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Artificial cavernosa-like tissue based on multibubble Matrigel and a human corpus cavernous fibroblast scaffold

Asian Journal of Andrology 2024年第3期26卷 260-267页

作者： Yu-Zhuo Chen Yi-Hong Zhou Min-Bo Yan Ming xiao Biao liu Ying-Hao Yin xiao-li tan Yong-Quan Huang Yu-Hong lin Ting Xie Jia-li Tian Qi Wang Jian-Ying li Zi-Zhou Meng Zheng li Emily Xing Yu-Xin tang Ya-Wei li Zhong-Zhen Su liang-Yu Zhao Department of Ultrasound The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Interventional Medicine Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Andrology the Center for Men’s HealthUrologic Medical CenterShanghai Key Laboratory of ReproductiveMedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Cedars-Sinai Medical Center Los AngelesCA 90024USA

Ex vivo tissue culture of the human corpus cavernosum(cc)can be used to explore the tissue structural changes and complex signaling *** present,artificial Cc-like tissues based on acellular or three-dimensional(3D)-printed scaffolds are used to solve the scarcity of primary penis tissue ***,inconvenience and high costs limit the wide application of such ***,we describe a simple,fast,and economical method of constructing artificial CC-like *** Cc fibroblasts(FBs),endothelial cells(ECs),and smooth muscle cells(SMCs)were expanded in vitro and mixed with Matrigel in specific proportions.A large number of bubbles were formed in the mixture by vortexing combined with pipette blowing,creating a porous,spongy,and spatial *** Cc FBs produced a variety of signaling factors,showed multidirectional differentiation potential,and grew in a 3D grid in Matrigel,which is necessary for CC-like tissue to maintain a porous structure as a cell *** the C-like tissue,ECs covered the surface of the lumen,and SMCs were located inside the trabeculae,similar to the structure of the primary *** cell components remained stable for 3 days in vitro,but the EC content decreased on the 7th ***/integrated(WNT)signaling activation led to lumen atrophy and increased tissue fibrosis in CC-like tissue,inducing the same changes in characteristics as in the primary *** study describes a preparation method for human artificial cC-like tissue that may provide an improved experimental platform for exploring the function and structure of the cC and conducting drug screening for erectile dysfunction therapy.

关键词： artificial tissue corpus cavernosum ex vivo fibroblasts

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Higher-order expansions of powered extremes of logarithmic general error distribution

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 47-54页

作者： tan xiao-feng li li-hui School of Mathematics and Statistics Southwest UniversityChongqing 400715China

In this paper,Let M_(n)denote the maximum of logarithmic general error distribution with parameter v≥***-order expansions for distributions of powered extremes M_(n)^(p)are derived under an optimal choice of normalizing *** is shown that M_(n)^(p),when v=1,converges to the Frechet extreme value distribution at the rate of 1/n,and if v>1 then M_(n)^(p)converges to the Gumbel extreme value distribution at the rate of(loglogn)^(2)=(log n)^(1-1/v).

关键词： logarithmic general error distribution convergence rate higher-order expansion powered ex-treme

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High molecular weight guar gum assisted settling of fine solids in diluted bitumen:Effect of solvents

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Petroleum Science 2021年第6期18卷 1877-1886页

作者： Camila Santander Jing liu xiao-li tan Qi liu Hong-Bo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada

As water-based extraction technologies for producing bitumen from oil sands have received increasing environmental concerns,developing non-aqueous extraction(NAE)technique is of both fundamental and practical ***,the relatively high concentration of fine solids trapped in the extracted bitumen presents an obstacle for pipeline transport as well as upgrading and refining *** research attempts to provide a solution to fine solids removal without using synthetic additives or affecting bitumen recovery from NAE ***,naturally hydrophilic additives(i.e.,water and high molecular weight guar gum(HGG)produced from Cyamopsiste tragonolobuosr ***.)were introduced to promote the settling of fine solids suspended in bitumen-solvent solution,and the effects of solvents(i.e.,toluene,cyclohexane and their mixtures)were systematically *** size distribution analyzed by the focused beam reflectance measurements confirmed that the addition of water and HGG could promote the agglomeration and settling of fine solids in all solvents ***,the size range and quantity of the agglomerates vary significantly with the solvent's aromatic *** mixtures demonstrate a superior performance on removing fine solids from bitumen over single ***,in a 3:2 toluene/cyclohexane mixture,the solid content was lowered from 0.66 wt%to 0.09 wt%.

关键词： Non-aquoues extraction Fine solids Guar gum Agglomeration Settling

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Destabilization of bitumen-coated fine solids in oil through water-assisted flocculation using biomolecules extracted from guar beans

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Petroleum Science 2020年第6期17卷 1726-1736页

作者： Camila Santander Jing liu xiaoli tan Qi liu Hongbo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada

Non-aqueous extraction(NAE)of bitumen from oil sands has been gaining great attention from both the industry and academia as an alternative to the water-based extraction.A fine solids removal step is important for a NAE process in order to obtain high-quality bitumen product,which,however,remains a great challenge to reduce the fine solids content to the desired ***,we introduce a strategy of destabilizing the bitumen-coated silica particles in toluene with the addition of water and biomolecules extracted from Cyamopsiste tragonolobuosr ***.,i.e.,high molecular weight guar gum(HGG)and low molecular weight guar gum(LGG),*** virtue of sedimentation tests and focused beam reflectance measurement analysis,we demonstrate that the introduced water droplets modified with these biomolecules can facilitate the settling of the solid particles in toluene although the underlying mechanisms differ between these two biomolecule ***,in the case of LGG,the added water droplets with the interfacial amphiphilic LGG can strengthen the attachment of solid particles from bulk toluene to the LGG *** research work provides useful insight into the development of effective approaches for destabilization and removal of bitumen-coated fine solids from NAE bitumen.

关键词： Non-aqueous extraction Guar gum Fine solids Aggregates Solid content Chord length

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Fabrication of UV-Curing linalool-Polysiloxane Hybrid Films with High Refractive Index and Transparency

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Journal of Renewable Materials 2024年第3期12卷 569-583页

作者： Wenqing xiao Lewen tan Xunjun Chen Qiaoguang li Yunqing Ruan College of Chemistry and Chemical Engineering Zhongkai University of Agriculture and EngineeringGuangzhou510225China R&D Department Guangzhou Silicon Core Material Technology Co.Ltd.Guangzhou510220China

In this article,a series of high refractive indices(1.50-1.53)thiol phenyl polysiloxane(TPS)were synthesized via hydrolytic sol-gel *** Fourier transform infrared spectra(FT-IR)and nuclear magnetic resonance spectra(NMR)results showed that TPS conformed to the predicted *** terpene linalool was exploited as photocrosslinker to fabricate UV-curing linalool-polysiloxane hybrid films(LPH)with TPS via photoinitiated thiol-ene *** rapidly cured under UV irradiation at the intensity of 80 mW/cm^(2) in 30 s,exhibiting good UV-curing *** optical transmittance of LPH in the wavelength of 300-800 nm was over 90%,exhibiting good optical *** water contact angle and water vapor permeability results showed that the introduction of phenyl groups enhance the hydrophobicity and water vapor barrier properties of *** results indicated the potential of LPHs in the applications of optical functional coatings.

关键词： UV-curing polysiloxane hybrid films high refractive index transparency

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Facile preparation of Fe/N-based biomass porous carbon composite towards enhancing the thermal decomposition of DAP-4

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Defence Technology（防务技术） 2024年第1期31卷 288-294页

作者： Er-hai An xiao-xia li Cun-juan Yu Ying-xin tan Zi-jun Fan Qing-xia li Peng Deng Xiong Cao School of Environment and Safety Engineering North University of ChinaTaiyuan030051PR China College of Safety and Emergency Management Engineering Taiyuan University of Science and TechnologyTaiyuan030024PR China

Fe/N-based biomass porous carbon composite(Fe/N-p Carbon) was prepared by a facile high-temperature carbonization method from biomass,and the effect of Fe/N-p Carbon on the thermal decomposition of energetic molecular perovskite-based material DAP-4 was *** porous carbonaceous materials was considered as the micro/nano support layers for in situ deposition of Fe/N ***/Np Carbon was prepared simply by the high-temperature carbonization *** was found that it showed the inherent catalysis properties for thermal decomposition of *** heat release of DAP-4/Fe/N-p Carbon by DSC curves tested had increased slightly,compared from DAP-4/Fe/N-p *** decomposition temperature peak of DAP-4 at the presence of Fe/N-p Carbon had reduced by 79°C from384.4°C(pure DAP-4) to 305.4°C(DAP-4/Fe/N-p Carbon-3).The apparent activation energy of DAP-4thermal decomposition also had decreased by 29.1 J/*** possible catalytic decomposition mechanism of DAP-4 with Fe/N-p Carbon was proposed.

关键词： Biomass materials Porous carbon DAP-4 Thermal decomposition Facile method

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Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction

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Journal of Geriatric Cardiology 2024年第4期21卷 421-430页

作者： Jing tan Jin SI Ke-ling xiao Ying-Hua ZHANG Qi HUA Jing li Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Geriatric Medicine Xuanwu Hospital Capital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction(STEMI) are *** We analyzed 2313 patients admitted for acute STEMI between October 2013 and December 2020. In-hospital outcomes and mortality during the 49 months(interquartile range: 26–73 months) follow-up period were compared between patients with the low prealbumin level(lization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class Ⅲ(9.9%vs. 4.4%, P = 0.034), cardiovascular death(8.4% vs. 3.4%, P = 0.035) and the composite of major adverse cardiovascular events(19.2%vs. 10.3%, P = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level(line prealbumin level(170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent *** Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently assoc

关键词： patients admitted infarction

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Enhancing photoresponsiveness of metal-organic polyhedra by modifying microenvironment

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Nano Research 2024年第6期17卷 5712-5717页

作者： Long Zheng Peng tan Qian Song Sheng-Tao Wang Min li xiao-Qin liu lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Photoresponsiveness of materials is critical to their tunability and efficiency in terminal *** metal-organic polyhedra(PMOPs)feature intrinsic pores and remote controllability,but aggregation of PMOPs in solid state hampers their photoresponsiveness ***,we report the construction of a new PMOP(Cu_(24)(C_(16)H_(12)N_(2)O_(4))_(12)(C_(18)H_(22)O_(5))12,denoted as MOP-PR-LA),where long alkyl(LA)chains act as the intermolecular poles,propping against adjacent PMOP molecules to create individual microenvironment benefiting the isomerization of photoresponsive(PR)*** ultraviolet(UV)-and visible-light irradiation,MOP-PR-LA is much easier to isomerize than the counterpart MOP-PR without *** propylene adsorption,MOP-PR has a low change of adsorption capacity(9.9%),while that of MOP-PR-LA reaches 58.6%.Density functional theory calculations revealed that PR in the cis state has a negative effect on adsorption,while the trans state of PR favors *** work might open an avenue for the construction of photoresponsive materials with high responsiveness and controllability.

关键词： photoresponsive adsorption metal-organic polyhedra azobenzene long alkyl chains propylene capture

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An Improved Method for Approximating the Infinite-Horizon Value Function of the Discrete-Time Switched LQR Problem

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Journal of Systems Science & Complexity 2024年第1期37卷 22-39页

作者： HOU tan li Yuanlong liN Zongli Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China Shanghai Engineering Research Center of Intelligent Control and Management Shanghai 200240China Charles L.Brown Department of Electrical and Computer Engineering University of VirginiaCharlottesvilleVA 22904-4743USA

This paper considers the problem of approximating the infinite-horizon value function of the discrete-time switched LQR *** particular,the authors propose a new value iteration method to generate a sequence of monotonically decreasing functions that converges exponentially to the value *** method facilitates us to use coarse approximations resulting from faster but less accurate algorithms for further value iteration,and thus,the proposed approach is capable of achieving a better approximation for a given computation time compared with the existing *** numerical examples are presented in this paper to illustrate the effectiveness of the proposed method.

关键词： Optimal control switched linear systems switched LQR problem.

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Resilience conferred by APOE-R136S:a defense bestowed by nature to combat Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2024年第3期9卷 831-832页

作者： Bin xiao Joshua Kuruvilla Eng-King tan Department of Neurology National Neuroscience InstituteSingaporeSingapore Neuroscience Academic Clinical Program Duke-NUS Medical SchoolSingaporeSingapore Neuroscience and Behavioural Disorders Program Duke-NUS Medical SchoolSingaporeSingapore

In two recent articles published in Nature Neuroscience and Cell,Nelson et al.1 and Chen et al.2 have shown that a rare APOE3 Christchurch(APOE3Ch)variant,R136S,has protective effects on neurodegeneration in various Alzheimer’s disease(AD)model systems through attenuating tau pathology and regulating its related neuroimmune *** et *** Chen et *** provided evidence that identifying the pathophysiologic clues and potential molecular targets from a protective variant such as APOE R136S,can be an attractive viable approach to develop AD therapeutics.

关键词： protective al. Alzheimer

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