检索结果-南通市图书馆

International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 417-431页

作者： Chun-bao Sun xiao-liang zhang Jue Kou Yi Xing School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory of the Ministry of Education of China for High-Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China

Alkaline sulfur-containing lixiviants,including thiosulfate,polysulfides,and alkaline sulfide solutions,stand out as a promising class of alternatives to cyanide because of their low toxicity,high efficiency,and strong *** this paper,we summarized the research progress and remaining challenges in gold extraction using these noncyanide *** a brief introduction to the preparation method,the transformation process of various sulfur-containing species in alkaline solutions was ***,some insights into the mechanism of gold leaching in alkaline sulfur-containing solutions were presented from different aspects,including thermodynamics analysis,electrochemical dissolution,and leaching ***,recent progress in in-situ generation of sulfur-containing anions from gold-bearing sulfide minerals was outlined as *** passivation caused by sulfur species was discussed in particular because it is considered the greatest challenge facing sulfur-containing leaching *** sulfur-containing lixiviants are expected to serve as alternatives in industrial applications of gold extraction,particularly for refractory gold ores containing copper and carbonaceous matter.

关键词： gold extraction sulfur-containing lixiviants degradation in-situ generation passivation

Mineralogical characterization of copper sulfide tailings using automated mineral liberation analysis: A case study of the Chambishi Copper Mine tailings

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2021年第6期28卷 944-955页

作者： xiao-liang zhang Jue Kou Chun-bao Sun Rui-yang zhang Min Su Shuo-fu Li School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Non-ferrous Corporation Africa Mining Public Limited Company Kitwe 22592Zambia

As ore grades constantly decline,more copper tailings,which still contain a considerable amount of unrecovered copper,are expected to be produced as a byproduct of froth *** research reveals the occurrence mechanism of copper minerals in typical copper sulfide tailings using quantitative mineral liberation analysis(MLA)integrated with scanning electron microscopy–energy dispersive spectroscopy(SEM–EDS).A comprehensive mineralogical characterization was carried out,and the results showed that almost all copper minerals were highly disseminated within coarse gangue particles,except for 9.2wt%chalcopyrite that occurred in the 160–180μm size *** predominant copper-bearing mineral was chalcopyrite,which was closely intergrown with orthoclase and muscovite rather than *** flotation tailings sample still contained 3.28wt%liberated chalcopyrite and 3.13wt%liberated bornite because of their extremely fine *** SEM–EDS analysis further demonstrated that copper minerals mainly occurred as fine dispersed and fully enclosed structures in gangue *** information obtained from this research could offer useful references for recovering residual copper from flotation tailings.

关键词： copper tailings chalcopyrite mineral liberation analysis particle size boundary breakage

Molecular cloning and anti-HIV-1 activities of APOBEC3s from northern pig-tailed macaques(Macaca leonina)

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2016年第4期37卷 246-251页

作者： xiao-liang zhang Jia-Hao SONG Wei PANG Yong-Tang ZHENG Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Faculty of Life Science and Technology Kunming University of Science and Technology Institute of Health Sciences Anhui University Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of Zoology Chinese Academy of Sciences

Northern pig-tailed macaques （NPMs, Macaca leonina） are susceptible to HIV-1 infection largely due to the loss of HIV-l-restricting factor TRIM5a. However, great impediments still exist in the persistent replication of HIV-1 in vivo, suggesting some viral restriction factors are reserved in this host The APOBEC3 proteins have demonstrated a capacity to restrict HIV-1 replication, but their inhibitory effects in NPMs remain elusive. In this study, we cloned the NPM A3A-A3H genes, and determined by BLAST searching that their coding sequences （CDSs） showed 99% identity to the corresponding counterparts from rhesus and southern pig-tailed macaques. We further analyzed the anti-HIV-1 activities of the A3A-A3H genes, and found that A3G and A3F had the greatest anti-HIV-1 activity compared with that of other members. The results of this study indicate that A3G and A3F might play critical roles in limiting HIV-1 replication in NPMs in vivo. Furthermore, this research provides valuable information for the optimization of monkey models of HIV-1 infection.

关键词： Macaca leonina Northern pig-tailed macaques APOBEC3 HIV-1

Phonon thermal transport properties of XB_(2)(X=Mg and Al)compounds:considering quantum confinement and electron-phonon interaction

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2023年第9期42卷 3064-3074页

作者： Sen Liu Zheng Chang xiao-liang zhang Kun-Peng Yuan Yu-Fei Gao Da-Wei Tang Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education School of Energy and Power EngineeringDalian University of TechnologyDalian 116024China

XB_(2)(X=Mg and Al)compounds have drawn great attention for their superior electronic characteristics and potential applications in semiconductors and *** study of phonon thermal transport properties of XB_(2)is significant to their application and mechanism behind *** this work,the phonon thermal transport properties of three-dimensional(3D)and two-dimensional(2D)XB_(2)were studied by first-principles *** considering the electron-phonon interaction(EPI),the thermal conductivities(TCs)of 3D Mg B_(2)and 3D Al B_(2)decrease by 29%and 16%which is consistent with experimental ***,the underlying mechanisms of reduction on lattice TCs are the decrease in phonon lifetime and heat capacity when considering quantum confinement *** importantly,we are surprised to find that there is a correlation between quantum confinement effect and *** quantum confinement will change the phonon and electron characteristics which has an impact on ***,our work is expected to provide insights into the phonon thermal transport properties of XB_(2)compounds considering EPI and quantum confinement effect.

关键词： Superconductor Phonon thermal transport properties Electron-phonon interaction(EPI) Quantum confinement effect

Flow cytometric characterizations of leukocyte subpopulations in the peripheral blood of northern pig-tailed macaques （Macaca leonina）

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2014年第6期35卷 465-473页

作者： Hong-Yi ZHENG Ming-Xu zhang Lin-Tao zhang xiao-liang zhang Wei PANG Long-Bao LYU Yong-Tang ZHENG Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China School of Life Sciences University of Science and Technology of China Hefei Anhui 230026 China Kunming College of Life Science University of Chinese Academy of Sciences Kunming Yunnan 650204 China Faculty of Life Science and Technology Kunming University of Science and Technology Kunming Yunnan 650500 China Kunming Primate Research Center Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China

Pig-tailed macaques(Macaca nemistrina group) have been extensively used as non-human primate animal models for various human diseases in recent years, notably for AIDS research due to their sensitivity to HIV-1. Northern pig-tailed macaques(M. leonina) are distributed in China and other surrounding Southeast Asia countries. Although northern pig-tailed macaques have been bred on a large scale as experimental animals since 2012, the reference value of normal levels of leukocytes is not available. To obtain such information, 62 blood samples from male and female healthy northern pig-tailed macaques at different ages were collected. The normal range of major leukocyte subpopulations, such as T lymphocytes, B lymphocytes, natural killer(NK) cells, monocytes, and the expression levels of activation or differentiation related molecules(CD38, HLA-DR, CCR5, CD21, IgD, CD80 and CD86) on lymphocytes were analyzed by flow cytometry. The counts of B cells decreased with age, but those of CD8+ T cells and NK cells and the frequency of CD38+HLA-DR+CD4+ T cells were positively correlated with age. The counts of leukocyte subpopulations were higher in males than those in females except for CD4+ T cells. Males also showed higher expression levels of Ig D and CD21 within B cells. This study provides basic data about the leukocyte subpopulations of northern pig-tailed macaques and compares this species with commonly used Chinese rhesus macaques(M. mulatta), which is meaningful for the biomedical application of northern pig-tailed macaques.

关键词： Northern pig-tailed macaque Flow cytometry Leukocyte subpopulation Age Sex

HIV-1 can infect northern pig-tailed macaques(Macaca leonina) and form viral reservoirs in vivo

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2017年第19期62卷 1315-1324页

作者： Wei Pang Gao-Hong zhang Jin Jiang Hong-Yi Zheng Lin-Tao zhang xiao-liang zhang Jia-Hao Song Ming-Xu zhang Jia-Wu Zhu Ai-Hua Lei Ren-Rong Tian xiao-Ming Liu Liguo zhang Guangxia Gao Lishan Su Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences University of Chinese Academy of Sciences Institute of Health Sciences Anhui University South China Institute of Endangered Animal Guandong Academy of Sciences Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of Sciences Department of Microbiology and Immunology School of MedicineThe University of North Carolina at Chapel Hill

Viral reservoirs of HIV-1 are a major obstacle for curing AIDS. The novel animal models that can be directly infected with HIV-I will contribute to develop effective strategies for eradicating infections. Here, we inoculated 4 northern pig-tailed macaques （NPM） with the HIV-1 strain HIV-1NL4.3 and moni- tored the infection for approximately 3 years （150 weeks）. The HIV-l-infected NPMs showed transient viremia for about 10 weeks after infection. However, cell-associated proviral DNA and viral RNA persisted in the peripheral blood and lymphoid organs for about 3 years. Moreover, replication-competent HIV-1 could be successfully recovered from peripheral blood mononuclear cells （PBMCs） during long-term infection. The numbers of resting CD4~ T cells in HIV-1 infected NPMs harboring proviruses fell within a range of 2- to 3-1oglo per million cells, and these proviruses could be reactivated both ex vivo and in vivo in response to co-stimulation with the latency-reversing agents JQ1 and prostratin. Our results suggested that NPMs can be infected with HIV-1 and a long-term viral reservoir was formed in NPMs, which might serve as a potential model for HIV-1 reservoir research.

关键词： Northern pig-tailed macaquesHIV-1 Viral reservoir JQ1 Prostratin

Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques （Macaca leonina）

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2014年第3期35卷 196-203页

作者： xiao-liang zhang Wei PANG De-Yao DENG Long-Bao LV Yue FENG Yong-Tang ZHENG Faculty of Life Science and Technology Kunming University of Science and Technology Kunming Yunnan 650500 China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China Department of Clinical Laboratory the Second Hospital of Yunnan Province Kunming Yunnan 650021 China Kunming Primate Research Center Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China

The northem pig-tailed macaque （NPM, Macaca leonina） has become a widely used animal model in biomedical research. In this study, we measured serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP levels in 3-11 year old captive northem pig-tailed macaques using HITACHI 7600-20 automated chemistry analyzer in order to determine the influences of age and gender on these items. The results showed that serum IgA, IgM, C3 and C4 levels were not correlated with age （P〉0.05）, while serum IgG levels increased progressively with age （r=0.202; P=0.045）. Serum IgG, IgA, IgM and C3 levels were higher in females than in males （P〈0.05）. Moreover, serum C3 concentration was both positively and strongly correlated with that of C4 （r=0.700; P〈0.0001）. This study provides basic serum immunoglobulin and complement data of captive northem pig-tailed macaques, which may prove useful for future breeding efforts and biomedical research.

关键词： Northern pig-tailed macaque (Macaca leonina) Immunoglobulin Complement C-reactive protein

Synthesis of Poly(aryl ether ketone) Copolymers Containing Adamantyl-substituted Naphthalene Rings

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2009年第2期25卷 261-264页

作者： ZHU xiao-liang zhang Shu-ling REN Dian-fu GUAN Shao-wei WANG Gui-bin JIANG Zhen-hua College of Chemistry Jilin University Changchun 130012 P R. China

High performance polymers have received considerable attention over the past decade owing to their increased demands as replacements for metals or ceramics in automotive, aerospace, and microelectronic industries. Poly（aryl ether ketone）s（PAEKs） are a class of important high-performance aromatic polymers with excellent mechanical properties, good solvent resistance, size-accuracy, electrical characteristics, and superior thermal stability. However,

关键词： Adamantyl group Naphthalene Poly(aryl ether ketone) Synthesis

Experimental primates and non-human primate(NHP) models of human diseases in China: current status and progress

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2014年第6期35卷 447-464页

作者： xiao-liang zhang Wei PANG Xin-Tian HU Jia-Li LI Yong-Gang YAO Yong-Tang ZHENG Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Faculty of Life Science and Technology Kunming University of Science and Technology Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of Zoology Chinese Academy of Sciences

Non-human primates （NHPs） are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China＇s growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China＇s life sciences and pharmaceutical industry, and enhance China＇s position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective to better utilize NHP resources and further foster NHP research in China.

关键词： Non-human primates Experimental primates Animal models Current status

Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第8期27卷 1029-1036页

作者： Long CHEN Bi-cheng LIU~2 xiao-liang zhang Jian-dong zhang Hong LIU Min-xia LI Institute of Nephrology,Zhong Da Hospital,Southeast University School of Medicine,Nanjing 210009,China Institute of Nephrology Zhong Da Hospital Southeast University School of Medicine Nanjing China

Aim:The present study was designed to further investigate the effect of connec-tive tissue growth factor antisense oligonucleotide(CTGF-AS)on angiotensin Ⅱ(Ang Ⅱ)-induced tubular cell epithelial mesenchymal transition(EMT)in ***:The human proximal tubular cell line(HK2)was grown in Dulbecco’smodified Eagle’s medium containing 10% heat inactivated fetal calf *** rested in serum-free medium for 24 h,the influence of CTGF-AS(20 μg/mL)on Ang Ⅱ-induced(1×10-7mol/L)CTGF mRNA and the protein expression wereexamined by using reverse transcription-polymerase chain reaction and *** effect of CTGF-AS on Ang Ⅱ-induced cellular ultra-structure was observed using a transmissive electronic *** expres-sion of or-smooth action(α-SMA)was assayed by *** allexperiments,the control group was treated with scrambled ***:It was shown that Ang Ⅱ significantly induced the increasing expressionof CTGF mRNA and protein(P<0.01,respectively),which were significantly abol-ished by treatment with *** stimulating cells with Ang Ⅱ,the cellularultrastructure showed mesenchymal *** effects were partially inhib-ited by *** Ⅱ significantly resulted in the expression of α-SMA in timedependent manner,which was markedly attenuated by the treatment with CTGF-AS(P<0.01,respectively).In contrast,no similar effects were observed in thecontrol group treated with scrambled ***:Ang Ⅱ-in-duced EMT in human proximal tubular epithelial cells(PTC)can be attenuated bytreatment with *** data provides further evidence that CTGF might beinvolved in Ang Ⅱ-induced EMT in PTC.

关键词： connective tissue growth factor angiotensin Ⅱ epithelial mesenchymal transition proximal kidney tubules humans