC).However,the 5-year recurrence rates of HCC after surgery have been reported to range from 50%to 70%.In this review,we evaluated the available evidence for the efficiency of adjuvant treatments to prevent HCC recurrence after curative liver *** therapy has potential advantages in terms of reducing the recurrence rate and improving the overall survival(OS)and/or disease-free survival of patients with hepatitisrelated *** adjuvant transarterial chemoembolization can significantly reduce the intrahepatic recurrence rate and improve OS,especially for patients with a high risk of *** efficacy of molecular targeted drugs as an adjuvant therapy deserves further *** adoptive immunotherapy can significantly improve the clinical prognosis in the early *** controlled trial(RCT)studies evaluating adjuvant immune checkpoint inhibitors are ongoing,and the results are highly *** hepatic artery infusion chemotherapy might be beneficial in patients with vascular *** granule,a traditional Chinese medicine,has been proved to be effective in prolonging the recurrence-free survival and reducing extrahepatic *** efficiency of other adjuvant treatments needs to be further confirmed by large RCT studies.

关键词： hepatocellular carcinoma adjuvant treatment hepatic resection recurrence

A spatially triggered dissipative resource distribution policy for SMT processors

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第8期9卷 1070-1082页

作者： Hong-zhou chen Xue-zeng PAN Ling-di ping Kui-jun LU xiao-ping chen School of Computer Science and Technology Zhejiang University Hangzhou 310027 China

Programs take on changing behavior at nmtime in a simultaneous multithreading （SMT） environment. How reasonably common resources are distributed among the threads significantly determines the throughput and fairness performance in SMT processors. Existing resource distribution methods either mainly rely on the front-end fetch policy, or make distribution decisions according to the limited information from the pipeline. It is difficult for them to efficiently catch the various resource requirements of the threads. This work presents a spatially triggered dissipative resource distribution （SDRD） policy for SMT processors, its two parts, the self-organization mechanism that is driven by the real-time instructions per cycle （IPC） performance and the introduction of chaos that tries to control the diversity Of trial resource distributions, work together to supply sustaining resource distribution optimization for changing program behavior. Simulation results show that SDRD with fine-grained diversity controlling is more effective than that with a coarse-grained one. And SDRD benefits much from its two well-coordinated parts, providing potential fairness gains as well as good throughput gains. Meanings and settings of important SDRD parameters are also discussed.

关键词： Simultaneous multithreading (SMT) Resource distribution Dynamic optimization Dissipative structures

Dilated left ventricle with multiple outpouchings—a severe congenital ventricular diverticulum or left-dominant arrhythmogenic cardiomyopathy:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6289-6297页

作者： Xin Zhang Run-Yu Ye xiao-ping chen Department of Cardiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Left-dominant arrhythmogenic cardiomyopathy(LDAC)is a relatively rare disease characterized by poor prognosis that exacerbates the incidence of sudden cardiac death and ventricular ***,LDAC is constantly overlooked or misdiagnosed as myocardial infarction,myocarditis,and dilated cardiomyopathy,owing to atypical and nonspecific clinical manifestations at an early *** SUMMARY A 57-year-old woman was diagnosed with sinus bradycardia and chronic bifascicular block during a health *** occasionally experienced mild chest pain and paroxysmal palpitation during activity in the past 2 *** auxiliary examinations,including electrocardiogram,echocardiography,coronary computerized tomography angiography,and magnetic resonance imaging,revealed that she had LDAC instead of congenital ventricular *** physicians prescribed standard oral therapy for heart failure and implantable ***,her left ventricular systolic function and symptoms remained stable at the 2-year follow-up after *** Based on this case,clinicians need to be aware of LDAC in patients with localized left ventricular lesions and multiple electrocardiographic *** cardiovascular imaging is effective in identification of multiple types of cardiomyopathy and cardiac inner structures.

关键词： Congenital ventricular diverticulum Left-dominant arrhythmogenic cardiomyopathy Magnetic resonance imaging Case report