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Homoclinic Solutions for a Class of Second Order Discrete Hamiltonian Systems

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Acta Mathematica Sinica,English Series 2012年第3期28卷 609-622页

作者： Xian Hua TANG xiao yan lin School of Mathematical Sciences and Computing Technology Central South University Department of Mathematics Huaihua College

Consider the second order discrete Hamiltonian systems

关键词： Homoclinic solution discrete Hamiltonian system critical point

Analysis of the management and therapeutic performance of diabetes mellitus employing special target

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World Journal of Diabetes 2023年第12期14卷 1721-1737页

作者： Hong-yan Sun xiao-yan lin Department of Endocrine and Metabolic Diseases Yantaishan HospitalYantai 264003Shandong ProvinceChina

Diabetes mellitus (DM) is a chronic metabolic condition characterized predominantlyby hyperglycemia. The most common causes contributing to the pathophysiologyof diabetes are insufficient insulin secretion, resistance to insulin’stissue-acting effects, or a combination of both. Over the last 30 years, the globalprevalence of diabetes increased from 4% to 6.4%. If no better treatment or cure isfound, this amount might climb to 430 million in the coming years. The major fact-ors of the disease’s deterioration include age, obesity, and a sedentary *** new therapies to manage diabetes safely and effectively without jeopardizingpatient compliance has always been essential. Among the medicationsavailable to manage DM on this journey are glucagon-like peptide-1 agonists,thiazolidinediones, sulphonyl urease, glinides, biguanides, and insulin-targetingreceptors discovered more than 10 years ago. Despite the extensive preliminarystudies, a few clinical observations suggest this process is still in its early *** present review focuses on targets that contribute to insulin regulation andmay be employed as targets in treating diabetes since they may be more efficientand secure than current and traditional treatments.

关键词： Diabetes mellitus Hyperglycemia Therapeutic performance Management Special target Literature review

Genetic perspectives on childhood monogenic diabetes:Diagnosis,management,and future directions

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World Journal of Diabetes 2023年第12期14卷 1738-1753页

作者： Hong-yan Sun xiao-yan lin Department of Endocrine and Metabolic Diseases Yantaishan HospitalYantai 264003Shandong ProvinceChina

Monogenic diabetes is caused by one or even more genetic variations, which maybe uncommon yet have a significant influence and cause diabetes at an early *** diabetes affects 1 to 5% of children, and early detection and geneticallyfocused treatment of neonatal diabetes and maturity-onset diabetes of theyoung can significantly improve long-term health and well-being. The etiology ofmonogenic diabetes in childhood is primarily attributed to genetic variationsaffecting the regulatory genes responsible for beta-cell activity. In rare instances,mutations leading to severe insulin resistance can also result in the developmentof diabetes. Individuals diagnosed with specific types of monogenic diabetes,which are commonly found, can transition from insulin therapy to sulfonylureas,provided they maintain consistent regulation of their blood glucose *** have successfully devised materials and methodologies to distinguishindividuals with type 1 or 2 diabetes from those more prone to monogenicdiabetes. Genetic screening with appropriate findings and interpretations isessential to establish a prognosis and to guide the choice of therapies andmanagement of these interrelated ailments. This review aims to design a comprehensiveliterature summarizing genetic insights into monogenetic diabetes inchildren and adolescents as well as summarizing their diagnosis and management.

关键词： Monogenic diabetes Maturity-onset diabetes of the young Insulin resistance Genetic mutation Beta-cell function

Hydroxylation Reaction Mechanism for Nitrosodimethylamine by Oxygen Atom

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Chemical Research in Chinese Universities 2011年第6期27卷 1006-1009页

作者： LI Lan lin xiao-yan LI Zong-he College of Sciences Shanghai Institute of Technology Shanghai 200235 P. R. China College of Chemistry Beijing Normal University Beijing 100875 P. R. China

The hydroxylation reaction mechanism of nitrosodimethylamine（NDMA） by oxygen atom was theoretically investigated at the B3LYP/6-31G＊＊ level. It has been found that the path of the oxydation of the C―H bond is easier than the path involving a Singlet/Triplet crossing. The study of the potential surface shows that both solvent effect at B3LYP/6-31G＊＊ level and different method at more credible MP2/6-311G＊＊ level in the gas phase have no effect on the hydroxylation reaction mechanism. The oxidation hydroxylation process of NDMA by O is exothermic reaction and easy to occur.

关键词： Nitrosodimethylamine(NDMA) Hydroxylation B3LYP MP2

Inversion analysis of the shear strength parameters for a high loess slope in the limit state

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Journal of Mountain Science 2021年第1期18卷 252-264页

作者： lin xiao-yan ZHANG lin-fan yanG Ze LI Ping LI Tong-lu School of Earth Sciences and Engineering Xi'an Shiyou UniversityXi'an 710065China Shaanxi Key Laboratory of Petroleum Accumulation Geology Xi'an Shiyou UniversityXi'an 710065China School of Geological Engineering and Surveying Chang'an UniversityXi'an 710061China

It is difficult to obtain reliable shear strength parameters for the stability analysis and evaluation of high loess ***,this paper determines slope elements and physical parameter of 79 slopes with heights of[40,120]m based on the measured loess slopes in the Ganquan and Tonghuang subregions of northern Shaanxi Province,*** the limit state of the loess slope(stability factor Fs is 1.0),a fitting equation for the slope height and width is ***,the model is developed by stability analysis software-SLOPE/W,and the comprehensive shear strength parameters corresponding to different slope heights of the high slope in the study area are obtained by inversion using the Morgenstern-Price *** results show that when the height of the slope increases,the cohesion c increases in the soil,and the internal friction angle j *** change is consistent with the characteristics reflected in the composition and physical properties of the slopes,and the comprehensive strength parametric curves are very similar between the Ganquan subregion and the Tonghuang subregion.A landslide that occurred in Miaodian-zaitou of Jingyang County,Shaanxi Province,is selected to verify this inversion method,and the results show that the calculated shear strength parameters of the inversion are consistent with the measured value of the actual slope.

关键词： Loess High slope Shear strength Inversion SLOPE/W

A sparse matrix model-based optical proximity correction algorithm with model-based mapping between segments and control sites

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第5期12卷 436-442页

作者： Bin lin xiao-lang yan Zheng SHI Yi-wei yanG Institute of VLSI Design Zhejiang University Hangzhou 310027 China

Optical proximity correction (OPC) is a key step in modern integrated circuit (IC) *** quality of model-based OPC (MB-OPC) is directly determined by segment offsets after OPC ***,in conventional MB-OPC,the intensity of a control site is adjusted only by the movement of its corresponding segment;this scheme is no longer accurate enough as the lithography process *** the other hand,matrix MB-OPC is too time-consuming to become *** this paper,we propose a new sparse matrix MB-OPC algorithm with model-based mapping between segments and control *** put forward the concept of 'sensitive area'.When the Jacobian matrix used in the matrix MB-OPC is evaluated,only the elements that correspond to the segments in the sensitive area of every control site need to be calculated,while the others can be set to *** new algorithm can effectively improve the sparsity of the Jacobian matrix,and hence reduce the *** theoretical analysis and experiments show that the sparse matrix MB-OPC with model-based mapping is more accurate than conventional MB-OPC,and much faster than matrix MB-OPC while maintaining high accuracy.

关键词： Matrix sparsity Optical proximity correction (OPC) Convergence Segment Sensitive area

Spindle and Chromosome Analysis of Non-Fertilized Oocytes from Conventional in vitro Fertilization for Non-Male Factor Infertiliy: Significance of Rescue ICSI?

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Journal of Reproduction and Contraception 2011年第1期22卷 1-10页

作者： xiao-lin LONG, Han-yan LIU Xin-jie CHEN xiao-fang SUN Center for Reproductive Medicine Research Institute of Gynecology and Obstetrics of Guangzhou Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150 China

Objective To determine whether rescue intracytoplasmic sperm injection （ICSI） is associated with improved outcomes for non-male factor infertility. Methods The changes of micro-structure, including meiotic spindle and chromosome distribution, sperm penetration, as well as oocyte activation were compared in IVF （in vitro fertilization）fertilization failure （1VF FF） patients, ICSI patients with non-fertilized oocytes （ICSI NF） and oocytes in vitro maturation （IVM）. Results A total of 164 unfertilized oocytes （93 oocytes in IVF and 71 oocytes in ICSI） and 56 IVM oocytes were available for this study. The abnormality of spindle and chromosomes was significantly higher in IVF FF group than that in ICSI NF group or IVM group （abnormal spindle rates were 80.6%, 64.8% and 57.1%, respectively; abnormal chromosome rates were 91.4%, 80.3% and 75.0%, respectively）. No sperm penetration after IVF and sperm expulsion after ICSI were 78.5% and 40.8%, respectively. Activation failure occurred in 16.1% of the IVF FF cases and 49.3% of ICSI NF oocytes. Conclusion Rescue ICSI of fertilization-failed oocytes fails to lead outcome improvement due to the internal defects of oocytes.

关键词： IVF failure ICSI rescue ICSI spindle chromosome outcome

Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma

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Chinese Medical Journal 2018年第1期131卷 16-24页

作者： Ying-Hua Song Cai-Qing Zhang Fang-Fang Chen xiao-yan lin Department of Respiratory Medicine Shandong Qianfoshan Hospital Shandong University Jinan Shandong 250014 China Department of Pathology Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China

Background： The E3 ubiquitin ligasc neural precursor cell expressed developmentally downregulated 4-1（N EDD4-1） negatively regulates phosphatase and tensin homolog deleted on chromosome 10 （PTEN） protein levels through polyubiquitination and proteolysis, but its significance in lung cancer is still unclear. This study investigated the expression and the role of NEDD4-1 in tumor developnaent and chemosensitivity of lung adenocarcinoma （ADC）. Methods： We retrospectively investigated the expression and significance ofNEDD4-1, PTEN, and p-Akt proteins in 135 paired A DC and adjacent noncancerous tissue specimens using immunohistochemistry. Furthemaore, we evaluated the relationship between NEDD4-1 expression and clinicopathologic characteristics and prognosis. The effects of small interfering RNA against NEDD4-1 on proliferation and chemosensitivity were examined in A549 cells in vitro using 3- （4,5-dimethylthiazol-2-yl） -5-（3-carboxymethoxyphenyl） -2-（4-sulfophenyl）- 2H-tetrazoliunl method. The ability of migration and invasion ofA549 cells was tested by transwell assay. Moreover, reverse-transcription quantitative polymerase chain reaction and Western blotting analyses were used to determine the expression of NEDD4-1, PTEN, phosphoinositide 3-kinase （PI3K）/Akt activity, and its downstream target proteins. Results： NEDD4-1 protein was significantly upregulated in lung ADC tissues, whereas it was weak or negative in normal lung epithelial cells. The expression ofNEDD4-1 in ADC （78.5%, 106/135） was significantly much higher than that in adjacent normal lung tissue （ 13.3%, 29/135, P 〈 0.01）, and it was associated with lymph node metastasis, tumor-node-metastasis （TNM） stage, and chemotherapy resistance. PTEN expression was downregulated in lung ADC （60.7% vs. 100.0% in noncancerous specimens, P - 0.007）, and was negatively correlated with lymph node metastasis, histological variants, clinical stage, chemoresistance. In addition, expression of p-Akt in ADC tissues （71.1%

关键词： Chemoresistance Lung Adenocarcinoma: NEDD4-1: PTEN 10 Prognosis

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铁路旅客期望与旅客满意关系研究

铁道学报 2010年第4期32卷 23-26页

作者：陈小君林晓言北京交通大学经济管理学院北京100044

客运服务质量优劣取决于旅客对服务预期和实际感知之间的对比,从某种意义上讲,服务质量可以认为是主观范畴。由此引来对客运企业质量优劣的评价在很大程度上由旅客期望所决定。本文首先探讨顾客期望及满意含义。接着在此基础上,说明旅... 详细信息

客运服务质量优劣取决于旅客对服务预期和实际感知之间的对比,从某种意义上讲,服务质量可以认为是主观范畴。由此引来对客运企业质量优劣的评价在很大程度上由旅客期望所决定。本文首先探讨顾客期望及满意含义。接着在此基础上,说明旅客期望和旅客满意的对应关系。并利用博弈的方法推导出铁路客运服务业中旅客满意的一般均衡条件。最后基于该均衡条件,铁路客运企业可以通过合理引导旅客期望,进而使得旅客满意。

关键词：铁路旅客期望铁路旅客满意顾客期望层次信息不对称