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Current status of fecal calprotectin as a diagnostic or monitoring biomarker for cow's milk protein allergy in children:a scoping review

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World Journal of Pediatrics 2021年第1期17卷 63-70页

作者： li-Jing Xiong xiao-li xie Yang li xiao-Zhi Deng Chengdu Women's and Children's Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaSichuan ProvinceNo.1617Riyue AvenueChengdu 610091China

Background There are few approved biomarkers for diagnosis and monitoring of cow's milk protein allergy(CMPA),thus the oral food challenge remains to be the golden diagnostic standard.A potential biomarker is fecal calprotectin,a cytosolic protein,elevating in the presence of intestinal mucosal *** aimed to undertake a scoping review of the evi-dence pertaining to the current status of fecal calprotectin used for diagnosis and monitoring CMPA in children,and tried to indicate the aspects needed to be concerned in the future investigations and *** A scoping review was performed using the literature searched from PUBMED,EMBASE,and Web of Science Databases until July 2019 on the studies about the application of fecal calprotectin as a biomarker of CMPA in *** were examined according to the inclusion and exclusion *** were extracted,and a narrative synthesis was conducted to summarize and *** Thirteen studies with different study design embracing 1238 children were *** age range was from infants to *** children with CMPA presented gastrointestinal symptoms,among which hematochezia was most *** of data suggested that infants with CMPA represented elevated levels of fecal calprotectin,particularly with distinct significance in non-IgE-mediated CMPA *** of fecal calprotectin after elimination diet were demon-strated in enrolled ***,no matter in the CMPA positive or negative groups,the changes of fecal calprotectin before or after challenge showed no *** results were generated from studies on the role of fecal calprotectin in predicting allergic *** Available evidence is not sufficient to confirm the utilization of fecal calprotectin both in diagnosis and moni-toring of CMPA and predicting for allergic *** clinical and bench researches with elaborate design should be conducted and the exact cut-off values of

关键词： Cow's milk protein allergy Fecal calprotectin Scoping review

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Theoretical study on the reaction of VS^+(~3∑^-,~1Γ)with CO

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Chinese Chemical Letters 2008年第8期19卷 1008-1011页

作者： Shi Wen Yu li Qing Yin li Feng Yao Ming li xiao Guang xie Department of Chemistry Yunnan University Kunming 650091 China

Two possible reaction mechanisms of VS^＋（^3∑^-, 1^Г） with CO in the gas phase have been studied by using B3LYP/TZVP and CCSD（T）/6-311＋G （3df, 3pd） methods： the O/S exchange reaction （VS^＋＋CO→VO^＋＋CS） and the S-transfer reaction （VS^＋＋ CO → V^＋＋ COS）. The two reactions proceed via two-step and one-step mechanism, respectively. The barriers of the triplet and singlet PESs are 30.6 and 50.9 kcal/mol, respectively, for O/S exchange reaction and 7.3 and 50.2 kcal/mol, respectively, for the S-transfer reaction. The results indicate that the triplet ground state reaction is more favorable, and the S-transfer reaction is more favorable than the O/S exchange reaction, which is in good agreement with the experimental observation.

关键词： Vanadium sulfide ion CO Reaction CCSD(T)

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Fanconi-Bickel syndrome in an infant with cytomegalovirus infection: A case report and review of the literature

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World Journal of Clinical Cases 2020年第21期8卷 5467-5473页

作者： li-Jing Xiong Mao-ling Jiang li-Na Du Lan Yuan xiao-li xie Department of Gastroenterology Hepatology and NutritionChengdu Women's and Children's Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610091Sichuan ProvinceChina

BACKGROUND Fanconi–Bickel syndrome(FBS)is a rare autosomal recessive disorder caused by mutation of the SLC2A2 gene,which encodes glucose transporter protein 2(GLUT2).CASE SUMMARY We report a 7-mo-old girl with cytomegalovirus infection presenting hepatomegaly,jaundice,liver transaminase elevation,fasting hypoglycemia,hyperglycosuria,proteinuria,hypophosphatemia,rickets,and growth *** prescription of ganciclovir,the levels of bilirubin and alanine aminotransferase decreased to normal,while she still had aggravating hepatomegaly and severe ***,whole exome sequencing was conducted and revealed a homozygous c.416delC mutation in exon 4 of SLC2A2 inherited from her parents,which was predicted to change alanine 139 to valine(p.A139Vfs*3),indicating a diagnosis of *** the follow-up,the entire laboratory test returned to normal with extra supplement of vitamin D and corn *** weight increased to normal range at 3 years old without ***,she still had short *** there was heterogeneity between phenotype and genotype,Chinese children had typical clinical *** hot spot mutation or association between severity and mutations was found,but nonsense and missense mutations were more *** of long-term follow-up were rare,leading to insufficient assessment of the prognosis in Chinese *** FBS is a rare genetic metabolic disease causing impaired glucose liver homeostasis and proximal renal tubular *** of urine and blood testing suggesting abnormal glucose metabolism could be the clues for FBS in neonates and *** sequencing is indispensable for *** the diversity of disease severity,early identification and long-term follow-up could help improve patients’quality of life and decrease mortality.

关键词： Fanconi–Bickel syndrome Glucose transporter protein 2 Case report Children Chinese

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Protein sequence analysis based on hydropathy profile of amino acids

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第2期13卷 152-158页

作者： xiao-li xie li-fei ZHENG Ying YU li-ping liANG Man-cai GUO John SONG Zhi-fa YUAN College of Sciences Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F University Yangling 712100 China College of Animal Science and Technology China Agriculture UniversityBeijing 100193China Department of Animal and Avian Sciences University of MarylandCollege ParkMD 20742USA

Biology sequence comparison is a fundamental task in computational *** to the hydropathy profile of amino acids,a protein sequence is taken as a string with three *** curves of the new protein sequence were defined to describe the protein sequence.A new method to analyze the similarity/dissimilarity of protein sequence was proposed based on the conditional probability of the protein ***,the protein sequences of ND6(NADH dehydrogenase subunit 6)protein of eight species were taken as an example to illustrate the new *** results demonstrated that the method is convenient and efficient.

关键词： Protein sequence Sequence comparison Similarity/dissimilarity Conditional probability

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Tumor targeting of HPMA copolymer conjugates containing sulfadiazine groups

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Chinese Chemical Letters 2012年第7期23卷 875-878页

作者： Jian Chao Yuan xiao li xie Xian Wu Zeng Hong Yun Guo Cheng Ping Miao Key Laboratory of Eco-Environment-Related Polymer Materials of Ministry of Education Key Laboratory of Polymer Materials of Gansu ProvinceCollege of Chemistry&Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Department of Nuclear Medicine Gansu Academy of Medical Sciences&Gansu Provincial Tumor HospitalLanzhou 730050China

To develop new tumor targeting macromolecular conjugates,poly（HPMA）-SD-APMA-DTPA（HPMA：N-（2-hydroxypropyl）- methacrylamide;APMA：N-（3-ammopropyl）methacrylamide;DTPA：diethylenetriaminepentaacetic acid;SD：sulfadiazine） was synthesized and *** poly（HPMA）-SD-DTPA conjugates were radiolabeled with the radionuclide ^（99m）Tc and tested for uptake by cultured H22 cells in ***-^（99m）Tc（radiotracer 1） and poly（HPMA）-DTPA-^（99m）Tc（radiotracer 2） were also synthesized and characterized for *** uptake of poly（HPMA）-SD-DTPA-^（99m）Tc（radiotracer 3,34.76%） was significantly higher than that of poly（HPMA）-DTPA-^（99m）Tc（16.40%）,indicating that uptake of the poly（HPMA）-SD-DTPA-^（99m）T was active *** uptake of poly（HPMA）-DTPA-^（99m）Tc was significantly higher than that of DTPA-^（99m）Tc（2.98%）, suggesting that uptake of the poly（HPMA）-DTPA-^（99m）T was passive *** data suggest that the poly（HPMA）-SDAPMA -DTPA conjugates might be useful as tumor targeting macromolecular conjugates.

关键词： Tumor targeting HepatoceUular carcinoma HPMA copolymer conjugates Radiotracer

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Rare neonatal malignant primary orbital tumors: Three case reports

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World Journal of Clinical Cases 2021年第26期9卷 7825-7832页

作者： Yan Zhang Yue-Yue li Han-Yang Yu xiao-li xie Hui-Min Zhang Fang He Hong-Yang li Department of Ophthalmology The Seventh Medical Center of PLA General HospitalBeijing 100700China Department of Ophthalmology The Third Medical Center of PLA General HospitalBeijing 100039China Department of Pathology The Seventh Medical Center of PLA General HospitalBeijing 100700China Department of Ophthalmology The Eighth Medical Center of PLA General HospitalBeijing 100842China Beijing Friendship Hospital Capital Medical UniversityBeijing 100050China

BACKGROUND Aggressive malignant primary orbital tumors are extremely rare in *** current cases further clarify the clinical features of malignant primary orbital tumors in *** SUMMARY At the time of presentation at the Seventh Center of People’s liberation Army General(PLAG)Hospital,the children were 1-,2-and 5-mo-old,respectively,and included 2 boys and 1 *** three cases had unilateral proptosis at birth,and underwent mass excision and histopathologic examination.A peripheral primary neuroectodermal tumor,an aggressive infantile fibromatosis and an embryonic rhabdomyosarcoma were diagnosed,*** first case underwent routine chemotherapy following surgery but died within three months due to worsening condition as the tumor spread throughout the *** other two children were treated by surgery,and at the follow-up visits 6 mo and 1 year after surgery,respectively,the wound was completed healed,and they had normal growth and development without radiotherapy or chemotherapy.A review of highly uncommon orbital tumors in newborns is also *** Malignant primary tumors should be considered in the presence of unilateral proptosis in newborns.

关键词： Malignant primary orbital tumors Newborn Characteristics Treatment Outcome Case report

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Effects of Ru on microstructure stability and mechanical properties of Ni3Al single crystal alloy

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Progress in Natural Science:Materials International 2011年第4期21卷 286-292页

作者： Shu-suo li,xiao-ying xie,li-wu JIANG,Ya-fang HAN School of Materials Science and Engineering,Beihang University,Beijing 100191,China School of Materials Science and Engineering Beihang University Beijing 100191 China

The effect of Ru on microstructure stability and stress rupture properties of a Ni3Al single-crystal alloy was investigated. The experimental results showed that the addition of 2%Ru(mass fraction) improved the microstructure stability due to the restraint of harmful Y-NiMo phase formation during the thermal exposure at the high temperature above 1 000℃.And the reason may be that the addition of Ru increased the degree of Mo supersaturation in bothγandγ’ phases,and hence suppressed the precipitation of Y-NiMo *** results of stress rupture tests under the testing condition of 1100℃,120 MPa showed that the addition of 2% Ru in the alloy improved the stress rupture lives significantly for thermal exposed *** improvement of the stress rupture properties may be attributed to the restraint of Y-NiMo phase precipitation and growth by the addition of the proper amount Ru.

关键词： Ni3Al microstructure stability Ru Y-NiMo phase stress rupture

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Intake of tobacco nitrosamines of smokers in various provinces of China and their cancer risk:A meta-analysis

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Journal of Environmental Sciences 2024年第7期141卷 249-260页

作者： xiao li Zhiwei Ye Jun Wang Pengfei lin xiaojin Zhang Shuguang xie Chao Chen Research Institute for Environmental Innovation(Suzhou) TsinghuaSuzhouJiangsu 215163China State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Shenzhen Key Laboratory of Organic Pollution Prevention and Control State Key Laboratory of Urban Water Resource and EnvironmentHarbin Institute of TechnologyShenzhen 518055China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Science and EngineeringPeking UniversityBeijing 100871China

Nitrosamines are a class of carcinogens which have been detected widely in food,water,some pharmaceuticals as well as *** objectives of this paper include reviewing the basic information on tobacco consumption and nitrosamine contents,and assessing the health risks of tobacco nitrosamines exposure to Chinese *** searched the publications in English from“Web of Science”and those in Chinese from the“China National Knowledge Infrastructure”in 2022 and collected 151 literatures with valid *** content of main nitrosamines in tobacco,including 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK),N-nitrosonornicotine(NNN),N-nitrosoanatabine(NAT),N-nitrosoanabasine(NAB),total tobacco-specific nitrosamines(TSNA),and N-nitrosodimethylamine(NDMA)were *** information of daily tobacco consumption of smokers in 30 provinces of China was also ***,the intakes of NNN,NNK,NAT,NAB,TSNAs,and NDMA via tobacco smoke were estimated as 1534ng/day,591 ng/day,685 ng/day,81 ng/day,2543 ng/day,and 484 ng/day by adult smokers in30 provinces,*** cancer risk(CR)values for NNN and NNK inhalation intake were further calculated as 1.44×10^(-5)and 1.95×10^(-4).The CR value for NDMA intake via tobacco smoke(inhalation:1.66×10^(-4))indicates that NDMA is similarly dangerous in tobacco smoke when compared with the *** China,the CR values caused by average nitrosamines intake via various exposures and their order can be estimated as the following:smoke(3.75×10^(-4))>food(1.74×10^(-4))>drinking water(1.38×10^(-5)).Smokers in China averagely suffer 200%of extra cancer risk caused by nitrosamines in tobacco when compared with non-smokers.

关键词： N-nitrosamine Tobacco Cancer risk Tobacco specific nitrosamines(TSNAs) N-nitrosodimethylamine(NDMA)

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Milling degree affects the fermentation properties of rice:perspectives from the composition of nutrients and gut microbiota via in vitro fermentation

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Food Science and Human Wellness 2024年第3期13卷 1578-1588页

作者： Yu Zhang Fan li Shutong Pan Bing Bai Kai Huang Sen li Hongwei Cao Tian xie Jian xie xiao Guan School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China National Grain Industry(Urban Grain and Oil Security)Technology Innovation Center Shanghai 200093China Nutrition&Health Research Institute Co.Ltd. COFCO CorporationBeijing 102209China China Grain Wuhan Scientific Research&Design Institute Co.Ltd. Wuhan 430079China

Fermentation substrates of rice with different milling degrees(MDs) were prepared and fermented with human feces to compare their fermentation properties and effects on gut *** 0s,MD 5s and MD 60s represented brown rice,moderately-milled rice and white rice,*** in vitro fermentation,the MD 5s group showed higher starch utilization,compared with the MD 0s and 60s groups evaluated by Fourier transform infrared spectrometer,and confocal laser scanning *** of fermentation substrates of rice with different MDs on gut microbiota were evaluated by 16S rDNA *** the sample groups reduced the pH and produced short-chain fatty acids(SCFAs) and branched-chain fatty *** MD 5s group exhibited higher α-diversity than the MD 0s and 60s *** of Phascolarctobacterium,Blautia and norank_f_Ruminococcaceae were higher in the MD 0s and 5s groups,compared with the MD 60s *** bacteria were also positively correlated with the SCFAs production via Spearman correlation *** vitro culture assay revealed that fermentation substrates of MD 0s and 5s promoted the growth of two probiotics(Akkermansia muciniphila and Bifidobacterium adolescentis).Our results showed that moderate milling might be an appropriate way to produce rice products with richer nutrients and better fermentation properties.

关键词： Rice processing Milling Whole grains Gut microbiota

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Mesenchymal stem cell-derived exosomes: Versatile nanomaterials for skin wound treatment

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Nano Research 2024年第4期17卷 2836-2856页

作者： Yuzhen xiao Hexi li Junhui Zhang Songyun Yang Chunsen Zhang Yizhou Huang Xin Tang Huiqi xie Department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue EngineeringState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China School of Basic Medical Sciences and Forensic Medicine Sichuan UniversityChengdu 610041China West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610041China Sports Medicine Center West China HospitalSichuan UniversityChengdu 610041China

Accumulating studies reveal that mesenchymal stem cells(MSCs)promote skin wound healing mainly through the paracrine ***,one of the crucial paracrine mediators in wound healing,are cell-derived nanosized membranous vesicles containing diverse bioactive *** the potent ability of modulating skin cell behaviors,MSC-derived exosomes(MSC-Exos)are regarded as a promising nanomaterial for regenerative wound *** hostile conditions,MSC-Exos are efficient in protecting skin cells from severe damage and restoring their *** to recent studies,MSC-Exos possess remarkable pro-healing effects in a variety of skin wounds,typically resulting in increased wound closure,inhibited scar tissue formation,and better restoration of skin *** further enhance the therapeutic potential of MSC-Exos,the development of applicable pretreatment strategies and the optimization of exosome delivery are under intensive ***,we summarize current research progress of MSC-Exos for skin wound treatment,with an emphasis on the biological effects of these nanovesicles,the repair mechanisms,and future challenges in clinical translation.

关键词： exosomes mesenchymal stem cells diabetic wounds burn wounds scar wound healing

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