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Comparison of 25-gauge sutureless vitrectomy and 20-gauge vitrectomy in the treatment of posterior capsule opacification in pseudophakic children

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1179-1183页

作者： xiao-ming wu Li-Xin Xie Qingdao University Medical College Shandong Eye Institute

AIMTo compare the effectiveness and safety of pars plana capsulotomy and vitrectomy using 25-gauge tansconjunctival sutureless vitrectomy system and 20-gauge vitrectomy system for posterior capsule opacification (PCO) in pseudophakic *** study. Pars plana capsulotomy and vitrectomy using 25-gauge sutureless vitrectomy system was performed for PCO in the study group (32 eyes). Patients in the control group (34 eyes) underwent capsulotomy and vitrectomy using standard 20-gauge vitrectomy system, providing a comparison between 2 groups with regard to preoperative and postoperative best corrected visual acuity (BCVA), intraocular pressure (IOP), and intraoperative and postoperative complications. The two groups were performed consequentially. The patients ages ranged from 2 to 13y (means: 6.61±2.73y). Surgical technique, intraoperative and postoperative complications, visual acuity, IOP, and recurrent PCO were *** surgical procedure was performed uneventfully in all patients. Visual acuity improved significantly in both groups. BCVA improved in 22 eyes (81.5%) in the study group and in 28 eyes (87.5%) in the control group. There was no statistical difference of visual acuity that were attainable in two groups (H=0.115, P=0.909). Mean postoperative IOP showed no significant difference between the groups at 1wk. All sort of PCO were accomplished by 20-gauge system, while 25-gauge system was effective for pearls style and 2 grade of fibrous PCO, and was insufficient to grade 3 of PCO. In the study group two cases were not accomplished by 25-gauge system while 20-gauge system conquered them. Compared with the control group, mean operative time for opening and closing the sclerotomy in the study group was considerably reduced. The mean follow-up was 38.2mo (range: 8-79mo). During the follow-up period, no incision leakage, corneal edema, vitreous loss, IOL damage, retinal detachment, recurrent PCO, or other complications wer

关键词： posterior capsular opacity vitrectomy cataract children

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An unexpected Hoffmann elimination during the alkylation of dihydrotetrabenazine

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Chinese Chemical Letters 2010年第11期21卷 1334-1337页

作者： Zhang Yu Yao Hao Zhang Huan ming Sheng xiao ming wu Hong Bin Sun Center for Drug Discovery College of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Dihydrotetrabenazine(DTBZ) is the major pharmacologically active form of tetrabenazine(TBZ),which was approved by FDA for the treatment of chorea associated with Huntington’s disease(HD).An unexpected Hoffmann elimination was observed during the treatment of DTBZ with sodium hydrogen and alkyl halides,leading to the formation of both eliminated products(major) and hydroxyl-alkylated products(minor).

关键词： Tetrabenazine Dihydrotetrabenazine Alkylation Hoffmann elimination

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Synthesis and antitumor activity of nitric oxide releasing derivatives of AT1 antagonist

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Chinese Chemical Letters 2009年第3期20卷 302-305页

作者： Yan Chun Zhang Jin Pei Zhou xiao ming wu Wei Hong Pan Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of novel nitric oxide-donating derivatives （7a-e, 8a-e） were synthesized by coupling furoxan and nitric oxide with irbesartan analogue and their cytotoxicity against BEL7402 cells in vitro were evaluated by MTT method. It was found that 8c exhibits the most cytotoxic activities with ICso value of 12.5 μmol/L. The hybrids of AT1 antagonist and nitric oxide donor appear to have beneficial effects on antitumor.

关键词： AT1 antagonist Nitric oxide-donating Antitumor Synthesis

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Carrier Dynamics Determined by Carrier-Phonon Coupling in InGaN/GaN Multiple Quantum Well Blue Light Emitting Diodes

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Chinese Physics Letters 2019年第2期36卷 92-95页

作者： Sheng Cao xiao-ming wu Jun-Lin Liu Feng-Yi Jiang National Institute of LED on Si Substrate Nanchang University

Phonon sidebands in the electrolumiescence(EL) spectra of InGaN/GaN multiple quantum well blue light emitting diodes are investigated. S-shaped injection current dependence of the energy spacing(ES) between the zero-phonon and first-order phonon-assisted luminescence lines is observed in a temperature range of 100–150 *** S-shape is suppressed with increasing temperature from 100 to 150 K, and vanishes at temperature above200 K. The S-shaped injection dependence of ES at low temperatures could be explained by the three stages of carrier dynamics related to localization states:(i) carrier relaxation from shallow into deep localization states,(ii) band filling of shallow and deep localization states, and(iii) carrier overflow from deep to shallow localization states and to higher energy states. The three stages show strong temperature dependence. It is proposed that the fast change of the carrier lifetime with temperature is responsible for the suppression of S-shaped *** proposed mechanisms reveal carrier recombination dynamics in the EL of InGaN/GaN MQWs at various injection current densities and temperatures.

关键词： Carrier Dynamics Determined Carrier-Phonon Coupling InGaN/GaN Multiple Quantum Well Blue Light Emitting Diodes

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Blast-Resistance Inheritance of Space-Induced Rice Lines and Their Genomic Polymorphism by Microsatellite Markers

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Agricultural Sciences in China 2009年第4期8卷 387-393页

作者： xiao wu-ming YANG Qi-yun CHEN Zhi-qiang WANG Hui GUO Tao LIU Yong-zhu ZHU xiao-yuan Plant Protection Research Institute Guangdong Academy of Agricultural Sciences Guangzhou 510640 P.R.China College of Agriculture South China Agricultural University Guangzhou 510642 P.R.China

To understand the resistance inheritance basis of space-induced rice lines to blast, and to probe mutants＇ genomic DNA polymorphism compared with ground control by microsatellite markers, three space-induced lines were crossed with a highly susceptible variety LTH, and their F1 and F2 populations were inoculated by two representative blast isolates with broad pathogenicity to analyze their resistance inheritance basis. Meanwhile three mutant lines and the ground control were analyzed by 225 rice SSR （simple sequence repeat） primer pairs selected throughout the 12 chromosomes of whole rice genome, to scan the mutagenesis in genome of the mutant lines. The results indicated the blast-resistant genes harbored in these mutant lines were dominant. It was demonstrated that the resistance of mutant H1 to isolate GD0193 and GD3286 was controlled by a single gene, respectively; while mutants H2 and H3 were controlled by two pairs of major genes against isolate GD3286 and H2 showed complicated genetic mechanism to isolate GD0193. H3＇s resistance to isolate GD0193 was verified to be controlled by a single gene. According to the results of SSR analysis, three mutant lines showed different mutant rates as compared with the ground control, and the mutant rates also varied. Resistance genes can be induced from rice by space mutation, and different genomic variations were detected in blast-resistant lines.

关键词： blast space mutation inheritance analysis microsatellite DNAs polymorphism

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Synthesis and antitumor activity of derivatives of 23-hydroxybetulinic acid

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Chinese Chemical Letters 2007年第10期18卷 1195-1198页

作者： Jin Pei Zhou Dan Li xiao ming wu Wen Cai Ye Lu Yong Zhang Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China Department of Phytochemistry China Pharmaceutical University Nanjing 210009 China National Drug Screening Center China Pharmaceutical University Nanjing 210038 China

A series of natural product 23-hydroxybetulinic acid derivatives were prepared. In the preparation of mono-O-benzoyl ester derivative, it was observed that benzoyl group migrated from 3-0- to 23-O-position during the ... 详细信息

关键词： 23-Hydroxybetulinic acid Triterpenoid Antitumor Synthesis

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Magnetic cell sorting and flow cytometry sorting methods for the isolation and function analysis of mouse CD^4+ CD25^+ Treg cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第12期10卷 928-932页

作者： Hang YAN Chen-guang DING Pu-xun TIAN Guan-qun GE Zhan-kui JIN Li-ning JIA xiao-ming DING xiao-ming PAN wu-jun XUE Department of Renal Transplantation Center of Nephropathy the First Affiliated Hospital Medicine College Xi'an Jiaotong University Xi'an 710061 China

Objective: In this paper we compared the two methods of cell sorting (magnetic cell sorting and flow cytometry sorting) for the isolation and function analysis of mouse CD4+ CD25+ regulatory T (Treg) cells, in order to inform further studies in Treg cell function. Methods: We separately used magnetic cell sorting and flow cytometry sorting to identify CD4+ CD25+ Treg cells. After magnetic cell separation, we further used flow cytometry to analyze the purity of CD4+ CD25+ Treg cells, trypan blue staining to detect cell viability, and propidium iodide (PI) staining to assess the cell viability. We detected the immune inhibition of CD4+ CD25+ Treg cells in the in vitro proliferation experiments. Results: The results showed that compared to flow cytometry sorting, magnetic cell sorting took more time and effort, but fewer live cells were obtained than with flow cytometry sorting. The CD4+ CD25+ Treg cells, however, obtained with both methods have similar immunosuppressive capacities. Conclusion: The result suggests that both methods can be used in isolating CD4+ CD25+ Treg cells, and one can select the best method according to specific needs and availability of the methodologies.

关键词： CD4+ CD25+ Treg cells Flow cytometry sorting Magnetic cell sorting

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Design and synthesis of 2-alkylbenzimidazole derivatives as novel non-peptide angiotensin Ⅱ AT1 receptor antagonists

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Chinese Chemical Letters 2007年第3期18卷 251-254页

作者： Jin Yi Xu Qian Ran Wei Yi Hua xiao ming wu Qiu Juan Wang Jing Zhang Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China Department of Physiology China Pharmaceutical University Nanjing 210009 China

A series of 2-alkylbenzimidazole derivatives 9a-n have been designed and synthesized as a novel class of non-peptide angiotensin H AT1 receptor antagonists. The synthesized compounds were evaluated for their antagonism of angiotensin H, induced contraction in the rabbit thoracic aortic ring and the results showed that compounds 9a, 9g and 9j exhibited potent antagonistic activity of AT1 receptor.

关键词： 2-Alkylbenzimidazole AT1 receptor antagonists Synthesis Hypertension

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A new isochroman-4-one derivative from the peel of Musa sapientum *** its total synthesis

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Chinese Chemical Letters 2007年第10期18卷 1227-1230页

作者： Hai Qian Wen Long Huang xiao ming wu Hui Bin Zhang Jin Pei Zhou Wen Cai Ye Center of Drug Discovery China Pharmaceutical University Nanjing 210009 China Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China Department of Phytochemistry China Pharmaceutical University Nanjing 210009 China

A new isochroman-4-one, 7,8-dihydroxy-3-methylisochroman-4-one was isolated from water soluble fraction of Musa sapientum L. Its structure was determined by spectroscopic evidences and its total synthesis has also bee... 详细信息

关键词： Isochroman-4-one Musa sapientum L. Isolation Total synthesis

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Pyramiding of Pi46 and Pita to improve blast resistance and to evaluate the resistance effect of the two R genes

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Journal of Integrative Agriculture 2016年第10期15卷 2290-2298页

作者： xiao wu-ming LUO Li-xin WANG Hui GUO Tao LIU Yong-zhu ZHOU Ji-yong ZHU xiao-yuan YANG Qi-yun CHEN Zhi-qiang National Engineering Research Center of Plant Space Breeding South China Agricultural University Plant Protection Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of High Technology for Plant Protection

Utilization of R（resistance） genes to develop resistant cultivars is an effective strategy to combat against rice blast disease. In this study, R genes Pi46 and Pita in a resistant accession H4 were introgressed into an elite restorer line Hang-Hui-179（HH179） using the marker-assisted backcross breeding（MABB） procedure. As a result, three improved lines（e.g., R1791 carrying Pi46 alone, R1792 carrying Pita alone and R1793 carrying both Pi46 and Pita） were developed. The three improved lines had significant genetic similarities with the recurrent parent HH179. Thus, they and HH179 could be recognized as near isogenic lines（NILs）. The resistance spectrum of the three improved lines, which was tested at seedling stage, reached 91.1, 64.7 and 97.1%, respectively. This was markedly broader than that of HH179（23.5%）. Interestingly, R1793 showed resistance to panicle blast but neither R1791 nor R1792 exhibited resistance at two natural blast nurseries. The results implied that the stacking of Pi46 and Pita resulted in enhanced resistance, which was unachievable by either R gene alone. Further comparison indicated that the three improved lines were similar to HH179 in multiple agronomic traits; including plant height, tillers per plant, panicle length, spikelet fertility, and 1 000-grain weight. Thus, the three improved lines with different R genes can be used as new sources of resistance for developing variety. There is a complementary effect between the two R genes Pi46 and Pita.

关键词： rice blast resistance gene improvement marker-assisted selection

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