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Relationship between lymph node sinuses with blood and lymphatic metastasis of gastric cancer

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World Journal of Gastroenterology 2003年第1期9卷 40-43页

作者： Tong Yin xiao-Long Ji min-shi Shen General Hospital of PLA,28 Fu Xing Road,Beijing 100853,China General Hospital of PLA 28 Fu Xing Road Beijing 100853 China.

AIM: To elucidate the relationship between lymph nodesinuses with blood and lymphatic metastasis of gastric ***: Routine autopsy was carried out in the randomlyselected 102 patients (among them 100 patients died ofvarious diseases, and 2 patients died of non-diseasedreasons), their superficial lymph nodes locating in bilateralnecks (include supraclavicle), axilla, inguina, thorax, andabdomen were sampled. Haematoxylin-Eosin staining wasperformed on 10 % formalin-fixed and paraffin-embeddedlymph node tissue sections (Sum). The histological pattemsof the lymph sinuses containing blood were observed underlight microscope. The expression of CD31, a marker forendothelial cell, was detected both in blood and non-bloodcontaining lymph node sinuses with the method ***: Among the 1322 lymph nodes sampled fromthe autopsies of 100 diseased cases, lymph node sinusescontaining blood were found in 809 lymph nodes sampledfrom 91 cases, but couldn't be seen in the lymph nodessampled from the non-diseased cases. According to histology,we divided the blood containing lymph node sinuses intofive categories: vascular-opening sinus, blood-deficient sinus,erythrophago-sinus, blood-abundant sinus, vascular-formative sinus. Immunohistochemical findings showed thatthe expression of CD31 was strongly positive in vascular-formative sinuses and some vascular-opening sinuses whileit was faint in blood-deficient sinuses, erythrophago-sinusesand some vascular-opening sinuses. It was almost negativein blood-abundant sinus and non-blood containing ***: In the state of disease, the phenomenonof blood present in the lymph sinus is not uncommon. Bloodcould possibly enter into the lymph sinuses through thelymphaticovenous communications between the veins andthe sinuses in the node. Lymph circulation and the bloodcirculation could communicate with each other in the lymphnode sinuses. The skipping and distal lymphatic metastasisof gastric cancer may have

关键词：胃癌血行转移淋巴结转移淋巴结窦免疫组织化学

Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis

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World Journal of Hepatology 2024年第4期16卷 625-639页

作者： xiao-Wei Tang Wen-Sen Ren Shu Huang Kang Zou Huan Xu xiao-min shi Wei Zhang Lei shi Mu-Han Lü Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Nuclear Medicine and Molecular Imaging Key Laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology Lianshui People’Hospital of Kangda College Affiliated to Nanjing Medical UniversityHuaian 223499Jiangsu ProvinceChina

BACKGROUND Liver cirrhosis patients admitted to intensive care unit(ICU)have a high mortality *** To establish and validate a nomogram for predicting in-hospital mortality of ICU patients with liver *** We extracted demographic,etiological,vital sign,laboratory test,comorbidity,complication,treatment,and severity score data of liver cirrhosis patients from the Medical Information Mart for Intensive Care IV(MIMIC-IV)and electronic ICU(eICU)collaborative research database(eICU-CRD).Predictor selection and model building were based on the MIMIC-IV *** variables selected through least absolute shrinkage and selection operator analysis were further screened through multivariate regression analysis to obtain final *** final predictors were included in the multivariate logistic regression model,which was used to construct a ***,we conducted external validation using the *** area under the receiver operating characteristic curve(AUC),decision curve,and calibration curve were used to assess the efficacy of the *** Risk factors,including the mean respiratory rate,mean systolic blood pressure,mean heart rate,white blood cells,international normalized ratio,total bilirubin,age,invasive ventilation,vasopressor use,maximum stage of acute kidney injury,and sequential organ failure assessment score,were included in the multivariate logistic *** model achieved AUCs of 0.864 and 0.808 in the MIMIC-IV and eICU-CRD databases,*** calibration curve also confirmed the predictive ability of the model,while the decision curve confirmed its clinical *** The nomogram has high accuracy in predicting in-hospital *** the included predictors may help improve the prognosis of patients.

关键词： Liver cirrhosis Intensive care unit Nomogram Predicting model Mortality

Criteria-specific long-term survival prediction model for hepatocellular carcinoma patients after liver transplantation

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World Journal of Gastroenterology 2014年第31期20卷 10900-10907页

作者： Fei Teng Gui-Hua Wang Yi-Feng Tao Wen-Yuan Guo Zheng-Xin Wang Guo-Shan Ding xiao-min shi Zhi-Ren Fu Organ Transplantation Institute of Changzheng Hospital Second Military Medical University

AIM: To establish a model to predict long-term survival of hepatocellular carcinoma (HCC) patients after liver transplantation (MHCAT).

关键词： Criteria Hepatocellular carcinoma Liver transplantation MHCAT Survival model

Reconstruction of the middle hepatic vein tributary in adult right lobe living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 581-586页

作者： xiao-min shi, Yi-Feng Tao, Zhi-Ren Fu, Guo-Shan Ding, Zheng-Xin Wang and Liang xiao Division of Liver Transplantation, Department of Organ Transplantation, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China Division of Liver Transplantation Department of Organ Transplantation Shanghai Changzheng Hospital Second Military Medical University Shanghai 200003 China

BACKGROUND: In adult-to-adult living donor liver transplantation (LDLT), the use of a right lobe graft without the middle hepatic vein (MHV) can cause hepatic congestion and disturbance of venous drainage. To solve this problem, we successfully used cadaveric venous allografts preserved in 4 ℃ University of Wisconsin (UW) solution within 10 days as interposition veins for drainage of the paramedian portion of the right lobe in adult LDLT. METHODS: From June 2007 to January 2008, 11 adult LDLT patients received modified right liver grafts. The major MHV tributaries (greater than 5 mm in diameter) of 9 cases were preserved and reconstructed using cadaveric interposition vein allografts that had been stored for 1 to 10 days in 4 ℃ UW solution. The regeneration of the paramedian sector of the grafts and the patency of the interposition vein allografts were examined by Doppler ultrasonography after the operation. RESULTS: MHV tributaries were reconstructed in 9 recipients. Only 1 recipient died of renal failure and severe pulmonary infection on day 9 after transplantation without any hemiliver venous outflow obstruction. The other 8 recipients achieved long-term survival with a median follow-up of 30 months. The cumulative patency rates of the 8 recipients were 63.63% (7/11), 45.45% (5/11), 45.45% (5/11) and 36.36% (4/11) at 3, 6, 12 and 24 months, respectively. Regeneration of the paramedian sectors was ***: The cadaveric venous allograft preserved in 4 ℃ UW solution within 10 days serves as a useful alternative for interposition veins in facilitating implantation of a right lobe graft and guarantees outflow of the MHV.

关键词： adult-to-adult living donor liver transplantation middle hepatic vein venous allograft reconstruction

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《论语》“四科十哲”及其存疑考辨

陕西师范大学学报（哲学社会科学版） 2014年第3期43卷 49-54页

作者：肖世民西安文理学院西安经济社会发展中心陕西西安710065

四科诸哲,伯牛无考,仲弓存歧;宰予名不副实,子游稍逊其称;其余诸贤,皆名至实归。四教以四科彰显其价值追求,四科因四教而成十哲之名。颜回德望名重,而为颜氏之儒;然子夏西河教授,儒学始兴。

关键词：《论语》四科十哲四教儒学传承

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《说文解字·艹部》草药类植物词语补释

南昌大学学报（人文社会科学版） 2010年第1期41卷 123-129页

作者：萧世民萧红艳井冈山大学人文学院江西吉安343009 北京中医药大学基础医学院北京100029

《说文解字·艹部》的说解有三点可商之处:一是以通名释专名,未直接点明该词语的确切名称,或曰"艹也"、"XX艹",或曰"菜也"、"XX菜";二是对《尔雅》说解正确的词语也不采纳,仍旧释为"艹也"、"菜也"。这两种说解不符合解释学的要求,也与... 详细信息

《说文解字·艹部》的说解有三点可商之处:一是以通名释专名,未直接点明该词语的确切名称,或曰"艹也"、"XX艹",或曰"菜也"、"XX菜";二是对《尔雅》说解正确的词语也不采纳,仍旧释为"艹也"、"菜也"。这两种说解不符合解释学的要求,也与全书条例不合;三是将一些中草药植物名词释为其他名词或形容词性、动词性词组。有鉴于此,对这些词语很有必要再作补充解释,以便读者知晓其确切名称。

关键词：许慎《说文解字》艹部中草药植物词语补释

Prevention of hepatitis B virus reinfection after orthotopic liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 345-348页

作者： Zheng-Xin Wang, Guo-Shan Ding, Hong Fu, Jian-Jun Zhang, xiao-Song Chen,Wen-Yuan Guo, xiao-min shi and Zhi-Ren Fu Liver Transplantation Group of Transplantation Cen-ter , Changzheng Hospital, Second Military University, Shanghai 200003,China Liver Transplantation Group of Transplantation Center Changzheng Hospital Second Military University Shanghai 200003 China.

BACKGROUND: Hepatitis B virus reinfection is an impor-tant problem after liver transplantation. The aim of thisstudy was to discuss the prevention of hepatitis B virus rein-fection following orthotopic liver ***: Sixty-eight cases of chronic fulminant hepatitisB, end-stage liver cirrhosis, and liver carcinoma complicat-ed with HBV cirrhosis were given anti-viral drugs beforeand after transplantation to prevent hepatitis B virus rein-fection. Lamivudine was administered in 2 patients, lami-vudine + hepatitis B immunoglobulin ( HBIG ) in 63, andadefovir + HBIG in 3. The measurement of serum HBV,HBV DNA, liver biopsy immunohistochemistry and clini-cal study were ***: In 1 of the 2 patients who developed reinfectionafter lamivudine administration, serum HBsAg, HBeAb,HBcAb, HBV DNA were positive and liver biopsy immu-nohistochemistry showed HBsAg phenotype. In 2 of 63 pa-tients who developed reinfection after use of lamivudine +HBIG, serum HBsAg, HBeAb, HBcAb were positive andliver biopsy immunohistochemistry showed HBsAg pheno-type. Serum HBV DNA was positive in one of *** patients developed no reinfection with HBV after useof ***: Orthotopic liver transplantation is effectivein the treatment of HBV-infected diseases. Lamivudine +HBIG or adefovir + HBIG could effectively prevent hepatitisB virus reinfection.

关键词： hepatitis B hepatitis B immunoglobulin prophylaxis liver transplantation lamivudine reinfection

Tangled but ordered human mitochondrial tRNA maturation

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Science China Life Sciences 2025年

作者： shi-Ying Yao xiao-Long Zhou Key Laboratory of RNA Innovation Science and Engineering CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences

Mitochondria are cellular organelles that originate from an endosymbiotic bacterial ancestor and are primarily responsible for ATP generation via oxidative phosphorylation (OXPHOS). OXPHOS is conducted by five mitochondrial respiratory complexes in the inner mitochondrial membrane. Human mitochondria possess a distinct genome, a small, circular, doublestranded DNA (mtDNA) of 16,569 base pairs.

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang xiao-Qian Yang Chun-Hao Yang shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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