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Current Medical Science 2019年第4期39卷 582-588页

作者： xiao-lu xiong Rong-xin ZHANG Yan BI Wei-hong ZHOU Yun YU Da-long ZHU Department of Endocrinology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing 210008China School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjing 211166China

Type 2 diabetes mellitus (T2DM) has become a prevalent health problem in China,especially in urban *** prevention strategies are needed to reduce the associated mortality and *** applied the combination of rules and different machine learning techniques to assess the risk of development of T2DM in an urban Chinese adult population.A retrospective analysis was performed on 8000 people with non-diabetes and 3845 people with T2DM in *** Perceptron (MLP),AdaBoost (AD),Trees Random Forest (TRF),Support Vector Machine (SVM),and Gradient Tree Boosting (GTB) machine learning techniques with 10 cross validation methods were used with the proposed model for the prediction of the risk of development of *** performance of these models was evaluated with accuracy,precision,sensitivity,specificity,and area under receiver operating characteristic (ROC) curve (AUC).After comparison,the prediction accuracy of the different five machine models was 0.87,0.86,0.86,0.86 and 0.86 *** combination model using the same voting weight of each component was built on T2DM,which was performed better than individual *** findings indicate that,combining machine learning models could provide an accurate assessment model for T2DM risk prediction.

关键词： type 2 diabetes risk prediction machine learning

Pharmacokinetics of Cyadox and Its Major Metabolites in Swine After Intravenous and Oral Administration

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Journal of Integrative Agriculture 2013年第3期12卷 495-501页

作者： ZHAO Ning WANG Lin lu xiao-xiong JIA Hui-qin FANG Bing-hu ZENG Zhen-ling DING Huan-zhong Laboratory of Veterinary Pharmacology College of Veterinary Medicine South China Agricultural University

Pharmacokinetics of cyadox （CYX） and its major metabolites in healthy swine was investigated in this paper. 1,4- Bisdesoxycyadox （BDCYX）, cyadox-1-monoxide （CYX-1-O） and quinoxaline-2-carboxylic acid （QCA）, three main metabolites of cyadox, were synthesized by College of Science, China Agricultural University. Cyadox （CYX） was administered to 8 healthy cross-bread swine intravenously （i.v.） and orally （p.o.） at a dosage of 1 mg kg^-1 body weight and 40 mg kg-1 body weight respectively in a randomized crossover design test with 2-wk washout period. A sensitive high-performance liquid chromatography-tandem mass spectrometry （LC-ESI-MS/MS） method was developed for the determination of cyadox and its major metabolites in plasma. CYX and its major metabolites BDCYX, and CYX-1-O can be detected after intravenous administration of cyadox while CYX and its metabolites BDCYX, CYX-1-O and QCA can be detected after oral administration of CYX. Plasma concentration vs. time profiles of CYX and its major metabolites were analyzed by non-compartmental pharmacokinetic method. Following i.v. administration, the areas under the plasma concentration-time curve （AUC0-∞） were （0.38±0.03） lag mL-I h （CYX）, （0.018±0.002） lag mL-1 h （BDCYX） and （0.17±0.02） lag mL^-1 h （CYX- 1-O）, respectively. The terminal elimination half-lives （t1/2kz） were determined to be （0.93±0.07） h （CYX）, （1.45±0.04） h （BDCYX）, and （0.92±0.04） h （CYX-1-O）, respectively. Steady-state distribution volume （Vss） of （2.14±0.11） L kg^-1 and total body clearance （CL） of （2.84±0.19） L h^-1 kg^-1 were determined for CYX after i.v. dosing. The bioavailability （F） of CYX was 2.85% for oral administration. After single i.v. administration, peak plasma concentrations （Cmax） of （1.08±0.06） lag mL^-1 （CYX）, （0.0068~ 0.0004） lag mL-1 （BDCYX） and （0.25~0.03） gg mL-~ （CYX-I-O） were observed at Tmax of 0.033 h （CYX）, 1 h （BDCYX） and 0.033 h （CYX-1-O）, respectively. The main pharmacokinetic parameters after p.o. administration were as

关键词： cyadox metabolites pharmacokinetics LC-MS/MS swine

Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis

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Chinese Medical Journal 2009年第12期122卷 1449-1454页

作者： DENG Zi-yu LI Jun JIN Yong CHEN xiao-liang lu xiong-wen School of Pharmacy Anhui Medical University Hefei Anhui 230032 China

Background Recent studies have suggested that p38 mitogen-activated protein kinases （MAPK） signalling pathway plays an important role in hepatic fibrosis. This study explored the antifibrotic effect of oxymatrine on tetrachloromethane induced liver fibrosis in rats and its modulation on the p38 MAPK signalling pathway. Methods One hundred and twenty healthy male Sprague-Dawley rats were randomly assigned to six groups： normal （n=20）, induced fibrosis （n=20）, colchicine （n=20） and three treatment groups of oxymatrine （n=20x3）. We obesrved changes in deposition of collagen, hyaluronic acid （HA）, laminin （LN）, collagen type IV （CIV）, procollagen III （PCIll） and hydroxyproline （Hyp）, a-smooth muscle actin （α-SMA） and phosphor-p38 （pp38）. Results The relative indicators of changes in histopathology, HA, LN, CIV, PCIII, Hyp, a-SMA and pp38 were raised significantly in the induced fibrosis group （P〈0.01 vs normal group）. The semiquantitative hepatic fibrosis staging scores of middle dose group and high dose group were decreased （P 〈0.05 and P 〈0.01 respectively vs the induced fibrosis group）, as was the average area of collagen in rats＇ liver, the concentrations of serum HA, LN, CIV, PCIII and liver tissue homogenate Hyp. The gene expression of α-SMA mRNA was considerably decreased in the treated animals, as was the protein espression of pp38 protein. Conclusions Oxymatrine is effective in reducing the production and deposition of collagen in the liver tissue of experimental rats in ways which relate to modulating the fibrogenic signal transduction via p38 MAPK signalling pathway.

关键词： oxymatrine liver fibrosis p38 mitogen-activated protein kinase signalling pathway

Progress in Ti_(3)O_(5):Synthesis,properties and applications

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Transactions of Nonferrous Metals Society of China 2021年第11期31卷 3310-3327页

作者： Peng-fei ZHAO Guang-shi LI Wen-li LI Peng CHENG Zhong-ya PANG xiao-lu xiong Xing-li ZOU Qian XU xiong-gang lu School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel&Shanghai Key Laboratory of Advanced Ferrometallurgy Shanghai UniversityShanghai 200444China School of Materials Science Shanghai Dianji UniversityShanghai 201306China

The crystal structure,physical,chemical and phase transition properties of trititanium pentoxide(Ti_(3)O_5)have aroused a broad range of research effort since the *** crystalline forms(α,β,γ,δandλ)of Ti_(3)O_5 exhibit various ***,reversible phase transitions betweenλ-andβ-Ti_(3)O_5 have been attracting increasing research interest,which brings new potential applications of Ti_(3)O_5 materials in the field of energy and data *** recently,Ti_(3)O_5 materials have shown excellent performance in trace detection,microwave absorption and virus adsorption,which has expanded its application ***,the essential properties of different crystal forms of Ti_(3)O_5 are described in *** intensive overview of Ti_(3)O_5 preparation methods and applications is comprehensively summarized.

关键词： Ti_(3)O_(5) phase transition pressure induction data storage catalyst support

Retrospective Examination of Q Fever Endocarditis： An Underdiagnosed Disease in the Mainland of China

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Chinese Medical Journal 2017年第1期130卷 64-70页

作者： xiao Han Jeffrey Hsu Qi Miao Bao-Tong Zhou Hong-Wei Fan xiao-lu xiong Bo-Hai Wen Lian Wu xiao-Wei Yan Quan Fang Wei Chen Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Cardiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Cardiac Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Infection Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China ing 100071 China Department of Internal Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730. China

Background： Q fever endocarditis, a chronic illness caused by Coxiella burnetii, can be fatal ifmisdiagnosed or left untreated. Despite a relatively high positive rate of Q fever serology in healthy individuals in the mainland of China, very few cases of Q fever endocarditis have been reported. This study summarized cases of Q fever endocarditis among blood culture negative endocarditis （BCNE） patients and discussed factors attributing to the low diagnostic rate. Methods： We identified confirmed cases of Q fever endocarditis among 637 consecutive patients with infective endocarditis （IE） in the Peking Union Medical College Hospital between 2006 and 2016. The clinical findings for each confirmed case were recorded. BCNE patients were also examined and each BCNE patient＇s Q fever risk factors were identified. The risk factors and presence of Q fever serologic testing between BCNE patients suspected and unsuspected of Q fever were compared using the Chi-squared or Chi-squared with Yates＇ correction for continuity. Results： Among the IE patients examined, there were 147 BCNE patients, of whom only 11 patients （7.5%） were suspected of Q fever and undergone serological testing for C. burnetii. Six out of 11 suspected cases were diagnosed as Q fever endocarditis. For the remaining 136 BCNE patients, none of them was suspected of Q fever nor underwent relevant testing. Risk factors for Q fever endocarditis were comparable between suspected and unsuspected patients, with the most common risk factors being valvulopathy in both groups. However, significantly more patients had consulted the Infectious Diseases Division and undergone comprehensive diagnostic tests in the suspected group than the unsuspected group （100% vs. 63%, P = 0.03）. Conclusions： Q fever endocarditis is a serious yet treatable condition. Lacking awareness of the disease may prevent BCNE patients from being identified, despite having Q fever risk factors. Increasing awareness and guideline adherence are cruc

关键词： Blood Culture Endocarditis Q Fever

Molten salt electrosynthesis of silicon carbide nanoparticles and their photoluminescence property

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Transactions of Nonferrous Metals Society of China 2022年第11期32卷 3790-3800页

作者： Zhong-ya PANG Xiang LI Xue-qiang ZHANG Jin-jian LI Shu-juan WANG xiao-lu xiong Guang-shi LI Qian XU Zhong-fu ZHOU Xing-li ZOU xiong-gang lu State Key Laboratory of Advanced Special Steel&Shanghai Key Laboratory of Advanced Ferrometallurgy School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Institute of Mathematics and Physics Aberystwyth UniversityAberystwyth SY233BZUK School of Materials Science Shanghai Dianji UniversityShanghai 201306China

A one-step molten salt electrochemical strategy was proposed to synthesize SiC nanoparticles from ultra-fine silicon dioxide/carbon(SiO_(2)/C)*** electrosynthesis process and physicochemical properties of the synthesized products were systematically analyzed via X-ray diffraction,electron microscopy,Raman spectroscopy and photoluminescence spectroscopy,etc.A combined chemical/electrochemical reaction,electrochemical deoxidation,and in-situ carbonization reaction mechanism was proposed to reveal the electrochemical synthesis process of SiC nanoparticles from SiO_(2)/C in molten CaCl_(2).The as-prepared SiC with particle size ranging from 8 to 14 nm possesses a polycrystalline *** addition,the SiC nanoparticles demonstrate obvious photoluminescence property due to the synergetic size effect and microstructural characteristics.

关键词： SiC nanomaterials molten salt electrosynthesis deoxidation photoluminescence

阿尔茨海默病患者早老素-1基因突变检测及其突变后对早老素-1和淀粉样前体蛋白表达功能的影响

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中华神经科杂志 2013年第1期46卷 5-9页

作者：卢晓雄吕清浦佳丽张宝荣浙江大学医学院附属第二医院神经内科杭州310009

目的探讨阿尔茨海默病（AD）患者早老素-1（PS-1）基因突变情况及PS-1基因起始密码子ATG—GTG突变对PS-1和淀粉样前体蛋白（APP）mRNA水平及P-1蛋白表达的影响。方法（1）对2004年7月至2010年6月我院神经内科收治的111例AD患者行PS-1基... 详细信息

目的探讨阿尔茨海默病（AD）患者早老素-1（PS-1）基因突变情况及PS-1基因起始密码子ATG—GTG突变对PS-1和淀粉样前体蛋白（APP）mRNA水平及P-1蛋白表达的影响。方法（1）对2004年7月至2010年6月我院神经内科收治的111例AD患者行PS-1基因突变筛查；（2）将筛查发现的突变型PS-1C．1A〉G和野生型PS-1基因全长cDNA克隆入增强型绿色荧光蛋白表达载体；以空质粒、野生型和突变型PS-1转染人胚肾（HEK）293和小鼠成神经瘤（N2a）细胞，利用实时荧光定量PCR检测转染后细胞PS-1和APPmRNA水平及蛋白质印迹检测PS-1蛋白的表达，以研究PS．1基因突变后的功能改变原因。结果（1）1例患者（编号M766）PS一1基因3号外显子起始密码子发生了杂合突变ATG--→GTG；（2）PS．1基因mRNA水平在HEK293细胞和N2a细胞中野生型均明显高于突变型（116．8±3．9与49．5±3．3，t=13．27，P〈0．01；69．0±1．9与29．5±1．3，t=17．20，P〈0．01），APP基因mRNA水平突变型和野生型比较差异无统计学意义。蛋白质印迹结果显示野生型和突变型PS．1在HEK293细胞中均表达，且突变型表达量较野生型少，而N2a细胞仅表达野生型PS-1。结论PS-1基因检测仅发现1个新的杂合突变ATG→GTG，AD患者PS-1基因突变频率很低；PS．1基因起始密码子突变导致PS-1蛋白表达减少，PS-1蛋白部分减少可能不是引起致病的独立因素，但可能是AD的一个危险因子。

关键词：阿尔茨海默病早老素1 淀粉样β蛋白前体突变密码子起始

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程序CRC自校验方法与实现

岳阳职业技术学院学报 2008年第1期23卷 87-89页

作者：卢晓雄岳阳职业技术学院计算机系湖南岳阳414000

通过介绍基于CRC校验的基本原理入手,旨在探讨一种嵌入式系统程序代码自动校验的方法和实现步骤。

关键词： CRC校验原理方法实现

超级电容和IGBT在停电保磁控制装置中的应用研究

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岳阳职业技术学院学报 2010年第3期25卷 68-70页

作者：李锋卢晓雄岳阳职业技术学院湖南岳阳414000

停电保磁控制装置是起重电磁铁的配套控制装置,起重电磁铁是高耗能设备,原有控制装置不节能、可靠性差、操作不方便。将超级电容和IGBT模块应用到停电保磁装置中,从根本上解决停电保磁设备节能降耗问题,提高设备运行可靠性,运行参数指... 详细信息

停电保磁控制装置是起重电磁铁的配套控制装置,起重电磁铁是高耗能设备,原有控制装置不节能、可靠性差、操作不方便。将超级电容和IGBT模块应用到停电保磁装置中,从根本上解决停电保磁设备节能降耗问题,提高设备运行可靠性,运行参数指示更直观、操作更简便。新型装置的研发应用将显著提高我国停电保磁产品的档次与水平,促进超级电容在工业产品的应用,推动行业节能减排。

关键词：停电保磁电磁铁超级电容节能

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在役刚架拱桥病害分析及加固设计研究

浙江交通职业技术学院学报 2023年第1期24卷 18-22,35页

作者：陆潇雄李鑫陈露晔浙江数智交院科技股份有限公司浙江杭州310030 华设设计集团股份有限公司江苏南京210000

基于某在役刚架拱桥次拱腿断裂及横向连杆脱落等病害问题,通过建立多种工况有限元分析模型,对比分析了不同工况下的内力,进一步了解病害产生原因,提出了对应的加固措施,并开展了桥梁荷载试验。结果表明:该桥病害中破损及缺失构件并非主... 详细信息

基于某在役刚架拱桥次拱腿断裂及横向连杆脱落等病害问题,通过建立多种工况有限元分析模型,对比分析了不同工况下的内力,进一步了解病害产生原因,提出了对应的加固措施,并开展了桥梁荷载试验。结果表明:该桥病害中破损及缺失构件并非主要受力构件,可以采用粘贴钢板的加固方案对桥梁病害出现的位置及主要受力部分进行加固,以此满足公路Ⅱ级荷载标准。

关键词：刚架拱桥病害分析加固方案粘贴钢板