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Advances in viral encephalitis:Viral transmission,host immunity,and experimental animal models

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Zoological Research 2023年第3期44卷 525-542页

作者： Dan Yang xiao-jing li De-Zhen Tu Xiu-li li Bin Wei State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesWuhanHubei 430071China School of Medicine Shanghai UniversityShanghai 200444China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Department of Cardiology Lanzhou University Second HospitalLanzhouGansu 730030China School of life Sciences Shanghai UniversityShanghai 200444China

Viral infections have led to many public health crises and pandemics in the last few centuries.Neurotropic virus infection-induced viral encephalitis(VE),especially the symptomatic inflammation of the meninges and brain parenchyma,has attracted growing attention due to its high mortality and disability rates.Understanding the infectious routes of neurotropic viruses and the mechanism underlying the host immune response is critical to reduce viral spread and improve antiviral therapy outcomes.In this review,we summarize the common categories of neurotropic viruses,viral transmission routes in the body,host immune responses,and experimental animal models used for VE study to gain a deeper understanding of recent progress in the pathogenic and immunological mechanisms under neurotropic viral infection.This review should provide valuable resources and perspectives on how to cope with pandemic infections.

关键词： Neurotropic viruses Viral encephalitis Meningeal immunity Experimental animal models

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Modifying Poly(propylene carbonate) with Furan-based Non-Isocyanate Polyurethanes

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Chinese Journal of Polymer Science 2023年第7期41卷 1069-1077页

作者： xiao-jing li Ying-Feng Wen Yong Wang Xing-Ping Zhou xiao-lin Xie Key Laboratory for Material Chemistry of Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China

Poly(propylene carbonate) (PPC) is gaining significant momentum as a biodegradable polymer using CO_(2) as an abundant, low-cost and renewable feedstock. Yet, PPC suffers from unsatisfactory thermal and mechanical properties, and its blends with other synthetic polymers as the second component typically exhibit poor compatibility. Herein, novel furan-based non-isocyanate polyurethanes (NIPUs) with high molecular weights and narrow distributions have been synthesized starting from 5-hydroxymethylfurfural (HMF) via a four-step procedure including reduction, glycidylation, carbonation of CO_(2) and step-growth polymerization with diamines. Owing to the structural similarity and intermolecular hydrogen bonding interactions, furan-based NIPUs display good compatibility with PPC. A sea-island morphology can be observed in SEM images of PPC/NIPU blends, where the NIPU phases are randomly dispersed in the PPC matrix. Moreover, the blends exhibit only one Tg (higher than both that of PPC and the corresponding NIPU) on the DSC curves, which first increase and then decrease when increasing the content of NIPUs from 0 wt% to 15 wt%. Notably, the physical crosslinking formed by hydrogen bonding interactions, coupled with the rigidity of furan rings, confer simultaneous improvements of elongation at the break and tensile strength, affording high-performance CO_(2)-based biodegradable polymeric materials with low carbon footprint, good sustainability, and ideal biocompatibility.

关键词： PPC CO_(2) NIPU HMF Blends

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CO_(2)-based Biodegradable Supramolecular Polymers with Well-tunable Adhesive Properties

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Chinese Journal of Polymer Science 2022年第1期40卷 47-55页

作者： xiao-jing li Ying-Feng Wen Yong Wang Hai-Yan Peng Xing-Ping Zhou xiao-lin Xie Key Laboratory for Material Chemistry of Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Supramolecular adhesives that enable debonding on-demand are of significant research interest for the development of adaptive and smart materials,yet,biodegrable supramolecular adhesives have been rarely exploited.Herein,telechelic,three-armed and four-armed CO_(2)-based polyols with close molecular weights and various content(or carbonate unite content)have been synthesized via a zinc-cobalt double metal cyanide complex catalyzed ring-opening copolymerization of CO_(2) and propylene oxide,and further exploited as sustainable and biodegradable building blocks for supramolecular polymers(SMPs)with 2-ureido-4[1H]-pyrimidinone(UPy)motifs.Notably,the orthogonal modulation of the CO_(2) content and the topology of CO_(2)-based polyols provide a unique opportunity to fine-tune the surface energy as well as the cohesive strength of the resulting CO_(2)-based SMPs.Notably,a three-armed SMP with 44%CO_(2)(3UPy-CO_(2)-44%)can well balance the trade-off between surface energy and cohesive strength,therefore bestowing a high adhesive strength of 7.5 and 9.7 MPa towards stainless steel and wood substrates respectively by testing the corresponding single lap joints.Moreover,the light-responsive adhesion property of 3UPy-CO_(2)-44%has been demonstrated exemplarily by blending with a UV sensitizer.

关键词： Biodegradable polymer Adhesive CO_(2)-based polyol ROCOP Supramolecular polymer

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Semaphorin 7a participants in pterygium by regulating vascular endothelial growth factor

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 892-897页

作者： Yun-Fei Han Zhen liu Bang Wang Wei Zhu jing-Zhen li Yue-Qin Qi xiao-jing li Yan-Yun Xu xiao-xiao Dou Guo-Ying Mu Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Aier Eye Hospital Group Hubin Aier Eye HospitalBinzhou 256600Shandong ProvinceChina Department of Ophthalmology the Second People’s Hospital of LiaochengLinqing 252600Shandong ProvinceChina Neonatal Intensive Care Unit Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Ophthalmology Jinan Central Hospital Affiliated to Shandong UniversityJinan 250013Shandong ProvinceChina Department of Cardiovascular Medicine the Second Affiliated Hospital of Zhejiang University College of MedicineHangzhou 310009Zhejiang ProvinceChina

AIM: To investigate the relationship between semaphorin 7a expression and cell proliferation and migration in pterygium fibroblasts. METHODS: Twenty-six patients with surgically diagnosed pterygium were enrolled, including 15 cases of primary pterygium and 11 cases of recurrent pterygium. In addition, 12 cases of normal conjunctival tissue were collected. The expression of semaphorin 7a in normal conjunctival tissue, primary pterygium and recurrent pterygium was detected by real-time polymerase chain reaction. Recurrent pterygium fibroblasts were isolated and cultured, and the expression of semaphorin 7a was silenced by small interfering RNA(siRNA) interference technique. Furthermore, the effects of si-semaphorin 7a interference on the mRNA and protein levels of β1-integrin, vascular endothelial growth factor A(VEGFA) and vascular endothelial growth factor receptor(VEGFR), and on fibroblast proliferation were analyzed. Transwell assay was used to detect the effect of semaphorin 7a interference on fibroblast migration. RESULTS: Semaphorin 7a was highly expressed in the primary pterygium and recurrent pterygium samples than that of the normal conjunctival tissue. Compared with the primary pterygium, the expression of semaphoring 7a in the recurrent pterygium samples was significantly increased(Pliferation and migration. CONCLUSION: Semaphorin 7a might play important roles in the pathogenesis of pterygium by affecting the expression of β1-integrin, VEGFA and VEGFR.

关键词： semaphorin 7a pterygium β1-integrin vascular endothelial growth factor fibroblast

Evaluation of elastography combined with serological indexes for hepatic fibrosis in patients with chronic hepatitis B

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World Journal of Gastroenterology 2018年第37期24卷 4272-4280页

作者： Bin Xu Ning-Ming Zhou Wei-Tian Cao xiao-jing li Department of ultrasound Fudan University affiliated Shanghai fifth people’s hospital Department of pathology Fudan University affiliated Shanghai fifth people’s hospital

AIM To investigate the value of ultrasound elastography combined with serological indexes in diagnosing liver fibrosis and assessing its severity.METHODS A total of 338 chronic hepatitis B(CHB) patients were divided into a disease group(patients with hepatic fibrosis) and control group(subjects without hepatic fibrosis). The disease group was further divided into S1-S4 according to the degree of fibrosis. Independent risk factors for hepatic fibrosis were analyzed using multivariate logistic regression. The diagnostic values of hepatic fibrosis from different indicators were compared using receiver operating characteristic(ROC) curves. The combination of elastography and serological indexes was explored to assess the severity of hepatic fibrosis.RESULTS The multivariate logistic regression analysis results revealed that shear wave velocity(SWV), hyaluronic acid(HA), type Ⅳ collagen(CⅣ) and aspartate aminotransferase-to-platelet ratio index(APRI) significantly affected the occurrence of hepatic fibrosis. The ROC curve revealed that the accuracy of the diagnosis of hepatic fibrosis for SWV and HA were 87.3% and 84.8%, respectively. The accuracy of SWV combined with HA was 88.9%. The multiple linear regression analysis revealed that SWV, aspartate aminotransferase(AST)/alanine aminotransferase(ALT), HA, CⅣ, APRI and fibrosis index based on the 4 factor(FIB-4) were screened as statistically significant independent factors. The established regression equation was: Fibrosis level =-4.046 + 1.024 × SWV + 1.170 × AST/ALT + 0.011 × HA + 0.020 × CⅣ + 0.719 × APRI + 0.379 × FIB-4. CONCLUSION SWV combined with serological indexes can improve the accuracy of diagnosis for CHB hepatic fibrosis. Serum indexes can help diagnose the degree of hepatic fibrosis.

关键词： Elastography Serology Hepatic fibrosis Non-invasive diagnosis

Biliary stent combined with iodine-125 seed strand implantation in malignant obstructive jaundice

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World Journal of Clinical Cases 2021年第4期9卷 801-811页

作者： Hui-Wen Wang xiao-jing li Shi-Jie li Jun-Rong Lu Dong-Feng He Department of Interventional Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Malignant obstructive jaundice is mainly caused by cholangiocarcinoma.Only a few patients are indicated for surgical resection,and the 3-year survival rate is<50%.For patients who are not eligible for surge... 详细信息

BACKGROUND Malignant obstructive jaundice is mainly caused by cholangiocarcinoma.Only a few patients are indicated for surgical resection,and the 3-year survival rate isligible for surgery,biliary stent placement can relieve biliary obstruction and improve liver function and quality of life.However,restenosis after biliary stents has a poor prognosis and is a clinical challenge.Biliary stent combined with iodine-125(125I)seed implantation can prolong stent patency and improve survival.AIM To evaluate the safety and efficacy of biliary stent combined with 125I seed strand implantation in malignant obstructive jaundice.METHODS We enrolled 67 patients between January 2016 and June 2018 with malignant obstructive jaundice and randomized them into a biliary stent combined with 125I seed strand treatment(combined)group(n=32)and biliary stent(control)group(n=35).All patients underwent enhanced computed tomography and magnetic resonance imaging and were tested for biochemical and cancer markers.Twelve patients underwent pathological examination before surgery.All patients were followed up by telephone or clinical visit.Postoperative liver function improvement,postoperative complications,stent patency time,and survival time were compared between the two groups.Prognostic risk factors were evaluated.RESULTS Technical success was achieved in all patients in both groups.Postoperative liver function improved significantly in all patients(total bilirubin,direct bilirubin,alanine aminotransferase,and aspartate aminotransferase decreased significantly in all patients,the P values were less than 0.05).There was no significant difference in preoperative or postoperative indexes between the two groups for changes in total bilirubin(P=0.147),direct bilirubin(P=0.448),alanine aminotransferase(P=0.120),and aspartate aminotransferase(P=0.387)between the two groups.The median stent patency time of the combined group was 9.0±1.4 mo[95%confidence interval(CI):6.3-11.8 mo],which was significantly longer than

关键词： Biliary stent 125I Obstructive jaundice Malignant tumor Clinical research Surgery

Prevalence of depressive and anxiety disorders in Chinese gastroenterological outpatients

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World Journal of Gastroenterology 2012年第20期18卷 2561-2568页

作者： xiao-jing li Yan-ling He Hong Ma Zhe-Ning liu Fu-Jun Jia ling Zhang Lan Zhang Mental Health Center of West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Shanghai Mental Health Center Shanghai Jiao Tong University Shanghai 200030 China Peking University Institute of Mental Health Bei-jing 100007 China Mental Health Institute of the Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China Guangdong Mental Health Center Guangdong General Hospital Guangzhou 510120 Guangdong Province China

AIM:To investigate the prevalence and physicians' detection rate of depressive and anxiety disorders in gastrointestinal(GI)outpatients across China. METHODS:A hospital-based cross-sectional survey was conducted in the GI outpatient departments of 13 general hospitals.A total of 1995 GI outpatients were recruited and screened with the Hospital Anxiety and Depression Scale(HADS).The physicians of the GI departments performed routine clinical diagnosis and management without knowing the HADS score results.Subjects with HADS scores≥8 were subsequently interviewed by psychiatrists using the Mini International Neuropsy-chiatric Interview(MINI)to make further diagnoses. RESULTS:There were 1059 patients with HADS score ≥8 and 674(63.64%)of them undertook the MINI interview by psychiatrists.Based on the criteria of Diagnostic and Statistical Manual of Mental Disorders (4th edition),the adjusted current prevalence for depressive disorders,anxiety disorders,and comorbidity of both disorders in the GI outpatients was 14.39%, 9.42%and 4.66%,respectively.Prevalence of depressive disorders with suicidal problems[suicide attempt or suicide-related ideation prior or current;module C (suicide)of MINI score≥1]was 5.84%in women and 1.64%in men.The GI physicians'detection rate of depressive and anxiety disorders accounted for 4.14%. CONCLUSION:While the prevalence of depressive and anxiety disorders is high in Chinese GI outpatients, the detection rate of depressive and anxiety disorders by physicians is low.

关键词：胃肠道抑郁症焦虑症门诊部患病率中国人综合性医院临床诊断

Penile cutaneous horn： a rare case report and review of the literature

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Asian Journal of Andrology 2018年第4期20卷 407-408页

作者： Ying Wang Min-Qi Tu xiao-jing li Qiang Fu Guo-Wei Shi Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China Department of Urology The Fifth People's Hospital of Shanghai Fudan University Shanghai 200240 China Department of Pathology The Fifth People's Hospital of Shanghai Fudan University Shanghai 200240 China

Dear Editor, Cutaneous horn is a clinical term describing a conical hyperkeratotic nodule above the surface of the skin organized in the shape of a miniature horn. Cutaneous horns most frequently appear in sun-exposed areas, typically being found on the face and scalp. We report an unusual case of a cutaneous horn on the penis. Few such cases have been reported in the literature.

关键词： GLANS-PENIS

全球视野下的全纳教育:概念阐释、政策演进与多元实践

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清华大学教育研究 2024年第2期45卷 24-32页

作者：拉特纳·戈什荆晓丽谢芸佳麦吉尔大学综合教育系加拿大北京师范大学国际与比较教育研究院北京100875

本文深度解析了全纳教育这一概念,并以加拿大和中国为例,探讨了全纳教育在西方国家和非西方国家的政策与实践。虽然全纳教育的理念得到了国际社会的广泛认可,但是在实际执行过程中,由于历史文化、社会经济等方面不同,呈现出不同的表现... 详细信息

本文深度解析了全纳教育这一概念,并以加拿大和中国为例,探讨了全纳教育在西方国家和非西方国家的政策与实践。虽然全纳教育的理念得到了国际社会的广泛认可,但是在实际执行过程中,由于历史文化、社会经济等方面不同,呈现出不同的表现形式。推行全纳教育需要对现行教育范式进行深刻改革,以更好地满足所有学生,特别是被排斥和被边缘化的学生群体的个性化教育需求,而实现这一目标需要教育政策制定者、学校管理者、教师、家长等在内的所有利益相关者的共同努力。

关键词：全纳全纳教育全民教育特殊教育

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