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Long-term adaptive evolution of Shewanella oneidensis MR-1 for establishment of high concentration Cr(Ⅵ) tolerance

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 65-75页

作者： Yong xiao Changye xiao feng Zhao CAS Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

Acclimation is the main method to enhance the productivity of microorganisms in environmental biotechnology,but it remains uncertain how microorganisms acquire resistance to high concentrations of pollutants during long-term *** oneidensis MR-1 was acclimated for 120 days with increasing hexavalent chromium(Cr(VI))concentrations from 10 to 190 mg/*** bacterium was able to survive from the highly toxic Cr(VI)environment due to its enhanced capability to reduce Cr(VI)and the increased cell membrane *** sequenced 19 complete genomes from 7 populations of MR-1,including the ancestral strain,the evolved strains in Cr(VI)environment on days 40,80 and 120 and their corresponding controls.A total of 27,49 and 90 single nucleotide polymorphisms were found in the Cr(VI)-evolved populations on days 40,80 and 120,*** substitutions were clustered according to gene functions,and the gene mutations related to integral components of the membrane,including efflux pumps and transporters,were the key determinants of chromate *** addition,MR-1 strengthened the detoxification of Cr(VI)through gene variations involved in adenosine triphosphate binding,electron carrier activity,signal transduction and DNA *** results provide an in-depth analysis of how Cr(VI)resistance of *** MR-1 is improved by acclimation,as well as a genetic understanding of the impact of longterm exposure of microorganisms to pollution.

关键词： Environmental biotechnology Acclimation Chromate resistance Efflux pumps Detoxification

Emergy evaluation of aromatics production from methanol and naphtha

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Chinese Journal of Chemical Engineering 2022年第6期35卷 134-141页

作者： Siyue Ren xiao feng School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China

Aromatics are traditionally produced by the catalytic reforming of ***,with the demand of aromatics increasing and the reserves of petroleum resources declining,measures should be made to reduce the dependence of aromatics production on petroleum ***-to-aromatics is proved to be an effective way to replace traditional naphtha-to-aromatics *** order to compare the economic and environmental performance of aromatics production from naphtha and methanol,this paper carries out an emergy evaluation for each system by sorting out the simulation and literature *** on the emergy data collected,the emergy indices of each system are *** results show that the sustainabilities of methanol-to-aromatics systems are higher than that of the naphtha-toaromatics system,indicating the advantages of aromatics production from *** the methanol-to-aromatics systems,the aromatics from biomass-methanol system has the highest sustainability,indicating that the biomass based methanol-to-aromatics system is worth *** sustainability indexes of methanol-to-aromatics systems based on coal and coke oven gas are less than 1,which means ***,the sustainability of natural gas based system is slightly higher than *** economic and environmental benefits of these systems can be optimized by improving resource utilization and reducing investment ***,the combination of different raw materials for methanol production should be considered.

关键词： Aromatics production Naphtha Methanol Emergy Sustainability

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo Hong-Bo Jin Cong-feng Qiao Yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

Treatment of Pneumocystis jirovecii pneumonia in non-human immunodeficiency virus-infected patients using a combination of trimethoprim-sulfamethoxazole and caspofungin

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World Journal of Clinical Cases 2022年第9期10卷 2743-2750页

作者： Huan-Huan Wu Shuang-Yan Fang Yan-xiao Chen lan-Fang feng Department of Respiratory Medicine Dongyang Hospital Affiliated to Wenzhou Medical UniversityDongyang 322100Zhejiang ProvinceChina

BACKGROUND Pneumocystis jirovecii pneumonia(PJP)is an infectious disease common in immunocompromised ***,the currently,the clinical characteristics of non-HIV patients with PJP infection have not been fully *** To explore efficacy of trimethoprim–sulfamethoxazole(TMP-SMX)and caspofungin for treatment of non-human immunodeficiency virus(HIV)-infected PJP *** A retrospective study enrolled 22 patients with non-HIV-infected PJP treated with TMP-SMX and caspofungin from 2019 to *** manifestations,treatment and prognosis of the patients were *** Five patients presented with comorbidity of autoimmune diseases,seven with lung cancer,four with lymphoma,two with organ transplantation and four with membranous nephropathy associated with use of immunosuppressive *** main clinical manifestations of patients were fever,dry cough,and progressive *** patients presented with acute onset and respiratory *** most common imaging manifestation was ground glass opacity around the hilar,mainly in the upper *** patients were diagnosed using next-generation sequencing,and were treated with a combination of TMP-SMX and *** them,17 patients received short-term adjuvant glucocorticoid *** patients recovered well and were discharged from *** Non-HIV-infected PJP have rapid disease progression,high risk of respiratory failure,and high *** of TMP-SMX and caspofungin can effectively treat severe non-HIVinfected PJP patients with respiratory failure.

关键词： Acquired immunodeficiency syndrome Non-human immunodeficiency virus-infected patients Immunosuppression caspofungin Mortality Pneumocystis jirovecii pneumonia

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan Yang feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： feng He Sitong Chen Ruili Zhou Hanyu Diao Yangyang Han xiaodong Wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

High Level Expression of Grass Carp Reovirus VP7 Protein in Prokaryotic Cells

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Virologica Sinica 2008年第1期23卷 51-56页

作者： lan-lan ZHANG Jin-yu SHEN Cheng-feng LEI xiao-ming LI Qin FANG State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071China Graduate School of the Chinese Academy of Sciences Beijing 100039 China Zhejiang Institute of Freshwater Fisheries Huzhou313001 Basic Medical School Wuhan University Wuhan 430072 China

Sequences analysis revealed Grass carp reovirus (GCRV) s10 was 909 nucleotides coding a 34 kDa protein denoted as VP7, which was determined to be a viral outer capsid protein (OCP). To obtain expressed OCP in vitro, a full length VP7 gene was produced by RT-PCR amplification, and the amplified fragment was cloned into T7 promoted prokaryotic expression vector pRSET. The recombinant plasmid,which was named as pR/GCRV-VP7,was then transformed into *** BL21 host cells. The data indicated that the expressed recombinant was in frame with the N-terminal fusion peptide. The over-expressed fusion protein was produced by inducing with IPTG, and its molecular weight was about 37kDa, which was consistent with its predicted size. In addition, the fusion protein was produced in the form of the inclusion body with their yield remaining steady at more than 60% of total bacterial protein. Moreover,the expressed protein was able to bind immunologically to anti-his-tag monoclonal antibody (mouse) and anti-GCRV serum (rabbit). This work provides a research basis for further structure and function studies of GCRV during entry into cells.

关键词： Grass carp reovirus (GCRV) VP7 protein Prokaryotic expression

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腹茧症的病因与诊治(附9例临床分析)

广东药学院学报 2005年第6期21卷 743-744,750页

作者：何博华邱烺王华钱聚标肖兰凤杨建新广东药学院外科教研室广东广州510006

目的探讨腹茧症的病因、临床表现、诊断和治疗.方法对1987～2003年9例腹茧症的病史、临床表现、影像学检查及术中所见进行总结分析.结果术前9例全部被误诊,分别误诊为:急性机械性肠梗阻3例,急性阑尾炎4例,肠套叠1例,小肠平滑肌肉瘤1例.... 详细信息

目的探讨腹茧症的病因、临床表现、诊断和治疗.方法对1987～2003年9例腹茧症的病史、临床表现、影像学检查及术中所见进行总结分析.结果术前9例全部被误诊,分别误诊为:急性机械性肠梗阻3例,急性阑尾炎4例,肠套叠1例,小肠平滑肌肉瘤1例.术中见小肠部分(5例)或全部(4例)被一层灰白色光滑、质韧而厚的纤维膜包裹,纤维膜与肠管及肠管与肠管之间黏连疏松,大网膜缺如.手术松解黏连,切除部分纤维包膜.切除的包膜术后作病理检查,9例均为纤维组织.结论腹茧症病因未明确,可能与腹膜发育异常及腹膜炎有关.临床表现以腹部包块和肠梗阻为主要表现,无明显的特征性,术前难以作出明确诊断;术中所见为全部或部分小肠被一层灰白或淡黄色的质韧而厚的纤维膜包裹,切除的包膜术后作病理检查,如为纤维组织,即可确诊;治疗方法为手术松解黏连,切除部分纤维包膜.

关键词：腹茧症纤维膜病因诊断

Proper Biharmonic Submanifolds in a Sphere

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Acta Mathematica Sinica,English Series 2012年第1期28卷 205-218页

作者： Xian feng WANG lan WU School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071P.R.China Department of Mathematics Renmin University of ChinaBeijing 100872P.R.China

In this paper, we obtain a constraint of the mean curvature for proper biharmonic submanifolds in a sphere. We give some characterizations of some proper biharmonic submanifolds with parallel mean curvature vector in ... 详细信息

关键词： Proper biharmonic map parallel mean curvature vector mean curvature