检索结果-南通市图书馆

Screening of amino acids in dried blood spots by stable isotope derivatization-liquid chromatography-electrospray ionization mass spectrometry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第9期31卷 2423-2427页

作者： Huaming xiao Ping Liu Shujian Zheng Xian wang Jun Ding Yuqi Feng Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education) Department of ChemistryWuhan UniversityWuhan 430072China Key Laboratory of Analytical Chemistry of State Ethnic Affairs Commission College of Chemistry and Materials ScienceSouth-Central University for NationalitiesWuhan 430074China Pharmaceutical College Guangxi Medical UniversityNanning 530021China

Direct infusion mass spectrometry(DIMS) is a powerful technique in clinical diagnosis for screening neonatal amino acid metabolic disorders from dried blood spots(DBS).However,DIMS sometimes generated false-positive results for analysis of amino *** this work,we utilized a stable isotope derivatization method,combining with liquid chromatography tandem mass spectrometry(SID-LC-MS),to improve the specificity for screening amino acids in DBS specimens.A pair of isotope reagents,p-(dimethylamino)phenyl isothiocyanate(DMAP-NCS) and 4-isothiocyanato-N,N-bis(methyl-[2H2])aniline([2H4]DMAP-NCS),was synthesized and used to label amino acids in DBS *** [2H4]DMAP-NCS labelled amino acid standards were used as internal standards to compensate the matrix *** method was validated by measuring linearity,recovery and *** results showed that the developed SID-LC-MS method can be used for sensitive and selective determination of 12 diagnostically important amino acids in DBS specimens.

关键词： Amino acids Dried blood spots Stable isotope derivatization LC-MS Newborn screening

Future changes of cluster high temperature events over China from RegCM4 ensemble under RCP4.5 scenario

在线全文

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2020年第4期11卷 349-359页

作者： ZHOU Bo-Tao CHENG Yang HAN Zhen-Yu XU Ying wang xiao-Long Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjing210044China School of Atmospheric Sciences Chengdu University of Information TechnologyChengdu610225China national Climate Center China Meteorological AdministrationBeijing100081China Zhengzhou Meteorological Service Zhengzhou450000China

Using the daily maximum temperature of the RegCM4 dynamical downscaling from four global climate models under the historical and RCP4.5 simulations,this study firstly identified the cluster high temperature event(CHTE)occurring in China through a simplified objective method,and then projected its change during the 21st century in terms of the CHTE metrics including frequency,duration,extreme intensity,cumulative intensity,maximum influential area,average influential area,and comprehensive *** ensemble projection indicates that all the CHTE metrics tend to increase toward the end of the 21st century on the national ***,the occurrence of CHTE shows a longer month span during the middle and the end of the 21st century(from April to October)compared to the present(from April to September),accompanied with the peaks of the frequency,duration,and cumulative intensity shifting from the present July ahead to *** to 1986-2005,the projected slight,moderate,and extreme CHTEs increase by 55%,50%,and 50%(58%,43%,and 60%)during 2046-2065(2080-2099),respectively;the projected severe CHTE increases by 11%during 2046-2065 while decreases by 11% during ***,the CHTE frequency,duration,and cumulative intensity are projected to increase in a widespread *** largest increase appears in southern China for the frequency and in Xinjiang and Southeast China for the duration and cumulative *** further divided China into five sub-regions to examine the regional features of CHTE *** is found that in addition to the increase of CHTEs in each single subregion,a pronounced enhancement is also projected for the occurrence of cross-regional CHTEs,particularly for that across more than two subregions.

关键词： Cluster high temperature event Regional climate model Dynamical downscaling Ensemble projection

Wetting behaviors of molten melt drops on polycrystalline Al2O3 substrates in high magnetic fields

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第6期41卷 187-190页

作者： Tie Liu Yubao xiao Zhengyang Lu Noriyuki Hirota Guojian Li Shuang Yuan Qiang wang Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang110819China School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Metallurgy Northeastern UniversityShenyang110819China Tsukuba Magnet Laboratory National Institute for Materials ScienceIbaraki305-0003Japan

We measured the contact angles of Al and Sn drops on polycrystalline Al2O3 substrates in various high magnetic fields at different *** contact angles of both Al and Sn drops on the Al2O3 substrates decreased under high magnetic *** decreases strongly depend on the temperature,magnetic flux density,magnetic properties of the metal drops,and the reactivity of the metal drops with *** results reveal that the wetting behavior of molten metal drops on ceramics can be modified by a high magnetic field.

关键词： Wetting Contact angle High magnetic field Molten metal

Exercise as a prescription for patients with various diseases

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2019年第5期8卷 422-441页

作者： Xin Luan Xiangyang Tian Haixin Zhang Rui Huang na Li Peijie Chen Ru wang School of Kinesiology Shanghai University of SportShanghai 200438China Department of Sport Huainan Normal UniversityHuainan 232038China

A growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise *** each sport has its own set of characteristics and physiological complications that tend to occur during exercise training,the effects and underlying mechanisms of exercise remain ***,the first step in probing the effects of exercise on different diseases is the selection of an optimal exercise *** review summarizes the latest exercise prescription treatments for 26 different diseases:musculoskeletal system diseases(low back pain,tendon injury,osteoporosis,osteoarthritis,and hip fracture),metabolic system diseases(obesity,type 2 diabetes,type 1 diabetes,and nonalcoholic fatty liver disease),cardio-cerebral vascular system diseases(coronary artery disease,stroke,and chronic heart failure),nervous system diseases(Parkinson’s disease,Huntington’s disease,Alzheimer’s disease,depression,and anxiety disorders),respiratory system diseases(chronic obstructive pulmonary disease,interstitial lung disease,and after lung transplantation),urinary system diseases(chronic kidney disease and after kidney transplantation),and cancers(breast cancer,colon cancer,prostate cancer,and lung cancer).Each exercise prescription is displayed in a corresponding *** recommended type,intensity,and frequency of exercise prescriptions are summarized,and the effects of exercise therapy on the prevention and rehabilitation of different diseases are discussed.

关键词： Diseases Exercise prescription Patients

Achieving a high energy storage density in Ag(Nb,Ta)O_(3) antiferroelectric films via nanograin engineering

在线全文

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2023年第1期12卷 196-206页

作者： Hongbo CHENG xiao ZHAI Jun OUYANG Limei ZHENG Nengneng LUO Jinpeng LIU Hanfei ZHU Yingying wang Lanxia HAO Kun wang Institute of Advanced Energy Materials and Chemistry School of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China College of Electronic and Optical Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Physics Shandong UniversityJinan 250100China Guangxi Key Laboratory of Processing for Non-ferrous Metallic and Featured Materials School of ResourcesEnvironment and MaterialsCenter on Nanoenergy ResearchSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key Laboratory for Liquid-Solid Structure Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Jinan Cigarette Factory China Tobacco Shandong Industrial Co.Ltd.Jinan 250104China

Due to its lead-free composition and a unique double polarization hysteresis loop with a large maximum polarization(Pmax)and a small remnant polarization(Pr),AgNbO_(3)-based antiferroelectrics(AFEs)have attracted extensive research interest for electric energy storage ***,a low dielectric breakdown field(Eb)limits an energy density and its further *** this work,a highly efficient method was proposed to fabricate high-energy-density Ag(Nb,Ta)O_(3) capacitor films on Si substrates,using a two-step process combining radio frequency(RF)-magnetron sputtering at 450℃and post-deposition rapid thermal annealing(RTA).The RTA process at 700℃led to sufficient crystallization of nanograins in the film,hindering their lateral growth by employing short annealing time of 5 *** obtained Ag(Nb,Ta)O_(3) films showed an average grain size(D)of~14 nm(obtained by Debye-Scherrer formula)and a slender room temperature(RT)polarization-electric field(P-E)loop(Pr≈3.8 mC·cm^(−2) and P_(max)≈38 mC·cm^(−2) under an electric field of~3.3 MV·cm^(−1)),the P-E loop corresponding to a high recoverable energy density(W_(rec))of~46.4 J·cm^(−3) and an energy efficiency(η)of~80.3%.Additionally,by analyzing temperature-dependent dielectric property of the film,a significant downshift of the diffused phase transition temperature(T_(M2-M3))was revealed,which indicated the existence of a stable relaxor-like AFE phase near the *** downshift of the T_(M2-M3) could be attributed to a nanograin size and residual tensile strain of the film,and it led to excellent temperature stability(20-240℃)of the energy storage performance of the *** results indicate that the Ag(Nb,Ta)O_(3) film is a promising candidate for electrical energy storage applications.

关键词： antiferroelectrics(AFE) AgNbO_(3) Ag(Nb Ta)O_(3) energy storage film capacitors nanograin engineering

Astrocyte-neuron communication mediated by the Notch signaling pathway:focusing on glutamate transport and synaptic plasticity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第10期18卷 2285-2290页

作者： Ke-Xin Li Meng Lu Meng-Xu Cui xiao-Ming wang Yang Zheng Department of Radiology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Maintaining glutamate homeostasis after hypoxic ischemia is important for synaptic function and neural cell activity,and regulation of glutamate transport between astrocyte and neuron is one of the important modalities for reducing glutamate ***,further research is needed to investigate the dynamic changes in and molecular mechanisms of glutamate transport and the effects of glutamate transport on *** aim of this study was to investigate the regulatory mechanisms underlying Notch pathway mediation of glutamate transport and synaptic *** this study,Yorkshire neonatal pigs(male,age 3 days,weight 1.0–1.5 kg,n=48)were randomly divided into control(sham surgery group)and five hypoxic ischemia subgroups,according to different recovery time,which were then further subdivided into subgroups treated with dimethyl sulfoxide or a Notch pathway inhibitor(N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester).Once the model was established,immunohistochemistry,immunofluorescence staining,and western blot analyses of Notch pathway-related proteins,synaptophysin,and glutamate transporter were ***,synapse microstructure was observed by transmission electron *** the early stage(6–12 hours after hypoxic ischemia)of hypoxic ischemic injury,expression of glutamate transporter excitatory amino acid transporter-2 and synaptophysin was downregulated,the number of synaptic vesicles was reduced,and synaptic swelling was observed;at 12–24 hours after hypoxic ischemia,the Notch pathway was activated,excitatory amino acid transporter-2 and synaptophysin expression was increased,and the number of synaptic vesicles was slightly *** amino acid transporter-2 and synaptophysin expression decreased after treatment with the Notch pathway *** suggests that glutamate transport in astrocytes-neurons after hypoxic ischemic injury is regulated by the Notch pathway and affects vesicle release and synapt

关键词： astrocyte astrocyte-neuron communication glutamate glutamate transporter hypoxic-ischemic injury magnetic resonance spectroscopy neonate Notch signaling pathway plasticity synapse

Dithieno[3′,2′:3,4;2″,3″:5,6]benzo[1,2-c][1,2,5]oxadiazole-based polymer donors with deep HOMO levels

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2021年第6期42卷 13-16页

作者： Xiongfeng Li Jingui Xu Zuo xiao Xingzhu wang Bin Zhang Liming Ding College of Chemistry Xiangtan UniversityXiangtan 411105China Center for Excellence in nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China School of Materials Science and Engineering Changzhou UniversityChangzhou 213164China

Star nonfullerene acceptors like ITIC[1],IDIC[2],O-IDTBR[3],IT-4 F[4],COi8 DFIC[4],Y6[6]*** emerge and keep pushing the power conversion efficiency(PCE)of organic solar cells *** small molecules generally show narrow ... 详细信息

关键词： harvesting narrow visible

Estimation of generalized soil structure index based on differential spectra of different orders by multivariate assessment

在线全文

学校读者我要写书评

暂无评论

International Soil and Water Conservation Research 2024年第2期12卷 313-321页

作者： Sha Yang Zhigang wang Chenbo Yang Chao wang Ziyang wang xiaobin Yan Xingxing Qiao Meichen Feng Lujie xiao Fahad Shafiq Wude Yang College of Agriculture Shanxi Agriculture UniversityTaiguChina College of Smart Agriculture Shanxi Agriculture UniversityTaiguChina Department of Botany Government College University LahorePakistan

Better soil structure promotes extension of plant roots thereby improving plant growth and *** in soil structure can be determined by changes in the three phases of soil,which in turn affect soil function and fertility *** compare the quality of soil structure under different conditions,we used Generalized Soil Structure Index(GSSI)as an indicator to determine the relationship between the“input”of soil three phases and the“output”of soil *** achieve optimum monitoring of comprehensive indicators,we used Successive Projections Algorithm(SPA)for differential processing based on 0.0–2.0 fractional orders and 3.0–10.0 integer orders and select important wavelengths to process soil spectral *** addition,we also applied multivariate regression learning models including Gaussian Process Regression(GPR)and Artificial Neural Network(ANN),exploring potential capabilities of hyperspectral in predicting *** results showed that spectral reflection,mainly contributed by long-wave near-infrared radiation had an inverse relationship with GSSI *** wavelengths between 404-418 nm and 2193–2400 nm were important GSSI wavelengths in fractional differential spectroscopy data,while those ranging from 543 to 999 nm were important GSSI wavelengths in integer differential spectroscopy ***,non-linear models were more accurate than linear *** addition,wide neural networks were best suited for establishing fractional-order differentiation and second-order differentiation models,while fine Gaussian support vector machines were best suited for establishing first-order differentiation *** terms of preprocessing,a differential order of 0.9 was found as the best *** the results,we propose that when constructing optimal prediction models,it is necessary to consider indicators,differential orders,and model *** all,this study provided a new method for an in-depth analyses of generalized soil *** also fills

关键词： Three-phase soil Generalized soil structure index Hyperspectral Differential spectrum Regression learning model

Wide temperature range,air stable,transparent,and self-powered photodetectors enabled by a hybrid film of graphene and singlewalled carbon nanotubes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

nano Research 2024年第7期17卷 6582-6593页

作者： Ying Yue Di Zhang Pengyu wang Xin Wu Yuejuan Zhang Yanchun wang xiao Zhang xiaojun Wei Huaping Liu Weiya Zhou Beijing national Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences and College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Beijing Key Laboratory for Advanced Functional Materials and Structure Research Beijing 100190China

Transparent photovoltaic devices(TPVDs)have attracted increasing attention in emerging electronic *** the application scenarios extend,there raise higher requirements regarding the stability and operating temperature range of *** this work,a unique preparation strategy is proposed for air stable TPVD with a wide operating temperature range,i.e.,a nanoscale architecture termed as H-TPVD is constructed that integrates a free-standing and highly transparent conductive hybrid film of graphene and single-walled carbon nanotubes(G-SWNT TCF for short)with a metal oxide NiO/TiO_(2)*** preparation approach is suitable for scaling *** to the excellent transparent conductivity of the freestanding G-SWNT hybrid film and the ultrathin NiO/TiO_(2)heterojunction(100 nm),H-TPVD selectively absorbs the ultraviolet(UV)band of sunlight and has a transparency of up to 71%in the visible *** integrated nanoscale architecture manifests the significant holecollecting capability of the G-SWNT hybrid film and the efficient carrier generation and separation within the ultrathin NiO/TiO_(2)heterojunction,resulting in excellent performance of the H-TPVD with a specific detectivity of 2.7×10^(10) ***,the freestanding G-SWNT TCF is a super stable and non-porous two-dimensional film that can insulate gas molecules,thereby protecting the surface properties of NiO/TiO_(2)heterojunctions and enhancing the stability of *** subjected to 20,000 cycles and storage in air for three months,the performance parameters such as photo-response signal,output power,and specific detectivity show no noticeable *** particular,the as-fabricated self-powered H-TPVD can operate over a wide temperature range from −180 to 300℃,and can carry out solar-blind UV optical communication in this *** addition,the 4×4 array H-TPVD demonstrates clear optical *** results make it possible for H-TPVD to expand its potential application scenarios.

关键词： transparent photovoltaic devices hybrid films of graphene and single-walled carbon nanotubes metal oxides stability wide temperature range