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Pulmonary vein isolation implemented by second-generation cryoballoon for treating hypertrophic cardiomyopathy patients with symptomatic atrial fibrillation:a case-control study

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Journal of Geriatric Cardiology 2020年第8期17卷 476-485页

作者： Zhong-Jing CAO xiao-Gang GUO Qi SUN Jian-du YANG hui-Qiang WEI Shu ZHANG Jian MA Arrhythmia Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical ScienceGuangzhouChina

Background Atrial fibrillation(AF)is a generally acknowledged turning-point of the natural history of hypertrophic cardiomyopathy(HCM);however,data from the cryoballoon ablation(CBA)for AF in HCM patients are relatively *** study aimed to evaluate the efficacy and safety of CBA in HCM patients with *** We retrospectively analyzed HCM patients among 1253 patients with symptomatic AF who underwent CBA for pulmonary vein isolation in a single *** study analyzed the AF recurrence and assessed the CBA indexes,including nadir temperature,time-to-isolation,CBA failure,pulmonary vein potentials(PVPs),and redo *** A total of 108 patients were included(mean age:59.0±6.9 years),27 patients(25%)had HCM,with the median follow-up duration of 25.5 *** one-year AF-free rates were 79.0%vs.63.0%(non-HCM ***),while the two-year AF-free rates were 77.8%vs.55.1%[hazard ratio(HR)=2.758,log-rank P=0.024].Patients with persistent AF had poor AF-free rates compared to those with paroxysmal AF(P<0.001).The CBA failure was the most common in the right inferior pulmonary veins,which had the lowest *** Cox regression analysis indicated that HCM and persistent AF were risk factors for AF recurrence(HR=2.74,95%CI:1.29–5.79,P=0.008;and HR=3.97,95%CI:1.85–8.54,P<0.001,respectively).Conclusions The CBA can be effectively and safely used to treat HCM patients with symptomatic *** freedom from AF for HCM patients after CBA is relatively low compared to that for non-HCM patients.

关键词： Atrial fibrillation Cryoballoon ablation Hypertrophic cardiomyopathy Pulmonary vein isolation

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First report of Athelia bombacina causing postharvest fruit rot on pear

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Journal of Integrative Agriculture 2018年第11期17卷 2596-2599页

作者： JIA xiao-hui FU Jun-fan WANG Wen-hui CUI Jian-chao du Yan-min ZHOU Ru-jun SUN Ping-ping Plant Protection College Shenyang Agricultural University Research Institute of Pomology Chinese Academy of Agricultural Sciences

Pear is an important fruit crop in the world. An uncharacterized disease has been observed on pear fruits during cold storage ir~ Suning, Shenzhou, Xinji and other locations in Hebei Province, China. The incidence rate of the disease has reached 10%, and sometimes up to 20%. A particular fungus was consistently isolated from the infected pear fruit and cultured. Based on its morphology, molecular characteristics, pathogenicity and ITS sequence, the fungus was identified as Athelia bombacina. To our knowledge, this is the first report of Athelia bombacina causing postharvest fruit rot on pear.

关键词： pear pathogenicity postharvest Athelia bombacina fruit rot

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Application of a pre-filled tissue expander for preventing soft tissue incarceration during tibial distraction osteogenesis

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World Journal of Clinical Cases 2020年第11期8卷 2181-2189页

作者： hui Chen Xing Teng xiao-Hua Hu Lin Cheng Wei-Li du Yu-Ming Shen Department of Burns and Plastic Surgery Beijing Jishuitan HospitalBeijing 100035China Department of Traumatic Orthopedics Beijing Jishuitan HospitalBeijing 100035China

BACKGROUND Bone transport and distraction osteogenesis has been widely used to treat bone defects after traumatic surgery,but,skin and soft tissue incarceration can be as high as 27.6%.AIM To investigate the efficacy of inserting a tissue expander to prevent soft tissue *** Between January 2016 and December 2018,12 patients underwent implantation of a tissue expander in the subcutaneous layer in the vicinity of a tibial defect to maintain the soft tissue in position.A certain amount of normal saline was injected into the tissue expander during surgery and was then gradually extracted to shrink the expander during the course of transport distraction *** tissue expander was removed when the two ends of the tibial defect were close *** In all 12 patients,the expanders remained intact in the subcutaneous layer of the bone defect area during the course of transport distraction *** bone transport was adequate,the expander was removed and the bone transport process was *** the whole process,there was no incarceration of skin and soft tissue in the bone defect *** occurred in one patient,who experienced poor wound *** The pre-filled expander technique can effectively avoid soft tissue *** authors’primary success with this method indicates that it may be a valuable tool in the management of incarcerated soft tissue.

关键词： Tissue expander Tibial defect Bone transport Skin and soft tissue incarceration Distraction osteogenesis

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Fabrication and Characterizations of Metallic Mg Containing PMMA-Based Partially Degradable Composite Bone Cements

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Acta Metallurgica Sinica(English Letters) 2019年第7期32卷 808-816页

作者： xiao Lin Adrian Chan xiao-xiao Tan hui-Lin Yang Lei Yang Orthopaedic Institute Soochow University Suzhou 215006 China Department of Orthopaedics The First Affiliated Hospital of Soochow University Suzhou 215006 China Waterloo Institute for Nanotechnology (WIN) University of Waterloo 200 University Ave West Waterloo ON Canada School of Materials Engineering Shanghai University of Science and Engineering Shanghai 201620 China

Inadequate strength at the bone/cement interface is one of the main drawbacks of poly(methylmethacrylate)(PMMA) bone cement in the current orthopedic surgeries. In the present work, a partially degradable PMMA/Mg composite bone cement (PMC) was developed for enhancing the bone/cement interfacial strength, which is proposed to be accomplished by increasing the osteo-conductivity of PMMA and enhancing the mechanical interlocking between bone tissue and the porous PMMA surface formed by the degradation of Mg on the surface of the cement. PMCs were prepared with various concentrations of Mg particles with different sizes and alloy compositions. The effects of Mg particle size, composition and content on the injectability, mechanical and degradation properties, and biocompatibility of PMCs were evaluated. The results show that these parameters affected the properties of the PMCs simultaneously. The good injectability and compressive strengths of PMMA were preserved, while the compatibility to osteoblasts was enhanced when adding Mg particles in a proper manner. The PMCs degraded at the surface with time and formed porous surface structures in the physiological environment, while maintaining the original compressive strengths. This preliminary study shows that the PMC is promising for minimally invasive orthopedic surgery;however, it still requires to be optimized and evaluated in the future.

关键词： Biomaterials Composite Magnesium Poly(methylmethacrylate) Bone cement Kyphoplasty

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生物材料促进角膜碱烧伤修复的作用机制和应用途径

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中国组织工程研究 2025年第10期29卷 2162-2170页

作者：肖辉李冬妍汲婧王丽珍北京航空航天大学生物与医学工程学院生物力学与力生物学教育部重点实验室北京市生物医学工程高精尖创新中心北京市100083

背景:在角膜碱烧伤治疗中,传统治疗方法存在多种局限,尤其在控制炎症、预防新生血管形成和抑制角膜瘢痕化方面表现不佳。天然材料、合成材料或复合材料为治疗提供了多元化的选择,然而生物材料促进角膜碱烧伤修复的相关机制尚未形成系统... 详细信息

背景:在角膜碱烧伤治疗中,传统治疗方法存在多种局限,尤其在控制炎症、预防新生血管形成和抑制角膜瘢痕化方面表现不佳。天然材料、合成材料或复合材料为治疗提供了多元化的选择,然而生物材料促进角膜碱烧伤修复的相关机制尚未形成系统深入的认识。目的:对目前生物材料促进角膜碱烧伤修复的国内外研究进行梳理,综述生物材料修复角膜碱烧伤的机制及其应用途径。方法:第一作者以“角膜,碱烧伤,羊膜,透明质酸,胶原,壳聚糖,高分子材料”“Amniotic membrane,Hyaluronic acid,Collagen,Chitosan,Polymer,Cornea,Alkali burn”为关键词在Pub Med、Web of Science、中国知网和万方文献数据库内检索,根据纳入标准和排除标准,最终纳入符合要求的76篇文献进行综述。结果与结论:(1)在角膜碱烧伤修复领域,羊膜、透明质酸、胶原、壳聚糖和可降解高分子材料等生物材料被广泛研究和应用,这些生物材料各有其特点和优缺点,在不同方面都有所突出。(2)首先,羊膜因含丰富的生物活性因子而被认为是最有前景的生物材料之一,其生物相容性良好,并且能够调节角膜炎症反应,但是存在供体短缺和易感染疾病的问题。(3)透明质酸具有良好的保湿性和生物相容性,并且能够提高角膜细胞的生存率和增加角膜透明度。(4)胶原具有良好的生物相容性和支架结构,能够促进角膜细胞的黏附和增殖,促进角膜组织结构的重建。(5)壳聚糖具有良好的生物相容性和可降解性,可作为载体用于药物递送和细胞移植。(6)可降解高分子材料具有较好的降解可控性,可为角膜碱烧伤的修复提供良好的支持和递送平台,但其稳定性和生物相容性仍需进一步研究。(7)综合来看,目前还没有一种生物材料能够完全解决角膜碱烧伤的修复问题,每种生物材料都有其特定的适用场景和局限性。(8)未来的研究方向应该是通过进一步改进生物材料的性能和结构,探索更有效的组合应用方式,以及深入了解生物材料与角膜组织的相互作用机制,以提高角膜碱烧伤的治疗效果和患者的生活质量。

关键词：角膜碱烧伤生物材料修复机制羊膜透明质酸壳聚糖高分子材料综述

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Elevated levels of serum antibodies against alpha-1,6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis

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Protein & Cell 2011年第9期2卷 739-744页

作者： hui Dai xiao-Ming Gao Department of Immunology Peking University Health Science CenterPeking UniversityBeijing 100083China Institute of Biology and Medical Sciences Soochow UniversitySuzhou 215123China

This study was undertaken to investigate whether levels of anti-alpha-1,6-glucan antibodies in human sera correlate with rheumatoid arthritis(RA)and systemic lupus erythematosus(SLE).Serum samples were collected from patients with SLE(n=30),RA(n=30)and healthy adult ***,IgA and IgM levels against alpha-1,6-glucan were measured using enzyme linked immunosorbent ***-alpha-1,6-glucan IgG prevalence was raised in patients with active SLE(73.3%)and RA(60%)compared with healthy controls(13.3%).Strong correlation between anti-alpha-1,6-glucan-IgG levels and anti-perinuclear factor(r=0.642;p<0.05)in RA patients or anti-nuclear antibodies(r=0.675;p<0.05)in SLE patients was *** significant differences in anti-alpha-1,6-glucan-IgA or-IgM levels were noted between different *** conclude that anti-alpha-1,6-glucan-IgG levels were significantly elevated in patients with SLE or RA and positively correlated with disease activity.

关键词： autoantibody anti-alpha-1 6-glucan autoimmune diseases systemic lupus erythematosus rheumatoid arthritis

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Exponential stabilization of an ODE system with Euler-Bernoulli beam actuator dynamics

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Science China(Information Sciences) 2022年第5期65卷 278-279页

作者： xiao-hui WU Hongyinping FENG School of Mathematical Sciences Shanxi University

Dear editor,Recently, finite-dimensional systems with infinitedimensional actuator or sensor dynamics have drawn the attention of researchers worldwide. Many real-world systems can be modeled as ordinary differential equation (ODE)-partial differential equation (PDE) cascade systems, such as traffic flows, chemical reactor processes, heat exchangers,and oil well drilling. In this study, we consider the problem of compensating the actuator dynamics modeled by the Euler-Bernoulli beam (EBB) equation.

关键词： Actuator dynamics compensation Backstepping Euler-Bernoulli Beam ODE-PDE cascade systems Stabilization

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Polarised radio emission associated with HESS J1912+101

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Research in Astronomy and Astrophysics 2019年第3期19卷 123-130页

作者： Wolfgang Reich xiao-hui Sun Max-Planck-Institut für Radioastronomie Department of Astronomy Yunnan Universityand Key Laboratory of Astroparticle Physics of Yunnan Province

The shell-type TeV source HESS J1912+101 was tentatively identified as an old supernova remnant, but is missing counterparts at radio and other frequencies. We analysed the Sino-German Urumqiλ6 cm survey and the Effelsberg λ11 cm and λ21 cm surveys to identify radio emission from HESS J1912+101 to clarify the question of a supernova origin. We find a partial shell of excessive polarisation at λ6 cm at the periphery of HESS J1912+101. At λ11 cm, its polarised emission is faint and suffers from depolarisation, while at λ21 cm, no related polarisation is seen. We could not separate the shell's total intensity signal from the confusing intense diffuse emission from the inner Galactic plane. However, a high percentage of polarisation in the shell's synchrotron emission is indicated. Our results support earlier suggestions that HESS J1912+101 is an old supernova remnant. The synchrotron emission is highly polarised,which is typical for evolved supernova remnants with low surface brightness.

关键词： radio continuum ISM-ISM individual objects HESS J1912+101-ISM magnetic fields

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Embracing the age of artificial intelligence:paradigm shifts,opportunities,and challenges in the treatment of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Science China(Life Sciences) 2024年第6期67卷 1302-1304页

作者： Zhuo-Yu An xiao-hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China

Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an important medical development in treating hematological ***,the risk of acute graft-versus-host disease(a GVHD)severely limits its use.a GVHD is a sev... 详细信息

关键词： hematopoietic graft artificial

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BGP-Reflection Functors and Lusztig's Symmetries of Modified Quantized Enveloping Algebras

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Acta Mathematica Sinica,English Series 2013年第10期29卷 1833-1856页

作者： Jie xiao Ming hui ZHAO Department of Mathematical Sciences Tsinghua University College of Science Beijing Forestry University

Let U be a quantized enveloping algebra and U its modified form. Lusztig gives some symmetries on U and U. In view of the realization of U by the reduced Drinfeld double of the Ringel- Hall algebra, one can apply the BGP-refiection functors to the double Ringel-HM1 algebra to obtain Lusztig＇s symmetries on U and their important properties, for instance, the braid relations. In this paper, we define a modified form Hof the Ringel-Hall algebra and realize the Lusztig＇s symmetries on U by applying the BGP-reflection functors to H

关键词： BGP-reflection functors Lusztig's symmetries Ringel-Hall algebras

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