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Clinical efficacy of Baijin pills in the treatment of generalized tonicclonic seizure epilepsy with cognitive impairment

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World Journal of Psychiatry 2024年第6期14卷 938-944页

作者： Jing-Bo li Jing Jiang lian Xue Shuai Zhao Hong-Quan liu Department of Neurology The Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Neurology Jiangsu Province Academy of Traditional Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND The generalized tonic-clonic seizure(GTCS)is the most usual variety of epileptic *** is mainly characterized by strong body muscle rigidity,loss of consciousness,a disorder of plant neurofunction,and significant damage to cognitive *** effect of antiepileptic drugs on cognition should also be *** present,there is no effective treatment for patients with epilepsy,but traditional Chinese medicine has shown a significant effect on chronic disease with fewer harmful side effects and should,therefore,be considered for the therapy means of epilepsy with cognitive *** To investigate the clinical efficacy of Baijin pills for treating GTCS patients with cognitive *** This prospective study enrolled patients diagnosed with GTCS between January 2020 and December 2023 and separate them into two groups(experimental and control)using random number table *** control group was treated with sodium valproate,and the experimental group was Baijin pills and sodium valproate for three *** frequency and duration of each seizure,the Montreal Cognitive Assessment Scale(MoCA),and the Quality of life Rating Scale(QOliE-31)were recorded before and after *** There were 85 patients included(42 in the control group and 43 in the experimental group).After treatment,the seizure frequency in the experimental group was significantly reduced(Plization ability,significantly increased(PliE-31 score of the experimental group increased significantly after treatment compared to before treatment(Plinical effect on epilepsy with cognitive dysfunction.

关键词： Epilepsy Generalized tonic-clonic seizure Cognitive impairment Traditional Chinese medicine Baijin pills

Emerging materials and transistors for integrated circuits

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National Science Review 2024年第3期11卷 7-8页

作者： Ming liu lian-Mao Peng Lab of Nanofabrication and Novel Device Integration Institute of Microelectronics Chinese Academy of Sciences Key Laboratory for the Physics and Chemistry of Nanodevices and Center for Carbon-based Electronics School of Electronics Peking University

The device technology for integrated circuits(ICs) has received a great deal of attention in the past decade since the mainstream silicon-based complementary metal-oxide-semiconductor(CMOS) field-effect transistor(FET) for modern ICs had been encountering development bottlenecks due to the combination of power constraints, physics, cost and fabrication processes.

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Compact mid-infrared dual-comb spectrometer over 3-4μm via intra-pulse difference frequency generation in liNbO_(3) waveguides

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High Power Laser Science and Engineering 2024年第3期12卷 1-8页

作者： lian Zhou Haipeng Lou Zejiang Deng Xiong Qin Jiayi Pan Yuanfeng Di Chenglin Gu Daping Luo Wenxue li State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghaiChina Joint Research Center of light Manipulation Science and Photonic Integrated Chip of East China Normal University and Shandong Normal University East China Normal UniversityShanghaiChina

The mid-infrared optical frequency comb is a powerful tool for gas *** this study,we demonstrate a simple midinfrared dual-comb spectrometer covering 3±4μm in li Nb O_(3)*** on a low-power fiber laser system,the mid-infrared comb is achieved via intra-pulse difference frequency generation in the li Nb O_(3)*** construct pre-chirp management before supercontinuum generation to control spatiotemporal alignment for pump and signal *** supercontinuum is directly coupled into a chirped periodically poled li Nb O_(3)waveguide for the 3±4μm idler generation.A mid-infrared dual-comb spectrometer based on this approach provides a 100 MHz resolution over25 THz *** evaluate the applicability for spectroscopy,we measure the methane spectrum using the dualcomb *** measured results are consistent with the HITRAN database,in which the root mean square of the residual is 3.2%.This proposed method is expected to develop integrated and robust mid-infrared dual-comb spectrometers on chip for sensing.

关键词： difference frequency generation dual-comb spectroscopy mid-infrared gas sensing nonlinear optics

Recent Advances in Nickel Catalyzed Carbonylative Reactions via the Insertion of Carbon Monoxide

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Chinese Journal of Chemistry 2024年第2期42卷 177-189页

作者： Xinzhou Chen Gang Chen Zhong lian Department of Dermatology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China

Carbonyl compounds have attracted considerable attention due to their extensive applications in drug ***,they are important synthetic intermediates for the construction of carbon-carbon and carbon-heteroatom ***-metal-catalyzed carbonylation via the insertion of co is one of the most efficient and straightforward strategies to access carbonyl ***,most of the transition-metal-catalyzed carbonylative reactions require expensive and toxic noble-metal ***,there is a growing demand for the exploration of nickel-catalyzed carbonylative reactions via the insertion of CO due to the earth abundance and low cost of *** with the well-established palladium-catalyzed carbonylative reactions,nickel-catalyzed analogous transformations have been relatively *** is primarily because CO strongly binds to nickel,often resulting in catalyst *** recent years,some research groups have focused on using CO surrogates or NN_(2) pincer nickel catalyst to circumvent the formation of Ni(CO)_(4).Nickel-catalyzed carbonylation has been applied in the construction of carbonyl-containing compounds,such as ketones,carboxylic acids,thioesters,acyl chloride and carboxamides.

关键词： Carbonylation Nickel catalysis Carbon monoxide C1 chemistry Carbonyl-containing compounds

Generation of macroscopic entanglement in ensemble systems based on silicon vacancy centers

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Chinese Physics B 2024年第9期33卷 308-315页

作者： Jian-Zhuang Wu Ying Xi Bo-Ya li lian-E Lu Yong-Hong Ma School of Science Inner Mongolia University of Science and TechnologyBaotou 014010China

Entanglement in macroscopic systems,as a fundamental quantum resource,has been utilized to propel the advancement of quantum technology and probe the boundary between the quantum and classical *** study focuses on a unique hybrid quantum system comprising of an ensemble of silicon vacancy(SiV)centers coupled to phononic waveguides in diamond via strain *** employing two sets of time-dependent,non-overlapping driving fields,we investigate the generation process and dynamic properties of macroscopic quantum entanglement,providing fresh insights into the behavior of such hybrid quantum ***,it paves the way for new possibilities in utilizing quantum entanglement as an information carrier in quantum information processing and quantum communication.

关键词： quantum entanglement silicon vacancy centers diamond waveguide

Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-Xiang Gu Xian-Xia Yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao xiao-Die liu Bao-Juan li Ming-Hui Wang Hai-Long Dong Hao-Hong li Peng-Cheng Huang Yun-Qing li Wu-Gang Hou Jin-lian li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

渭河干流(陕西段)水污染现状及控制对策研究

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西北大学学报（自然科学版） 2008年第5期38卷 823-828页

作者：李孝廉杜新黎王安林西北大学城市与资源学系陕西西安710069 陕西省环境保护局陕西西安710004 陕西省环境监测中心站陕西西安710061 渭南市环境监测站陕西渭南714000

目的找出渭河水污染产生的原因,提出控制渭河水污染对策。方法在大量现场监测数据的基础上,利用标准比照法分析渭河干流(陕西段)的水质现状,利用相关分析法分析水质与水量的关系及水质变化趋势。结果从高锰酸盐指数和氨氮两个主要污染... 详细信息

目的找出渭河水污染产生的原因,提出控制渭河水污染对策。方法在大量现场监测数据的基础上,利用标准比照法分析渭河干流(陕西段)的水质现状,利用相关分析法分析水质与水量的关系及水质变化趋势。结果从高锰酸盐指数和氨氮两个主要污染指标看,渭河干流水质2002年以后有逐年好转的趋势;生态用水的严重缺乏和水污染物排放量大是导致渭河污染严重的重要原因。结论提出合理调配水资源、调整区域工业发展战略、加强城市水污染源防治力度、提高种养殖业的科技水平等4方面控制渭河干流水污染措施。

关键词：渭河流域水污染污染控制污染物排放量水质变化

Hierarchically Macroporous Zeolite ZSM-5 Microspheres for Efficient Catalysis

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Chemical Research in Chinese Universities 2024年第4期40卷 704-711页

作者： ZHENG Mingdan CHEN Ya liU Zhan LYU Jiamin YE Bo SUN Ming-Hui CHEN li-Hua SU Bao-lian State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070P.R.China Laboratory of Inorganic Materials Chemistry(CMI) University of Namur5000NamurWalloniaBelgium

Hollow zeolite microspheres have recently attracted much attention for their applications in catalysis,microreactors and ***,we present hierarchically structured zeolite ZSM-5 microspheres with unique,abundant macropores that allow more efficient use for *** hierarchically macroporous zeolite ZSM-5 microspheres are synthesized under the assistance of water/oil emulsions and using polystyrene nanospheres as *** zeolite microsphere is assembled by uniform hollow zeolite *** large inner cavities and thin zeolite shells lead to smaller diffusion channel and higher improved accessibility to active sites,contributing to high catalytic performance in the catalytic conversion of benzyl alcohol in *** novel zeolite microspheres with impressive performance will be applied to numerous other industrial catalytic reactions.

关键词： Hierarchically porous structure Hollow structure Microsphere Zeolite ZSM-5 Alkylation

Herb pair of Huangqi-Danggui exerts anti-tumor immunity to breast cancer by upregulating PIK3R1

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Animal Models and Experimental Medicine 2024年第3期7卷 234-258页

作者： Hai-Xin liu li lian li-li Hou Cai-Xia liu Jin-Hong Ren Yuan-Biao Qiao Shi-Yuan Wen Qing-Shan li College of Traditional Chinese Medicine and Food Engineering Shanxi University of Chinese MedicineTaiyuanChina Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation College of Traditional Chinese Medicine and Food EngineeringShanxi University of Chinese MedicineTaiyuanChina College of Basic Medical Sciences Shanxi Medical UniversityTaiyuanChina

Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host *** objective of this study is to investigate the underlying immune mechanisms of anti-tumor activity associated with Qi-supplementing herbs,specifically the paired use of Huangqi and ***:Analysis of compatibility regularity was conducted to screen the combination of Qi-supplementing *** the MTT assay and a transplanted tumor mice model,the anti-tumor effects of combination TCMs were investigated in vitro and in *** content analysis and flow cytometry were then used to evaluate cellular immunity,followed by network pharmacology and molecular docking to dissect the significant active compounds and potential ***,the anti-tumor activity and the mechanism of the active ingredients were verified by molecular ***:There is an optimal combination of Huangqi and Danggui that,administered as an aqueous extract,can activate immunity to suppress tumor and is more effective than each drug on its own in vitro and in *** on network pharmacology analysis,PIK3R1 is the core target for the anti-tumor immunity activity of combined Huangqi and *** docking analysis shows 6 components of the combined Danggui and Huangqi extract(quercetin,jaranol,isorhamnetin,kaempferol,calycosin,and suchilactone)that bind to *** is the most important component against breast *** suchilactone/jaranol combination and,especially,the suchilactone/kaempferol combination are key for immunity enhancement and the anti-tumor effects of the ***:The combination of Huangqi and Danggui can activate immunity to suppress breast cancer and is more effective than the individual drugs alone.

关键词： anti-tumor Danggui Huangqi immunity