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Application of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal lesions

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Chinese Medical Journal 2011年第23期124卷 3988-3992页

作者： ZHAO Hui WANG jun ZHOU Zu-li LI Yun BU Liang YANG Fan SUI Xi-zhao CHEN Ke-zhong LI xiao liu jun LI Jian-feng JIANG Guan-chao Department of Thoracic Surgery Peking University People＇s Hospital Beijing 100044 China

Background Mediastinal lesions are often difficult to diagnose in clinical practice because of the unique anatomical position of the mediastinum, which makes performance of biopsy difficult. The value of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lung cancer and mediastinal lymph node staging has been widely accepted. However, few studies have been conducted on the value of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis and differential diagnosis of mediastinal lesions. The current study was conducted to investigate the value of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis and differential diagnosis of isolated mediastinal lesions without lung abnormalities. Methods We retrospectively analyzed the data of patients with isolated mediastinal lesions without lung abnormalities for whom endobronchial ultrasound-guided transbronchial needle aspiration examination was performed at the Department of Thoracic Surgery of Peking University People＇s Hospital, between September 2009 and December 2010. For patients who could not be diagnosed with endobronchial ultrasound-guided transbronchial needle aspiration, surgical biopsy or more than 6 months of clinical and imaging follow-up was carried out. Results Endobronchial ultrasound-guided transbronchial needle aspiration was performed for 60 patients with isolated mediastinal lesions. Correct diagnosis was made in 48 cases. Nineteen cases were malignant, and 29 were benign. The rate of correct diagnosis was 80%. The sensitivity, specificity, and accuracy of endobronchial ultrasound-guided transbronchial needle aspiration in distinguishing benign from malignant mediastinal lesions were 95%, 100%, and 98%, respectively. The examination was tolerable for all patients. No associated complications were observed. Conclusion Endobronchial ultrasound-guided transbronchial needle aspiration is a safe and effective method of di

关键词： endobronchial ultrasound transbronchial needle aspiration mediastinal lesion diagnosis

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Wavelength Dependence of Atomic Excitation for Ar Subject to Intense Midinfrared Laser Pulses

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Chinese Physics Letters 2023年第10期40卷 44-48页

作者：刘阳妮许松坡朱穆峰肖峥嵘余少刚华林强赖炫扬全威杨文星柳晓军 School of Physics and Optoelectronic Engineering Yangtze UniversityJingzhou 434022China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Wuhan Institute of Quantum Technology Wuhan 430206China

We report experimental and theoretical investigations of wavelength dependence of Rydberg state excitation(RSE)process of Ar subject to intense laser *** simultaneously measuring ionization and RSE yields of Ar atoms subject to strong laser fields at a series of wavelengths,we obtain the wavelength scaling law of the ratio of Ar^(*)over Ar^(+)with respect to the laser intensity,and this result can be well reproduced by a nonadiabatic model,but not by the classical-trajectory Monte Carlo *** results indicate that the nonadiabatic corrections of the photoelectron tunneling exit and tunneling probability play a significant role at shorter *** shows that the wavelength dependence phenomenon is due to the interplay of the nonadiabatic effect,wave-packet diffusion and Coulomb focusing effect of the liberated electron.

关键词： tunneling effect correction

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Idiopathic inflammatory demyelinating diseases of the central nervous system in patients following allogeneic hematopoietic stem cell transplantation： a retrospective analysis of incidence, risk factors and survival

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Chinese Medical Journal 2013年第6期126卷 1096-1102页

作者： ZHANG xiao-hui HUANG xiao-jun liu Kai-yan XU Lan-ping liu Dai-hong CHEN Huan HAN Wei CHEN Yu-hong WANG Feng-rong WANG Jing-zhi WANG Yu ZHAO Ting CHEN Yao FU Hai-xia WANG Min Peking University People's Hospital Peking University Institute of Hematology Beijing 100044 China

Background AIIogeneic hematopoietic stem cell transplantation （allo-HSCT） is a curative therapy for many hematological diseases, but there are many complications following alIo-HSCT, among which neurological complications （NC） are one of the most commonly described ones. However, little is known about idiopathic inflammatory demyelinating diseases （IIDDs） of the central nervous system （CNS） in patients following alIo-HSCT. Methods A nested case-control study was conducted in a large cohort of 1365 patients, who underwent alIo-HSCT at the Institute of Hematology and Peking University People＇s Hospital, between January 2004 and December 2009, 36 patients of whom developed CNS IIDDs. Kaplan-Meier method, univariate and multivariate Cox regression were applied in our statistical analysis using SPSS 16.0. Results The cumulative incidence of all cases of IIDDs at 6 years posttransplantation was 3.6%. Thirty-five patients （97.2%） suffered IIDDs after transplantation, 16 patients （44.4%） between day 0 to day 100 post-transplantation, 10 patients （27.8%） between day 100 to 1 year post-transplantation, and 9 patients （25.0%） 1 year post-transplantation. Multivariate regression analysis identified donor type （P=0.031）, infection （P=0.009）, and acute lymphatic leukemia （P=0.017） as independent risk factors for posttransplantation IIDDs. The median survival time of patients with IIDDs was 514 days after transplantation （95% CI： 223-805）. Survival at 6 years was significantly lower in patients who developed the diseases compared to those who did not （26.6% vs. 73.5%, P 〈0.001）. Of the 36 patients experiencing IIDDs, 58.3% （n=21） died. The causes of death were graft-versus-host disease （GVHD）（n=4）, underlying disease relapse （n=3）, infections （n=12）, and other causes （n=2）. Conclusions IIDDs is an uncommon but serious complication of alIo-HSCT, especially in patients with a primary diagnosis of acute lymphatic leukemia, mismatched transplants, and infections. Our study results in

关键词： hematopoietic stem cell transplantation idiopathic inflammatory demyelinating diseases central nervous system risk factors survival

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Hemorrhagic cystitis following hematopoietic stem cell transplantation:incidence,risk factors and association with CMV reactivation and graft-versus-host disease

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Chinese Medical Journal 2007年第19期120卷 1666-1671页

作者： XU Lan-ping ZHANG Hong-yu HUANG xiao-jun liu Kai-yan liu Dai-hong HAN Wei CHEN Huan CHEN Yu-hong GAO Zhi-yong ZHANG Yao-chen LU Dao-pei Peking University Institute of Hematology Peking University People＇s Hospital Beijing 100044 China

Background The definite pathogenesis of hemorrhagic cystitis （HC） after allogenic hematopoietic stem cell transplantation （allo-HSCT） has not been well elucidated. The role of cytomegalovirus （CMV） reactivation and graft-versus-host disease （GVHD） in the development of HC remains obscure. This study determined the incidence and risk factors for HC after alIo-HSCT and analyzed its association with CMV reactivation and GVHD. Methods We retrospectively studied 250 patients at high risk for CMV disease who underwent alIo-HSCT all based on busulfan/cyclophosphamide （BU/CY） myloablative regimens. The incidence, etiology, risk factors and clinical management of HC were investigated. Results HC developed within 180 days of transplant in 72 patients, with an overall incidence of 28.8% and an incidence of 12.6% in patients with HLA-matched related donors （MRD）, 34.38% in those with HLA-matched unrelated donors （MUD）, 49.45% in those with mismatched related donors （MMRD）. CMV-viremia significantly increased the incidence of later onset HC （LOHC）; however, only 9 out of 15 patients with CMV viruria actually developed LOHC. Multiple regression analysis identified grade II-IV acute GVHD （RR=2.75; 95% CI 1.63-4.66; P〈0.01） and grafts from MUD or MMRD （RR=2.60; 95% CI 1.52-5.20; P〈0.01） as independent risk factors for HC. Event sequence analysis indicated a majority of HC episodes began around GVHD initiation. Conclusions CMV-viremia is a high risk factor for LOHC. Our data also showed a correlation between acute GVHD and HC, which suggested that alloimmunity may be involved in the pathogenesis of HC.

关键词： hemorrhagic cystitis allogeneic hematopoietic stem cell transplantation cytomegalovirus graft-versus-host disease

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Clinical outcomes and immune reconstitution in 103 advanced AIDS patients undergoing 12-month highly active antiretroviral therapy

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Chinese Medical Journal 2006年第20期119卷 1677-1682页

作者： DAI Yi QIU Zhi-feng LI Tai-sheng HAN Yang ZUO Ling-yan XIE Jing MA xiao-jun liu Zheng-yin WANG Ai-xia Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Background Highly active antiretroviral therapy （HAART） produces profound suppression of HIV replication, substantial increase in CD4^＋ T cells, and partial reconstitution of the immune system. However, the numbers of subjects were small in previous Chinese studies. This study evaluated the efficacy and side effects of HAART in Chinese advanced AIDS patients.Methods One hundred and three antiretroviral drug naive AIDS patients were enrolled in this study and were divided into two groups by their baseline CD4^＋ count：〈 100 cells/μl or ≥ 100 cells/μl. Clinical, virological and immunological outcomes were monitored at baseline and at 1, 3, 6, 9 and 12 months during the course of treatment with HAART.Results One patient died and another was lost from the follow-up. For the remaining 101 HIV/AIDS patients at the 12th month during the HAART, the plasma viral load （VL） was reduced to （3.2±0.7） lg copies/ml, the CD4^＋ count increased to （168 ±51） cells/μl [among which the naive phenotype （CD45RA^＋CD62L^＋） increased to （49 ±27） cells/μl and the memory phenotype （CD45RA^-） increased to （119 ±55） cells/μl], and the percentage of CD4^＋CD28^＋ cells increased. At the same time, there was a significant reduction of CD8^＋ T cell activation. In the 69 patients with the baseline CD4^＋ count 〈100 cells/μl, 37 had a VL 〈50 copies/ml; while in the 34 patients with the baseline CD4^＋ count ≥ 100 cells/μl, 25 had a VL 〈50 copies/ml, the difference between the two groups was statistically significant. The CD4^＋ T cell count showed a two-phase increase during HAART and a significant positive correlation was shown between the change of CD4^＋ count and plasma VL. Over 12 months of HAART, 10 patients had gastrointestinal side effects, 13 peripheral neuritis, 7 hepatic lesions, 8 hematological side effects, 8 skin rashes, 10 lipodystrophy and 1 renal calculus.Conclusions Immune reconstitution as well as the significantly improved clinical outcomes is observed in Chinese advanced AIDS pat

关键词： acquired immunodeficiency syndrome antiretroviral therapy, highly active CD4 lymphocyte count immune reconstitution adverse effects

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Microstructural evolution and sintering kinetics during spark plasma sintering of Fe and Al blended powder

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Transactions of Nonferrous Metals Society of China 2017年第7期27卷 1594-1601页

作者： Rui-di LI Tie-chui YUAN xiao-jun liu Ji-wei WANG Hong WU Fan-hao ZENG Xiang ZHOU State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China Shenzhen Institute of Information Technology Shenzhen 518172 China

The reaction diffusion between Fe and Al during spark plasma sintering(SPS)was *** evolution wasinvestigated by X-ray diffraction(XRD)and scanning electron microscopy(SEM)and the sintering kinetics was *** maininterphase of the SPS sample was ***-milling enabled a large number of lattice defects and grain boundariesthus the reaction kinetics was accelerated,although the direct current can also promote those *** milling,the phasetransformation kinetics was improved from0.207before mill to4.56×***,this work provided more details for thegeneration of Joule *** resistance offered to the electric path was considered to be the source of Joule heating,andparticularly the resistance offered by the different contact interfaces of die,punch,graphite foil and the sample played a leading rolefor the generation of Joule heating during spark plasma sintering.

关键词： Fe-Al blended powder spark plasma sintering sintering kinetics diffusion reaction Joule heating

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Cloning, Expression of apxl Gene of Actinobacillus pleuropneumoniae and Development of ELISA

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Agricultural Sciences in China 2003年第5期2卷 578-582页

作者： liu Jian-jie, HE Qi-gai, CHEN Huan-chun, WU Bin, XU xiao-juan, liu jun-fa, TANG Xian-chun and BEI Wei-chengCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070 , P.R. China

Based on the published nucleotide sequence of the apxICA of Actinobacillus pleuropneumoniae in Genbank(S4074), a pair of primers were designed. A 3 640 bp(4 687 - 8 326 bp)gene fragment was amplified by PCR from the isolated strain of A. pleuropneumoniae serovar 1. Then, it was cloned into pMD18-T, identified by both restriction endonuclease and sequence analysis, and inserted into pET-28a expression vector to yield the expression plasmid. SDS-PAGE result indicated expression of apxICA in BL21 (DE3), Western blot analysis showed the protein's immunogenicity. Using the expressed protein, ELISA was established to detect serum antibody against ApxI. The feature of ELISA to detect highly virulent A. pleuropneumoniae strains infection was proved by primary clinical application.

关键词： Actinobacillus pleuropneumoniae apxICA gene Cloning Prokaryotic expression ELISA

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免疫检查点抑制剂耐药机制分析

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世界华人消化杂志 2020年第17期28卷 857-864页

作者：刘小军关泉林甘肃省人民医院放疗二科甘肃省兰州市730000 兰州大学第一医院肿瘤外科甘肃省兰州市730000

免疫检查点抑制剂(immune checkpoint inhibitor,ICI)自问世以来用于治疗多种肿瘤,取得了一定的疗效.但是,仍有相当部分患者初始治疗无效,或出现继发耐药.近年来,免疫新药的耐药机制得以不断阐明.癌细胞和免疫细胞之间复杂的相互作用介... 详细信息

免疫检查点抑制剂(immune checkpoint inhibitor,ICI)自问世以来用于治疗多种肿瘤,取得了一定的疗效.但是,仍有相当部分患者初始治疗无效,或出现继发耐药.近年来,免疫新药的耐药机制得以不断阐明.癌细胞和免疫细胞之间复杂的相互作用介导了耐药性的出现.肿瘤微环境、肿瘤免疫原性的异常改变,以及癌细胞信号通路的异常激活在耐药过程中发挥重要作用.恰当处理耐药有助于ICI疗效的进一步提高.免疫新药的联合治疗策略有助于减少耐药发生.本综述将讨论ICI的不同耐药机制,以及克服耐药的策略.

关键词：恶性肿瘤免疫检查点抑制剂耐药

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快速实时大规模互联网广告流量检测系统

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北京邮电大学学报 2016年第5期39卷 61-66页

作者：方澄赵晓星刘军雷振明北京邮电大学信息与通信工程学院北京100876

提出一种适用于大规模互联网流量的实时广告流量检测系统,系统以目前最为流行的Adblock规则列表作为基本规则库,将Hash Table快速匹配算法和Aho-Corasick快速匹配算法相结合,对广告流量进行快速实时匹配.此外,为了适应大规模流式数据的... 详细信息

提出一种适用于大规模互联网流量的实时广告流量检测系统,系统以目前最为流行的Adblock规则列表作为基本规则库,将Hash Table快速匹配算法和Aho-Corasick快速匹配算法相结合,对广告流量进行快速实时匹配.此外,为了适应大规模流式数据的需求,将匹配算法部署在并行流式工作框架Spark Streaming之上.模型系统分别在实验室和运营商真实网络环境下的超大规模数据集进行了测试,结果表明,检测系统具有较高的准确率和计算效率.

关键词：广告流量实时匹配算法流式工作框架大规模数据

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环氧合酶-2和基质金属蛋白酶-2在大鼠非酒精性脂肪肝炎中的作用

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世界华人消化杂志 2007年第9期15卷 947-952页

作者：刘晓珺沈滨杜雅菊哈尔滨医科大学附属第二医院急诊内科黑龙江省哈尔滨市150086 哈尔滨医科大学附属第二医院普外二科黑龙江省哈尔滨市150086 哈尔滨医科大学附属第二医院消化内科黑龙江省哈尔滨市150086

目的:探讨环氧合酶-2(cyclooxygenase,COX-2)和基质金属蛋白酶-2(matrix metalloproteinase,MMP-2)在非酒精性脂肪性肝炎(nonalcoholic steamhepatitis,NASH)的发生、发展过程的作用.方法:取30只Wistar大鼠随机分成2组:模型组24只饲以高脂饲料(100 g/L猪油、20 g/L胆固醇、5 g/L胆酸钠、875 g/L基础饲料)和正常对照组6只以基础饲料饲养.分别于实验第12,16,24周随机处死模型组大鼠8只和正常对照组2只,取肝组织用于HE染色和RNA提取,应用逆转录聚合酶链反应(RT-PCR)检测肝组织COX-2 mRNA和MMP-2 mRNA的相对含量.结果:正常对照组肝组织COX-2 mRNA无表达;模型组均表达,并且随着造模时间延长COX-2 mRNA表达增强,造模第24周肝组织COX-2 mRNA表达明显高于第12,16周(1.035±0.040 vs 0.699±0.062,0.533±0.059,P<0.05);MMP-2 mRNA相对表达量在造模第12周与正常组相比无明显升高,而造模第16,24周,显著高于第12周(0.952±0.124,0.726±0.064 vs 0.454±0.06l,P<0.05),造模第24周和第16周之间亦有差别(P<0.05);NASH大鼠肝组织COX-2 mRNA和MMP-2 mRNA表达有相关性(r=0.794,P<0.05).结论:NASH大鼠肝组织中高表达COX-2 mRNA和MMP-2 mRNA,他们可能共同参与了NASH的形成、发展过程.

关键词：环氧合酶-2 基质金属蛋白酶-2 逆转录聚合酶链反应非酒精性脂肪性肝炎大鼠

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