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Precipitation kinetics of NZ30K-Mg alloys based on electrical resistivity measurement

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Transactions of Nonferrous Metals Society of China 2014年第6期24卷 1690-1697页

作者：王小娜韩利战顾剑锋上海交通大学材料科学与工程学院上海市激光制造与材料改性重点实验室上海200240

The electrical resistivity of NZ30K-Mg alloy was measured at different heating rates during continuous heating to stud the precipitation *** kinds of metastable phases,β＂ and β＇,formed during the *** method and differentia isoconversional method were employed to assess the precipitation kinetic parameters of NZ30K-Mg alloy,activation energy Eα an pre-exponential factor A＇α.The fraction of transformation（α） and the precipitation sequence in NZ30K-Mg alloy were determinec Continuous heating transformation（CHT） and isothermal heating transformation（IHT） diagrams were further obtained for guidin the aging of NZ30K-Mg *** analysis shows that the precipitation kinetic parameters of NZ30K-Mg alloy can be obtaine accurately using isoconversional method.

关键词： NZ30K-Mg alloy precipitation kinetics differential isoconversional method continuous heating transformation isothermal heating transformation

空气介质阻挡放电对超高分子量聚乙烯纤维表面性能及粘结力的影响研究

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高分子学报 2016年第10期26卷 1439-1446页

作者：任煜张银王晓娜臧传锋张伟南通大学纺织服装学院南通226019

利用空气介质阻挡放电(DBD)等离子体对超高分子量聚乙烯(UHMWPE)纤维进行表面改性处理研究以提高纤维表面的润湿和粘结性能.分别研究了等离子体处理时间及电压对UHMWPE纤维拉伸断裂强力、接触角、表面形貌、表面化学成分和粘结性能等的... 详细信息

利用空气介质阻挡放电(DBD)等离子体对超高分子量聚乙烯(UHMWPE)纤维进行表面改性处理研究以提高纤维表面的润湿和粘结性能.分别研究了等离子体处理时间及电压对UHMWPE纤维拉伸断裂强力、接触角、表面形貌、表面化学成分和粘结性能等的影响规律.SEM分析结果表明,空气DBD等离子体处理后UHMWPE纤维表面出现垂直于纤维轴向分布的凹坑和裂纹,使得纤维表面粗糙度显著增加.XPS分析表明空气DBD处理后纤维表面碳元素含量显著下降;同时氧元素和氮元素的含量均较处理前增加,但氧元素含量增加的幅度显著高于氮元素.XPS分峰结果表明等离子体处理后UHMWPE纤维纤维表面C—O/C—N基团含量显著增加,同时出现了C O和O—C O这2种新的含氧官能团.同时,接触角及和与环氧树脂之间的界面剪切力(IFSS)测试结果表明DBD等离子体处理后UHMWPE纤维表面润湿性能和粘结力均产生显著提高,且随着等离子体处理时间或电压的增加,UHMWPE纤维的表面润湿性能和粘结力均呈现先上升后下降的趋势.空气DBD等离子体处理对UHMWPE纤维的力学性能影响较小,当处理电压低于200 V,处理时间小于100 s,纤维强力下降比率小于5.2%.

关键词：超高分子量聚乙烯纤维介质阻挡放电表面性能粘结力

高度近视患者血清中MMP-2和TIMP-2的含量与眼轴长度的相关性（英文）

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国际眼科杂志 2016年第9期16卷 1619-1624页

作者：王晓娜吴志鸿张小丽张翠中国辽宁省锦州医科大学武警总医院研究生培养基地 121001 中国北京市海淀区武警总医院眼科 100039 北京市海淀区武警总医院检验科 100039

目的：检测高度近视患者血清中MMP-2和TIMP-2的含量并探究它们与眼轴长度之间的相关性。方法：选取2015-05/2015-12在武警总医院就诊的13例高度近视患者为观察组,并以同期的13例性别、年龄相匹配的正常眼轴患者为对照组。用A超测量眼轴... 详细信息

目的：检测高度近视患者血清中MMP-2和TIMP-2的含量并探究它们与眼轴长度之间的相关性。方法：选取2015-05/2015-12在武警总医院就诊的13例高度近视患者为观察组,并以同期的13例性别、年龄相匹配的正常眼轴患者为对照组。用A超测量眼轴长度,ELISA检测两组患者血清中MMP-2及TIMP-2含量,并比较两检测指标与眼轴长度值之间的相关关系。结果：高度近视组血清中MMP-2和TIMP-2的含量均低于对照组（分别为P_1=0.027和P2=0.048）。MMP-2含量在高度近视组为10.21（9.26~11.49）pg/mL,而在对照组为11.56（11.03~15.14）pg/mL;TIMP-2含量在高度近视组为79.69（72.86~93.89）pg/mL,而在对照组中为93.16（87.54~100.97）pg/mL。TIMP2/MMP2两组患者之间差异无统计学意义（P=0.216）。血清中MMP-2及TIMP-2含量均与眼轴长度呈负相关（r_1=-0.512,P1=0.007;r_2=-0.604,P_2=0.001）;TIMP2/MMP2与眼轴长度之间的相关性无统计学意义（r=0.385,P=0.052）。结论：血清中MMP-2及TIMP-2的含量随眼轴的增加而降低,且均与眼轴长度呈负相关。

关键词：血清眼轴长度 MMP-2 TIMP-2

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing wang Wei Pi Sheng Hu Haifeng Bao na Yao Wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： Zhi-Da Long xiao Yu Zhi-Xiang Xing Rui wang Department of Hepatobiliary and Pancreaticosplenic Surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RFM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RFM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats

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Activation of ATP-sensitive potassium channels antagonize no...

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： xiao-na DU,Chao wang,Hai-Lin ZHANG~* The Key Laboratory of Neural and Vascular Biology,Ministry of Education,Department of Pharmacology,Hebei Medical University,Shijiazhuang,China

Nociceptive responses to noxious stimuli are initiated at peripheral nociceptor *** channels play a vital role in pain signal initiation and *** of K channels has been implicated in mediating the analgesic effects of agents such as ***,systematic studies regarding the effects of K activators on nociception and neuronal excitability are *** this study,we describe the antagonistic effects of K activators pinacidil and diazoxide on nocifensive behavior induced by bradykinin(BK),thermo and mechanical stimuli,and the bradykinin-induced hyperexcitability of DRG *** also found that K activators can moderately activate K in DRG *** the effects of K activators can be reversed by the K blocker glyburide,direct activation of K is most likely the underlying *** systematic study clearly demonstrates that activation of K could have significant modulatory effects on the excitability of sensory neurons and thus on sensory behaviors,such as nociception.K activators can be evaluated clinically for the treatment of pain symptoms.

关键词： KATP potassium channels DRG excitability nociception pinacidil diazoxide glyburide

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin wang Qing-Rong Li Lei Xu Zi-Chun Yuan xiao Liu Mao-Ju Tang Man Luo xiao-Wu Zhong Qiang Ma xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are Dna-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an Rna-dependent Dna polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase Dna damage response Telomere-binding proteins

血流感染洋葱伯克霍尔德菌多位点序列分型研究

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中华医院感染学杂志 2017年第20期27卷 4564-4567页

作者：邢欢董爱英肖盟王娜杨杰华北理工大学附属医院检验科河北唐山063000 北京协和医院检验科北京100000

目的探讨血流感染洋葱伯克霍尔德菌的同源性,以便更好地控制短时间内洋葱伯克霍尔德菌引起的院内感染。方法对医院2013年5-6月分离的15株血流感染洋葱伯克霍尔德菌的菌株应用多位点序列分型方法(MLST),聚合酶链式反应(PCR)扩增atpD、glt... 详细信息

目的探讨血流感染洋葱伯克霍尔德菌的同源性,以便更好地控制短时间内洋葱伯克霍尔德菌引起的院内感染。方法对医院2013年5-6月分离的15株血流感染洋葱伯克霍尔德菌的菌株应用多位点序列分型方法(MLST),聚合酶链式反应(PCR)扩增atpD、gltB、gyrB、recA,lepA、phaC和trp B7个管家基因片段,测序结果与MLST数据库中的数据比对分析,获得菌株各管家基因的编号和ST型,研究其同源性。结果 15株菌中,13株菌的7个管家基因完全相同,同时gyrB管家基因出现新的序列型,为新的序列型(ST)。15株洋葱伯克霍尔德菌被分为3个基因型,分别为ST482、ST608和一个新的ST序列,来自神经外科的13株菌为同一个ST型。结论医院短时间内洋葱伯克霍尔德菌引起的血流感染属医院感染暴发,神经外科的13株菌为同一ST型。其中13株菌的ST型不仅相同且是新的ST型,与另外两科室的菌株不同。MLST在洋葱伯克霍尔德菌的分子生物学分型中的应用,表现出了较高的分辨率,对医院洋葱伯克霍尔德菌血流感染暴发的调查有重要意义。

关键词：血流感染洋葱伯克霍尔德菌多位点序列分型同源性

Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin xiao Liang Shu-Peng Liu Rui-Lan wang Qing-Wei Zhang Yu-Feng Shen xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,Pnally,the positive rate of parietal cell antibody(PCA)antibody was higher in these patients than in those without GPs(88.6%vs 73.6%,Pnalyses revealed that PCA positivity[odds ratio(OR)=2.003,P=0.017],pepsinogen II(OR=1.053,P=0.015),and enterochromaffin like cells hyperplasia(OR=3.116,Pnaging GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram