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High-order harmonic generation in a two-color strong laser field with Bohmian trajectory theory

Chinese Physics B 2018年第7期27卷 295-300页

作者： Yi-Yi Huang Xuan-Yang Lai xiao-jun liu State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences. Wuhan 430071 China University of Chinese Academy of Sciences Beijing 100049 China

We theoretically study the high-order harmonic generation （HHG） in a two-color laser field using the Bohmian mechanics. Our results show that, for tile case of a weak second-color laser field, the simulation of the HHG with only one central Bohmian trajectory is in a good agreement with the ab initio time-dependent Schrodinger equation （TDSE） results. In contrast, with the increase of the amplitude of the second-color laser field, the HHG spectra from the single central Bohmian trajectory deviate from the TDSE results more and more significantly. By analyzing the Bohmian trajectories, we find that the significant deviation is due to the fact that the central Bohmian trajectory leaves the core quickly in the two-color laser field with the breaking of inversion symmetry. Interestingly, we find that another Bohmian trajectory with different initial position, which keeps oscillating around the core, could qualitatively well reproduce the TDSE results. Furthermore, we study the HHG spectrum in a two-color laser field with inversion symmetry and find that the HHG spectrum in TDSE can be still well simulated with the central Bohmian trajectory. These results indicate that, similar to the case of one color laser field, the HHG spectra in a two-color laser field can be also reproduced with a single Bohmian trajectory, although the initial position of the trajectory is dependent on the symmetry of the laser field. Our work thus demonstrates that Bohmian trajectory theory can be used as a promising tool in investigating the HHG process in a two-color laser field.

关键词： high-order harmonic generation two-color laser field Bohmian trajectory

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Visible light promoted polyhalomethylation of alkenes: alkylation and cyclization

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Organic Chemistry Frontiers 2022年第4期9卷 1004-1009页

作者： Tong-Lin Wang Bo-Sheng Zhang Jing-Jiang liu xiao-jun liu Xi-Cun Wang Zheng-jun Quan Laboratory of Eco-Environment-Related Polymer Materials Ministry of EducationChina.College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhouGansu 730070People’s Republic of China

We report a visible light promoted carbochloromethylation of 2-bromomethyl acrylate and N-arylmethacrylamide,and a series of trihalomethyl substituted allylic acid esters and indolone derivatives were *** reaction used common and inexpensive chloroform and tribromomethane as tri-halomethyl reagents,iodobenzene diacetate(PIDA)as an oxidant and Eosin Y as a *** reaction conditions are mild and the substrate scope is wide.

关键词： promoted light cyclization

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Listen to the chemical and histological information in biological tissue

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Chinese Chemical Letters 2015年第4期26卷 395-400页

作者： Jie Yin Fei Zhao Chao Tao Xue-Ding Wang xiao-jun liu MOE Key Laboratory of Modern Acoustics Nanjing University Department of Automation Nanjing College of Chemical Technology Department of Nephrology Nanjing Children's HospitalNanjing Medical University Department of Radiology University of Michigan School of Medicine

Photoacoustic imaging （PAl）, as an emerging biomedicine diagnostic technique that has been aevelopea quickly in the past decade, inherits the high spatial resolution of ultrasonography in imaging deep tissue and the high sensitivity of optical imaging in evaluating tissue chemical and physiological information. In this paper, after introducing the basic principles of PAl including both photoacoustic tomography and photoacoustic microscopy, we will review some recent progress of PAl in biomedicine and demonstrate the capability of PAl in detecting the chemical compositions and in evaluating the histological microstructures in biological tissue.

关键词： Photoacoustic imagingTomographyMicroscopyChemical compositionMicrostructure

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Downregulation of cold-inducible RNA-binding protein activates mitogen-activated protein kinases and impairs spermatoRenic function in mouse testes

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Asian Journal of Andrology 2012年第6期14卷 884-889页

作者： Zhi-Ping Xia Xin-Min Zheng Hang Zheng xiao-jun liu Gui-Yong liu Xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China Department of Urology Qianjiang Central Hospital Qianjiang 433100 China

Cold-inducible RNA-binding protein （CIRP） is an RNA-binding protein that is expressed in normal testes and downregulated after heat stress caused by cryptorchidism, varicocele or environmental temperatures. The purpose of this study was to investigate the functions of CIRP in the testes. We employed RNAi technique to knock down the expression of CIRP in the testes, and performed haematoxylin and eosin staining to evaluate morphological changes following knockdown. Germ cell apoptosis was examined by terminal deoxynucleotidal transferase-mediated dUTP nick end labelling （TUNEL） assay, and mitogen-activated protein kinase （MAPK） signalling pathways were investigated by Western blotting to determine the possible mechanism of apoptosis. We found that using siRNA is a feasible and reliable method for knocking down gene expression in the testes. Compared to controls, the mean seminiferous tubule diameter （MSTD） and the thickness of the germ cell layers decreased following siRNA treatment, whereas the percentage of apoptotic seminiferous tubules increased. The p44/p42, p38 and SAPK/JNK MAPK pathways were activated after downregulation of CIRP. In conclusion, we discovered that downregulation of CIRP resulted in increased germ cell apoptosis, possibly viathe activation of the p44/p42, p38 and SAPK/JNK MAPK pathways.

关键词： cold-inducible RNA-binding protein (CIRP) mitogen-activated protein kinase (MAPK) siRNA in vivo spermatogenesis heat stress male infertility

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Transrectal versus transperineal prostate biopsy for cancer detection in patients with gray-zone prostatespecific antigen:a multicenter,real-world study

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Asian Journal of Andrology 2024年第4期26卷 377-381页

作者： jun-xiao liu Ze-Yuan Wang Shao-Xi Niu xiao-Yong Sai Xu Zhang Xue-Pei Zhang Xin Ma The Graduate School Chinese PLA General HospitalBeijing 100853China Department of Urology The Third Medical CenterChinese PLA General HospitalBeijing 100853China Department of Urology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Urology The First Medical CenterChinese PLA General HospitalBeijing 100853China Faculty of Epidemiology and Statistics The Graduate SchoolChinese PLA General HospitalBeijing 100853China.

Knowledge about the effect of different prostate biopsy approaches on the prostate cancer detection rate(CDR)in patients with gray-zone prostate-specific antigen(PSA)is *** performed this study to compare the CDR among patients who underwent different biopsy approaches and had rising PSA levels in the gray *** hundred and twenty-two patients who underwent transrectal prostate biopsy(TRB)and 216 patients who underwent transperineal prostate biopsy(TPB)between june 2016 and September 2022 were reviewed in this *** addition,110 patients who received additional targeted biopsies following the systematic TPB were *** parameters,including age,PSA derivative,prostate volume(PV),and needle core count,were *** data were fitted via propensity score matching(PSM),adjusting for potential *** outperformed TRB in terms of the CDR(49.6%vs 28.3%,P=0.001).The clinically significant prostate cancer(csPCa)detection rate was not significantly different between TPB and TRB(78.6%vs 68.8%,P=0.306).In stratified analysis,TPB outperformed TRB in CDR when the age of patients was 65–75 years(59.0%vs 22.0%,P<0.001),when PV was 25.00–50.00 ml(63.2%vs 28.3%,P<0.001),and when needle core count was no more than 12(58.5%vs 31.5%,P=0.005).The CDR(P=0.712)and detection rate of csPCa(P=0.993)did not significantly differ among the systematic,targeted,and combined *** outperformed TRB in CDR for patients with gray-zone ***,performing target biopsy after systematic TPB provided no additional benefits in CDR.

关键词： biopsy detection of cancer prostate-specific antigen transperineal transrectal

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Universality of the Dynamic Characteristic Relationship of Electron Correlation in the Two-Photon Double Ionization Process of a Helium-Like System

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Chinese Physics Letters 2020年第11期37卷 27-32页

作者： Fei Li Yu-jun Yang Jing Chen xiao-jun liu Zhi-Yi Wei Bing-Bing Wang Laboratory of Optical Physics Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China Institute of Applied Physics and Computational Mathematics Beijing 100088China HEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100084China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Universality of the dynamic characteristic relationship between the characteristic time tc and the two-electron Coulomb interaction energy V12 of the ground state in the two-photon double ionization process is investigated via changing the parameters of the two-electron atomic system and the corresponding laser *** numerical results show that the product tcV12 keeps constant around 4.1 in the cases of changing the nucleus charge,the electron charge,the electron mass,and changing simultaneously the nucleus charge and the electron *** results demonstrate that the dynamic characteristic relationship in the two-photon double ionization process is *** work sheds more light on the dynamic characteristic relationship in ultrafast processes and may find its application in measurements of attosecond pulses.

关键词： conditions. charge characteristic

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Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus

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Biomedical and Environmental Sciences 2009年第5期22卷 359-368页

作者： YAN-LI YANG RUO-LAN XIANG CHANG YANG xiao-jun liu WEN-jun SHEN JIN ZUO YONG-SHENG CHANG Fu-DE FANG Department of Internal Medicine Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100730 China Department of Physiology and Pathophysiology Peking University Health Science Center BeiJing 100083 China National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100005 China Division of Endocrinology Stanford University and VA Palo Alto Health Care System 3801 Miranda Avenue Palo Alto CA 94304 USA

Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus （T2DM） patients and healthy subjects using DNA microarray analysis, Methods T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to anaIyze the relation between gene expressions and T2DM. Results The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscle of diabetes mellitus patients compared with control subjects. The 1320, 1143, and 2847 genes were modified in adipose tissue of the three groups. Among the genes surveyed, the change of 25 and 39 gene transcripts in skeletal muscle and adipose tissue was ≥2 folds, These differentially expressed genes were classified into 15 categories according to their functions. Conclusion New genes are found and T2DM can be prevented or cured.

关键词： Type 2 diabetes mellitus (T2DM) Microacray technology Skeletal muscle Adipose tissue

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Perioperative complications of radical retropubic prostatectomy in patients with locally advanced prostate cancer： a comparison with clinically localized prostate cancer

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Asian Journal of Andrology 2013年第2期15卷 241-245,I0007,I0008页

作者： Xu-Dong Yao xiao-jun liu Shi-Lin Zhang Bo Dai Hai-Liang Zhang Ding-Wei Ye Department of Urology Cancer Hospital Fudan University Shanghai 200032 China Shanghai Medical College Fudan University Shanghai 200032 China

Radical prostatectomy （RP） continues to be an effective surgical therapy for prostate carcinoma, particularly for organ-confined prostate cancer （PCa）. Recently, RP has also been used in the treatment of locally advanced prostate cancer. However, little research has been performed to elucidate the perioperative complications associated with RP in patients with clinically localized or locally advanced PCa. We sought to analyse the incidence of complications in these two groups after radical retropubic prostatectomy （RRP）. From june 2002 to July 2010, we reviewed 379 PCa patients who underwent RRP in our hospital. Among these cases, 196 had clinically localized PCa （Tla-T2c group 1）, and 183 had locally advanced PCa （ ≥ T3,： group 2）. The overall complication incidence was 21.9%, which was lower than other studies have reported. Perioperative complications in patients with locally advanced PCa mirror those in patients with clinically localized PCa （26.2% vs. 17.8%, P=0.91）. Our results showed that perioperative complications could not be regarded as a factor to consider in regarding RP in patients with cT3 or greater.

关键词： complications clinically localized prostate cancer locally advanced prostate cancer prostate cancer (PCa) prostatectomy radical retropubic prostatectomy (RRP)

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Femtosecond enhancement cavity with kilowatt average power

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Chinese Physics B 2019年第4期28卷 211-215页

作者： Jin Zhang Lin-Qiang Hua Shao-Gang Yu Zhong Chen xiao-jun liu State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences University of Chinese Academy of Sciences

Femtosecond enhancement cavity(fsEC) has been proved to be a powerful tool in a diverse range of ***, we report the recent progresses in building an fsEC on kilowatt level average power, with the aim of realization of intracavity high harmonic generation(HHG) and extension of the wavelength of femtosecond optical frequency comb from infrared(IR) to extreme ultraviolet(XUV). Upon mode-matching optimization and cavity length locking, an intracavity average power of 6.08 kW is reached and the corresponding buildup is 225. After introducing noble gas of Xe into the focus region, clear sign of plasma has been observed. The generated HHG is also coupled out by a sapphire plate placed at Brewster's angle for the fundamental laser. Our work paves the way for the realization of an XUV comb.

关键词： femtosecond enhancement cavity extreme ultraviolet optical frequency comb high-order harmonic generation

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Nonadiabatic and Multielectron Effects in the Attoclock Experimental Scheme

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Chinese Physics Letters 2020年第4期37卷 26-30页

作者： Zhi-Lei xiao Wei Quan Song-Po Xu Shao-Gang Yu Xuan-Yang Lai Jing Chen xiao-jun liu State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics.Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071 University of Chinese Academy of Sciences Beijing 100049 HEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100084 Institute of Applied Physics and Computational Mathematics P.O.Box 8009.Beijing 100088

The problem of how long it takes for an electron to tunnel from one side of a barrier to the other has been debated for decades and the attoclock is a promising experimental procedure to address this *** the attoclock experiment,,many physical effects will contribute to the experimental results and it is difficult to extract the t unneling time *** numerically investigate a method of measuring the residual equivalent temporal offset(RETO)induced by the physical effects except for tunneling *** Coulomb potential effect,the nonadiabatic effect,the multielectron effect,and the Stark effect are considered in the theoretical *** is shown that the ratio of the RETO of the target atoms to that of H is insensitive to the wavelength and is linearly proportional to(2IP)^-3/*** work can help to improve the accuracy of the attoclock technique.

关键词： technique. adiabatic effect

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