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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting Zhang xiao-jun liu Xue-Bin Peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie liu Changqing Xu Da-Jian Wu Ying Cheng xiao-jun liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

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A Criterion of Normality Based on a Single Holomorphic Function

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Acta Mathematica Sinica,English Series 2011年第1期27卷 141-154页

作者： xiao jun liu Shahar NEVO Department of Mathematics University of Shanghai for Science and Technology Shanghai 200093 P. R. China Department of Mathematics Bar-Ilan University 52900 Ramat-Gan Israel

Let F be a family of functions holomorphic on a domain D C C. Let k ≥ 2 be an integer and let h be a holomorphic function on D, all of whose zeros have multiplicity at most k- 1, such that h（z） has no common zeros with any f∈F. Assume also that the following two conditions hold for every f ∈F ：（a） f（z） = 0 == f （z） = h（z）; and （b） y（z） = h（z） == ｜f（k）（z）｜ ≤ c, where c is a *** F is normal on D.

关键词： Normal family holomorphic functions zero points

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Photoacoustic and Fluorescence Spectroscopy of Metallomesogens Containing Lanthanide Ions

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Chinese Journal of Chemical Physics 2008年第2期21卷 99-104页

作者： Yue-tao Yang jun-jia Li xiao-jun liu Shu-yi Zhang Jing liu Key Laboratory of Modern Acoustics Ministry of Education Institute of Acoustics Nanjing University Nanjing 210093 China Beijing Synchrotron Radiation Facility Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

Metallomesogens Ln（bta）3L2 （Ln^3＋： La^3＋, Eu^3＋, and Ho^3＋; bta： benzoyltrifluoroacetonate; L： Schiff base） were prepared. Photoacoustic （PA） spectroscopy was used to study physicochemical properties of the liquid crystalline metal complexes. In the region of ligand absorption, PA intensity increases for Eu（bta）3L2, La（bta）3L2, and Ho（bta）3L2, in that order. It is found that the PA intensity of the ligand bears a relation to the intramolecular energy transfer process. For the first time, phase transitions of Eu（bta）3L2 from glass state to smectic A （SmA） phase and SmA phase to isotropic liquid are monitored by PA and fluorescence （FL） spectroscopy from two aspects： nonradiative and radiative transitions. The results show that PA technique may serve as a new tool for investigating the spectral properties and phase transitions of liquid crystals containing metal ions.

关键词： Photoacoustic spectroscopy Lanthanide complex Liquid crystal Relaxation process Phase transition

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Bohmian trajectory perspective on strong field atomic processes

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Chinese Physics B 2020年第1期29卷 1-8页

作者： Xuan-Yang Lai xiao-jun liu State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China

The interaction of an atom with an intense laser field provides an important approach to explore the ultrafast electron dynamics and extract the information of the atomic and molecular structures with unprecedented attosecond temporal and angstrom spatial resolution. To well understand the strong field atomic processes, numerous theoretical methods have been developed, including solving the time-dependent Schr ?dinger equation(TDSE), classical and semiclassical trajectory method, quantum S-matrix theory within the strong-field approximation, etc. Recently, an alternative and complementary quantum approach, called Bohmian trajectory theory, has been successfully used in the strong-field atomic physics and an exciting progress has been achieved in the study of strong-field phenomena. In this paper, we provide an overview of the Bohmian trajectory method and its perspective on two strong field atomic processes, i.e., atomic and molecular ionization and high-order harmonic generation, respectively.

关键词： Bohmian trajectory strong-field ionization high-order harmonic generation

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An input-output model for energy accounting and analysis of industrial production processes： a case study of an integrated steel plant

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Journal of Iron and Steel Research International 2018年第5期25卷 524-538页

作者： xiao-jun liu Sheng-ming Liao Zheng-hua Rao Gang liu School of Energy Science and Engineering Central South University Changsha 410083 Hunan China

To promote sustainability, it has become increasingly vital to properly account material and energy flows in industrial production processes. Therefore, a generic process-level input-output （IO） model was developed to provide an integrated energy （material） accounting and analysis approach for industrial production processes. By extending the existing processlevel IO models, the production, usage, export and loss of by-products were explicitly considered in the proposed IO model. Moreover, the by-products allocation procedures were incorporated into the proposed IO model to reflect individual contributions of products to energy consumption. Finally, the proposed model enabled calculating embodied energy of main products and total energy consumption under hierarchical accounting scope. Plant managers, energy management consultants, governmental officials and academic researchers could use this input-output model to account material and energy flows, thus calculating energy consumption indicators of a production process with their specific system boundary requirements. The accounting results could be further used for energy labeling, identifying bottlenecks of production activities, evaluating industrial symbiosis effects, improving materials and energy utilization efficiency, etc. The model could also be used as a planning tool to determine the effect that a particular change of technology and supply chains may have on the industrial production processes. The proposed model was tested and applied in a real integrated steel mill, which also provided the reference results for related researches. At last, some concepts, computational issues and limi- tations of the proposed model were discussed.

关键词： Input-output model · Energy consumption · Energy accounting · Embodied energy · Industrial production process · Integrated steelmaking process

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Diferential Inequalities,Normality and Quasi-normality

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Acta Mathematica Sinica,English Series 2014年第2期30卷 277-282页

作者： xiao jun liu Shahar NEVO Xue Cheng PANG Department of Mathematics University of Shanghai for Science and Technology Department of Mathematics Bar-Ilan University Department of Mathematics East China Normal University

We prove that ifD is a domain in C,α 〉 1 and C 〉 0,then the family F of functions f meromorphic in D such that ｜f′（z）｜/1 ＋｜f（z）｜α 〉 C for every z ∈ D is normal in *** α = 1,the same assumptions imply... 详细信息

关键词： Normal family quasi-normal family differential inequality

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One-dimensional PT-symmetric acoustic heterostructure

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Chinese Physics B 2022年第12期31卷 289-294页

作者： Hai-xiao Zhang Wei Xiong Ying Cheng xiao-jun liu Department of Physics MOE Key Laboratory of Modern AcousticsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China School of Electrical and Information Engineering Changzhou Institute of TechnologyChangzhou 213032China State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China

The explorations of parity-time(PT)-symmetric acoustics have resided at the frontier in physics,and the pre-existing accessing of exceptional points typically depends on Fabry-Perot resonances of the coupling interlayer sandwiched between balanced gain and loss ***,the concise PT-symmetric acoustic heterostructure,eliminating extra interactions caused by the interlayer,has not been researched in *** we derive the generalized unitary relation for one-dimensional(1D)PT-symmetric heterostructure of arbitrary complexity,and demonstrate four disparate patterns of anisotropic transmission resonances(ATRs)accompanied by corresponding spontaneous phase *** a special case of ATR,the occasional bidirectional transmission resonance reconsolidates the ATR frequencies that split when waves incident from opposite directions,whose spatial profiles distinguish from a unitary *** derived theoretical relation can serve as a predominant signature for the presence of PT symmetry and PT-symmetry-breaking transition,which may provide substantial support for the development of prototype devices with asymmetric acoustic responses.

关键词： acoustic PT-symmetric heterostructure anisotropic transmission resonance occasional bidirectional transmission resonance

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Erosion-corrosion investigation of high chromium cast irons using newly designed jet type tester

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中国有色金属学会会刊：英文版 2004年第z1期14卷 405-412页

作者： TU xiao-hui liu jun-quan LI Wei ZHANG Feng-hua SU jun-yi School of Materials Science and Engineering Xi''an Jiaotong University Xi''an 710049 China Wear Materials Research Center Guangzhou Research Institute of Nonferrous Metals Guangzhou 510651 China College of Industrial Equipment and Control Engineering South China University of Technology Guangzhou 510640 China Department of Chemistry Ji''nan University Guangzhou 510632 China Wear Materials Research Center Guangzhou Research Institute of Nonferrous Metals Guangzhou 510651 China School of Materials Science and Engineering Xi''an Jiaotong University Xi''an 710049 China

A jet type erosion-corrosion tester was developed for the erosion-corrosion investigation of high-chromium cast irons. During tests the size and the shape of particles in the slurry can be maintained stable. The jet velocity and attack angle can be accurately controlled. The repeatability and ranking consistency of the test results are satisfactory. The test parameters can be adjusted in a wide range, so that the tester can simulate various practical working conditions. Electrochemical test data can be automatically collected and processed. Dynamic polarization curves can be obtained during erosion-corrosion test, which can be used to study the dynamic corrosion *** high chromium cast irons were studied in hot concentrated alkaline slurry. The results show that the erosioncorrosion mass loss rate and dynamic corrosion rate of 295Cr26 iron is lower than that of 185Cr13 under the conditions similar to alumyte processing. The mechanism of erosion-corrosion of 295Cr26 and 185Cr13 was studied by using the tester. The interaction between erosion and corrosion was also quantitatively evaluated.

关键词： erosion-corrosion tester repeatability chromium cast iron hot concentrated alkali

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A Normal Criterion about Two Families of Meromorphic Functions Concerning Shared Values

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Acta Mathematica Sinica,English Series 2013年第1期29卷 151-158页

作者： xiao jun liu San Hua LI Xue Cheng PANG Department of Mathematics University of Shanghai for Science and Technology Department of Mathematics East China Normal University

In this paper, we mainly discuss the normality of two families of functions concerning shared values and proved： Let F and G be two families of functions meromorphic on a domain D C C, a1, a2, a3, a4 be four distinct finite complex numbers. If G is normal, and for every f 9~, there exists g C G such that f（z） and g（z） share the values a1, a2, a3, a4, then F is normal on D.

关键词： Normal family shared values meromorphic functions

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